Ungasisebenzisa kanjani isidakamizwa i-Simbalta?

Umuthi iSimbalta usetshenziswa ngenkuthalo emsebenzini wabo ngabaningi bezengqondo nodokotela bengqondo. Kuyasiza ukwenza ngcono isimo seziguli ezinokudangala, ukubonakaliswa kwe-neuropathy yesifo sikashukela kanye nokunye ukuphazamiseka.

Igama Lezwe elingafanele

Duloxetine

I-ATX

N06AX21.

I-Simbalta isiza ukuthuthukisa isimo seziguli ezinokudangala, ukubonakaliswa kwe-neuropathy yesifo sikashukela kanye nokunye ukuphazamiseka.

Khipha amafomu nokwakheka

Umkhiqizo uyatholakala kumakhompiyutha amancane. I-1 capsule iqukethe ama-30 noma ama-60 mg wesakhi esisebenzayo se-duloxetine hydrochloride. Ezinye izithako:

• i-hypromellose acetate faidi;
• ushukela obunjiwe kanye ne-sucrose;
• i-talc;
• i-hypromellose;
• udayi omhlophe, i-triethal citrate;
• titanium dioxide;
• indigo carmine;
• Ama-inkPrint ama-inks aluhlaza namhlophe;
• i-sodium lauryl sulfate;
• i-gelatin.

Umkhiqizo uyatholakala kumakhompiyutha amancane.

Isenzo se-Pharmacological

I-Duloxetine iyisidambisigciwane. Umuthi awuhlobene ne-cholinergic, adrenergic, dopaminergic kanye ne-histaminergic receptors. Umgomo wokusebenza kwengxenye esebenzayo yesidakamizwa usekelwe ekucindezelweni kokubuya kwe-norepinephrine, i-serotonin, kanye nokubanjwa kwe-dopamine. Ngenxa yalokhu, iziguli ezinenkinga yokudangala ziyathuthuka

Umuthi uvimbela izinhlungu. Ngobuhlungu be-neuropathic, umphumela ofanayo uboniswa ngokwanda komkhawulo wokuzwela kobuhlungu.

I-Pharmacokinetics

Umuthi ungenwa ngokushesha emgodini wokugaya ukudla ngemuva kokuphatha. Iqoqo elikhulu kakhulu le-duloxetine ku-plasma livela ngemuva kwamahora ayi-6. Ukudla akuchaphazeli izinqubo zokumuncwa, kepha isikhathi sokufinyelela ekugxambeni kwe-plasma yento sikhuphukela kumahora ayi-10.

Umuthi ungenwa ngokushesha emgodini wokugaya ukudla ngemuva kokuphatha.

Ama-duloxetine metabolites adalulwa ikakhulu yizinso. Ukuqedwa kwesigamu sempilo kufike emahoreni ayi-12.

Ngokuhluleka kwesibindi, ukuvimbela kwe-cleavage kanye ne-excretion yesithako esisebenzayo kungabonakala.

Izinkomba zokusetshenziswa

• ukuphazamiseka okujwayelekile okuhambisana nokukhathazeka;
• amazwe acindezelayo (ukudangala);
• Ubuhlungu obungapheliyo bendawo ezingxenyeni ezihlukene zesistimu ye-musculoskeletal;
• i-neuropathy yesifo sikashukela esibuhlungu (i-peripheral);
• IStevens syndrome.

Umuthi ubekelwe izinkomba zokukhathazeka.

Symbal imiselwe ukucindezelwa.

Umuthi ubekelwe izinhlungu, okwenziwa ezindaweni ezingafani zohlelo lwe-musculoskeletal.

Contraindication

• ukuvalwa kwe-glaucoma ye-angle esigabeni sokubuyiselwa;
• umfutho wegazi ophakeme (ongalawulwa);
• i-hepatic pathology;
• ukwehluleka kwezinso okunzima (nge-CC kuze kufike ku-30 ​​ml / umzuzu);
• iminyaka engaphansi kweminyaka eyi-18;
• ukuhlanganiswa kwe-fluvoxamine, ciprofloxacin ne-enoxacin;
• ukungabekezelelani.

Ngokunakekela

Umuthi usetshenziswa ngokuqapha ku-pathologies elandelayo:

• ukuphazamiseka kwengqondo ngokuphefumula kanye ne-mania;
• ukuzama ukuzibulala nemicabango ehlobene;
• ubungozi be-hypertension (intraocular) ne-glaucoma;
• iminyakazo
• i-hepatic cirrhosis;
• ukwehluleka kwesibindi nezinso.

Umuthi usetshenziswa ngokuqapha emiqondweni yokuzibulala.

Umuthi usetshenziswa ngokuqaphelisisa lapho uquleka.

Umuthi usetshenziswa ngokuqapha ku-hepatic cirrhosis.

Ungayithatha kanjani iSimbalta?

Ifomu le-capsule lomuthi lenzelwe ukusetshenziswa komlomo, kungakhathalekile isikhathi sokudla. Kuyinto engathandeki ukuhlafuna amakhebhulethi, ngaphandle kwalokho umsebenzi wabo we-pharmacological uzoba mncane. Imithamo emaphakathi

1. Iziqephu ezicindezelayo: ukulungiswa kanye nomthamo wokuqala - 60 mg / ngosuku. Umphumela omuhle uvela ezinsukwini eziyi-14-28 zokwelashwa.
2. Ukuphazamiseka okujwayelekile okuhambisana nokukhathazeka: umthamo wokuqala ngu-30 mg / ngosuku. Uma kungekho zinto ezisebenzayo ezinhle, umthamo ungakhushulwa ufike ku-60 mg / ngosuku. Isikhathi sokwelashwa sisuka kumaviki ayi-8 kuye kwayi-12.
3. Ubuhlungu obungapheli bokuhlangana kanye nemisipha nge-neuropathic etiology syndrome: ukwelashwa kuqala ngemithamo ye-30 mg / ngosuku izinsuku ezingama-7. Ngemuva komthamo ka-60 mg / ngosuku kuchaziwe. Isikhathi sokwelashwa sisuka kumaviki ayi-8 kuye kwayi-12.

Ifomu le-capsule lomuthi lenzelwe ukusetshenziswa komlomo, kungakhathalekile isikhathi sokudla.

Kuyadingeka ukuyeka ukwelashwa ngamaphilisi we-enteric-encibilike kancane kancane, ngaphandle kwalokho ungahlangabezana nesifo sokuhoxa.

Ukuthatha umuthi wesifo sikashukela

Kwabanesifo sikashukela, umthamo wesidakamizwa ukhethiwe ngokuhlukile, ngokuya ngenkambo ye-pathology. Kulokhu, isiguli sinikezwa ngokulawulwa kokuxubha kwe-glucose, kanye nokukhethwa kwemithamo efanelekile ye-Insulin.

Imiphumela emibi ye-Simbalt

Amapheshana wesisu

• ukuthopha;
• Izimpawu dyspeptic;
• ubuhlungu be-peritoneum;
• ukugabha kanye nenausea;
• dysphagia;
• i-hematochesia;
• i-halitosis kanye nomlomo owomile;
• i-gastritis;
• ukopha.

Umphumela wecala le-Symbalt ovela emgodini wesisu: ukuthopha.

Umphumela wecala le-Symbalt ovela emgodini wesisu: ukugabha.

Umphumela wecala le-Symbalt ovela emgodini wesisu: i-gastritis.

Isistimu yezinzwa ephakathi

• ikhanda elibuhlungu nelingamahlalakhona;
• umuzwa wokudakwa kanye nethonya;
• ukungahambi kahle kwemizwa
• ukuqina kwemizwa;
• ukuphazamiseka kwe-extrapyramidal;
• ukuzamazama kwemilenze;
• imicabango yokuzibulala;
• Ukukhathazeka
• ukuyaluza kanye mania;
• i-dyskinesia;
• ukwanda kokuphenduka kwengqondo.

Kusuka ohlelweni lomchamo

• ukuchama njalo;
• shintsha iphunga nokuqina komchamo;
• i-polyuria;
• ukubambezeleka nobunzima bokuchama;
• i-nocturia;
• Ubuhlungu ngenkathi uchama.

Umphumela wecala le-Symbalt ovela ohlelweni lomchamo: i-nocturia.

Umphumela wecala le-Symbalt ovela ohlelweni lokuchama: ubuhlungu ngesikhathi sokuchama.

Umphumela wecala le-Symbalt ovela ohlelweni lokuchama: ukuchama kaningi.

Kusuka ohlelweni lwe-musculoskeletal

• izicubu zomsipha;
• Ubuhlungu bemisipha nobuhlungu bethambo;
• ukuqina kokunyakaza;
• i-trismus (ezimweni ezingavamile).

Kusuka ohlelweni lwezitho zofuzo

• ukwephulwa kwe-ejaculation;
• ukungabi namandla
• ukungahambi kahle kokuya esikhathini;
• i-galactorrhea;
• izimpawu zokunqamuka kokuya esikhathini;
• i-hyperprolactinemia;
• usizi nokungajabuli kuma testicles.

Umphumela wecala le-Symbalt ovela ohlelweni lwe-genitourinary: usizi nokungajabuli kuma-testicles.

Umphumela wecala le-Symbalt ovela ohlelweni lwezitho zofuzo: ukungahambisani menstrual.

Umphumela wecala le-Symbalt ovela ohlelweni lwezitho zofuzo: ukungabi namandla.

Kusuka ohlelweni lwezinhliziyo

• gxuma ekucindezelweni kwegazi;
• indlela ye-orthostatic ye-hypotension;
• izimo zokwehluleka;
• ubunzima be-hypertensive;
• ukubanda ezingalweni nasemilenzeni;
• amagagasi.

Allergies

• imivimbo yesikhumba;
• ukulunywa
• Idumela likaQuincke.

Umthelela ekhonweni lokulawula izindlela

Ngesikhathi sokulashwa kwezidakamizwa, ukuphaphama okuphezulu kufanele kusetshenziswe ngokulawula izindlela nezithuthi zeselula, kanye nokwenza umsebenzi obandakanya ukugcwala okwengeziwe kokunakwa.

Ngesikhathi sokulashwa kwezidakamizwa, ukuphaphama okuphezulu kufanele kusetshenziswe lapho ushayela izimoto.

Imiyalo ekhethekile

Ngenxa yokuthi umuthi uthinta uhlelo lwangaphakathi lwezinzwa, kunqunywa ngokuqapha ezigulini ezinesithuthwane neziqephu ze-manic.

Ngenxa yamathuba wemicabango yokuzibulala lapho usebenzisa umuthi, isiguli kufanele siqashwe ngabasebenzi bezokwelapha nabathandekayo.

Kuyadingeka ukufaka iziguli ekuxhumaneni, ukuze ube nentshisekelo yemicabango ebaphazamisayo. Kufanele kukhunjulwe ukuthi ukusetshenziswa kwesidakamizwa isikhathi eside kungaba yizinkinga zokulutha futhi zokugaya ukudla.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ngesikhathi sokukhulelwa, umuthi ungasetshenziselwa kuphela injongo yawo okuhlosiwe futhi ngaphansi kokuhlolwa ngudokotela. Nge-lactation, umuthi awusetshenziswa. Lokhu kufakazelwa yimiyalo yokusebenzisa umkhiqizo.

Ngesikhathi sokukhulelwa, umuthi ungasetshenziselwa kuphela injongo yawo okuhlosiwe futhi ngaphansi kokuhlolwa ngudokotela.

Ukuqokwa kweSimbalta ezinganeni

Ithuluzi alisetshenziselwa ukwelapha iziguli ezincane.

Sebenzisa ebudaleni

Kulesi sigaba seziguli, umuthi ubekelwe imithamo emincane. Ngaphezu kwalokho, lezi ziguli zidinga ukuqashwa okukhethekile ngabasebenzi bezokwelapha.

Isicelo sokusebenza kokulimala kwezinso

Ukwelashwa nomuthi kuhlukaniswe ukwehluleka kwesibindi okukhulu.

Ukwelashwa nomuthi kuhlukaniswe ukwehluleka kwesibindi okukhulu.

Sebenzisa umsebenzi wesibindi okhubazekile

Ukwelashwa kwezidakamizwa kwenqatshelwe ekwehlulekeni kwesibindi okunzima.

Ukweqisa kweSimbalta

Kunezimo zokuphazamiseka kuze kube sekufeni ezigulini ezisebenzisa i-3 g ye-duloxetine 1 isikhathi. I-overdose ehlanganisiwe nehlukanisiwe ibanga kakhulu izimpawu ezilandelayo:

• iminyakazo
• coma
• i-mydriasis;
• ukozela;
• isicanucanu nokuhlanza;
• ukuthuthumela
• i-ataxia
• ukonakala kwesistimu yezinzwa ephakathi kanye nohlelo lokugaya ukudla.

I-overdose imvamisa ibangela ukozela okwandayo.

Ukweqisa izidakamizwa kuvame ukudala ukonakala ohlelweni lokugaya ukudla.

I-overdose imvamisa ibanga ukuthuthumela.

Ukwelashwa kwalezi zimo kuqukethe ukuthatha ukumunca, ukuvuvukala kwamathumbu nokuqinisekisa ukuhamba kwe-oxygen. Ngaphezu kwalokho, isisulu sinikezwa ngokulawulwa kwenhliziyo kanye nezinkomba eziphambili zomtholampilo. Ukwelashwa okulandelayo kufanele kube nezimpawu.

Ukuxhumana nezinye izidakamizwa

Kuhlanganiswe nomuthi neminye imithi, ukusabela okunjalo kuyabonakala:

• i-histamine receptor antacid kanye nabaphikisi: ayithinti ukumunwa komuthi;
• I-Fluoxetine, iParoxetine, iVenlafaxine, iQuinidine, iTramadol, iTryptophan, iSt John's wort: kukhona ubungozi be-serotonin syndrome.

Ngaphezu kwalokho, uma uthatha umuthi ngasikhathi sinye njenge-MAO inhibitors, khona-ke kuvela ingozi ye-serotonin syndrome.

Ukuhambisana notshwala

Ngenxa yengozi ephezulu yokuvela okungathandeki okubi, kufanele wenqabe ukuthatha amakhompiyutha ngotshwala ngasikhathi sinye.

Kufanele wenqabe ukuthatha amakhompiyutha ngotshwala ngasikhathi sinye.

Ama-Analog

Ama-generator ashibhile kakhulu futhi asebenzayo amuthi:

• I-Duloxetine;
• Duloxent;
• Duloxetine Canon.

Imibandela yekhefu lekhemisi

Ngingakwazi ukuthenga ngaphandle kadokotela?

Umuthi awunakuthengwa ngaphandle kwemithi kadokotela.

Inani lentengo

Izindleko zalo muthi zivela kuma-ruble ayi-1600-1800 ngephakethe ngalinye lama-capsule angama-28.

Umuthi awunakuthengwa ngaphandle kwemithi kadokotela.

Izimo zokugcina zomuthi

Umkhiqizo ugcinwa endaweni engafinyeleleki yezingane, ngamazinga okushisa we- + 15 ... + 30 ° C.

Isikhathi sokuphelelwa yisikhathi

Iminyaka emithathu

Umkhiqizi

U-Eli Lilly & Inkampani (USA) noLilly S.A. (Spain).

Ukubuyekezwa mayelana neSimbalt

UTamara Kupriyanova (neuropathologist), oneminyaka engama-40, uVoronezh.

Umuthi ubhekana ngempumelelo nezifo ezingamahlalakhona ezingapheli ezijwayelekile. Ngaphezu kwalokho, kuvame ukusetshenziswa ekwelapheni i-fibromyalgia. Umphumela wemithi yesidakamizwa ichazwa ngumgomo wokuphindwaphindwa kwe-serotonin. Ngenxa yalokhu, hhayi kuphela ukuthi ubunzima bususwa, kepha futhi nesizinda esingokomzwelo siyalungiswa, okuwusizo ekuphazamisekeni kwengcindezi. Intengo yomuthi ingaphansi kwemikhawulo enengqondo.

UFedor Arkanov (owelaphi), oneminyaka engama-37, uTver.

I-Duloxetine iyisidambisigciwane esidume kakhulu e-United States. Kodwa-ke, ezweni lethu uthola ukuthandwa kwalo kuphela. Into esebenza kahle, kepha kuze kube manje iyabiza, futhi ama-analogues atholakalayo awatholakali kakhulu emakethe yamahhala.

ILyudmila Guseva, eneminyaka engama-45 ubudala, idolobha laseVoskresensk.

Ngashintsha lesi sidakamizwa ngivela kuStimulon, ngoba kusuka kuso ngaqala ukuba nemiphumela emibi. Manje sengizizwa ngingcono, njengoba kufakazelwa yimiphumela yokuhlolwa engisanda kuyiqeda emtholampilo wendawo.