I-Reduxin Met isidakamizwa esihlanganisiwe. Kuthinta izinqubo ze-biochemical ezixhumene: kurejista izinga likashukela emzimbeni, kuthuthukisa ukwehla kwesisindo. Umuthi ukhiqizwa ngezindlela ezahlukene zemithamo. Ngokwamukelwa kwabo okuyinkimbinkimbi kunikeza ukusebenza kahle okuphezulu uma kuqhathaniswa nontanga.
Igama Lezwe elingafanele
I-Metformin + Sibutramine + Microcrystalline Cellulose
I-Reduxin Met isidakamizwa esihlanganisiwe.
I-ATX
A08a
Khipha amafomu nokwakheka
Umuthi uyatholakala kumathebulethi namaphilisi. Kubandakanya izinto ezahlukahlukene ezisebenzayo. Iphakheji liqukethe amaphilisi angama-20 noma angama-60. Inani lamaphilisi liyi-2 times ngaphansi: ama-10 noma ama-30 ama-pcs.
Amaphilisi
Ku-1 pc iqukethe i-850 mg ye-metformin hydrochloride. Ukuqanjwa kubandakanya ezinye izinto:
- i-croscarmellose sodium;
- i-microcrystalline cellulose;
- amanzi ahlanziwe;
- i-povidone K-17;
- i-magnesium stearate.
Amakhandlela
Ku-1 pc iqukethe i-sibutramine hydrochloride monohydrate, i-microcrystalline cellulose. Ukuqoqwa kwento yokuqala kungaba ngu-10 no-15 mg, inani le-cellcose ye-microcrystalline - 158,5 mg. Umthamo wengxenye yokugcina awuguquki lapho kusetshenziswa inani elihlukile le-sibutramine. Abahambeli:
- titanium dioxide;
- amadayi;
- i-gelatin.
Umuthi uyatholakala kumathebulethi namaphilisi.
Isenzo se-Pharmacological
Into ngayinye ekwakhiweni kwalesi sidakamizwa inezici ezihlukile. I-Metformin hydrochloride iyi-greatuanide. Le nto ibonakaliswa ngumphumela we-hypoglycemic - umsebenzi wayo oyinhloko ukunciphisa i-glucose egazini iye ezingeni elijwayelekile. Ngesikhathi sokwelashwa, le nto ayithinti ukukhiqizwa kwe-insulin. Ngaphezu kwalokho, i-metformin ithuthukisa ukuthathwa koshukela ngamaseli emisipha. Ezinye izici zifaka:
- ukucindezelwa kokukhiqizwa kwamafutha acid;
- ukwehla kwesilinganiso sama-oxidation;
- ukuqedwa kokuphulwa kokuphendula komzimba kwe-insulin, okuholela ekwandeni kokuhlushwa kwayo egazini;
- ukuncishiswa kokuqukethwe kwezinto eziningi eziphilayo: ama-lipoproteins aphansi, triglycerides;
- ukubuyiselwa kokwakhiwa kwegazi.
Ukuhlelwa ngokwejwayelekile kwamazinga kashukela kungenxa yomsebenzi owandayo wabo bonke abathutha be-membrane. I-Metformin isiza ukwehlisa isisindo, ngoba yehlisa ukutholwa kwama-carbohydrate ngezindonga zamathumbu.
I-Metformin ikhuthaza ukunciphisa umzimba.
Le ngxenye isiza ekuthini i-metabolism engasebenzi kahle (dyslipidemia), inciphise izinga le-cholesterol ephelele, i-lipoproteins ephansi. Ngenxa yalokhu, inqubo yokuthola ukungalawulwa kwesisindo somzimba iyaqina, ngokudla okukhethwe kahle, isisindo singehla.
ISibutramine hydrochloride monohydrate ifeza umphumela wayo ngokubamba iqhaza kwama-amines (metabolites). Njengomphumela wenqubo eminingana ye-biochemical ye-sibutramine hydrochloride, i-monohydrate iguqulwa ibe yinto yokuqala. Ngaphansi kwesenzo sale ngxenye, umsebenzi we-adrenergic ne-central serotonin receptors uyanda. Ngenxa yalokhu, umuzwa wokugcwala uvela, isidingo sokudla siyancipha isikhashana.
Ngaphezu kwalokho, i-microcrystalline cellulose inomthelela ekunciphiseni isisindo. Kuyi-enterosorbent eqeda izimpawu zokudakwa. I-Cellulose inomphumela omuhle ohlelweni lokugaya ukudla.
I-Pharmacokinetics
I-enterosorbent ekwakhiweni kweReduxin Met ayihlangani nezinye izinto zokwelapha futhi ayithakwa yizindonga zamathumbu, iyakhishwa ngesikhathi sokuhamba kwamathumbu. I-bioavailability ye-metformin ingama-50-60%. Le nto ingena ngokushesha kuyi-plasma. Umsebenzi we-Peak ufinyelelwa ngemuva kwamahora we-2,5. I-Metformin ayisebenzi kahle. Into isuswa emzimbeni lapho uchama. Ukuqedwa kwesigamu sempilo akudluli amahora angama-6.5.
ISibutramine idonswa kancane kakhulu. Le nto isebenza ngenkani. Inani eliphakeme lokusebenza kwalo litholakala ngemuva kwamahora ayi-1,2. Izinto ezikhishwa ngesikhathi se-metabolism nazo ziyasebenza, kepha ziqala ukusebenza amahora ama-3-4 ngemuva kokuthatha umuthi. Iningi le-sibutramine likhishwa ngendlela yama-metabolites ngokubamba iqhaza kwezinso. Ukuphila kwesigamu sento okungashintshiwe yihora eli-1. Imikhiqizo yokuguqulwa kwayo isuswa ngaphezulu kwamahora ayi-14-16.
Izinkomba zokusetshenziswa
Umuthi unqunyelwe ukukhuluphala noma ukuthambekela kokuthola isisindo esingalawulwa ezigulini ezinesifo sikashukela sohlobo 2 sikashukela, i-dyslipidemia, iziguli ezine-prediabetes futhi ezimweni lapho ukulungiswa kokudla okunempilo kanye nokuzivocavoca okulinganiselayo kungazange kunikeze imiphumela edingekayo. Isizathu esinqumayo sokuqokwa kwalo muthi siyinkomba yenkomba yomzimba omkhulu - ama-27 kg / m² nangaphezulu.
Umuthi ubekelwe ukukhuluphala noma ukuthambekela kokuthola isisindo esingalawulwa ezigulini ezinesifo sikashukela sohlobo 2.
Contraindication
Kunemikhawulo eminingi ekusebenziseni ithuluzi okukhulunywa ngalo:
- ukusabela ngakunye kunoma iyiphi ingxenye yomkhiqizo;
- isimo esizithandayo, ukoma;
- i-ketoacidosis ngokumelene nesizinda sokuthuthukisa i-mellitus yesifo sikashukela;
- umsebenzi wezinso ongonakalisiwe uma imvume ye-creatinine ingaphansi kuka-45 ml / min;
- i-pathology yesibindi;
- izinto ezingezinhle ezifaka isandla ekuphazamiseni isibindi: ukugabha, isifo sohudo esingalawulwa, izimo zokushaqeka ezivele ngezizathu ezahlukahlukene, kanye nezifo ezinzima;
- ukungasebenzi kwenhliziyo: ischemia, umfutho wegazi ophezulu, njll;
- i-hypoxia kanye nanoma yiziphi izinto ezingezinhle ezifaka isandla ekuthuthukiseni lesi simo se-pathological;
- ubuthi botshwala;
- i-hyperplasia yezicubu zesikhumba se-Prostate yesimo esincanyana, okuholela kokusebenza kokuchama kokuchama, ngenxa yalokho, ukuqoqwa kwezinto ezisebenzayo okufanele kudalulwe yizinso kukhuphuke;
- ukuphazamiseka kohlelo lwe-endocrine (thyrotooticosis);
- pheochromocytoma;
- ukuvala i-glaucoma;
- i-lactic acidosis;
- ukuncika kwamakhemikhali ezidakamizweni noma ezidakamizweni;
- usizi, ukuhlinzwa, lapho ukwelashwa kwe-insulin kudingekile;
- ukuhlolwa kwakamuva kusetshenziswa ama-ejenti wokuqhathanisa, uma sekudlule amahora angama-48 ngaphambi kwenqubo;
- ukudla okujwayelekile kosuku okungadluli ku-1000 kcal;
- ukuphazamiseka kwemizwa ye-anorexic, i-bulimia;
- imisindo yemvelo yovalo;
- ukuphazamiseka kwengqondo okunzima.
Ngokunakekela
Imibandela eminingi iyaphawuleka lapho kuvunyelwe ukusebenzisa umuthi okukhulunywa ngawo, kepha ukwelashwa kwenziwa ngaphansi kokuqondisa kukadokotela, ngaphezu kwalokho, ukuqapha isimo somzimba ngokucophelela kuyadingeka. Ukuphulwa okuhlobene:
- ukwehluleka kokujikeleza kwegazi okungapheli;
- umlando we-pathology arterial;
- cholelithiasis;
- izimo zokugula ezihambisana nokuqunjelwa, ukungazi kahle;
- ukungasebenzi kwezinso kanye nesibindi ngokuqina okuncane noma okulinganiselayo kokubonakaliswa;
- isithuthwane
- ukuthambekela kokopha;
- ukwelashwa ngama-ejenti athinta umsebenzi we-heestasis kanye ne-platelet;
- ukukhulisa ukusebenza komzimba emzimbeni weziguli ezingaphezulu kweminyaka engama-60.
Ungayithatha kanjani i-Reduxine Met
Umuthi ngezindlela ezahlukahlukene (amaphilisi, amaphilisi) uphuzwa nokudla, mhlawumbe ekuseni.
Umuthi uphuzwa nokudla, mhlawumbe ekuseni.
Ungayithatha kanjani ukuze unciphise isisindo
Ukudaya irejimeni esigabeni sokuqala: i-1 ithebhulethi kanye ne-1 capsule, kanye nethamo le-sibutramine kufanele libe ngu-10 mg. Ngesikhathi sokulashwa, isisindo somzimba kanye noshukela kugadwe. Uma isimo sesiguli singazange sithuthuke kungakapheli izinsuku eziyi-14, khuphula umthamo we-metformin amahlandla ama-2, qhubeka uthathe i-1 capsule. Kulokhu, inani lomuthi osezibhebheni kufanele lihlukaniswe ngemithamo emibili, ezonciphisa ubungozi bokungaphenduki okuhle. Inani eliphakeme lemihla ngemihla le-metformin liyi-2550 mg, noma amaphilisi ama-3.
Uma kungakapheli amasonto amane isisindo somzimba singakashintshi kakhulu, kuvunyelwe ukwandisa kancane kancane isilinganiso se-sibutramine ku-15 mg / ngosuku.
Uma umuthi ungasizi ukwehlisa isisindo kungakapheli izinyanga ezintathu, ukwelashwa kuyamiswa.
Futhi, umuthi ubhekwa njengengasebenzi uma, ekugcineni kwenkambo, isisindo somzimba sanda futhi. Kulokhu, ukusetshenziswa kabusha kwesidakamizwa akunconywa.
Ukuthatha umuthi wesifo sikashukela
Kulesi simo se-pathological, kuvunyelwe ukusebenzisa uhlelo olujwayelekile: i-10-15 mg ye-sibutramine ne-850-1700 mg ye-metformin. Umthamo wasekuseni - 1 ithebhulethi kanye 1 capulethi. Kusihlwa, uma kunesidingo, thatha elinye ithebhulethi eli-1. Isikhathi esivumelekile sokwelashwa kwesifo sikashukela unyaka owodwa. Uma ufuna ukuqhubeka nenkambo yokwelashwa, i-sibutramine iyakhanselwa, ngemuva kwalokho kuthathwe kuphela i-metformin.
Imiphumela emibi Reduxine Met
Izimpawu ezingase zivele nomkhuhlane ziyaphawulwa, ubungozi bokukhula kwe-edema, i-thrombocytopenia, kanye nokuvela kobuhlungu emuva kubuhlungu.
Amapheshana wesisu
Izitulo ezinamanzi, ukuqunjelwa, ukuphefumula, isicanucanu, ukuhlanza, isifiso sokulimala, izinhlungu esiswini, ukungasebenzi kahle kwesibindi, i-hepatitis.
Isistimu yezinzwa ephakathi
Ukudana, ukozela, ukuqina. Kukhona ukwephula ukunambitheka. Ubuhlungu bekhanda, isiyezi, ukoma kwezwumbu lwama-mucous asemgodini womlomo kuvela.
Kusuka ohlelweni lomchamo
Jade esigabeni esibuhlungu.
Kusuka ohlelweni lwezitho zofuzo
I-Dysmenorrhea.
Kusuka ohlelweni lwezinhliziyo
Ukushintsha kwesilinganiso senhliziyo, ukukhuphuka komfutho wegazi.
Allergies
Ukulunywa, ukuqunjelwa, i-erythema, ukukhuphuka kokukhula kwezinsini zamathumbu.
Umthelela ekhonweni lokulawula izindlela
Ayikho imikhawulo eqinile, noma kunjalo, umuthi ungathinta kabi amandla okushayela izimoto. Ngalesi sizathu, kufanele kuqashelwe ngenkathi ushayela.
Umuthi ungathinta kabi amandla okushayela izimoto.
Imiyalo ekhethekile
Kubantu abangaphezu kweminyaka yobudala engama-65, lesi sidakamizwa asinqunyelwe.
Ezigulini ezinesifo sikashukela okuthiwa i-mellitus esihlulekile ngokwezinso, ubungozi bokukhula kwe-lactic acidosis luyakhula.
Umuthi awuthathwa ngaphambi kokuhlinzwa. Yekani ukwelashwa amahora angama-48 ngaphambi kokuhlinzwa.
Ngokulashwa isikhathi eside ngokumelene nesizinda sokungasebenzi kahle kwezinso, imvume ye-creatinine kufanele ibhekwe kanye ngonyaka.
Umuthi ungasetshenziswa kuphela ezimweni lapho izinyathelo ezingezona izidakamizwa okuhloswe ngazo ukunciphisa isisindo somzimba zinganikanga ngomphumela oyifunayo.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ithuluzi livinjelwe ukusetshenziswa.
Ukuqokwa kwe-Reduxine Met ezinganeni
Ayisebenzi kuze kube yiminyaka eyi-18.
Ukweqisa kwe-Reduxine Met
Uma usebenzisa inani elandayo le-metformin, ubungozi bokukhula kwe-lactic acidosis luyanda. Ukuguqula isimo sesiguli sibe nalesi sifo esinjalo, inkambo yokwelashwa ngeReduxin Met iyamiswa, i-hemodialysis yenziwa esibhedlela.
ISibutramine kuyaqabukela ivuse ukuthuthukiswa kokungaphenduki okuhle, noma kunjalo, kwezinye izimo, i-tachycardia, ikhanda kanye nesiyezi kungenzeka, ingcindezi iyanda. Izimpawu ziyanyamalala uma uphazamisa isifundo.
ISibutramine kuyaqabukela ivuse ukuthuthukiswa kokungaphenduki okuhle, kepha kwezinye izimo, ingcindezi iyanda.
Ukuxhumana nezinye izidakamizwa
Kwenqatshelwe ukuhlanganisa ama-metformin nama-ejenti we-radiological umehluko aqukethe iodine.
Ngokuqapha, umuthi okukhulunywa ngawo usetshenziswa kanye ne-Chlorpromazine, iDanazole, i-glucocorticosteroids, i-diuretics, iNifedipine, i-ACE inhibitors kanye ne-beta-2-adrenergic agonists ngendlela yesisombululo somjovo.
Ukuhambisana notshwala
Umuthi unesandla ekuthuthukiseni i-lactic acidosis, uma ihlanganiswa neziphuzo eziqukethe utshwala.
Ama-Analog
Ukufakwa esikhundleni okusebenzayo:
- Ukukhanya kweReduxin;
- IGoldline Plus;
- I-Turboslim.
Umehluko weReduxin Met kusuka kuReduxin
Umenzeli okukhulunywa ngaye uqukethe izinto ezi-3 ezisebenzayo, ezenza ukuthi zisebenze kakhulu kunama-analogues amaningi. I-Reduxin ibonakala ngokwakhiwa kwezakhi ezimbili, i-sibutramine, i-cellcose ye-microcrystalline njengezakhi ezisebenzayo.
Imibandela yekhefu lekhemisi
Umuthi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Cha.
Intengo yeReduxin Met
Izindleko ezijwayelekile ngama-ruble ayi-3000.
Izimo zokugcina zomuthi
Amazinga okushisa aphezulu egumbini: + 25 ° C. Umkhiqizo akufanele udalulwe ukukhanya kwelanga.
Isikhathi sokuphelelwa yisikhathi
Ithuluzi ligcina izakhiwo zeminyaka engu-3.
Umkhiqizi
E-OZONE, eRussia.
Ukubuyekezwa mayelana neReduxine Met
Odokotela
I-Aliluev A.A., i-Therapist, iminyaka engama-43, iKrasnodar
Umuthi udinga ukuqaphela lapho usebenzisa, ngoba unezinto eziningi eziphikisayo. Ngesikhathi sokwelashwa, igazi, ingcindezi, ukushaya kwenhliziyo kubhekwa.
UPavlova O. E., umondli wezempilo, oneminyaka engama-39 ubudala, Khabarovsk
Ikhambi elihle. Isiza ukuyeka ukukhuluphala ngokweqile emafutheni. Uma ulwakha kahle uhlelo lwamandla, ungathola imiphumela emihle.
Iziguli
U-Ana, oneminyaka engama-37, uPenza
Ngaphuza umuthi izinyanga eziningi. Umzimba awuzange ubekezelele kahle, ngakho-ke inkambo yema ngaphambi kwesikhathi.
U-Anastasia, oneminyaka engama-33, uBransk
Nginesifo sikashukela. Ngigcina ukweqa okungapheli kwesisindo - kukhuphuka kuphela ngendlela enkulu. Ngosizo lweReduxin, ungalawula le nqubo kancane.
Ukulahlekelwa isisindo
UValentina, oneminyaka engama-29 ubudala, eSt
Ngathatha umuthi lapho isisindo sanda ngesikhathi sokukhulelwa. Udokotela wathi okokuqala udinga ukuyeka ukuphuma kwe-lactation, ngakho-ke ukwelashwa kwaqala ngemuva kweminyaka eyi-1.5. Ngalandela ukudla, ngasebenza ejimini futhi ngasikhathi sinye amaphilisi namaphilisi. Ngemuva kwezinyanga ezi-2, umphumela wawusivele ubonakele kancane.
U-Olga, oneminyaka engama-30, uVladivostok
Ngesikhathi sokudla i-Reduxine, iMet yayisekela umzimba ngosizo lwamavithamini, ngoba kwakudingeka ukuthi kudliwe amakhalori aphansi. Isifundo sifushane impela - izinyanga ezi-3. Ngalesi sikhathi, bekungenakwenzeka ukunciphisa isisindo, kepha izinguquko ezincane bezisabonakala. Ngemuva kwesikhashana ngizoqhubeka nokuthatha lesi sidakamizwa.
