I-Rosinsulin C ilawulwa ngokungaziphathi izikhathi eziyi-1-2 ngosuku, cishe ingxenye yehora ngaphambi kokudla. Isikhathi ngasinye, indawo yomjovo kufanele ishintshwe.
Kwezinye izimo, i-endocrinologist ingabeka umjovo wesiguli umuthi obulala umuthi.
- ngesifo sikashukela mellitus 1 no-2;
- esigabeni sokumelana nemithi yomlomo ye-hypoglycemic;
- ekwelashweni okuhlangene (ukumelana kancane nezidakamizwa zomlomo ze-hypoglycemic);
- nge-mono - noma inhlanganisela yokwelashwa ngesikhathi sokungenelela kokuhlinzwa;
- ngezifo ezithinta umzimba;
- onesifo sikashukela kwabesifazane abakhulelwe, lapho ukwelashwa kokudla kunganikezi umphumela oyifunayo.
Imithamo nokuphatha
Ukumiswa komjovo ongaphansi komhlaba. Contraindication yi-hypoglycemia, hypersensitivity.
I-Rosinsulin C ilawulwa ngokungaziphathi izikhathi eziyi-1-2 ngosuku, cishe isigamu sehora ngaphambi kokudla. Isikhathi ngasinye, indawo yomjovo kufanele ishintshwe. Kwezinye izimo, i-endocrinologist ingabeka umjovo wesiguli umuthi obulala umuthi.
Nakani! Ukuphathwa okungaphakathi kwe-insulin yesikhathi esiphakathi kwenqatshelwe! Esimweni ngasinye ngasinye, udokotela ukhetha le ndlela umthamo ngamunye, ongaxhomekeka ezicini zenkambo yesifo kanye nokuqukethwe ushukela egazini nomchamo.
Umthamo ojwayelekile ngu-8-24 IU, ophethwe isikhathi esi-1 ngosuku, ngoba lokhu ungasebenzisa isirinji ye-insulin ngenaliti esikhiphekayo.
Ezinganeni nakubantu abadala abanokuzwela okuphezulu kwe-hormone, umthamo ungancishiswa uye ku-8 IU ngosuku, futhi, ngakolunye uhlangothi, ezigulini ezinokuzwa okuncishisiwe, ungakhushulelwa ku-24 IU ngosuku noma ngaphezulu.
Uma umthamo wosuku lomuthi udlula i-0.6 IU / kg, uhanjiswa amahlandla ama-2 ngosuku ezindaweni ezahlukahlukene. Uma umuthi uphathwa ngenani le-100 IU ngosuku noma ngaphezulu, isiguli kufanele silaliswe esibhedlela. Ukushintshwa kwe-insulin eyodwa kuya kwenye kufanele kwenziwe ngaphansi kokunaka kodokotela.
I-Pharmacokinetics
Umuthi ungowama-insulin aphakathi nendawo, aqondiswa:
- ukunciphisa ushukela wegazi;
- ukwandisa ukumunca ushukela ngama-tishu;
- ukuthuthukisa i-glycogenogeneis ne-lipogeneis;
- ukunciphisa izinga lokukhuphuka koshukela kwesibindi;
- ngokuhlanganiswa kwamaprotheni.
Imiphumela emibi
Ukuphendula komzimba:
- i-angioedema;
- ukuphefumula
- i-urticaria;
- ukuncipha kwengcindezi yegazi;
- umkhuhlane.
Izimpawu ze-Hypoglycemic:
- ukukhuphuka kokujuluka;
- indlala yesikhumba;
- umuzwa wendlala;
- izibuko
- Ukukhathazeka
- umjuluko;
- ukuvuka
- ukuthuthumela
- i-paresthesia emlonyeni;
- ukozela
- ukudangala komoya;
- ukuziphatha okungajwayelekile;
- ukungahambi kahle;
- ukungaqiniseki kokunyakaza;
- ukwesaba
- ukukhuluma okungaboni kahle;
- ukuqwasha
- ikhanda.
Uma uphuthelwa umjovo, umthamo ophansi, ngemuva kwemvelaphi yokutheleleka noma umkhuhlane, uma ungalandeli ukudla, ungahlakulela isifo sikashukela kanye ne-hyperglycemia:
- ukwehla kwesifiso sokudla;
- ukoma
- ukozela
- hyperemia yobuso;
- ukwazi ukungasebenzi kahle kuze kufike ekhefeni;
- ukulimala okubukwayo okwesikhashana ekuqaleni kokwelashwa.
Izincomo ezikhethekile
Ngaphambi kokuthi uqoqe umuthi kusuka ku-vial, qiniseka ukuthi isisombululo sisobala. Uma indle noma ukungasebenzi kubonwa kulungiselelwa, khona-ke ngeke kusetshenziswe
Izinga lokushisa lesisombululo sokuphatha kufanele lihambisane lokushisa kwekamelo.
Kubalulekile! Uma isiguli sinezifo ezithathelwanayo, ukuphazamiseka kwe-yegilo, i-hypopituitarism, isifo sika-Addison, ukwehluleka okungamahlalakhona kwezinso, kanye nakubantu abaneminyaka engaphezu kwengama-65 ubudala, kulungiswa ukulungiswa komthamo we-insulin.
Izimbangela ze-hypoglycemia zingaba:
- Ukubuyiselwa umuthi.
- Ukweqisa.
- Yeqa ukudla.
- Izifo ezinciphisa isidingo somuthi.
- Ukuqhaqha, isisu.
- I-Hypofunction ye-adrenal cortex.
- Ukucindezela ngokomzimba.
- Ukuguqulwa kwendawo yomjovo.
- Ukuxhumana nezinye izidakamizwa.
Lapho udlulisela isiguli esivela ku-insulin yezilwane siyiswa kwi-insulin yabantu, ukuncipha kokuhlushwa kashukela egazini kungenzeka.
Incazelo yesenzo somuthi i-Rosinsulin P
I-Rosinsulin P isho izidakamizwa ezinomphumela omfushane we-hypoglycemic. Ukuhlanganiswa ne-receptor ye-membrane yangaphandle, ikhambi lakha inkimbinkimbi ye-insulin receptor. Le yinkimbinkimbi:
- kwandisa ukwakheka kwe-cyclic adenosine monophosphate esibindini nakumaseli wamafutha;
- ivuselela izinqubo ze-intracellular (pyruvate kinases, hexokinases, glycogen synthases nabanye).
Ukwehla kokuhlushwa kashukela egazini kwenzeka ngenxa:
- ukukhulisa ukuthuthwa okungaphakathi;
- ukukhuthaza kwe-glycogenogeneis, i-lipogenesis;
- synthesis amaprotheni;
- kutfutfukisa kufakwa kwemuthi ngeticubu;
- ukwehla kokuwohloka kwe-glycogen (ngenxa yokwehla kokukhiqizwa kwe-glucose ngesibindi).
Ngemuva kokuphathwa kwe-subcutaneous, umphumela wesidakamizwa wenzeka ngemizuzu engama-20-30. Ukuhlushwa okuphezulu egazini kutholakala ngemuva kwamahora ama-1-3, futhi ukuqhubeka kwesenzo kuncike endaweni nakwindlela yokuphatha, umthamo kanye nezimpawu zomuntu ngamunye zesiguli.
Izinkomba zokusetshenziswa
I-Rosinsulin P isetshenziswa emacaleni alandelayo:
- Isifo sikashukela mellitus 1 no 2.
- Ukumelana ngokwengxenye kwemithi yomlomo ye-hypoglycemic.
- Ukwelapha okuhlanganayo
- I-Ketoacidotic ne-hyperosmolar coma.
- Isifo sikashukela sikashukela.
- Isifo sikashukela senzeka ngesikhathi sokukhulelwa.
Ukusetshenziswa kwezikhathi ezithile:
- ngesikhathi sokuzalwa kwengane, ukulimala, ukuhlinzwa okuzayo;
- ngaphambi kokushintsha imijovo ngamalungiselelo we-insulin isikhathi eside;
- nezinkinga ze-metabolic;
- ngezifo ezihambisana nomkhuhlane omkhulu.
Contraindication dechibini
Contraindication yi-hypoglycemia, hypersensitivity.
Indlela yokuphatha umuthi kanye nomthamo esimweni ngasinye kunqunywa ngokuhlukile. Isisekelo sokuthola umthamo wukuqukethwe ushukela osegazini ngaphambi nangemva kokudla, izici zenkambo yesifo kanye ne-glucosuria.
I-Rosinsulin P yenzelwe ukuphatha ngokuqopha, ukufakwa kwamathambo nokuqina kwemithambo. Imijovo yenziwe imizuzu engu-15-30 ngaphambi kokudla. Imvamisa, ikhambi liphathwa ngokungaziphathi.
ekusebenzeni kokuhlinzwa, i-ketoacidosis yesifo sikashukela nethala, i-rosinsulin P ilawulwa ngokuhlinzwa nangaphakathi emgomeni, ngoba lokhu kuyadingeka ukwazi ukuthi ungayifaka kanjani injulansi i-insulin kahle nangokufanele.
Nge-monotherapy, inani lemijovo ngosuku liyizikhathi ezi-3. Uma kunesidingo, angakhushulwa aze afike ezikhathini ezi-5-6. Ukugwema ukuthuthukiswa kwe-lipodystrophy, i-hypertrophic ye-adipose izicubu, i-atrophy, kuyadingeka ukuguqula indawo yomjovo ngaso sonke isikhathi.
Ukuphendula komzimba:
- i-angioedema;
- ukuphefumula
- ukuncipha kwengcindezi yegazi;
- i-urticaria;
- umkhuhlane.
Izimpawu ze-hypoglycemia:
- ukukhuphuka kokujuluka;
- i-tachycardia;
- ukuvuka
- ukozela
- indlala yesikhumba;
- umuzwa wendlala;
- umuzwa wokukhathazeka;
- umjuluko;
- ukuthuthumela
- i-paresthesia emlonyeni;
- ukukhuluma okungaboni kahle;
- ukungaqiniseki kokunyakaza;
- Ukudana
- isimangaliso;
- ukungahambi kahle;
- ukunganaki
- ukuqwasha
- ikhanda.
Ngokwemuva kokutheleleka noma umkhuhlane, ngomjovo ophuthelwe, umthamo ophansi, futhi uma ukudla kungalandelwa, isiguli singaba nesifo sikashukela kanye ne-hyperglycemia:
- ukulahleka kwesifiso
- ukoma
- ukozela
- ukuvuvukala kobuso;
- ukwazi ukungasebenzi kahle kuze kufike ekhefeni;
- ukulimala okubukwayo okwesikhashana ekuqaleni kokwelashwa.
Izincomo ezikhethekile
Ngaphambi kokuqoqa i-rosinsulin C kusuka ku-vial, qiniseka ukuthi isisombululo sisobala. Uma i-sediment noma i-turbidity ibonwa ku-insulin, ayikwazi ukusetshenziswa. Izinga lokushisa lomjovo kufanele libe lokushisa lasekamelweni.
Nakani! Uma isiguli sinezifo ezithathelwanayo, ukuphazamiseka kwe-thymus gland, hypopituitarism, isifo sika-Addison, ukwehluleka okungamahlalakhona kwezinso, kanye nakubantu abaneminyaka engaphezu kwengama-65 ubudala, kulawulwa umthamo we-insulin.
Umphumela we-hypoglycemia ungaba:
- Ukuguqulwa kwezidakamizwa.
- Umthamo owedlulele.
- Yeqa ukudla.
- Izifo ezinciphisa isidingo somuthi.
- Isicanucanu, isifo sohudo.
- Umsebenzi we-adrenal cortex onganele.
- Umsebenzi womzimba.
- Ukuguqulwa kwendawo yomjovo.
- Ukuxhumana neminye imithi.
Lapho udlulisela isiguli sisuka ku-insulin yezilwane siyiswa kwi-insulin yabantu, ukwehla kwamazinga kashukela wegazi kungenzeka.
