Inkinga ye-cholesterol ephezulu egazini namuhla ibhekene nabaningi. Abelaphi nezazi zezinhliziyo baqapha le nkomba ngokucophelela okuthile, ngoba ikhuluma ngesimo lapho imikhumbi itholakala khona, ubunikazi bayo, kanye nekhono lazo lenkontileka.
Shintsha amazinga e-cholesterol ngemithi. Imvamisa, i-Atorvastatin ilungile kulo msebenzi. Udinga ukukuthatha kuphela ngemuva kokubonana nodokotela futhi ukuhlolwa okufanele, okuzoqinisekisa ukuba khona kwezinkomba futhi kukuvumele ukuthi ukhethe idosi ngokwalo.
Lesi sidakamizwa singokwesigaba semithi yama-statin, asiza ukumisa ukuqhubeka kwama-cholesterol plaque ezindongeni zemithambo yegazi. Ngasikhathi sinye, indawo yezindawo ezithintekile zemithambo ngemuva kokwelashwa ihlala ifana. Izinto eziqukethwe umuthi zinganciphisa kakhulu ukuqhubekisela phambili kwesifo senhliziyo, ukuntuleka kwamalungu emilenzeni kanye nesifo sokuqina kwemizwa.
I-Atorvastatin igxiliwe kahle, kepha ukudla kungasithinta kancane lesi sikhombisi, yize ukwehla kokuxineka kwe-LDL egazini kungaguquki.
Yini ingxenye yalesi sidakamizwa? I-calcium calcium ukwedlula konke kuyisakhi esisebenzayo somuthi, futhi ezinye izinto zihlanganisa:
- cellulose;
- i-calcium carbonate;
- isilika;
- titanium;
- i-macrogol.
Umuthi ungathengwa kumthamo wamamitha ayi-10, 20, 40 no-80.
Ukuze ubone umphumela wokusetshenziswa, udinga ukuthatha amaphilisi njalo amasonto amabili ngaphandle kokudlula. Ngemuva kwenyanga eyodwa, umphumela omkhulu wokwemukelwa kwenzeka, ozogcinwa ezingeni elifanayo phakathi nayo yonke inkambo yokwelashwa.
Imiyalo yokusebenzisa umuthi
Indlela yokwelashwa kwe-atherossteosis ne-cholesterol ephakeme yegazi kufanele ibe ephelele. Ngakho-ke, i-atorvastatin iyanconywa ukuba ithathwe kanyekanye ngokugcinwa kokudla kwe-anticholesterol, okufanele ihlale phakathi nenkambo yonke yokwelapha.
Ungaphuza umuthi ngaphandle kokubhekisa ekuthatheni kokudla, okungukuthi, nganoma yisiphi isikhathi esivumelana nomuntu. Umthamo ubekwa ngudokotela ohamba yedwa ngokwesisekelo sokuhlaziywa. Kuyo yonke le nkambo, amapharamitha we-cholesterol kufanele abhekwe, futhi, ngokusekelwe kulokhu, uma kunesidingo, alungisa umthamo nobude besikhathi sokwelashwa ngemuva kwamasonto amabili kuya kwamane.
Ukwelapha kuqala ngamamiligiramu ayi-10 ale nto, kumele aphuzwe kanye ngosuku. Ngemuva kwalokho inani lemithi lingahluka phakathi kwama-milligram angama-10-80 ngosuku. Uma umuthi unqunyelwe ngokuhambisana neCyclosporine, khona-ke inani le-Atorvastatin alikwazi ukuba ngaphezu kwamamayela ayi-10.
Uma ukuthatha lo muthi kuhlotshaniswa nokukhula komndeni noma i-homozygous hypercholesterolemia, khona-ke lokho kudla kufanele kube ngu-80 mg ngosuku. Lelinani kufanele lihlukaniswe ngama-application amane ama-milligram angama-20 lilinye. Iziguli ezinokwehluleka kwe-renal azidingi ukulungisa umthamo womuthi, ngokungafani neziguli ezihluleka isibindi.
Uma okweqisa izidakamizwa noma komzimba kwenzeka, kufanele uvakashele udokotela ngokushesha ukuze akunikeze ukwelashwa okubonakalayo.
Izinkomba futhi contraindication
Lapho unquma umuthi, ubukhona be-contraindication kungenzeka busetshenziswe umuthi kufanele bunakwe.
Ukuzilawula kwalo muthi akuvunyelwe nakancane.
Ukuqokwa kufanele kwenziwe ngudokotela oholayo, kucatshangelwa ukwephulwa okungase kube khona kanye nezimpawu zomzimba wesiguli.
Kungani i-Atorvastatin ivame ukubekwa?
Lo muthi uyakhonjiswa:
- Nge-cholesterol ephezulu.
- Ngama-pathologies emithambo yegazi nenhliziyo (noma ngabe lezi zifo bezingatholakalanga, kepha kunezici zobungozi, ezifana nokukhuluphala, isifo sikashukela, ukuguga, umfutho wegazi ophakeme kanye ne-hereditary predisposition).
- Ngemuva kokuba isiguli sizwe imivimbo, ukuhlaselwa yisifo senhliziyo, kwatholakala nokuthi angina pectoris.
Njengoba kushiwo ngaphambili, ukwelashwa ne-Atorvastatin kumele kuhlanganiswe nokudla.
Njengezinye izidakamizwa, lo muthi unezimpawu ezithile zokuzisebenzisa.
Ukuphulwa okunjalo yile:
- ukwehluleka kwezinso;
- izifo zesibindi ezisebenzayo;
- isikhathi sokukhulelwa nokukhulelwa;
- iminyaka efinyelela eminyakeni eyishumi nesishiyagalombili;
- ukungabekezelelani ezingxenyeni zomuthi, maqondana nokuvela kokungezwani komzimba.
I-Atorvastatin akufanele ithathwe yizingane, kanye nentsha engaphansi kweminyaka yobuningi, ngenxa yokuthi ukuphepha kokusetshenziswa kanye nokusebenza kahle kokwelashwa nalesi sidakamizwa ezinganeni akukasungulwa ngokuthembekile.
Akukacaci nokuthi umuthi ungakhishwa ubisi lwebele yini. Kodwa-ke, ngokubheka amathuba okuvela kwemicimbi engemihle ezinganeni, kanye nezinkomba zokusebenzisa umuthi kwabesifazane ngesikhathi sokudla, kubalulekile ukuyeka ukuncelisa ibele.
Ngokuqondene nabesifazane abelashwa ngesikhathi sokuzala, kufanele basebenzise izindlela zokuvimbela inzalo ngesikhathi sokwelashwa.
Ngokuvamile, ukuqokwa kwe-Atorvastatin ngalesi sikhathi kufanelekile lapho kunethuba eliphansi kakhulu lokukhulelwa, futhi lapho umuntu wesifazane esazi ukuthi kungaba nengozi yokwelashwa kwengane.
Njengazo zonke izidakamizwa, i-atorvastatin inemiphumela emibi eminingana eyenzeka lapho isetshenziswa inqubo yokwelashwa.
Ukuvela kwemiphumela emibi kufanele kubhekwe lapho uphuza umuthi.
Ukuvimbela imiphumela emibi engaba khona emzimbeni, umuthi kufanele unikezwe udokotela wakho kuphela.
Ukusetshenziswa kwesidakamizwa i-Atorvastatin kungadala imiphumela emibi:
- ukushisa kwenhliziyo, isicanucanu, ukuqhakaza, kanye nokuphazamiseka kwesisu;
- ukungahambi kahle komzimba;
- i-thrombocytopenia, i-anemia;
- i-rhinitis ne-bronchitis;
- ukutheleleka kwe-urogenital, kanye ne-edema;
- ukukhuphuka kokujuluka;
- ukulahlekelwa izinwele
- ukuvela kokuzwela okwengeziwe
- Amehlo omile, i-hemorrhage ebuyayo;
- i-tinnitus, ikhanda kanye nesiyezi;
- ukuqwasha
- seborrhea, eczema;
- ukujuluka ngokweqile;
- ukuluma nokuqhaqha esikhunjeni;
- kwehlise i-libido kwabesifazane, ukumiswa kwemizwa nokungasebenzi kahle kwabesilisa;
- i-myalgia, isifo samathambo, ukuqina kwemisipha.
Ukuxhumana nezinye izidakamizwa
Akunconyelwe ukusebenzisa umuthi kanyekanye nge:
- Izidakamizwa ze-antifungal.
- Ama-antibacterial agents, ama-antibacterial agents.
- ICyclosporine.
- Okususelwa ku-fibroic acid.
Ngale nhlanganisela yezidakamizwa, kukhuphuka ukwanda kokuhlushwa kwe-Atorvastatin kanye nengozi eyengeziwe ye-myalgia.
Ukusetshenziswa kokumiswa, okufaka i-aluminium ne-magnesium, kungasiza ekunciphiseni ukuhlangana kwomuthi. Kodwa azithinti isilinganiso sokuncipha kwe-cholesterol ephelele ne-LDL.
Ngokuqapha ngokweqile, umuntu kufanele aphathe inhlanganisela ye-Atorvastatin nezidakamizwa ezinciphisa ukugcwala kwamahomoni e-steroid (ngokwesibonelo, uKetoconazole noma uSpironolactone).
Ngaphambi kokuthatha i-Atorvastatin, kunconyelwa ukuthi ufeze amazinga e-cholesterol ajwayelekile ngokuguqula indlela ophila ngayo nangokulungisa indlela odla ngayo. Lezi izindlela eziyinqayizivele zokuvimbela nokwelapha imithambo yegazi nezinye izifo zezitho.
Lapho uthatha umuthi, ama-myopathies angavela - ubuthakathaka nobuhlungu emisipha yomzimba. Uma kwenzeka izinsolo zalesi sifo, ukusetshenziswa kwomuthi kufanele kumiswe ngokushesha. Ngaphezu kwalokho, ingozi yokuthola le-pathology ingakhuphuka ngokusetshenziswa kanyekanye kwe-Atorvastatin nge-Erythromycin, iCyclosporine, ama-antifungal agents ne-nicotinic acid.
Lapho uthatha umuthi, kufanele uqaphele lapho wenza imisebenzi edinga ukunakwa okwengeziwe, kanye nalapho ushayela izimoto.
Akunconyelwe futhi ukuphuza ama-statin neziphuzo zotshwala, ngoba lokhu kungaguqula umphumela wemithi noma kubangele imiphumela emibi.
Imithi enezinto ezifanayo ezisebenzayo nomthelela emzimbeni, futhi engachazwa esikhundleni se-Atorvastatin (analogues), ifaka i-Atoris, Tulip, Lipoford, Ator, Torvakard, Lipramar, Rosulip neLiptonorm.
Bahluka kanjani? Uma wenza ukuqhathanisa, ungabona ukuthi ngokuyisisekelo umehluko ukhawulelwe kuphela izwe lokwenziwa kwalo muthi nomenzi. Zonke izinto zokwelapha ezinokwakhiwa okufanayo kwezakhi (okubizwa ngama-generics) zinamagama ahlukile, okwenza sikwazi ukuzikhulula. Njengoba kungekho mehluko wezithako ezisebenzayo, le mishanguzo ingabhekwa njengengxenye efanayo ye-Atorvastatin.
Ngesikhathi sokulashwa, i-Atorvastatin kufanele igcinwe endaweni eyihlane yezingane ukufinyelela kuyo, nalapho ukukhanya kwelanga kungashoni khona. Ngasikhathi sinye, kubalulekile ukuthi izinga lokushisa aliphezulu kune-25 degrees Celsius.
Intengo yomuthi yakhiwa ngawodwa yinkampani yemithi ngayinye. Izindleko ezimaphakathi zesidakamizwa esilinganisweni samathebulethi angama-30 yile:
- amaphilisi anomthamo we-10 mg - ama-ruble ayi-140-250;
- izibhebhe ezinomthamo we-20 mg - ama-ruble angama-220-390;
- amaphilisi ngomthamo wama-40 mg - ama-ruble ayi-170-610.
Izindleko zomuthi nazo zincike kakhulu esifundeni esithengiswayo.
Ngokusho kweziguli ezisebenzise lo muthi, zinomphumela omuhle kakhulu futhi zinomthelela ekuqineni okusheshayo kwe-cholesterol emzimbeni.
I-Atorvastatin ichazwe kuvidiyo kule ndatshana.
