I-pancreatitis engapheli ukuvuvukala okwenziwe ngaphakathi kumanyikwe, okuholela ekuguqukeni okungenakuguqulwa kumaseli nezicubu zesitho sangaphakathi. Ifomu elinzima, ingxenye enkulu yezicubu ze-gland ithathelwa indawo, yenziwa ikhiqizwa izicubu ze-lipid nezithinta.
Emzimbeni, kukhona ukwephulwa kokufihlwa kwangaphakathi nangaphandle. Ngokuphikisana nesizinda sokuntuleka kwemfihlo kwangaphandle, kutholakala ukuntuleka kwama-enzyme, futhi ngokumelene nesizinda sengxenye yangaphakathi, ukwephula ukubekezelela ushukela.
Ngakho-ke, umbuzo uwukuthi, ingabe i-pancreatitis ingaphenduka isifo sikashukela, impendulo inguyebo. Ngokwezibalo, indlela engamahlalakhona ye-pancreatitis iholela kwisifo sohlobo lwesibili kuma-35% wezithombe zemitholampilo.
Kodwa-ke, ukudla okulinganiselayo, okusho ukudla nokusetshenziswa kokudla okugunyaziwe kuphela, kukuvumela ukuthi uvikele isifo sikashukela ezigabeni zokuqala zokukhula kwenqubo ye-pathological.
Indlela yokuthuthukiswa kwesifo sikashukela se-pancreatic
Ochwepheshe bezokwelapha abafikanga esivumelwaneni mayelana ne-etiological pathogenesis yalesi sifo njengesifo sikashukela se-pancreatic. Ukuqalwa kwesifo "esimnandi" kuholela ekubhujisweni kancane kancane kanye nokuqina kwamathuluzi okufakelwa, okuwukuphendula kokuvuvukala emangqamuzaneni, okunomthelela ekwenzeni ama-enzyme wokugaya ukudla.
I-gland yomuntu ibonakala ngempahla yokufihla exubile. Umsebenzi wawo ukukhiqiza ama-enzyme akhishwa emgodini wokugaya ukudla, esiza ukwenza ngcono ukugaya ukudla. Umsebenzi wesibili ukukhiqizwa kwe-insulin. Yi-hormone elawula ushukela wegazi ngokusetshenziswa kwayo.
Inkambo ende ye-pancreatitis ephuza kakhulu noma engamahlalakhona, ukuphefumula ngokweqile kwalesi sifo kuholela ekutheni ngaphezu kwe-gland, ebhekele inqubo yokugaya, uhlelo lwe-insulin, olukuhlobo lweziqithi zeLangerhans, luyathinteka.
Imvamisa umfutho wokuthuthukiswa kwesifo sikashukela kungenye ukuphazamiseka okwenzeka ohlelweni lwe-endocrine. Izimpawu zesifo sikashukela sesibili zifana nohlobo lokuqala lwesifo, kepha umehluko ukuthi izicubu ze-gland azithinteki yi-autoantibodies.
Izimbangela ezilandelayo zingaholela ekumelaneni ne-insulin:
- Isifo sayo i-Itsenko-Cushing.
- Pheochromocytoma.
- I-Glucagonoma.
- I-Pathology kaWilson-Konovalov.
- I-Hemochromatosis.
Isifo sikaCohn sihambisana nokukhubazeka kwe-potassium metabolism emzimbeni. AmaHepatocytes wesibindi awakwazi ukusebenza ngokujwayelekile ngaphandle kwe-potassium eyanele yokusebenzisa ushukela. Kulokhu, kutholakala izimpawu zesifo sikashukela ezihambisana nesimo se-hyperglycemic.
Izinkinga ze-pancreatitis engapheli - i-parapancreatitis, i-tumor pancreatic neoplasms, somatostatinoma ingaholela ekwakhiweni kwesifo sikashukela i-mellitus.
Isitho sangaphakathi singaba ilitshe lezinhlungu nezinto ezinobuthi - ama-pesticides, corticosteroids, njll.
Izimbangela nezimpawu zesifo sikashukela nge-pancreatitis
I-pancreatitis kanye nesifo sikashukela yizifo ezimbili ezivame ukuhlangana nazo kwezokwelapha ngasikhathi sinye. Isifo sikashukela se-pancreatic sivela ngenxa yokubhujiswa kwezinto zokusebenza ze-insulin. Abanye odokotela bafike esiphethweni sokuthi ukuphazamiseka kwe-autoimmune emzimbeni kusebenza njengento evusayo.
Kuyaziwa ukuthi ukuhlukaniswa kwesifo sikashukela kuhlukanisa izinhlobo ezimbili ezivame kakhulu - lezi ezokuqala nezesibili. Kunezinhlobo zezinhlobo ezinqabile ezidalwa ukungasebenzi kahle kwe-autoimmune.
I-mancitus yesifo sikashukela i-pancreatogenic iyafana nasezibonakalweni ze-pathology zohlobo lokuqala, noma kunjalo ingeyesifo sohlobo "olu-3" oluhle. Ngokufanelekile, ukwelashwa nendlela yokuthola lesi sifo kwehlukile ekwelashweni kwesifo sikashukela.
Izici eziphambili ezihlukanisayo zesifo sikashukela se-pancreatogenic:
- Ngesikhathi ukwelashwa nge-insulin, izimo ze-hyperglycemic acute zivame ukukhula.
- Ukuntuleka kwe-insulin kuvame ukuholela ku-ketoacidosis.
- Ifomu le-pancreatic lalesi sifo lilungiswa kalula ngokusebenzisa imenyu yokudla equkethe inani elincane lama-carbohydrate asheshayo.
- Isifo sikashukela sohlobo lwe-pancreatic sisebenza kangcono ekwelapheni izidakamizwa zikashukela.
Isifo sikashukela se-Classical 2 senzeka ngenxa yokungapheleli ngokuphelele noma okuyingxenye kwe-insulin ye-hormone. Ukushoda kubangelwa ukumelana ne-insulin, okuwumphumela wokudla ngokweqile kwe-khalori ephezulu ngokweqile kwe-carbohydrate elula. Ngokungafani nesifo sikashukela i-mellitus sohlobo lwesibili, isifo sikashukela se-pancreatogenic sisuselwa kumonakalo oqondile kumaseli we-beta ngama-enzymes wokugaya.
I-pancreatitis engemuva kwesifo sikashukela i-mellitus (isifo sokuqala siyindlela yokuzimela, futhi isifo sikashukela "ingemuva" layo) iqhubeka ngokuhlukile: izinqubo zokuvuvukala zamanyikwe ziba nenkambo engapheli, umlingiswa ovilaphayo, ukuhlasela okukhohlakele kungenzeka.
Ukuboniswa okuyinhloko kliniki:
- Isifo sezinhlungu ngokuqina okuhlukahlukene.
- Ukuqunjelwa.
- Ukuqhakaza, isifo sohudo, ukushisa kwenhliziyo.
Isifo sikashukela sikhula ngo-35% weziguli ezinesifo sokuqina se-pancreatitis esisebenza isikhathi eside, futhi lokhu kuphindaphindwe kathathu njengesifo sikashukela esibangelwa amanye ama-pathologies.
Izici zokwelashwa okulondoloziwe
Ungakwazi ukuphuza i-pancreatin yesifo sikashukela sohlobo 2? Lo muthi ngeke usilaphe isifo sikashukela, kepha kuhloswe ngawo ukuthuthukisa ukugaya, ngakho-ke kuyamukeleka ukuwuthatha kanye nalesi sifo. Njengoba ama-analogues angancoma iPangrol, iMezim.
I-pancreatin yohlobo 2 lwesifo sikashukela inomthelela kulungiswa kwe-maldigestion syndrome. Kuyadingeka njengokwelashwa okubuyiselwa. Umuthi ungathathwa ngesikhathi sokukhulelwa, lapho usegugile.
Umyalo wokusetshenziswa uthi ukungabekezelelani kwezinto eziphilayo kungukuphambana. Kudingeka incwadi kadokotela. Umthamo unqunywa ngawodwana, kumele uthathwe ngokudla noma ngemuva kwawo.
Ukwelashwa kwesifo sikashukela, kungenzeka kunconywe umuthi i-Diabeteson MV. Umuthi ufakwa ohlwini lwezidakamizwa ezihamba phambili ze-hypoglycemic. Ngokunakekelwa okukhethekile kunconyelwa iziguli esezikhulile.
I-pancreatitis kusifo sikashukela iphathwa ngokudla okuqinile ikakhulukazi ezigulini. Lesi yisisekelo sesimo sezulu esihle. Awukwazi ukudla okunamafutha, okunosawoti, okunoshukela kanye nezinongo, kunqatshelwe ngokuphelele ukuphuza utshwala.
Ukugwema izinkinga ezinokubangela ukuphazamiseka emzimbeni, kufanele uhambisane nemigomo yezempilo:
- Yidla ukudla kwamaprotheni kuze kufike ku-200 g ngosuku.
- Ukudla okunezakhamzimba kuze kube izikhathi eziyisithupha ngosuku. Ukusebenzela usayizi 230 g
- Isisekelo sokudla imifino eluhlaza nezithelo.
Uhlobo lwe-pancreatic lwesifo sikashukela alukhuli kuzo zonke iziguli, kodwa luse-35% kuphela. Ukuhlanganiswa kwezifo ezimbili kugcwele ingozi enkulu. Ukuntuleka kokwelashwa okwanele kungaholela ekutheni kuxoxwe i-pancreatic abscess, isifo sikashukela, i-nephropathy kanye nezinye izinkinga eziningi, ngenxa yalokho, ukukhubazeka, ukufa akuhlanganisiwe.
Ukwelapha kugcwele. Izidakamizwa ze-enzyme zokwelapha i-gland dysfunction kanye ne-hypoglycemic drug (ifomu lethebhulethi, i-insulin therapy) zinconyelwa nakanjani.
Isazi kuvidiyo ekulesi sihloko sizokhuluma ngezici zepancreatitis yesifo sikashukela.
