I-Attokana yenzelwe ukwelashwa ngohlobo 2 lwesifo sikashukela. Iphathwa ngomlomo. Umuthi awungene esikhundleni se-insulin, kepha unomthelela ekujwayekeni kwe-glycemia.
Igama Lezwe elingafanele
INN - IKaragliflozin.
I-Attokana yenzelwe ukwelashwa ngohlobo 2 lwesifo sikashukela.
I-ATX
A10BX11
Khipha amafomu nokwakheka
Ukwenziwa kwamacwecwe kufaka i-canagliflozin hemihydrate ngesilinganiso esilingana ne-100-300 mg ye-canagliflozin. Ukwakheka kwezakhi ezisizayo kufaka phakathi izinto ezilungisa ukwakheka kwethebhulethi futhi zisize ukusakazwa kwento esebenzayo emzimbeni.
Kutholakala ngohlobo lwezibhebhe ze-100 noma ezingama-300 mg, ifilimu efakwe nge-tint ephuzi. Ithebhulethi ngayinye inengozi ehlukile yokuqhekeka.
Isenzo se-Pharmacological
Inomphumela we-hypoglycemic. I-Kanagliflosin uhlobo 2 sodium glucose cocransporter inhibitor. Ngemuva komthamo owodwa, umuthi unyusa ukuphuma kwe-glucose yizinso, esiza ukunciphisa ukuqina kwegazi lakho. Umuthi uyasebenza ekwelapheni isifo sikashukela esinga-insulin. Akhulisi ukufihlwa kwe-insulin.
Umuthi uyasebenza ekwelapheni isifo sikashukela esinga-insulin.
Kukhuphuka i-diuresis, okuholela nokuncipha kokuhlushwa koshukela egazini. Izifundo zemitholampilo zibonisa ukuthi ukusetshenziswa kwomuthi nsuku zonke kwehlisa umngcele we-renal we-glucose futhi kubenza kube yaphakade. Ukusetshenziswa kwamalungiselelo we-canagliflozin kunciphisa i-glycemia ngemuva kokudla. Ukusheshisa ukukhishwa kwe-glucose emathunjini.
Ekuqhubekeni kwezifundo, kuye kwafakazelwa ukuthi ukusetshenziswa kwe-invokana njenge-monotherapy noma njengesijobelelo ekwelashweni nezinye izidakamizwa ze-hypoglycemic, uma kuqhathaniswa ne-placebo, kusiza ukwehlisa i-glycemia ngaphambi kokudla nge-1.9-2.4 mmol ilitha ngalinye.
Ukusetshenziswa komuthi kusiza ukunciphisa i-glycemia ngemuva kokuhlolwa kokubekezelela noma ibhulakufesi elihlanganisiwe. Ukusetshenziswa kwe-canagliflozin kunciphisa ushukela nge-2.1-3.5 mmol ilitha ngalinye. Kulokhu, umuthi usiza ukuthuthukisa isimo samaseli e-beta kumanyikwe futhi andise inani lawo.
I-Pharmacokinetics
Ngemuva kokuphathwa ngomlomo, into esebenzayo igxiliselwa egazini iphuma emgudwini wokugaya ukudla. Iqoqo eliphezulu lezakhi ezisebenzayo ku-plasma lifinyelelwa ngemuva kwamahora we-1-2. Isikhathi umuthi osuswa uhhafu egazini ngamahora ayi-10-13. Iqoqo lokulinganisa lezinto ezisebenzayo egazini lifinyelelwa ezinsukwini ezi-4 ngemuva kokuqala kokwelashwa.
Ngemuva kokuphathwa ngomlomo, into esebenzayo igxiliselwa egazini iphuma emgudwini wokugaya ukudla.
I-bioavailability ye-Encokany ingama-65%. Ukudla ukudla okunamafutha akukuthinti kabi i-pharmacokinetics ye-canagliflozin. Ngokuvumelana nalokhu, umuthi uvunyelwe ukuthathwa womabili uma kudliwa ukudla, nangemva kwalokho. Ukuze uzuze ukubuyiswa okuphezulu kokufakwa kweglue, kunconywa ukuphuza la mapilisi ngaphambi kokudla kwasekuseni.
Umkhiqizo usatshalaliswa kahle kuwo wonke izicubu. Cishe igxile ngokuphelele ngamaprotheni e-plasma. Ngaphezu kwalokho, lobu budlelwano abuxhomekekile kumthamo futhi abuthinti ukusebenza kwezintso noma ukwehluleka kwesibindi.
I-metabolabolism yenziwa yi-glucuronidation. Le nqubo yenzeka ngenxa yomsebenzi wama-enzyme wesibindi. Ama-Metabolites atholakala emgodini, umchamo. Ingxenye encane yezidakamizwa ikhishwa emzimbeni yizinso ezingashintshiwe.
Umsebenzi wezinso ongasebenzi kahle awuthinti ukuhlangana kwe-plasma yomuthi. Ukuphazamiseka ekusebenzeni kwesibindi nobudala besiguli akuthinti ukwabiwa kwento esebenzayo kanye nokusebenza kwayo kwe-metabolism.
Ucwaningo lwe-pharmacokinetics kubantu abangaphansi kweminyaka engu-18 alwenziwe.
Izinkomba zokusetshenziswa
Kubhekiselwe ukwelashwa kwe-mellitus engavikelekile nge-insulin. Amaphilisi ahlanganiswa nokudla okuphansi kwe-carb nokuzivocavoca. Iphinde isetshenziswe njengengxenye yokwelashwa okuhlangene ezigulini ezinqunywe i-insulin.
Contraindication
Ngeke ithathwe nge:
- hypersensitivity engxenyeni esebenzayo;
- Uhlobo 1 sikashukela;
- i-ketoacidosis yesifo sikashukela;
- ukungasebenzi kahle kwe-renal noma hepatic;
- isikhathi sokumiswa komzimba;
- ngaphansi kweminyaka eyi-18.
Ngokunakekela
Sebenzisa ngokuqapha kubantu abanenkinga enkulu yezinso.
Uma isiguli siphuthelwa umthamo, khona-ke kufanele siphuze iphilisi ngokushesha okukhulu. Akudingekile ukunxephezela umthamo ophuthelwe ngethamo eliphindwe kabili (ukuze uvikele ukuthuthukiswa kwe-hypoglycemia).
Ungayithatha kanjani i-Invocana?
Ngoshukela
Ngohlobo 2 sikashukela, thatha ithebhulethi eyi-1 ngaphambi kokudla kwasekuseni. Umthamo onconyiwe ngu-0.1 noma 0,3 g.
Kuqala ngokushesha kangakanani ukwenza okuthile?
Amahora angama-1-2 ngemuva kokungenisa.
Imiphumela emibi
Ngokusetshenziswa okwengeziwe kwe-insulin, i-hypoglycemia ivame ukukhula. Kwezinye izimo, iziguli zingahle zikhuphule inani le-potassium ku-serum yegazi. Le nto ihamba kwesikhashana futhi ayidingi ukwelashwa okubonakalayo.
Ngokusetshenziswa okwengeziwe kwe-insulin, i-hypoglycemia ivame ukukhula.
Kwesinye isikhathi kuba nokwanda ekuqoqweni kwe-cholesterol esezingeni eliphansi. Ukusetshenziswa isikhathi eside komuthi kudinga ukulawulwa kwe-cholesterolemia.
Lapho usebenzisa i-Attokana ngokwesilinganiso semithamo yokwelapha, kukhuphuka amaphesenti ama-hemoglobin egazini. Le nto yinto yesikhashana futhi ayiholeli ezimeni ezingezinhle.
Amapheshana wesisu
Ukuthatha umuthi kubangela ukuphazamiseka kokusebenza okujwayelekile kwendlela yokugaya ukudla. Iziguli zizwa ukomela ngokweqile, umlomo owomile futhi uhlushwa ukuqunjelwa.
Kusuka ohlelweni lomchamo
Mhlawumbe ukwephulwa kokusebenza okujwayelekile kwezinso ngendlela yokuchama kaningi nokukhipha inani elikhulu loketshezi. Indlela yokuphuza yesiguli kuleli cala iyashintsha, futhi uqala ukusebenzisa isilinganiso esikhulu soketshezi. Izinkanuko ezingafanele zingahle zivele, inqobo nje uma kungekho mchamo esinyeni.
Mhlawumbe ukwephulwa kokusebenza okujwayelekile kwezinso ngendlela yokuchama kaningi nokukhipha inani elikhulu loketshezi.
Kusuka ohlelweni lwezitho zofuzo
Emadodeni, i-balanitis ne-balanoposthitis ingakhula. Abesifazane bavame ukuba ne-vaginal pathologies kanye ne-vulvovaginal candidiasis (thrush), izifo zangasese.
Kusuka ohlelweni lwezinhliziyo
Mayelana nokwehla kwethamo legazi, isiyezi, ukwehla kwengcindezi yegazi ngokushintsha kwesikhundla somzimba, ukuqubuka esikhunjeni nge-urticaria kungenzeka. Ukuphuza umuthi kudala ukomisa.
Engxenyeni yesibindi ne-biliary
Akubangeli ukulimala kwesibindi kanye noshintsho emsebenzini wama-enzyme wesibindi.
Allergies
Kwezinye izimo, kunomthelela ekubonakala kokuphendula komzimba ngesimo sokuqhuma kwesikhumba noma i-edema.
Kwezinye izimo, kunomthelela ekubonakala kokuphendula komzimba ngendlela yokuqhuma kwesikhumba.
Umthelela ekhonweni lokulawula izindlela
Ngenxa yobungozi be-hypoglycemia, ukushayela ngasikhathi sinye noma ukusebenza ngezinqubo eziyinkimbinkimbi akunconywa.
Imiyalo ekhethekile
Ukusetshenziswa kwalo muthi wesifo sikashukela sohlobo 1 akufundwanga. Imininingwane ngemiphumela yokwelashwa ayitholi imiphumela ye-mutagenic ne-carcinogenic emzimbeni.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Inhloso yalomuthi ngesikhathi sokukhulelwa nokuncelisa ibele ayenziwa. Yize ucwaningo lwezilwane lungakhombisanga imiphumela emibi yesidakamizwa esibelethweni, ama-gynecologists kanye nabezokubeletha abakukhuthazi ukusetshenziswa kwamaphilisi ngenkathi uphethe ingane.
Ukwelashwa kwezidakamizwa nakho kwenqatshelwe ngesikhathi sokubeletha, ngoba into esebenzayo yamathebulethi iyakwazi ukungena obisini lwebele futhi isebenze emzimbeni wosana olusanda kuzalwa.
Ukwelashwa kwezidakamizwa nakho kwenqatshelwe ngesikhathi sokubeletha, ngoba into esebenzayo yamathebulethi iyakwazi ukungena obisini lwebele futhi isebenze emzimbeni wosana olusanda kuzalwa. Umphumela womuthi ekuzalweni awuzange ufundwe.
Ukuqokwa izingane ezihilela izingane
Ukusetshenziswa kwalesi sidakamizwa kwenqatshelwe ngokuphelele ezigulini ezingaphansi kweminyaka engu-18.
Sebenzisa ebudaleni
Kuvunyelwe. Akudingi ushintsho kumthamo noma kuhlobo lomthamo.
Ukweqisa
Awekho amacala okweqile kwe-Invocana. Zonke iziguli zazibekezelela ukuphathwa isikhathi eside kwemithamo ephindwe kabili yomuthi. Umthamo owodwa wamathebulethi ayi-5 ku-300 mg awabanga nemiphumela emibi emzimbeni.
Uma kwenzeka kune-overdose, ukwelashwa okuxhasayo kuyadingeka. Ukususa izinsalela zomuthi ezingagxilile, umuthi wokuqunjelwa wesisu uyenziwa noma kunqunywe i-laxative. Ukuxilongwa ngocingo akuyona into engasebenzi.
Ukuxhumana nezinye izidakamizwa
Umuthi ushintsha kancane ukuhlangana kwe-digoxin ku-plasma yegazi. Abantu abathatha lo muthi kufanele baqaphele ikakhulukazi futhi bashintshe umthamo ngesikhathi.
Kwangathi kungashintsha kancane ukumunca nemetabolism yeLevonorgestrel, iGlibenclamide, iHydrochlorothiazide, Metformin, Paracetamol.
Ukuhambisana notshwala
Akukho.
Ama-Analog
Ama-Analogues we-Encokany afaka:
- I-Forsyga;
- I-Baeta;
- IVictoza;
- I-Guarem;
- I-Novonorm.
Imibandela yokuphumula Amakhemisi ekhemisi
Umuthi uhanjiswa emakhemisi kuphela ngemuva kokwethula incwadi kadokotela evela kudokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Amakhemikhali ngamanye angawuthengisa lo muthi ngaphandle kokudinga umuthi. Lapho uthenga umuthi, iziguli zisengozini ngenxa yokuqhamuka nezimo ezisongela impilo.
Intengo ye-Invocana
Izindleko zamathebhulethi angama-30 we-0.1 g - cishe ama-ruble ayizinkulungwane eziyisishiyagalombili. Intengo yamathebulethi angama-30 we-invokana 0,3 g - cishe ama-ruble ayizinkulungwane eziyi-13.5.
Izimo zokugcina zomuthi
Gcina endaweni emnyama futhi epholile, kude nezingane.
Isikhathi sokuphelelwa yisikhathi
Ilungele ukusetshenziswa kungakapheli iminyaka emi-2 kusukela ngosuku lokukhiqizwa. Musa ukusebenzisa amaphilisi ngemuva kwalesi sikhathi.
Umkhiqizi Encokany
Ikhiqizwa emabhizinisini aseJanssen-Ortho LLC, 00778, State Road, km 933. 0.1 Maimi Ward, Gurabo, Puerto Rico.
Phakathi kokufana kwesidakamizwa, i-Forsigu iyodwa.
Ukubuyekezwa mayelana ne-Invocane
Iningi labodokotela kanye neziguli libheka lo muthi njengempumelelo ekwelapheni uhlobo lwesifo sikashukela sohlobo 2.
Odokotela
U-Ivan Gorin, oneminyaka engama-48 ubudala, udokotela wobuchopho, i-Novosibirsk: "Ngincoma u-Invokan ukuthi asisebenzisele iziguli ezinesifo sikashukela esingancikeli i-insulin. Umuthi uphatha kahle ushukela wegazi futhi uvimbela ukukhula kwezinkinga zesifo sikashukela."
USvetlana Usacheva, oneminyaka engama-50, udokotela obulala izidakamizwa, uSamara: "Lesi sidakamizwa silwa ne-hyperglycemia futhi sivimbela ukwanda kwezinkinga zesifo sikashukela. Ngincoma ukuthi bangene esikhundleni salabo abamele i-hypoglycemic agents."
Ukugula
UMatvey, oneminyaka engama-45, eMoscow: "Amacwecwe e-invokana asiza ukulawula lesi sifo sikashukela futhi avikele nezigameko ze-hyperglycemia. Ngiyasibekezelela kahle. Angibonanga imiphumela emibi yokwelashwa."
U-Elena, oneminyaka engu-35 ubudala, uTambov: "Ukuphuza i-Advokana kungcono kunezinye izidakamizwa ukuqinisa inkomba ye-glycemic. Ngokusebenzisa indlela yokudla, kungenzeka ukukugcina kunemikhawulo enconyiwe - hhayi ephakeme kune-7.8 mmol ilitha ngalinye."
U-Olga, oneminyaka engama-47, eSt. Petersburg: "Ngosizo lwe-Attokana, ngilawula inkathi yesifo sikashukela futhi ngivikele i-hypoglycemia noma i-hyperglycemia. Ngemuva kokuqala izifundo ngalo muthi, ngaphawula ukuthi isimo sami nokusebenza kahle kuthuthuke kakhulu."
