I-Angiocardyl iyinhlangano yokulungisa umzimba. Inomphumela onenzuzo ekusebenzeni kwenhliziyo, yandisa ukukhuthazela, ivikela ekucindezelekeni, kepha ifaniswe ngokungalingani nemithi yokuphaka. Kusetshenziswa ekwelashweni okuyinkimbinkimbi kwama-pathologies wezinhliziyo, ku-ophthalmology nokusiza ngezimpawu zokuhoxisa.
Igama Lezwe elingafanele
Ngokwemithetho esekwe yi-WHO, i-INN inikezwa into esetshenziswayo. Ngakho-ke, igama laphesheya kwezidakamizwa yiMeldonium.
I-Angiocardyl inomphumela onenzuzo ekusebenzeni kwenhliziyo, yenyusa ukukhuthazela, ivikela ekucindezelekeni, kepha ifaniswe ngokungalingani nemithi yokuphaka.
I-ATX
Lesi sidakamizwa singokwesigaba se-pharmacological of metabolites futhi sinekhodi ye-ATX ye-C01EB.
Khipha amafomu nokwakheka
Umuthi ukhiqizwa ngesimo sesisombululo somjovo wokuhlushwa okukhona okukhona kwe-100 mg / ml. 5 ml ukufakwa. Ama-ampoule weglasi afakwa emabhokisini amakhadibhodi ama-10 ama-pcs. kanye ngommese / isikhafu esingenamikhawulo kanye nephepha lokufundisa. Isakhi esiyinhloko se-angiocardyl yi-meldonium dihydrate. I-solvent ingamanzi ahlanziwe okuhloswe ngawo ukulungiselela izixazululo zomjovo.
Umuthi nawo ukhiqizwa ngendlela yama-500 mg amaphilisi egobolondo elinzima le-gelatin. Zigcwele impuphu emhlophe eyi-hygroscopic ngephunga elithile. Izakhi ezisizayo: isitashi, i-calcium stearate, ifomu le-colloidal le-silicon dioxide. Amakhandlela 10 ama-PC. ibekwe emabhulini futhi ihlanganiswe ne-foil. Amabhuzu ama-2 noma ama-6 ama-pcs. ebekwe emabhodini amakhadibhodi. Umyalo unamathiselwe.
Umuthi nawo ukhiqizwa ngendlela yama-500 mg amaphilisi egobolondo elinzima le-gelatin.
Kukhona nethebulethi ye-angiocardyl. Ingxenye eyinhloko ivezwa ngesimo se-phosphate, futhi ukwakheka okwengeziwe kufaka i-mannitol, isitashi samazambane, i-magnesium stearate, i-microcrystalline cellulose ne-silicon dioxide. Amathebhulethi angama-500 mg abekwa emabhulini angama-10 ama-pcs.
Ungathola nomuthi ngendlela yesiraphu yokuphathwa komlomo.
Isenzo se-Pharmacological
Into esebenzayo ye-Angiocardyl yi-meldonium. Esakhiweni sayo, iyafana ne-gamma-butyrobetaine (GBB), eyenziwe ngaphakathi emzimbeni ngaphansi kwezimo ezicindezelayo, kufaka phakathi nokuntuleka komoya-mpilo.
Ngokuvimbela i-enzyme gamma-butyrobetaine hydroxynase, i-meldonium ivimba ukwakheka kwe-carnitine, ebhekene nokuhanjiswa kwamafutha acid kumaseli ezinhliziyo. Ukucindezelwa komsebenzi wokuhamba kubalulekile ekushoneni komoya-mpilo, ngoba kulokhu, i-oxidation engxenye yamafutha acid ibonwa ngokwakhiwa kwama-metabolites aphakathi athinta inhliziyo kabi. Isibonelo, bavimba ukungena kwamangqamuzana e-ATP kumaseli.
Ukwehla kokuxineka kwe-carnitine kuvuselela ukwakheka okuthuthukile kwe-GBB, okubonisa izakhiwo ze-vasodilating, nokuphazamiseka ekunikezelweni kwamafutha acid okubangelwa ukuntuleka kwe-carnitine kuholela eqinisweni lokuthi amandla akhiqizwa ngendlela ekonga umoya-mpilo. Ucwaningo lukhombisa ukuthi ngenxa yalezi zakhiwo, i-meldonium inyusa amandla okusebenza nokukhuthazela, isheshise ukululama ngemuva kokuzivocavoca, ithuthukise ukusebenza kwezemidlalo, ivuselele umsebenzi wohlelo lwezinzwa oluphambili, futhi iyi-cardioprotector.
Ngokushaywa yi-ischemic, umuthi ukhuthaza ukwenziwa kokusebenza kokujikeleza kwezitho zomzimba, wehlise indawo yomonakalo we-necrotic kwezicubu zobuchopho.
Ekushayweni kwe-ischemic, umuthi ukhuthaza ukwenziwa kokusebenza kokujikeleza kwezitho zomzimba, wehlise indawo yomonakalo we-necrotic kwezicubu zobuchopho futhi unciphise nesikhathi sokuvuselelwa kweziguli. Iyakwazi ukunciphisa imvamisa yokuhlaselwa i-angina, ikhuphule izinga elivumelekile lokuzivocavoca ngokomzimba ekuhlulekeni kwenhliziyo okungapheli, ileveli yezimpawu zezimpawu zokuhoxa. Leli thuluzi liyasebenza ku-ophthalmology. Lapha kusetshenziselwa ukuqeda ama-pathologies athile we-vascular.
I-Pharmacokinetics
Ukusuka kwipheshana lesisu, umuthi udonswa ngaphakathi kwamahora angama-1-2, ufinyelela ekugxileni kwe-plasma enkulu cishe ngo-78%. Lapho ihanjiswa ngqo emthanjeni wegazi, i-bioavailability ye-meldonium ingu-100%. Ukwenza umzimba ngale komkhompiyutha kwenzeka esibindini. Umuthi ukhishwa ikakhulukazi ezinso amahora ayi-6 kuya kwayi-12. Emithanjeni ephezulu, ukuhlanzwa ngokuphelele komzimba kungahlala izinyanga ezimbalwa, kepha ngasikhathi sinye, ukugcotshwa okuncane kwengxenye esebenzayo kuzohlala.
Izinkomba zokusetshenziswa
Umuthi ukhonjiswa ukusetshenziselwa ezimweni zokukhathala okwandayo, ngesikhathi sokuxineka kakhulu ngokomzimba, ngokwengqondo nangokwengqondo, kufaka phakathi kwezemidlalo. Kumele kwaziwe ukuthi i-Anti-Doping Agency iyifaka ohlwini lwemikhiqizo engavunyelwe ukusetshenziswa kwabasubathi ngesikhathi sokulungiselela nokuziphatha kwemincintiswano yezemidlalo. Lesi sinqumo besingenakulungiswa ngokuphelele, ngoba i-meldonium ayikuvumeli ukwandisa umthwalo noma ukwelula ukuqeqeshwa, kepha inomthelela ekuvuseleleni ngokushesha ngemuva kokuqeqeshwa kakhulu.
Umuthi ukhonjiswa ukusetshenziselwa ezimweni zokukhathala okwandayo, ngesikhathi sokuxineka kakhulu ngokomzimba, ngokwengqondo nangokwengqondo, kufaka phakathi kwezemidlalo.
Odokotela bafaka lo muthi ekwelashini okuyinkimbinkimbi yama-pathologies anjalo:
- isifo senhliziyo;
- angina pectoris;
- infarction myocardial;
- ukubonakaliswa okungapheli kokuhluleka kwenhliziyo;
- i-dishormonal cardiomyopathy;
- isifo sohlangothi;
- ingozi ye-cerebrovascular;
- ukuhoxa kwesifo.
Ekusebenzeni kwamehlo, ukusetshenziswa kwe-Angiocardil kuyasebenza ekwelapheni:
- i-retinal hemorrhage;
- hemophthalmus;
- i-retinal vein thrombosis;
- izinhlobo ezahlukahlukene ze-retinopathy;
- I-dystrophic pathologies ye-fundus.
Ekusebenzeni kwe-ophthalmic, ukusetshenziswa kwe-Angiocardil kuyasebenza ekwelapheni ama-retinal hemorrhages, hemophthalmus, retinal vein thrombosis, njll.
Contraindication
Ukwanda kokucabanga kokutholwa kwesenzo se-meldonium noma izingxenye ezisizayo zomuthi ukuphula umthetho okuqinile kusetshenziswa i-angiocardyl nganoma yiluphi uhlobo. Ngeke ithathwe kwezinye izimo ezithile. Contraindication:
- ingcindezi ephezulu ye-intracranial;
- ama-intracranial tumors;
- ukwephulwa kokugqashuka kwengqondo kwengqondo;
- isikhathi sokuzala umntwana;
- ukuncelisa;
- iminyaka engu-18.
Lapho kukhona okhubazekile we-renal noma we-hepatic, umuthi kufanele unikezwe ngokuqapha.
Ungayithatha kanjani i-angiocardil
Indlela ekhethiwe yokuphatha umuthi, umthamo wayo kanye nobude benkambo yokwelashwa inqunywa ngudokotela ngawodwana. Ngenxa yokuthi kungenzeka kube nomphumela othokozisayo we-meldonium ohlelweni lwangaphakathi lwezinzwa, kunconyelwa ukudlulisela ukusetshenziswa kwalo engxenyeni yokuqala yosuku. Ukusetshenziswa okuhlukanisiwe, umthamo wokugcina akufanele ube ngaphambi kuka-17,00.
Umuthi wokujova uphathwa ngaphakathi noma ngaphakathi emzimbeni ngendlela emfushane. Ngemuva kwalokho (uma kunesidingo) baphenduka bathathe indlela yomlomo ye-angiocardyl. Kwezinye izimo, kungaqokwa umthamo owodwa oncishisiwe, wehliselwe ku-125-250 mg. Uma kunesidingo, ukwelashwa kuyaphindwa emuva kwamasonto ambalwa. Njengoba kushiwo ngudokotela, inkambo yokwelapha ingenziwa izikhathi ezingama-2-3 ngonyaka.
Umuthi wokujova uphathwa ngaphakathi noma ngaphakathi emzimbeni ngendlela emfushane.
Ku-ophthalmology, umuthi usetshenziselwa kuphela ukuphathwa kwe-parabulbar. Esikhathini esinotshwala obungamahlalakhona, ukuphathwa ngomlomo kwamathebulethi noma amaphilisi kanye nokuphathwa kwama-angiocardil ngemijovo kungenzeka.
Ngoshukela
Umuthi ungabekelwa abanesifo sikashukela. IMeldonium iyakwazi ukwehlisa ushukela wegazi ngaphandle kokukhulisa ukuhlushwa kwe-insulin. Ukwemukelwa kwalo kukuvumela ukuvikela ukungasebenzi kahle kwe-endothelial, ukulahleka kokuzwela, ukuthuthukiswa kwe-acidosis. Ukusetshenziswa okufanayo kwe-angiocardyl ngezidakamizwa ezifana ne-metformin, kuthuthukisa umphumela we-hypoglycemic yazo zombili lezi zidakamizwa.
Imiphumela emibi ye-angiocardyl
Umuthi ubekezelelwa kahle yiziguli, kepha kwesinye isikhathi ukubonakala kwezimpawu zokwaliwa yilezi:
- i-rash, i-urticaria;
- i-erythema;
- isikhumba esikhanyayo;
- ukuthuthukiswa kwe-puffness.
Lapho wenza ukuhlolwa kwegazi, kunganda ukuqashelwa kokuxineka kwamangqamuzana amhlophe egazi eosinophilic. Ezimweni ezingavamile, iziguli zikhononda ngokuqhekeka.
Amapheshana wesisu
Ngezikhathi ezithile i-digestive upsets iyenzeka, ukungajabuli noma ubuhlungu ku-epigastrium kuyazwakala, futhi umuzwa wokugcwala uvuka esiswini. Isiguli singazizwa sigula.
Isistimu yezinzwa ephakathi
Phakathi kokuphazamiseka kwemizwa, ukukhathazeka okwandayo, ukuqubuka kobudlova, ukuthokomala okuphezulu, kanye nokuqwasha kungenzeka.
Kusuka ohlelweni lwezinhliziyo
Ingcindezi ingahlukahluka ngandlela thile. Akuvamile ukubonwa kukhuphuka kwenhliziyo.
Umthelela ekhonweni lokulawula izindlela
Ayikho imininingwane emiphumeleni emibi yesidakamizwa ekhonweni lokushayela izimoto nezinqubo eziyinkimbinkimbi. Kodwa ngenxa yokuthi kungenzeka ukuthi kube nokuvela kwemizwa engalindeleki ngesikhathi sokulashwa ne-Angiocardil, kunconyelwa ukwenqaba imisebenzi enjalo.
Lapho uthatha i-Angiocardil, ingcindezi ingashintsha endaweni eyodwa noma kwenye, ukwanda kwesilinganiso senhliziyo akuqapheleki.
Imiyalo ekhethekile
Ekubonakalisweni okukhulu kwe-coronary syndrome, amalungiselelo e-meldonium awathandwa, ukusetshenziswa kwawo kungakhethwa.
Sebenzisa ebudaleni
Umuthi ungadala i-tachycardia elinganiselayo. Ngakho-ke, kufanele isetshenziswe maqondana nabantu asebekhulile ngokuqapha, ngokunikezwa kokusebenzisana kwezidakamizwa, kanye nesimo sesibindi nesakhiwo sezinso sesiguli.
Isabelo sezingane
Ukusebenza kwe-angiocardil ezinganeni akukasungulwa. Imininingwane ekuphepheni kokusetshenziswa kwayo ezinganeni nayo ayikho. Ngakho-ke, lesi sidakamizwa asinqunyelwe iziguli ezingaphansi kweminyaka engu-18. Umkhawulo weminyaka wokuthatha i-meldonium ngendlela yesiraphu yiminyaka eyi-12.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umphumela we-angiocardil ekukhuleni kwesibeletho awucaciswanga. Kulokhu, abesifazane abakhulelwe kufanele benqabe ukuqokwa kwayo. Akunabufakazi bokuthi umuthi uyakwazi ukudlula ubisi lwebele. Endabeni yokudlula kwenkambo yokwelashwa, umama kufanele alahle okwesikhashana ukuncelisa nge-angiocardil.
Isicelo sokusebenza kokulimala kwezinso
Lapho kukhona ama-pathologies wezinso, thatha umuthi ngokuqapha.
Sebenzisa umsebenzi wesibindi okhubazekile
Ukuswelakala kwe-Hepatic kuholela ekunciphiseni kwe-metabolism ye-meldonium kanye nokwanda kokuhlushwa kwayo ku-plasma. Ngakho-ke, iziguli ezinesifo sesibindi kufanele zibe ngaphansi kokulawulwa okukhethekile, ikakhulukazi ngenkambo ende yokwelashwa nge-angiocardil.
Ukweqiwa kwe-Angiocardil
Ukuvezwa komthamo womuthi:
- umfutho wegazi ophansi;
- i-tachycardia;
- ikhanda;
- ukwehlukana;
- isiyezi.
Uma kuvela izimpawu ezinjalo, funa usizo lwezokwelashwa. Ukwelapha uma kwenzeka kwe-overdose kuhloswe ngakho ukuqeda izimpawu ezikhona.
Ukuxhumana nezinye izidakamizwa
I-Meldonium ihlangana nama-glycosides e-cardiac, izidakamizwa ze-antihypertensive nezidakamizwa ezidala ukwanda kwemikhumbi ye-coronary, ithuthukisa umphumela wale mishanguzo. Kukhona ubungozi bokuthola ukusabela kwe-hypotonic okuhambisana ne-tachycardia, ngakho-ke, kufanele kuqashelwe lapho kunqunywa i-Angiocardil kanye nama-block adrenergic blockers, ama-nitroglycerin kanye nama-vasodilators e-flow flow wegazi.
I-Meldonium ihlangana nama-glycosides e-cardiac, izidakamizwa ze-antihypertensive nezidakamizwa ezidala ukwanda kwemikhumbi ye-coronary, ithuthukisa umphumela wale mishanguzo.
Inhlanganisela yomuthi okukhulunywa ngayo namaqembu wezidakamizwa ayemukelekile:
- ama-antiplatelet agents;
- ama-bronchodilators;
- okokugcobisa;
- ama-anticoagulants;
- izidakamizwa ze-antianginal;
- izidakamizwa ze-antiarrhythmic.
Ukuhambisana notshwala
Ngesikhathi sokwelashwa, kufanele wenqabe ukuphuza iziphuzo ezidakayo nezidakamizwa eziqukethe utshwala.
Ama-Analog
IMeldonium iyingxenye yemithi enamagama ahlukahlukene okuhweba:
- Kapikor;
- I-Olvazole;
- Idrinol;
- I-Mildronate;
- I-Meldonium Organics;
- I-Cardionate;
- Midolate;
- I-Medatern;
- I-Mildrocard nabanye
Imibandela yekhefu lekhemisi
Ukuthengiswa kwezimpahla kukhawulelwe.
Ezinye izidakamizwa ezibandakanya i-meldonium, isibonelo, i-Idrinol, zingaba yimidwebo yesidakamizwa se-angiocardil.
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi usatshalaliswa ngomuthi.
Intengo
Izindleko ze-angiocardyl zivela kuma-ruble angama-262. ngama-ampoules ayi-10.
Izimo zokugcina zomuthi
Umuthi kumele ugcinwe ebumnyameni emazingeni okushisa +15 kuya + 25 ° C. Kufanele ukhawulele ukufinyelela kwezingane emithini yezemithi futhi uvikele umswakama ukuthi ungangeni kumathebulethi namaphilisi.
Isikhathi sokuphelelwa yisikhathi
Isixazululo somjovo silungele iminyaka engu-2 kusukela ngosuku lokwenziwa. Impilo yeshalofu yendlela yomlomo yesidakamizwa yiminyaka emi-4. Ukusetshenziswa kwemikhiqizo ephelelwe isikhathi kuvinjelwe.
Umkhiqizi
Umkhiqizi eRussia - INovosibkhimpharm OJSC, eLatvia - Grindeks JSC.
Ukubuyekezwa
Amelina A.N., udokotela ojwayelekile, uVoronezh
Lesi sidakamizwa siyasebenza futhi asibizi. Ngivame ukusinikeza iziguli zami isikhathi sokuvuselelwa kwe-postoperative. Ikuvumela ukuba uthole amandla ngesikhathi esifushane kunazo zonke. Iminyaka yokuhlangenwe nakho ifakazela ukuphepha kwayo. Imiphumela emibi ayivelakancane.
UValentine, oneminyaka engama-34, uPenza
Ngisebenza cishe izinsuku eziyisikhombisa ngesonto; angikaze ngibe seholidini iminyaka eminingi. Kusihlwa ngiguqe ngamadolo, futhi ngidinga nokugcina isimo sami somzimba, ngoba cishe angisuki etafuleni. Isixazululo size ngendlela ye-Angiocardil. Ngazizwa ngiphuphuma amandla, sengathi ngangimncane ngeminyaka elishumi nambili. Manje ngiya ejimini kathathu ngesonto futhi ngasikhathi sinye angikhathaleki ngempela.
UDaria, oneminyaka engama-52, eMoscow
Wahlinzwa inhliziyo. Ukululama kwakuhlala isikhathi eside futhi kubuhlungu, ngangihlala ngidangele. Ukuqokwa kuka-Angiocardil kwanikeza imiphumela emihle engalindelekile.Waqala ukuzizwa ejabule kakhudlwana, futhi imizwa yakhe yokudangala yanyamalala ngokuphelele.
I-Anastasia, eneminyaka engama-31, Ekaterinburg
Uye wenza izifundo ezimbili zokwelashwa nge-angiocardil isikhathi esingamaviki ama-3. Izinsuku zokuqala ezimbalwa kwaba nokuhlaselwa kwenhliziyo kancane ngemuva kokuthatha amaphilisi, khona-ke akukho miphumela engenasidingo eyaphawulwa. Vele ungaphuzi umuthi kusihlwa, kungenjalo kuzoba nzima ukulala. Umphumela wajabulisa. Sekuyinto engakhathazeki enhliziyweni, evame ukushaya ngaphandle kwendawo, sengikwazi ukukhuphukela esitezi sesi-5 ngaphandle kokuphefumula futhi ngilale ngokwanele emahoreni angama-5-6.
U-Alexey, oneminyaka engama-39, u-Evpatoria
Ngathenga amaphilisi omama, izinguquko ezinhle zabonwa ngokushesha. Ngosuku olulandelayo, wafona futhi wabonga ngalo muthi. Uthi ukuphefumula sekube lula, kwacwecwa ekhanda futhi kwaba nenjabulo enhliziyweni. Silangazelela ukuthola eminye imiphumela yokwelashwa.
