I-Metformin Teva ilungiselelo leqembu le-Biguanide, elibonakaliswa umphumela we-hypoglycemic. Kunconyelwa ukuthi zisetshenziswe iziguli ezinesifo sikashukela okuthiwa yi-mellitus. Leli thuluzi linemikhawulo eminingi yokusetshenziswa, futhi ubukhulu bawo bucishe babuncane. Phakathi kwezinzuzo zomuthi ukukwazi ukunciphisa isisindo somzimba.
Igama Lezwe elingafanele
I-Metformin.
I-ATX
A10BA02.
I-Metformin Teva ilungiselelo leqembu le-Biguanide, elibonakaliswa umphumela we-hypoglycemic.
Khipha amafomu nokwakheka
Umkhiqizo ubonakala ngefomu eliqinile. Amathebulethi ahlinzeka ngomphumela omude, ngenxa yokuba khona kwegobolondo lefilimu elikhethekile. Umuthi uhloselwe ukusetshenziswa komlomo. Into yegama elifanayo (metformin) isetshenziswa njengesithako esikhulu esisebenzayo. Ukuhlushwa kwayo kwithebhulethi eyi-1 kungahluka: 500, 850 no-1000 mg.
Ezinye izinto ezihlanganisiwe azibonisi umsebenzi we-hypoglycemic, lokhu kufaka:
- i-povidone K30 ne-K90;
- i-silicon dioxide colloidal;
- i-magnesium stearate;
- igobolondo Opadry elimhlophe Y-1-7000H;
- titanium dioxide;
- macrogol 400.
Ungasithenga lesi sidakamizwa okukhulunywa ngaso emaphepheni amakhadibhodi aqukethe 3 noma 6 amanxeba, kuthebhulethi eyishumi.
Isenzo se-Pharmacological
IBiguanides, iqembu okuyi-metformin, alikhulisi ubukhulu bokukhiqizwa kwe-insulin. Umgomo wesidakamizwa usekelwe ekushintsheni kwesilinganiso se-inulin ngezindlela ezahlukahlukene: nakanjani mahhala. Omunye umsebenzi waleli thuluzi ukwandisa isilinganiso se-insulin kuma-proinsulin. Ngenxa yalokhu, ukunqandwa kokuthuthukiswa kokumelana ne-insulin kuyaphawulwa (ukwephulwa kokuphendula kwe-metabolic ku-insulin, okuholela ekwandeni kokuhlushwa kwayo egazini).
Ngaphezu kwalokho, ukwehla kwe-plasma glucose kutholakala nangezinye izindlela. Kunomzila we-metabolic onomthelela ekwakhekeni kweglucose. Ngasikhathi sinye, isilinganiso sokumuncwa kwalesi sidalwa ngezindonga zesistimu yokugaya ukudla siyancipha. Izinga lokucubungula ushukela kwezicubu liyakhuphuka.
Ngenkathi udla umuthi, ukunciphisa umzimba kungenzeka.
Enye indawo yokusebenza kwe-metformin yikhono lokuthonya i-lipid metabolism. Kulokhu, kukhona ukwehla kokuqoqwa kwezinto eziningi ku-serum yegazi: cholesterol, triglycerides, low density lipoprotein. Ngaphezu kwalokho, ukugqugquzeleka kwe-cellular metabolism kuyaqapheleka, njengomphumela wokuthi i-glucose iguqulwa ibe yi-glycogen. Ngenxa yalezi zinqubo, ukwehla kwesisindo somzimba kuyabonakala, noma ukuthuthukiswa kokukhuluphala kuvinjelwe, okuyi-complication ejwayelekile kwisifo sikashukela i-mellitus.
Imiyalo yokusebenzisa iMetformin Richter.
Ngabe i-Detralex 1000 isetshenziselwe ini? Funda kabanzi esihlokweni.
Izibhebhe ze-Gentamicin ziyi-antibiotic ebanzi engabonakali.
I-Pharmacokinetics
Inzuzo yesidakamizwa ukutholwa kwayo ngokushesha emgudwini wokugaya ukudla. Amathebhulethi akhululwayo akhishwa yi-bioavailability ngezinga lama-50-60%. Umsebenzi ophakeme wento yesidakamizwa utholakala emahoreni angama-2,5 alandelayo ngemuva kokuthatha umuthi. Inqubo yokuhlehlisa (ukwehla kokuxineka kwekhompiyutha esebenzayo) iqala ukukhula ngemuva kwamahora ayi-7.
Njengoba kunikezwe ukuthi into esemqoka ayinawo amandla okubopha kumaprotheni egazi, ukusatshalaliswa kwezicubu kwenzeka ngokushesha okukhulu. I-Metformin ingatholakala esibindini, izinso, izidakamizwa zesisu, namaseli abomvu egazi. Izinso zinesibopho senqubo yokuphuma. Ingxenye eyinhloko isuswa emzimbeni ungashintshiwe. Isigamu sempilo ezimweni eziningi ngamahora ayi-6.5.
Izinkomba zokusetshenziswa
Inkomba eyinhloko yokusetshenziswa kwalesi sidakamizwa uhlobo 2 sikashukela. Umuthi ubekelwe ukwehla kwesisindo uma ukudla nokuzivocavoca kunganikanga ngomphumela oyifunayo. I-MS ingasetshenziswa njengengxenye yokwelapha okuyinkimbinkimbi noma njengesilinganiso esiyinhloko sokwelapha.
Inkomba eyinhloko yokusetshenziswa kwalesi sidakamizwa uhlobo 2 sikashukela.
Contraindication
Izimo eziningana ze-pathological lapho kwenqatshelwe ukusebenzisa isidakamizwa esivezwa ngumphumela we-hypoglycemic:
- ukusabela kwe-hypersensitivity emiphumeleni ye-metformin noma enye indawo ekwakhiweni kwe-ejenti;
- inani le-pathologies ebangelwa isifo sikashukela: i-thoroma ne-coma, i-ketoacidosis;
- ukungenelela kokuhlinzwa, ukulimala okukhulu, uma kulezi zimo kunconywa i-insulin;
- izifo ezihambisana ne-hypoxia: ukuhluleka kwenhliziyo, umsebenzi wokuphefumula okhubazekile, i-myocardial infarction;
- i-lactic acidosis;
- ubuthi umzimba ubuthi obungapheli botshwala;
- Ukudla lapho kunganconywa khona ukuthi kudlule umkhawulo wezinsuku eziyi-1000 kcal.
Ngokunakekela
Iziguli esezikhulile kufanele zelashwe ngaphansi kokuqashwa ngudokotela. Lesi sincomo sisebenza kubantu abangaphezu kweminyaka engama-60 uma benza umsebenzi onzima womzimba.
Iziguli esezikhulile kufanele zelashwe ngaphansi kokuqashwa ngudokotela.
Ungayithatha kanjani iMetformin Teva
Lapho ukhetha uhlobo lokwelashwa, izinhlobonhlobo nobunzima besimo se-pathological ziyabhekwa.
Ngaphambi noma ngemuva kokudla
Ukudla kunomthelela ongemuhle ekuthweni kwengxenye eyinhloko: kudonswa kancane, ngoba ngenxa yalokhu, umuthi uqala ukusebenza ngemuva kwesikhathi eside. Noma kunjalo, lokhu akukuthinti ukusebenza kahle kwethuluzi. Ngalesi sizathu, kuvunyelwe ukuthatha amaphilisi esiswini esingenalutho noma ngesikhathi sokudla, uma kunezinkomba zalokhu, ngokwesibonelo, izinqubo zokuguguleka esiswini noma emathunjini.
Ukudla kunomthelela omubi ekufakweni kwengxenye eyinhloko.
Ukuthatha umuthi wesifo sikashukela
Imiyalo yokusetshenziswa komuthi njengethamo elikhulu lokwelapha noma, kanye nezinye izindlela ezibonakaliswa ngumphumela we-hypoglycemic:
- Esigabeni sokuqala, i-0.5-1 g yento inqunywe kanye ngosuku (kuthathwe kusihlwa). Isikhathi sesifundo asisekho ngaphezu kwezinsuku eziyi-15.
- Kancane kancane, inani lezinto ezisebenzayo lenyuka ngezikhathi ezi-2, futhi leli dosi kufanele lihlukaniswe ngemithamo emi-2.
- I-1.5-2 g yesidakamizwa ichazwe njengokwelashwa kwesondlo, le mali ihlukaniswe ngemithamo engu-2-3. Kwenqatshelwe ukuthatha ngaphezu kwe-3 g yesidakamizwa ngosuku.
Umuthi unikezwa kanye ne-insulin. Kulokhu, thatha u-0.5 noma u-0,85 mg izikhathi ezingama-2-3 ngosuku. Umthamo onembe kakhudlwana ungakhethwa ngokususelwa ekuhlolweni kwe-glucose. Ukubalwa kabusha kwenani lomuthi kwenziwa ngemuva kwamaviki ayi-1-1,5. Uma ukwelashwa okuhlanganiswa kwenziwa, ngaphezu kwe-2 g yesidakamizwa ngosuku akubekiwe.
Umuthi unikezwa kanye ne-insulin.
Ungayithatha kanjani ukuze unciphise isisindo
Umuthi ubekwa njengenyathelo elisekelayo elinomthelela ekujwayekeni kwezinqubo ze-metabolic. Umthamo wansuku zonke onconywayo ngu-0.5 g kabili ngosuku; thatha ekuseni. Uma kunesidingo, kwethulwa umthamo wesithathu (kusihlwa). Isikhathi sesifundo akufanele singeqi izinsuku ezingama-22. Ukwelapha okuphindwayo kuvunyelwe, kepha hhayi ngaphambi kwenyanga eyi-1. Ngesikhathi sokwelashwa, landela ukudla (akukho ngaphezu kwe-1200 kcal ngosuku).
Imiphumela emibi yeMetformin Teva
Ezinye izimpawu zenzeka kaningi, ezinye zivela kaningi. Ezigulini ezinendlela efanayo yokwelashwa, kungavela ukusabela okuhlukahlukene.
Amapheshana wesisu
Kaningi kunezinye izimpawu, isicanucanu, ukuhlanza kwenzeka. Isifiso sokudla siyancipha, esivame ngenxa yobuhlungu esiswini noma ukunambitheka kokuncipha. Ngemuva kokuthatha amaphilisi, kunambitheka insimbi emlonyeni.
Akukabi lula ukwakhiwa kwe-pathologies yesibindi nezinso. Ngemuva kokuhoxiswa kwalo muthi, izibonakaliso ezingezinhle ziyanyamalala zizodwa. Ngenxa yokuphazamiseka komgudu wokugaya ukudla (isibindi), i-hepatitis ingakhula.
Engxenyeni yesikhumba
Ukusheha, ukulunywa, ubomvu esikhunjeni.
Uhlelo lwe-Endocrine
I-Hypoglycemia
Ngasohlangothini lwe-metabolism
I-Lactic acidosis. Ngaphezu kwalokho, lesi simo se-pathological singukuphikisana kokusetshenziswa okwengeziwe kwe-metformin.
Allergies
Kuyaqabukela, i-erythema iba.
Umthelela ekhonweni lokulawula izindlela
Lapho wenza ukwelashwa okuyinkimbinkimbi, kukhona ingozi ye-hypoglycemia. Ngenxa yalesi sizathu, kwenqatshelwe ukushayela izimoto ngesikhathi sokwelashwa nomuthi okukhulunywa ngawo. Uma iMetformin isetshenziswa njengesilinganiso esiyinhloko sokwelapha ngaphandle kweminye imiyalo, lokhu kuhlanganiswa akunakukhula.
Kwenqatshelwe ukushayela izimoto ngesikhathi sokwelashwa nomuthi okukhulunywa ngawo.
Imiyalo ekhethekile
Ngesikhathi sokwelashwa, kubalulekile ukulawula amazinga we-plasma glucose. Ngaphezu kwalokho, kuhlolwa ukwakheka kwegazi kunconyelwa ukwenziwa kwisisu esingenalutho nangemva kokudla.
Uma uhlela ukwenza isifundo se-x-ray usebenzisa umehluko, umuthi umiswa ukuthatha izinsuku ezi-2 ngaphambi kwenqubo. Kuvunyelwe ukuqhubeka nokwelashwa ezinsukwini ezi-2 ngemuva kokuhlolwa kwehadiwe.
Umuthi awusetshenziswa ngaphambi kokuhlinzwa (inkambo iphazamiseka izinsuku ezimbili). Kuyadingeka ukuqhubeka nokwelashwa kungakapheli amahora angama-48 ngemuva kokuhlinzwa.
Isimo sesiguli esinezinkinga zokuxilongwa kwe-renal siqashwa uma kwenziwa ukwelashwa ngama-NSAIDs, izidakamizwa ze-diuretic ne-antihypertensive.
I-Hypovitaminosis (ukusilela kwe-Vitamin B12) kwesinye isikhathi iba ngesikhathi sokwelashwa nge-metformin. Uma ukhansela leli thuluzi, izimpawu ziyanyamalala.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi lapho uzala ingane awuchaziwe. Uma ukukhulelwa kwenzeka ngesikhathi sokwelashwa ngeMetformin, kunconywa i-insulin.
Umuthi lapho uzala ingane awuchaziwe.
Uma unikezwe imininingwane yokuthi ngabe ingxenye eyinhloko ingenela egazini, kufanele uyeke ukuthatha umuthi ngesikhathi se-HB.
Ukunquma iMetformin Teva ezinganeni
Umuthi ungasetshenziswa kusuka eminyakeni eyi-10, kepha ukunakekelwa kumele kuthathwe.
Sebenzisa ebudaleni
Ngesikhathi sokwelashwa kufanele kuqashwe isimo sesiguli. Uma kunesidingo, kulungiswa umthamo. Kulokhu, kunomkhawulo - umthamo nsuku zonke wesidakamizwa akufanele udlule i-1 g.
Isicelo sokusebenza kokulimala kwezinso
Ngokuhluleka kwezinso, ukwehla kancane kwenqubo yokuphuma kwento esebenzayo emzimbeni kuyaqapheleka. Uma ukwelashwa kuqhubeka ngenkathi umthamo ungancishisiwe, ukugcwala kwama-metformin kuyakhuphuka, okungaholela ekwakhiweni kwezinkinga. Ngakho-ke, akufanele uthathe umuthi ngalokhu kutholwa. Ngaphezu kwalokho, ukungahambi kahle kwezinso, okuhambisana nokuncipha kokuvunyelwa kwe-creatinine kuya ku-60 ml / min. futhi ngezansi kusebenza futhi kuma-contraindication.
Ungawusebenzisi umuthi ukomisa, ohambisana nohudo.
Ungasisebenzisi isidakamizwa nangomzimba, okuhambisana nohudo, ukugabha. Iqembu elifanayo lemikhawulo lifaka izimo ezinzima ze-pathological ezibangelwa ukutheleleka, izifo ze-bronchopulmonary, sepsis, kanye nokutheleleka kwezinso.
Sebenzisa umsebenzi wesibindi okhubazekile
Izilonda ezinkulu zalesi sitho zingukuphikisana. Umuthi awusetshenziselwa ukwephula okuphakathi kwesibindi.
I-overdose yeMetformin Teva
Uma umthamo onomuthi owodwa ufinyelela ku-85 g, kukhona ubungozi be-lactic acidosis. Kodwa-ke, izimpawu ze-hypoglycemia azenzeki.
Izimpawu ze-lactic acidosis:
- isicanucanu, ukuhlanza;
- izihlalo ezikhululekile;
- ukwehla okukhulu kokushisa komzimba;
- ukuqina kwezicubu ezithambile, isisu;
- umsebenzi wokuphefumula okhubazekile;
- ukuphefumula ngokushesha;
- ukulahleka kwengqondo;
- coma.
Ukulahlekelwa ukwazi kungenye yezimpawu zokweqisa.
Ukuqeda izimpawu, umuthi ukhanseliwe, i-hemodialysis iyenziwa. Ngaphezu kwalokho, ukwelashwa okubonakalayo kunganqunyelwa. Nge-overdose yeMetformin, ukulaliswa esibhedlela kuyadingeka.
Ukuxhumana nezinye izidakamizwa
Kwenqatshelwe ukusebenzisa lesi sidakamizwa okukhulunywa ngaso nakuDanazol.
Ukuqapha kukhonjiswa lapho usebenzisa i-Chlorpromazine namanye ama-antipsychotic, izidakamizwa zeqembu le-GCS, ezinye izidakamizwa ze-diuretic, ze-sulfonylurea derivatives, i-ACE inhibitors, i-beta2-adrenergic agonists, NSAIDs. Ngasikhathi sinye, kunokungahambisani kahle kwalezi zimali neMetformin.
Ukuhambisana notshwala
Umuthi awuvunyelwe ukusetshenziswa neziphuzo eziqukethe utshwala, ngoba le nhlanganisela ingaholela ekubukekeni komphumela ofana ne-disulfiram, hypoglycemia, nokuphazamiseka kwesibindi.
Ama-Analog
Esikhundleni Kunconyiwe:
- Metformin Long;
- Metformin Canon;
- I-Glucophage Long, njll.
Umuthi awuvunyelwe ukusetshenziswa neziphuzo eziqukethe utshwala.
Umehluko phakathi kweMetformin Teva neMetformin
Le mishanguzo i-analogues eguqukayo, ngoba iqukethe into eyodwa esebenzayo; umthamo wabo nawo uyefana. Izindleko zeMetformin ziphansi, ngoba umuthi ukhiqizwa eRussia. I-analogue Teva yakhe kwa-Israyeli, okufaka isandla ekukhuleni kwenani.
Imibandela yekhefu lekhemisi
Umuthi okukhulunywa ngawo yiqembu lemithi kadokotela. Igama ngesiLatini nguMetformin.
Ngingakwazi ukuthenga ngaphandle kadokotela
Akunakwenzeka lokho.
Intengo yeMetformin Teva
Izindleko ezijwayelekile eRussia ziyahlukahluka kusuka kuma-ruble ayi-150 kuye kwangama-280, kuya ngokuthi ukuqoqwa kwento esemqoka nenani lezibhebhe ezikuphakeji.
Izimo zokugcina zomuthi
Ukushisa komoya okwamukelekayo - kufinyelela ku- + 25 ° ะก.
Isikhathi sokuphelelwa yisikhathi
Isikhathi esinconyelwe ukusetshenziswa siyiminyaka emi-3 ukusuka ngosuku lokukhishwa.
Umkhiqizi
I-Teva Pharmaceutical Enterprise Ltd., i-Israel.
Ukubuyekezwa ku-Metformin Teva
Ngenxa yokuhlolwa kwabathengi, ungathola umbono wezinga lokusebenziseka kahle kwalo muthi.
Odokotela
I-Khalyabin D.E., i-endocrinologist, iminyaka engama-47, iKhabarovsk
Umuthi awuvamile ukuholela ezinkingeni ezinzima. Ngibekela ama-pathologies ahlukahlukene acasulwa yisifo sikashukela, ngokwesibonelo, ngokuthambekela okuphindaphindiwe kokuzuza isisindo.
UGritsin, A.A., umondli wezempilo, oneminyaka engama-39 ubudala, eMoscow
Umuthi osebenzayo, kepha unemikhawulo eminingi ekuqokweni. Imvamisa kuyadingeka ukulungisa umthamo ezigulini ezineminyaka yobudala engama-60. Ngaphezu kwalokho, ngiyabela intsha. Imiphumela emibi ngesikhathi sokwelashwa kwezidakamizwa emikhubeni yami ayenzekanga.
Ukuthenga izidakamizwa ekhemisi, udinga ukuletha incwadi kadokotela.
Iziguli
U-Ana, oneminyaka engama-29, uPenza
Ngithatha i-850 mg, kepha inkambo imfushane. Ngemuva kwenyanga, ukwelashwa kuyaphindwa. Leli thuluzi lifana ngoba alishigi, libekezelelwa kahle. Kuphela kudingekile ukuyishintsha nezinye izidakamizwa ze-hypoglycemic, ngoba kunemikhawulo esikhathini seMetformin.
UValeria, oneminyaka engama-45, uBelgorod
Umuthi omuhle, kepha kimi umphumela wami awumuhle ngokwanele, bengingathi - ngibuthakathaka. Udokotela uphakamisa ukwandisa umthamo, kepha angifuni ukubhekana nemiphumela emibi.
Ukulahlekelwa isisindo
UMiroslava, oneminyaka engama-34 ubudala, uPret
Bengikhuluphele kusukela ebuntwaneni, manje bengilwa impilo yami yonke. Ngazama ukusebenzisa isidakamizwa esinjalo okokuqala. Iphango alinciphile, kepha ngesimo sokubala amakhalori, imiphumela iyabonakala, ngoba i-metformin ithinta umetabolism.
UVeronika, oneminyaka engama-33, eSt
Mina, umuthi awuzange usize.Futhi umthwalo wenyuka, futhi ngazama ukuhambisana nokudla, kepha ngiyabona ukuthi awukho umphumela, ngawuphonsa emavikini ambalwa.
