I-Mildronate 10 - i-analogue yento ekhona kumaseli womzimba womuntu.
Igama Lezwe elingafanele
IMeldonium.
I-Mildronate 10 - i-analogue yento ekhona kumaseli womzimba womuntu.
I-ATX
Ikhodi ATX С01ЕВ.
Khipha amafomu nokwakheka
Kwenziwa ngesimo sesisombululo somjovo ngaphandle kombala nephunga. Kuqukethe i-meldonium dihydrate namanzi afakwe emanzini. Amacwecwe namaphilisi we-250 no-500 mg nawo ayatholakala. Kwenziwe ngesimo isiraphu.
I-Mildronate 10 yenziwa ngendlela yesisombululo somjovo ngaphandle kombala nephunga.
Isenzo se-Pharmacological
Kusetshenziswa umthwalo omningi emzimbeni ukubuyisa ibhalansi ye-oxygen. Ukulwa i-hypoxia. Isusa ubuthi kanye nama-metabolites kumaseli, igcina ithoni, ikhuphule ukuhamba kwegazi, ivikele izitho zomzimba emonakalweni obangelwa ukungabikho komoya ophefumulayo. Umzimba uthola amandla okubekezelela umthwalo omkhulu futhi ululame ngokushesha.
Kuvikela amaseli ekugxileni kwe-ischemia noma ukushaya kwenhliziyo, kuvimbela ukubonakala kwe-necrosis. Khuphula ukuqina kokulethwa kwegazi kubuchopho.
I-Pharmacokinetics
Ngemuva kokuphathwa kwe-intravenous, ukugxilisa okukhulu kwe-plasma kufinyelelwa ngokushesha. I-bioavailability yesidakamizwa ngu-100%. Umuthi udonswa yizinso ngendlela yama-metabolites amabili kungakapheli amahora angama-3-6 ngemuva komjovo.
Ngemuva kokuphathwa kwe-intravenous, ukugxilisa okukhulu kwe-plasma kufinyelelwa ngokushesha.
Umuthi muphi?
IMeldonium isetshenziselwa ukuvikela i-necrosis nokufa kweseli ekulimaleni kobuchopho be-ischemic. Isetjentiswa ekwelapheni izifo ezibucayi nezingamahlalakhona ezihambisana nokuhlinzekwa kwegazi kwengqondo okulimazayo, kufaka phakathi imivimbo yohlobo obomvu nomhlophe.
Ixhasa ukuhamba kwegazi, igcwalise amaseli ngezakhi kanye nomoya-mpilo uma kwenzeka kukhula i-vasology pathology.
Kubekelwe ukuvikela uhlelo lwezinhliziyo zenhliziyo ekungaphelelini kwe-coronary, ukukhulula infarction ye-myocardial acute, kuyasiza ekunciphiseni i-lesion futhi kunciphise isikhathi sokutakula. Kubekelwe i-cardiomyopathy okubangelwa ukungalingani kwama-hormonal ukuvikela ubuchopho nokugcina ukusebenza lapho isiguli sithola ukucindezelwa kwengqondo okungapheli.
IMeldonium isetshenziselwa ukuvikela i-necrosis nokufa kweseli ekulimaleni kobuchopho be-ischemic.
Iphinde inqunyelwe ukwehlisa ukuhlaselwa kwe-angina, kuyasiza ukukhulisa igebe phakathi kwabo.
Futhi, umuthi usetshenziselwa ekwelapheni ama-heminal hemorrhages wemisuka ehlukahlukene, ngomonakalo we-retina wemvelo yesifo sikashukela. Vimbela ukulimala kwegazi okuphezulu esweni, kuvikela umthambo ophakathi kwe-ocular kusuka ku-thrombosis.
Ukusetshenziswa kweMildronate kwezemidlalo
I-Mildronate inyusa ukubekezelela umthwalo. Kwezemidlalo, kusetshenziselwa ukubuyisela izicubu zomzimba ngemuva kokuziqeqesha. Kunconywa ngezikhathi zokucindezela okukhulu kanye nokunxephezela imiphumela yokulimala.
Contraindication
Akubekelwe ukungabekezelelani ngomuthi ngamunye. Kuyenqatshelwa ukusebenzisa iminyaka engaphansi kweminyaka eyi-18, ngesikhathi sokukhulelwa nokukhulelwa. Umuthi awunqunyelwe futhi ngokwanda kwengcindezi ye-intracranial ebangelwa ukuvuvukala kwezicubu zomzimba noma zezinzwa.
Kuyenqatshelwa ukusebenzisa eminyakeni engaphansi kwe-18.
Ngokunakekela
Izifo ezingamahlalakhona zesibindi nezinso ngokuncipha kwemisebenzi yazo.
Ungayithatha kanjani iMildronate 10
Imiyalo ifakwe emthini, okufanele ngabe uyijwayele. Imithamo umuthi sinqunywe udokotela futhi kuncike kulesi sifo:
- Nge-ischemia ye-cardiac, i-5-10 ml yesisombululo sifakwa jet. Uma kudingekile, ungahlukanisa umthamo ngesigamu bese uphatha kabili ngosuku.
- Ngama-pathologies we-retina, imijovo yenziwa ijwabu leso elingaphansi. Umthamo wesidakamizwa ngu-0.5 ml. Inkambo ifaka ukwelashwa okungu-10.
- Ukhuphula ukukhuthazela ngesikhathi sokuzivocavoca ngokomzimba noma ngokomzimba - 5 ml ngosuku intramuscularly.
- Ukwelashwa kotshwala obungamahlalakhona kanye nokususwa kwesifo sokudakwa - ama-5 ml ngokungena emzimbeni noma ngezinsuku eziyishumi.
Uma kwenzeka kushoda umthamo wegazi lokubeletha, izifundo zigcina kumaviki angama-4-6. Izifundo zesibili zingenzeki esikhathini esingaphansi kwamasonto angama-4-8 kamuva kuphela emva kokubonisana nodokotela wakho.
Ngaphambi noma ngemuva kokudla
Ngengeniso ye-meldonium intravenous noma intramuscularly, isheduli yomjovo ayixhomekeki ekudleni kokudla, noma kunjalo, kunconywa ukusebenzisa umuthi engxenyeni yokuqala yosuku, imizuzu engama-20 kuye kwengama-30 ngaphambi kokudla. Kusihlwa, ukuphatha umuthi akukanconywa, ngoba kunomthelela we-tonic futhi kungaphazamisa amaphethini okulala.
Amathebulethi athathwa isigamu sehora ngaphambi kokudla, ukuze ingxenye eyinhloko idakwe kakhulu, noma ngemuva kwesikhashana ngemuva kokudla.
Amathebulethi athathwa isigamu sehora ngaphambi kokudla, ukuze ingxenye eyinhloko idakwe kakhulu, noma ngemuva kwesikhashana ngemuva kokudla.
Umthamo wesifo sikashukela
I-Mildronate isetshenziswa ngempumelelo kuhlobo lwe-2 yesifo sikashukela ukwehlisa amazinga kashukela futhi ivikele amaseli ezinqubweni ze-pathological. Esikhungweni sikashukela, i-10 ml ikhonjiswa ngaphakathi kumaviki awu-6. Inkambo yokwelashwa iphindwa njalo ezinyangeni ezingama-2-3. Ngasikhathi sinye, ukwehla kwamazinga kashukela egazini nokuthuthuka konke enhlalakahleni kwaphawulwa.
Imiphumela emibi ye-Mildronate 10
Umuthi yi-metabolite, ngakho-ke, unemiphumela emincane engezansi. Ezimweni ezingavamile, kuba nokuvela komzimba: ukulunywa, ukushiswa, i-urticaria, izimpawu ezifana nobuthi bokudla, ubuthakathaka obujwayelekile. Egazini, inani lama-eosinophils landa kancane.
Ezimweni ezingavamile, kuba nokuvela komzimba: ukulunywa, ukuvutha, urticaria.
Umthelela ekhonweni lokulawula izindlela
Akuthinti ijubane lokuphendula kwe-psychomotor; ukushayela imoto kuvunyelwe.
Imiyalo ekhethekile
Ekwelashweni kokuhlaselwa yisifo senhliziyo kanye nokuqwasha okwanele kwe-coronary akusona isidakamizwa esidingeka ngokuphuthumayo, sisetshenziswa njengesixazululo. Uma kwenziwa umjovo we-intramuscular, ama-deodorants noma eminye imikhiqizo yokuhlanzeka akufanele asebenze endaweni yomjovo ukuze angaqedi ukucasuka.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umphumela womuthi kwezicubu zezingane awukafundwa, ngakho-ke ukusetshenziswa kwe-meldonium kunoma iyiphi i-trimester yokukhulelwa akuvunyelwe.
Ngesikhathi sokukhulelwa, awukho umuthi obekiwe.
Akukho datha ethembekile yokuthi ingabe into enkulu idaluliwe ebisini, ngoba izivivinyo zomtholampilo ezidingekayo azenziwanga. Ngesikhathi sokukhulelwa, awukho umuthi obekiwe.
Sebenzisa ebudaleni
Ebudaleni, ukusetshenziswa kuvunyelwe ngaphansi kokuqashwa kukadokotela, njengakwiziguli esezikhulile, umfutho wegazi ungakhuphuka ngemuva kokujova.
Ukunquma uMildronate ezinganeni eziyi-10
Ayichaziwe kuze kube seminyakeni engu-18, ngoba akukho datha yomtholampilo enganele ngemiphumela emzimbeni wezingane.
I-overdose ye-Mildronate 10
Nge-overdose, ikhanda likhula, umfutho wegazi wehla. Ubuthakathaka obujwayelekile kanye ne-tachycardia kuyabukwa.
I-overdose iba nekhanda.
Ukuxhumana nezinye izidakamizwa
Kuvunyelwe ukuthatha ama-bronchodilators ngokuhlanganiswa nomuthi. Mhlawumbe inhlanganisela nama-anticoagulants nezidakamizwa ze-diuretic.
Ithuthukisa umphumela we-nitroglycerin, obangela i-tachycardia, inyusa ukugcwala kwama-alpha-blockers eplasma yegazi. Ngokuhlanganiswa kwezindlela phakathi kwemithamo, kunconywa ukubekezelela ikhefu lemizuzu engama-20-30.
Ukuhambisana notshwala
Akunconywa ukuhlanganisa izidakamizwa notshwala, ngoba kule ndaba ubungozi bemiphumela emibi buphakeme.
Akunconywa ukuthatha izithasiselo zokudla ngesikhathi sokwelashwa.
Akunconywa ukuhlanganisa izidakamizwa notshwala, ngoba kule ndaba ubungozi bemiphumela emibi buphakeme.
Ama-Analog
Ukufana kwezidakamizwa izidakamizwa ezifana ne-Idrinol neCardionate. Izindleko zama-analogues ngokwesilinganiso zingama-ruble angama-300.
Imibandela yekhefu lekhemisi
Ikhishwa ngomuthi kuphela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ngokwemithetho yamanje, umuthi ubonwa njenge-doping ejenti futhi wenqatshelwe ukuthengiswa kwamahhala, kodwa-ke, kwezinye izifunda, amaphilisi aqukethe isakhi esiyinhloko sama-250 mg asatshalaliswa ngaphandle komyalelo.
Intengo yeMildronate 10
Intengo yomuthi iyahlukahluka ngokuya ngesifunda futhi isuka kuma-ruble ayi-150 kuye kwangama-350.
I-Mildronate 10 itholakala ngomuthi kuphela.
Izimo zokugcina zomuthi
Gcina umuthi kuphela endaweni emnyama neyomile endaweni yokushisa yegumbi. Musa ukudalula umuthi ukuqondisa ukukhanya kwelanga. Gwema kude nezingane.
Isikhathi sokuphelelwa yisikhathi
Ilungele iminyaka engu-4 kusukela ngosuku lokukhiqizwa.
Umkhiqizi
- ISanitas JSC Lithuania;
- I-Elf Pharmaceutical Poland;
- I-PJSC "I-Pharmstandard-UfaVITA", iRussia, i-Ufa;
- IHSM Pharma, eSlovakia.
Ukubuyekezwa mayelana neMildronate 10
Ochwepheshe baphawula ukubekezelela okuhle komuthi. Kunomphumela omuhle osheshayo owenzeka ngemuva kokuphathwa komuthi.
Izazi zezenhliziyo
U-Iskrinskaya Evgenia, udokotela wezifo zenhliziyo, uSamara: "Isidakamizwa sisheshisa isikhathi sokutakula, sivikela izicubu zenhliziyo ekusebenzeni ngokweqile. Iziguli esezikhulile ziyelulekwa ukuba ziqaphele, ngoba isiyezi singakhula."
U-Belov Alexander, udokotela wezinhliziyo, u-Tver: "Umuthi uvamisa umsebenzi wenhliziyo, ukhulula ukukhathala okungapheli. Ngincoma ukuthi sisetshenziswe."
Ochwepheshe baphawula ukubekezelela okuhle komuthi.
Iziguli
U-Olga, oneminyaka engama-49, eMoscow: "Ngosuku lwesithathu, ukukhathala okungamahlalakhona kudlule, ngazizwa nginamandla amakhulu."
UPeter, oneminyaka engama-47, uStavropol: "Ngiphuza lesi sidakamizwa ngoba ngisebenza esakhiweni sokwakha. Ngemuva komsebenzi, ngisenawo amandla okwenza imisebenzi yasendlini, inhliziyo yami ayisihluphi, njengoba kwenzeka."
