Ukusetshenziswa kweGabapentin kungasusa ngisho nobuhlungu obukhulu futhi kugadwe nomsebenzi owethusayo. Ezimweni eziningi, umuthi usetshenziselwa ukwelapha abantu abadala, ngoba kungadala imiphumela emibi eminingana. Ukuze unciphise ubungozi bemiphumela emibi ekuphuzeni lo muthi, kufanele ulandele izincomo zikadokotela ngokuqinile futhi ungeqi imithamo eboniswe emiyalweni enamathiselwe ithuluzi. Naphezu kweqiniso lokuthi lesi sidakamizwa ekuqaleni senzelwe ukuqeda izimpawu zesifo sokuwa, manje sisetshenziswa ekwelapheni kwenhlobonhlobo ye-pathologies yohlelo lwezinzwa.
Igama lomhlaba jikelele
Igama lomkhiqizo wamazwe omhlaba ngomuthi yiGabapentin. Igama lesiLatin lomkhiqizo yiGabapentin.
Ukusetshenziswa kweGabapentin kungasusa ngisho nobuhlungu obukhulu futhi kugadwe nomsebenzi owethusayo.
I-ATX
Umuthi unekhodi iN03AX12 ekuhlukanisweni kwamakhemikhali aphathelene namakhemikhali emhlabeni jikelele.
Khipha amafomu nokwakheka
Umuthi ukhishwa ngendlela yamakhompiyutha, abonakala ngegobolondo eluhlaza. Ngaphakathi aqukethe i-powder emhlophe. Kungenzeka kube khona izigaxa ezingagaya kalula i-powder. Ngendlela yamathebulethi, umuthi awenziwa.
Umthamo we-capsule ngu-300 mg. Ukuqhuma kwepulasitiki kungaqukatha ama-pcs ayi-10 noma ayi-15. Esiqeshini sekhadibhodi kunezinhlayiya ezi-3 noma ezi-5. Qiniseka ukuthi uthola imiyalo.
Okuqukethwe kwesithako esiyisisekelo esisebenzayo - i-gabapentin - ifinyelela ku-300 mg. Ngaphezu kwalokho, i-macrogol, isitashi, i-calcium dihydrate, udayi, i-titanium dioxide, njll ifakiwe ekwakhiweni kwe-capsule.
Isenzo se-Pharmacological
Ingxenye esebenzayo yesidakamizwa inomphumela obizwa ngokuthi yi-anticonvulsant, ngoba yi-analogue yokwenziwa ye-neurotransmitter enjenge-gamma-aminobutyric acid. Umuthi lo uvuselela ukwakheka komzimba kwe-neurotransmitter yayo. Ithuluzi, ngaphandle kokufana kwesakhiwo, alihlangani nama-receptors.
Into esebenzayo yesidakamizwa inomphumela wokuvimbela ezikhungweni zezinzwa zesistimu yezinzwa ephakathi, ngaleyo ndlela inciphise umsebenzi kagesi we-pathological. Ngaphezu kwalokho, umuthi uvimbela i-calcium ukungena kumaseli. Lo mphumela ukuvumela ukuthi uvikele ukubonakala kobuhlungu bemvelo ye-neuropathic. Phakathi kokunye, leli thuluzi likuvumela ukuthi unciphise ingozi yokufa kwe-neuronal ngenxa yamazinga aphansi we-glutamate.
I-Pharmacokinetics
Into esebenzayo yesidakamizwa icishe ayondliwa izinguquko ze-metabolic emzimbeni womuntu. Ngasikhathi sinye, i-bioavailability yeGabapentin ayihambelani ngqo nemithamo yomuthi. Ukungezelela umthamo kuholela ekunciphiseni kwe-bioavailability. Ukufakwa kwento esebenzayo yesidakamizwa iyawohloka ngesikhathi sokudla.
Iqoqo eliphakeme kakhulu le-gabapentin ligcinwa emahoreni angama-2-3 ngemuva kokuphathwa.
Ukweqiwa komuthi osebenzayo wesidakamizwa ngendlela engashintshiwe kwenziwa izinso. Inqubo yokuqothula ingathatha amahora angama-18 kuye kwangama-24. Ukuqalwa kabusha kwe-Renal kuphansi kubantu abanomsebenzi wezinso ongasebenzi kahle. Kulezi zimo, ukuqedwa komuthi kungathatha isikhathi eside, ngakho-ke, ukulungiswa komthamo oqondile kuyadingeka.
Isetshenziselwa ini?
Lesi sidakamizwa siyindlela ephumelelayo yokuqeda ukubanjwa ngxenye kokubandakanywa. Umuthi ungasetjenziselwa ukubanjwa okubuthakathaka kulesimo se-pathological. Lo muthi uvame ukusetshenziswa njengento yokubulala izinzwa. Bamisa ngokuphelele ubuhlungu be-neuropathic, ngakho-ke kuya ngokuya kusetshenziselwa hhayi kuphela ukuqeda ukubanjwa.
IGabapentin isebenza kakhulu ekwelapheni ubuhlungu besifo esibuhlungu obonwa ku-trigeminal neuralgia. Lo muthi ungasetshenziselwa ukuqeda izinhlungu ezingapheli, ezingalapheki nge-shingles. Ukusetshenziswa kweGabapentin kukuvumela ukuthi ume kobuhlungu obukhulu, obubangelwa ukucindezelwa kwezimpande ze-hernia eyandayo, okhule ngokumelene nesizinda se-osteochondrosis eqhubekayo.
Isidakamizwa esilinganiselwe esisetshenziswe ku-narcology. Ikuvumela ukuthi uyeke ukuzilimaza ngokwenqaba okuphelele kweziguli ukuphuza utshwala noma izidakamizwa. Ekwelapheni umlutha, ukusetshenziswa kweGabapentin kuvunyelwe kuphela emtholampilo wasesibhedlela, lapho isiguli sihlala siqondiswa abasebenzi bezokwelapha.
Contraindication
Uma ungahambisani nanoma yiziphi izingxenye zomkhiqizo, awukwazi ukuzisebenzisa. Ngaphezu kwalokho, i-contraindication yokusetshenziswa komuthi iminyaka engu-3.
Imvamisa, ukusetshenziswa kweGabapentin kungenzeka kunganconyelwa isithuthwane, kuhambisane nokubanjwa okujwayelekile. Ngaphansi kwezimo ezithile, ukusetshenziswa kwalesi sidakamizwa kubi kakhulu isimo seziguli ezinokuhlaselwa okunjalo.
Ukusetshenziswa kweGabapentin ekwelapheni abantu abanezifo ezithinta ubuchopho kuqinisekisiwe.
Ngokunakekela
Ngokunakekelwa okukhethekile, umthamo wesidakamizwa ukhethiwe kubantu abaphethwe umsebenzi wezinso ongasebenzi. Ukwelashwa kweGabapentin kuyingozi ikakhulukazi ezigulini ezihlala zidinga izinqubo ze-hemodialysis.
Ungayithatha kanjani?
Umuthi uphuzwa ngomlomo. Musa ukuncibilikisa noma ukuhlafuna i-capsule. Umuthi kufanele ugezwe ngamanzi. Kubantu abanezinkinga zezinso, umthamo wokuqala uvela ku-150 kuya ku-250 mg wesidakamizwa ngosuku.Ukuba nabantu abadala abanempilo nezingane ezingaphezulu kweminyaka eyi-12, umthamo wansuku zonke wokuqala ungasukela kuma-300 kuye kuma-900 mg.
IGabapentin ithathwa ngomlomo, umuthi kufanele ugezwe ngamanzi.
Ukugwema imiphumela emibi, imvamisa kunconywa irejimeni yezigaba ezintathu. Ngosuku lokuqala, kunqunywa umthamo ka-300 mg, okuwukuthi, 1 capsule ekuseni. Ngosuku olulandelayo, i-600 mg yesidakamizwa ikhonjisiwe, okungukuthi, amaphilisi amabili ekuseni nakusihlwa. Ngosuku lwesithathu, umthamo ukhuphuka ufike ku-900 mg. Umthamo wansuku zonke uhlukaniswe ngemithamo emithathu. Ngokuzayo, umthamo wansuku zonke ungakhuphuka kancane kancane ube ngu-3600 mg.
Ngoshukela
Ukusetshenziswa kweGabapentin kunesizathu sokwelashwa kwe-neuropathy yesifo sikashukela. Umthamo wansuku zonke walesi sifo uvela ku-900 kuye ku-1800 mg.
Imiphumela emibi
Ngokuphikisana nesizinda sokuthatha iGabapentin, imiphumela emibi ehlukahlukene ihlala ivela. Ngesikhathi sokuhlolwa, ukuba khona kwemiphumela emibi kwaqinisekiswa ngisho nakulezo ziguli ezathatha i-placebo. Ngakho-ke, ezinye izifundazwe zingabangelwa yizici zengqondo.
Ngaphezu kwalokho, ngemuva kokusebenzisa isikhathi eside umuthi, ukwesulwa kwawo kusongela ngokubonakala kwezimpawu eziseceleni kohlelo lwezinzwa oluphakathi nendawo kanye nogunjini lwesisu.
Amapheshana wesisu
Ngokusetshenziswa njalo kweGabapentin, i-flatulence, izifo ezithathelwanayo zomgogodla womlomo kanye nokukhula kwe-anorexia. Izilonda zesisu, ukulimala kwesibindi, ne-pancreatitis kungavela. Ukuqunjelwa okungapheli noma isifo sohudo kungenza isiguli siphuze umuthi. Amathuba okukhulisa ama-hemorrhoid kanye ne-proctitis ephezulu.
Isistimu yezinzwa ephakathi
Imvamisa, iziguli ezihlangabezana nokwelashwa kweGabapentin zithola isiyezi. Ngaphezu kwalokho, kungenzeka ukuthi ushintshe umuzwa wezingxenye ezithile zomzimba, wehlise ingqondo, ukukhuluma okungasebenzi kanye ne-cerebellum, kanye nokuvela kokushintshana kwemizwelo engazelelwe. Iziguli eziningi zinemicabango yokuzibulala. Ithoni yemisipha ivame ukuncishiswa, futhi namakhono amahle ezimoto ayathinteka. Ezinye iziguli zithola ukudonswa phansi nokuqhekeka okungapheli. Ukuphazamiseka kokulala okungenzeka, i-psychosis ne-neurosis.
Uhlelo lwenhliziyo
Ngokuphikisana nesizinda sokuthatha iGabapentin, ukubonakala kwezimpawu ze-vasodilation kungenzeka. Kukhona ukwanda kwengcindezi yegazi kanye ne-tachycardia. Ukuthatha umuthi kungadala ukushayeka kwegazi nokuvuvukala kwezindonga zemithambo yegazi. Ngaphezu kwalokho, ngokuphendula okubi komzimba, izimpawu zokuhluleka kwenhliziyo ne-pericarditis zingavela. Ngaphezu kwalokho, kungahle kube nezimpawu ze-myocardial infarction.
Kusuka ohlelweni lokuphefumula
Imvamisa, ngokusetshenziswa kweGabapentin, iziguli zakha inyumoniya. Ukuhlaselwa i-apnea, i-hyperventilation, kanye no-snoring akuvamile. Ukuqongelela okungenzeka koketshezi izicubu zamaphaphu.
Isikhumba nezicubu ezingaphansi
Iziguli eziphathwa ngeGabapentin zingathola ukulahleka kwezinwele nokwanda kwesikhumba. Mhlawumbe ukubonakala kwezimpawu ze-seborrhea ne-psoriasis. Ngaphezu kwalokho, kunamathuba aphezulu wokujuluka kokujuluka. Ezimweni ezingavamile, ukwakheka kwama-cysts angama-subcutaneous nezilonda emilenzeni, kanye necrosis yesikhumba.
Izitho zeHematopoietic
Ezigulini, kaningi ngemuva kwenkambo ende ye-gabapentin, kuvela izimpawu ze-thrombocytopenia ne-anemia. Ukopha okungaba khona. Ukuthuthukiswa kwe-non-Hodgkin lymphoma kuyaqabukela kakhulu. Ukuphazamiseka okungenzeka komnkantsha wethambo.
Allergies
Imvamisa, ngokusetshenziswa kweGabapentin, ukusabela komzimba wesikhumba kuyabonakala, kubonakaliswa ukulunywa, i-urticaria kanye nokuvutha. Ezimweni ezingavamile, ukushaqeka kwe-anaphylactic ne-Quincke edema kwenzeka.
Imiyalo ekhethekile
Lapho usebenzisa iGabapentin ukwelashwa, kufanele wenqabe ukushayela imoto. Isikhathi sokulashwa, kufanele ukhohlwe ngokuphuza utshwala.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Sebenzisa umuthi lapho ukhulelwe kuphela uma kunesidingo. Abesifazane abelashwa i-Gabapentin badinga ukuyeka ukuncelisa ibele.
Kunquma uGabapentin ezinganeni
Ungasebenzisa umuthi ukwelapha izingane kusuka eminyakeni eyi-12. Lapho inzuzo okuhlosiwe idlula ukulimala, umuthi ubekelwe izingane ezingaphezulu kweminyaka emi-3.
Sebenzisa ebudaleni
Ukuqapha kufanele kusetshenziswe ekwelapheni asebekhulile. Umthamo uguqulwa ucatshangelwe ama-pathologies wesiguli esingamahlalakhona.
Ukweqisa
Ngomthamo owodwa wesidakamizwa esingaphezu kwama-49 g, ukuvela kwezimpawu ezinjalo zokweqisa njengokulimala kwenkulumo, ukugabha okukhulu nohudo kungenzeka. Iziguli zikhuphule ukuqwashisa kanye nokuqwashisa okonakele. I-lethargy kungenzeka. Kulokhu, udinga ukuhlanza isisu sesiguli bese unika abelungu. Ngemuva kwalokhu, kunikezwa ukwelashwa okubonakalayo.
Ukuxhumana nezinye izidakamizwa
Lapho isetshenziselwa ukwelashwa kweGabapentin, ezinye izidakamizwa nazo zivunyelwe ukususa umsebenzi owandayo kagesi. IGabapentin ayithinti ukusebenza kwezindlela zokuvimbela inzalo zamahomoni.
Ukusetshenziswa kwama-antacid kunciphisa ukumunca umuthi.
Izidakamizwa eziphakeme ze-myelotoxic zandisa i-hepatotoxicity yaseGabapentin.
Lesi sidakamizwa asithinti umphumela wamakhemikhali we-morphine, kodwa ngasikhathi sinye sandisa ubungozi bemiphumela emibi.
Ama-Analog
Ukulungiselela okunomphumela ofanayo wemithi nge-gabapentin kufaka:
- Pregabalin;
- Tebantin;
- Phenibut
- Ishosha esihlatshelelwayo
- Carbamazepine;
- Algerica.
Ukulungiselela okunomphumela ofanayo wemithi neGabapentin kufaka iPregabalin.
Abenzi
IGabapentin ikhiqizwa ngabakhiqizi abasebenza lapha ekhaya nabangaphandle:
- I-PIK-PHARMA;
- I-Canonpharma;
- I-Eco-Chemical Innovation;
- Aurobindo Pharma;
- UGideon Richter;
- ILecco
- IGedecke.
Imibandela yekhefu lekhemisi
Ukuthenga umkhiqizo, kudingeka udokotela.
Malini i- gabapentin
Intengo yomuthi incike ezweni lokukhiqiza. Umuthi owenziwe eRussia, ngokwesilinganiso, ubiza kusuka kuma-ruble angama-200 kuye kwangama-700. Izindleko zezichazi zakwamanye amazwe zisuka kuma-350 ziye ku-1400 p.
Izimo zokugcina zomuthi uGabapentin
Gcina umuthi emazingeni okushisa angaba ngu-25 ° C endaweni evikelwe ukukhanya kwelanga.
Gcina umuthi emazingeni okushisa angaba ngu-25 ° C endaweni evikelwe ukukhanya kwelanga.
Isikhathi sokuphelelwa yisikhathi
Umuthi ungasetjenziswa iminyaka emi-2 kusukela ngelanga lokukhishwa.
Ukubuyekezwa ku-Gabapentin
Lo muthi kudala wasetshenziswa ekwelapheni isithuthwane nobuhlungu be-neurogenic, ngenxa yalokho, unokubuyekezwa okuningi kweziguli nodokotela maqondana nomphumela wokwelapha.
Iziguli
U-Eugene, oneminyaka engama-28 ubudala, eSt
Isikhathi eside ngihlushwa isithuthwane. Izikhathi ezithile, udokotela ushintsha irejimeni yokwelashwa. Cishe izinyanga ezi-3 ezedlule, uthinte uGabapentin. Ngithatha ama-900 mg ngosuku. Kuqala bekuba nezinkinga ngesitulo, kepha imiphumela emibi yanyamalala. Akuzange kube nokuhlaselwa ngalesi sikhathi, ngakho-ke ngiyajabula ngomphumela.
UMaria oneminyaka engama-42, uVladivostok.
Ngiphethwe yisifo sikashukela. Eminyakeni engaba ngu-1.5 eyedlule, izinhlungu zobuhlungu nobusuku zaqala ukukhathazeka. Udokotela unqume ukusetshenziswa kweGabapentin. Ithuluzi lisiza ukuqeda izimpawu, kepha umthamo bekufanele ukhuphuke ube ngu-1800 mg ngalesi sikhathi. Cishe izinyanga eziyisithupha ezedlule, kwavela izinkinga, okungenzeka kubangelwa isenzo somuthi. Kwesinye isikhathi inhliziyo iqala ukushaya ngamandla, nengcindezi igxume kakhulu. Ngihlela uhambo lokuya kudokotela. Mhlawumbe ukuqondana kwaleli thuluzi kuzosebenza kangcono.
Odokotela
UGregory, isazi sezinzwa, oneminyaka engama-42, uKrasnodar
Sekuphele iminyaka eyi-16 ngisebenza ngudokotela wezifo zemizwa. Ukukhethwa kwezidakamizwa zokumisa izimpawu zesithuthwane kungumsebenzi onzima futhi kuhlale kudinga indlela yomuntu ngamunye eya esigulini. Ukusetshenziswa kweGabapentin kungafinyelela umphumela ohlala njalo futhi kunciphise imvamisa yokuhlaselwa. Iningi leziguli libekezelela ukwelashwa nalesi sidakamizwa kahle. Ngaphezu kwalokho, ukusetshenziswa kweGabapentin kungahlanganiswa neminye imishanguzo ye-antiepileptic. Lokhu kukuvumela ukuthi ukhethe inkimbinkimbi yezidakamizwa ngisho nasezimweni ezinzima.
UMargarita, i-endocrinologist, iminyaka engama-46, uRostov-on-Don
Ezigulini ezinesifo sikashukela i-mellitus, noma ngabe ukhetha kakhulu izidakamizwa, imithamo ye-insulin nokuqapha ngokucophelela amazinga kashukela, kungekudala kuba nezimpawu zokulimala kokuphela kwezinzwa. Lapho kuvela izimpawu zokuthi isifo sikashukela sinesifo sikashukela, ngibeka iGabapentin noma izifanekiselo zayo zeziguli. Ithuluzi likuvumela ukuthi ususe izinhlungu kanye nokuqunjelwa. Zimbalwa iziguli ezithola imiphumela emibi kakhulu.
