I-Desmopressin iyi-analogue yokwenziwa ye-vasopressin. Umuthi awunamphumela onoshevu emzimbeni, awusiwo umutagen. Faka isicelo ngemuva kokubonisana nodokotela; Ukuzilapha kungalimaza impilo nempilo yesiguli.
Igama Lezwe elingafanele
Igama elejwayelekile lomuthi yi-Desmopressin. NgesiLatin - Desmopressin.
I-Desmopressin iyi-analogue yokwenziwa ye-vasopressin.
Ath
Ikhodi yemithi yi-H01BA02.
Khipha ifomu
Umuthi ukhiqizwa ezinguqulweni eziningana. Ngaphambi kokukhetha ifomu, kufanele uthintane nodokotela wakho ukuze uthole okuyiyona efanele yokwelapha lesi sifo.
Isixazululo somjovo siphathwa nge-intramuscularly, intravenly, subcutaneously.
Amaphilisi
Umuthi uyatholakala ngesimo samacwecwe amhlophe, ayindilinga. Ngakolunye uhlangothi kukhona okubhaliwe "D1" noma "D2". Esiqeshini sokuhlukanisa sesibili. Ngaphezu kwengxenye esebenzayo, desmopressin, ukwakheka kufaka i-magnesium stearate, isitashi samazambane, i-povidone-K30, i-lactose monohydrate.
Umuthi uyatholakala ngesimo samacwecwe amhlophe, ayindilinga.
Amaconsi
Amaconsi e-Nasal awuketshezi olungenamibala. Abahambeli yi-chlorobutanol, i-sodium chloride, amanzi, i-hydrochloric acid. Umthamo we-0.1 mg nge-1 ml.
Futha
Kuketshezi olucacile. Kuqukethe ibhodlela elikhethekile elinelitsha. Abaxhamazelayo yi-potassium sorbate, amanzi, i-hydrochloric acid, i-sodium chloride.
Indlela yokusebenza
Umuthi unomphumela wokuphikisana nomzimba womuntu.
Into esebenzayo iyimolekyuli eguqulwe ngokwenziwe ye-vasopressin ye-hormone. Lapho umuthi ungena emzimbeni, ama-receptors akhethekile ayasebenza, ngenxa yokuthi inqubo yokuvuselelwa kwamanzi ithuthukiswa kanjani. Ukuhlangana kwegazi kuyathuthuka.
Ezigulini ezine-hemophilia, umuthi unyusa i-factor coagulation 8 ngezikhathi ezi-3-4. Ukwanda kwesilinganiso se-plasminogen ku-plasma yegazi kuyaphawulwa.
Ukuphathwa kwe-Intravenous kukuvumela ukuthi uzuze ngokushesha umphumela.
Umuthi uthuthukisa ukuguquguquka kwegazi.
I-Pharmacokinetics
Umuthi ulolongwa esibindini. Isuswa ngomchamo.
Ukuqedwa kwesigamu sempilo kwenza imizuzu engama-75. Kulokhu, ngemuva kwamahora ambalwa, kubalwa kakhulu umuthi osegazini lesiguli. Umphumela omkhulu ubonwa emahoreni angama-1.5-2 ngemuva kokuphatha.
Izinkomba zokusetshenziswa
Umuthi ubekelwe i-polyuria, ekwelapheni isifo sikashukela, i-nocturia, hemophilia, isifo se-Willebrand. Isifutho namaconsi asetshenziswa njengengxenye yokwelashwa okuyinkimbinkimbi kokuthola amandla okuqala ebusuku, ukuqubuka komchamo. Ngaphezu kwalokho, amaconsi asetshenziswa ngemuva kokusebenza ku-pituitary gland.
Contraindication
Kwenqatshelwe ukwelapha nge-desmopressin ye-anuria, ukuba khona kokuphendula komzimba, ukubekezelela umuntu ngamunye ezingxenyeni zomuthi, naku-plasma hypoosmolality. Umuthi awusetshenziselwa i-polydipsia, ukugcinwa kwe-fluid, ukuhluleka kwenhliziyo. Umuthi awuphathwanga ngemithambo ye-angina engazinzile kanye nohlobo lwe-2 von Willebrand isifo.
Umuthi awuphathwanga ngokuhlinzwa nge-angina engazinzile.
Ngokunakekela
Uma kwenzeka wephula ibhalansi ye-electrolyte esele, i-bladder fibrosis, izifo zesistimu yezinhliziyo noma izinso, ubungozi bokucindezela okucindezelekile kwe-intracranial, kufanele kuqashelwe ngesikhathi sokwelashwa. Ukwephulwa okuhlobene kubhekwa njengomuntu ongaphezulu kweminyaka engama-65.
Ungayithatha kanjani i-Desmopressin
Imithamo kanye nerejimeni yemithamo kuncike kulesi sifo, izici eziqondene nesiguli. Kufanele kukhethwe kanye nodokotela. Kufanele uzijwayeze nemiyalo yokuyisebenzisa.
Umthamo wokuqala wamaconsi emakhala, ukufafaza kuyahlukahluka kusuka ku-10 kuye ku-40 mcg ngosuku. Kufanele ithathwe kaningi. Izingane ezingaphansi kweminyaka eyi-12 zizodinga ukulungiswa. Kubo, kukhethwe umthamo wama-5- 30 we-30 kilo phakathi nosuku.
Ngokwazisa kwemijovo kubantu abadala, umthamo uqhamuka ku-1 kuye ku-4 μg ngekhilogremu yesisindo somzimba. Ebuntwaneni, ama-micrograms angama-0.4-2 kufanele aphathwe.
Uma ukwelashwa kungalethi umphumela olindelekile kungakapheli isonto, umthamo kuzodingeka ulungiswe.
Uma ukwelashwa kungalethi umphumela olindelekile kungakapheli isonto, umthamo kuzodingeka ulungiswe.
Ngoshukela
Umuthi kufanele usetshenziswe ngokuqapha futhi uqondiswe kuphela ngudokotela oya kuye.
Imiphumela emibi
Isiyezi, ikhanda, ukudideka kungenzeka. Akuvamile ukuthi, iziguli ziwe. Isisindo somzimba singakhuphuka, i-rhinitis kungenzeka. Kwezinye iziguli, ulwelwesi lwamafinyila ekhaleni livuvukala. Ukuqhaqhazela, isicanucanu, kanye nobuhlungu besisu kungenzeka. Umfutho wegazi ungakhuphuka noma wehlise. Kwesinye isikhathi i-oliguria, ukuqubuka okushisayo, ukusabela komzimba kwenzeka. I-Hyponatremia kungenzeka. Lapho usebenzisa imijovo, izinhlungu zingaphawulwa endaweni yomjovo. Uma umuthi usetshenziselwa ukwelapha izingane ezingaphansi kwezinyanga eziyi-12 ubudala, ukutholwa kungenzeka.
Umthelela ekhonweni lokulawula izindlela
Ukusetshenziswa kwomuthi akuchaphazi amandla okushayela imoto.
Imiyalo ekhethekile
Abanye abantu kufanele balandele imihlahlandlela ethile.
Sebenzisa ebudaleni
Ngemuva kweminyaka engama-65, kufanele kuqashelwe lapho kusetshenziswa umuthi.
Ukunquma i-Desmopressin ezinganeni
Ingasetshenziswa ukwelapha izingane kusuka ezinyangeni ezi-3. Kudingeka ukulungiswa kwesilinganiso
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kusetshenziswa ngokuqapha. Ukwelashwa kwenziwa ngaphansi kokubhekwa udokotela njalo.
Ngesikhathi sokukhulelwa, umuthi usetshenziswa ngokuqapha.
Ukweqisa
Izimpawu yi-hyponatremia, ukugcinwa kwamanzi. Ukuqeda lesi simo, ama-diuretics asetshenziswa, kukhishwa isixazululo esikhethekile.
Ukuxhumana nezinye izidakamizwa
Ngokusetshenziswa ngasikhathi sinye nama-ejenti aqukethe i-dopamine, umphumela wokucindezela uyathuthukiswa. I-Lithium carbonate yenza buthaka umphumela wesidakamizwa. Ukuqapha kufanele kuthathwe lapho kuhlanganiswa umuthi nezidakamizwa ezikhulisa ukukhishwa kwe-hormone ye-antidiuretic.
Ukuhambisana notshwala
Ukuphuza utshwala ngesikhathi sokwelashwa akunconywa, ngoba kwenza umuthi ungasebenzi kahle.
Ama-Analog
Umuthi unenombolo enkulu yamagama. Ama-Analogs angamathebhulethi iMinirin, iNativa, i-Adiuretin, izifutho zePreayneks, iVasomirin. I-Desmopressin Acetate nayo iyasetshenziswa. Kukhona namanye amaphilisi, amaphilisi nezixazululo ezinezakhi ze-antidiuretic. Mhlawumbe ukusetshenziswa kwezindlela zabantu.
IMinirin iyi-analogue yeDesmopressin.
Izimo Zamaholide Wokhemisi Desmopressin
Ungathenga umuthi kunoma iyiphi ikhemisi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Akunakwenzeka ukuthenga umuthi ngaphandle kadokotela.
Intengo ye-Desmopressin
Izindleko zihlukile ezifundeni ezahlukahlukene, kosokhemisi. Inkomba nayo incike ekutheni hlobo luni lomuthi umuntu aluthathayo. Ungathenga amaconsi ama-ruble angaba ngu-2 400, kuzodingeka ukhokhe ngaphezulu ngomjovo.
Izimo zokugcina zomuthi
Gcina umuthi endaweni engafinyeleleki ezinganeni, izinga lokushisa elingadluli kuma-30 degrees.
Gcina umuthi ungafinyeleleki ezinganeni.
Isikhathi sokuphelelwa yisikhathi
Umuthi ungasetjenziswa iminyaka emi-2,5. Lapho le nkathi iphela, umkhiqizo kufanele ulahlwe. Ukusetshenziswa komuthi ose kuphelelwe isikhathi kuvinjelwe.
Umkhiqizi we-Desmopressin
Umuthi lo ukhiqizwa e-Iceland.
Ukubuyekezwa kwe-Desmopressin
Umuthi uthole inani elikhulu lokubuyekezwa okuhle.
Odokotela
U-Anatoly, oneminyaka engama-38, uP Pskov: "Ngivame ukunikeza lo muthi ezigulini, ngoba imiphumela emibi ayiveli, umuthi awunobuthi, ubhekana ngempumelelo nezifo. Ngezinye izikhathi kuthatha amasonto ukuzama imithamo ehlukene uze uthole isiguli esifanele, kodwa ngemuva kwalokho kube yi-2-3 usuku, umphumela uyavela. "
Umuthi usetshenziselwa i-enicais eyinhloko yasesikhathini.
Iziguli
UDenis, oneminyaka engama-36, uKhabarovsk: "Ngenkathi indodana yami ineminyaka emihlanu ubudala, kwakukhona ukulala embhedeni. Bazama imishanguzo ehlukene, izindlela zokwelapha kodwa akukho okusizayo. Udokotela wathi le ndlela yokwelashwa i-Desmopressin. Umphumela awuzange uvele kusuka ngeviki lokuqala, kepha ikhambi lisizile. Inkinga ayisatholakali uvukile. "
U-Ana, oneminyaka engu-28 ubudala, uVologda: "Batholise i-insipidus yesifo sikashukela lapho behlolwa khona. Ngaya komunye udokotela nginethemba lokuthi kunephutha. Udokotela wakuqinisekisa ukutholwa kwalowo mtholampilo futhi wamyalela uDesmopressin. Waqala ukuzizwa engcono, ukoma kwakhe kwaphela kwaphela ebusuku. kuyabiza, kepha manje udinga ukukuphuza njalo. "
