C-PEPTIDES KUSHUKELA - UKULAWULWA KWESIFO SIKASHUKELA

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Nganoma uluphi uhlobo lwesifo sikashukela, ukuqapha isimo sakhe kubaluleke kakhulu esigulini.

Okokuqala, kubhekisisa ushukela ku-plasma. Le nqubo ingenziwa ngosizo lwamadivayisi okuxilonga ngamanye - ama-glucometer. Kepha akubaluleki kangako ukuhlaziya kwe-C-peptide - inkomba yokukhiqizwa kwe-insulin emzimbeni kanye ne-carbohydrate metabolism. Ukuhlaziywa okunjalo kwenziwa kuphela elabhorethri: inqubo kufanele yenziwe njalo ezigulini ezinesifo sikashukela salezi zinhlobo zombili.

Yini i-C-peptide

Isayensi yezokwelapha inikeza lencazelo elandelayo:

I-C-peptide ingcezu eqinile yento eyenziwe emzimbeni womuntu - i-proinsulin.

I-C-peptide ne-insulin zihlukaniswa phakathi nokwakhiwa kokugcina: ngakho-ke, izinga le-C-peptide libonisa ngokungaqondile izinga le-insulin.

Izimo eziphambili lapho kuchazwe khona i-assay ye-C-peptide yile:

Ukuxilongwa kwesifo sikashukela i-mellitus kanye nomehluko wohlobo I kanye nohlobo II lwesifo sikashukela;
Ukuxilongwa kwe-insulinoma (isimila esibi noma sokulimala kwamanyikwe);
Ukuhlonza izinsalela zezicubu ze-pancreatic ezikhona ngemuva kokukhishwa kwayo (komdlavuza wesitho);
Ukuxilongwa kwesifo sesibindi;
Ukuxilongwa kwe-ovary polycystic;
Ukuhlolwa kwamazinga e-insulin ezifweni zesibindi;
Ukuhlolwa kokwelashwa kwesifo sikashukela.

I-C-peptide yenziwe kanjani emzimbeni? I-Proinsulin, ekhiqizwa kuma-pancreas (ngokuqondile, kuma-isheyuli we-β-amaseli we-pancreatic is,), iketanga elikhulu le-polypeptide eliqukethe izinsalela ezingama-84 amino acid. Kuleli fomu, umuthi uncishiswa umsebenzi wamahomoni.

Ukuguqulwa kwama-proinsulin angasebenzi ku-insulin kwenzeka ngenxa yokuhamba kwe-proinsulin kusuka kuma-ribosomes ngaphakathi kwamangqamuzana kuya emakamelweni okugcina ngasese ngendlela yokubola okuyingxenye kwe-molecule. Ngasikhathi sinye, izinsalela ezingama-33 ze-amino acid, ezaziwa ngokuthi yi-peptide yokuxhuma noma i-C-peptide, zikhonkothwe zisuka komunye umkhawulo weteyini.

Egazini, Ngakho-ke, kukhona ukuxhumana okuveziwe phakathi kwenani le-C-peptide ne-insulin.

Kungani ngidinga ukuhlolwa kwe-C-peptide?

Ukuqonda okucacile kwesihloko, kufanele uqonde ukuthi kungani i-laboratories yokuziphatha ihlaziya kwi-C-peptide, hhayi kwi-insulin uqobo.

Izimo ezilandelayo zinomthelela kulokhu:

Ukuphila kwesigamu se-peptide esegazini kusekude kunokwe-insulin, ngakho-ke inkomba yokuqala izoqina kakhudlwana;
Ukuhlaziywa kwe-immunological ye-C-peptide kukuvumela ukukala ukukhiqizwa kwe-insulin ngisho nangasemuva kokubakhona kwe-hormone yezidakamizwa zokwenziwa esegazini (ngokwemibandela yezokwelapha - i-C-peptide ayenzi "ukuwela" nge-insulin);
Ukuhlaziywa kwe-C-peptide kunikeza ukuhlolwa okwanele kwamazinga e-insulin ngisho nalapho kukhona ama-autoimmune antibodies emzimbeni, okwenzeka ezigulini ezinesifo sikashukela sohlobo lwe-I.

Ukulungiswa kwe-insulin yezokwelapha akunayo i-C-peptide, ngakho-ke, ukunqunywa kwaleli cwecwe ku-serum yegazi kusivumela ukuthi sihlole umsebenzi wamaseli we-pancreatic beta ezigulini ezelashwa. Izinga le-basal C-peptide, futhi ikakhulukazi ukugxilwa kwalokhu ngemuva kokulayishwa kwe-glucose, kwenza ukuthi kunqume ukuba khona kokuzwela (noma ukumelana) kwesiguli ku-insulin. Ngakho-ke, izigaba zokuxolelwa noma zokudlanga ziyasungulwa futhi izindlela zokwelapha ziyaguqulwa.

Ngokudlanga kwesifo sikashukela i-mellitus (ikakhulukazi uhlobo I), okuqukethwe kwe-C-peptide esegazini kuphansi: lokhu kuwubufakazi obuqondile bokuntuleka kwe-insulin yangaphakathi (yangaphakathi). Ukutadisha kokuhlushwa kwe-peptide yokuxhuma kuvumela ukuhlolwa kwe-insulin secretion ezimweni ezahlukene zokwelashwa.

Isilinganiso se-insulin ne-C-peptide singashintsha uma isiguli sinezifo zesibindi nezinso.

I-insulin ifakwa emzimbeni we-parenchyma yesibindi, kuthi i-C-peptide idalulwe ngokusebenzisa izinso. Ngakho-ke, izinkomba zenani le-C-peptide ne-insulin zingabalulekile ekuchazweni okuyikho kwedatha ezifweni zesibindi nezinso.

Kuhlaziywa kanjani i-C-peptide

Ukuhlolwa kwegazi kwe-C-peptide kuvame ukwenziwa ngesisu esingenalutho, ngaphandle kokuthi kukhona ukuholwa okukhethekile okuvela ku-endocrinologist (lochwepheshe kufanele abonwe uma usola isifo se-metabolic). Isikhathi sokuzila ngaphambi kokunikela ngegazi amahora angama-6-8: isikhathi esingcono kakhulu sokunikela ngegazi ngakusasa ngemuva kokuvuka.

Isampula yegazi ngokwayo ayihlukile kuleyo ejwayelekile: kuthathwa umgogodla, igazi liqoqwa kushubhu elingenalutho (kwesinye isikhathi kusetshenziswa ishubhu le-gel). Uma i-hematomas ifomu ngemuva kokuthola amazinyo, udokotela ubeka i-compress efudumele. Igazi elithathiwe ligijinywa nge-centrifuge, lihlukanise i-serum, neqhwa, bese lihlolwa elabhorethri ngaphansi kwesibonakhulu usebenzisa ama-reagents.

Kwenzeka ukuthi esiswini esingenalutho izinga le-C-peptide esegazini lihambelana nokujwayelekile noma lisemngceleni walo ophansi. Lokhu akuniki odokotela isisekelo sokuxilongwa okuyiqiniso. Ezimweni ezinjalo isivivinyo esivuswe.

Njengezinto ezishukumisayo, izindlela ezilandelayo zingasetshenziswa:

Ukufakwa komphikisi we-insulin - i-glucagon (kubantu abane-hypertension, le nqubo iphikisiwe);
Isidlo sasekuseni esijwayelekile ngaphambi kokuhlaziywa (vele udle "izinkwa" eziyisithupha).

Inketho ekahle yokuxilongwa ukwenza izivivinyo ezi-2:

ukuhlaziya okusheshayo
zivuswe.

Lapho uhlaziya isisu esingenalutho, uvunyelwe ukuphuza amanzi, kepha kufanele wenqabe ukuphuza noma imiphi imithi engathinta ukunemba kwemiphumela yokuhlaziywa. Uma umuthi ungeke ukhanselwe ngenxa yezokwelapha, leli qiniso kufanele likhonjiswe kwifomu lokudluliselwa.

Isikhathi sokulungela okungenani sokuhlaziya amahora angama-3. I-Archiy Whey eligcinwe ku--20 ° C ingasetjenziswa izinyanga ezi-3.

Yiziphi izinkomba zokuhlaziywa kwe-C-peptides

Ukushintshashintsha kwezinga le-C-peptide ku-serum kufana namandla we-insulin egazini. Okuqukethwe kwe-peptide yokuzila kusukela ku-0.78 kuya ku-1.89 ng / ml (ohlelweni lwe-SI, 0.26-0.63 mmol / l).

Ngokuxilongwa kwe-insulinoma nokuhlukahlukana kwayo kusuka ku-hypoglycemia yamanga (eyiqiniso), isilinganiso se-C-peptide esilinganisweni se-insulin sinqunywa.

Uma isilinganiso sinye noma singaphansi kwaleli nani, lokhu kubonisa ukwakheka okwandisiwe kwe-insulin yangaphakathi. Uma izinkomba zinkulu kune-1, lokhu kuwubufakazi bokwethulwa kwe-insulin yangaphandle.

Ileveli ephakeme

Isimo lapho izinga le-C-peptide liphakanyisiwe lingakhombisa ama-pathologies alandelayo:

Isifo sikashukela sohlobo II;
I-Insulinoma;
Isifo se-Itsenko-Cushing's (isifo se-neuroendocrine esibangelwa yi-adrenal hyperfunction);
Ukwehluleka kwezinso;
Isifo sesibindi (i-cirrhosis, i-hepatitis);
I-ovary yePolycystic;
Ukukhuluphala kwabesilisa;
Ukusetshenziswa isikhathi eside kwama-estrogens, ama-glucocorticoids, nezinye izidakamizwa ze-hormonal.

Izinga eliphakeme le-C-peptide (futhi ngenxa yalokho i-insulin) lingakhombisa ukwethulwa kwama-glucose agents okwehliswayo. Kungaba futhi kube yimiphumela yokufakelwa kwamanyikwe noma ukufakelwa kwe-beta cell.

Izinga eliphansi

Iphansi ngokuqhathaniswa nezinga elijwayelekile le-C-peptide ibonwa lapho:

Uhlobo 1 sikashukela;
I-hypoglycemia yokwenziwa;
Ukuhlinzwa okususa ukuhlanza i-pancreatic.

Imisebenzi ye-peptide

Abafundi kungenzeka babe nombuzo onengqondo: kungani sidinga ama-C-peptides emzimbeni?

Kuze kube muva nje, bekukholelwa ukuthi le ngxenye yenxanxathela ye-amino acid ayisebenzi futhi ingumkhiqizo owenziwe ngokwakhiwa kwe-insulin. Kepha ucwaningo lwakamuva olwenziwe yi-endocrinologists kanye ne-diabetesologists luholele esiphethweni sokuthi le nto ayisebenzi neze futhi idlala indima emzimbeni, ikakhulukazi ezigulini ezinesifo sikashukela.

Ngokwemibiko engaqinisekisiwe, ukuphathwa ngokufana kwe-C-peptide ngesikhathi sokwelashwa kwe-insulin kweziguli ezinesifo sikashukela kuvumela ukugwema izinkinga ezinkulu zesifo njenge-nephropathy (ukungasebenzi kahle kwezinwele), i-neuropathy ne-angiopathy (ukulimala kwemizwa nemithambo yegazi, ngokulandelana).

Kungenzeka ukuthi esikhathini esizayo esiseduze amalungiselelo e-C-peptide azophathwa kanye ne-insulin kwabanesifo sikashukela, kepha kuze kube manje izingozi ezingaba khona nemiphumela emibi yokwelashwa okunjalo ayikaze inqunywe emtholampilo. Ucwaningo olwengeziwe ngalesi sihloko lusazofika.

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