Namuhla, esinye sezidakamizwa esidume kakhulu yi-Liraglutide ekwelashweni kwesifo sikashukela sohlobo 2.
Vele, ezweni lethu lithole ukuthandwa kwalo muva nje. Ngaphambi kwalapho, yayisetshenziswa kabanzi e-United States, lapho ibisetshenziswa khona kusukela ezinkulungwaneni ezimbili nesishiyagalolunye. Inhloso yayo eyinhloko ukwelashwa kwesisindo ngokweqile kwiziguli ezindala. Kepha ngaphandle kwalokhu, kusetshenziselwa futhi ukwelapha isifo sikashukela, futhi njengoba wazi, ngesifo sikashukela sohlobo 2, inkinga efana nokukhuluphala imvama kakhulu.
Ukusebenza kahle kwalesi sidakamizwa kungenzeka ngenxa yezakhi ezihlukile ezakha ukwakheka kwawo. Okungukuthi, yiLyraglutide. I-analogue ephelele ye-enzyme yomuntu, enegama elithi glucagon-like peptide-1, elinomphumela wesikhathi eside.
Le ngxenye iyi-analogue yokwenziwa yesici somuntu, ngakho-ke inomphumela omuhle kakhulu emzimbeni wayo, ngoba ayiveli nje ukuthi i-analogue yokufakelwa ikuphi nokuthi iyiphi i-enzyme yayo.
Le mishanguzo ithengiswa ngendlela yesisombululo somjovo.
Uma sikhuluma malini ngalo muthi, ke okokuqala, intengo yawo incike kumthamo wento eyinhloko. Izindleko ziyahlukahluka kusuka ku-9000 kuya kuma-ruble angama-27000. Ukuze uqonde kahle ukuthi yiluphi umthamo odinga ukuwuthenga, kufanele utadishe incazelo yomuthi kusengaphambili futhi, kufanele, uthintane nodokotela wakho.
Isenzo se-Pharmacological somuthi
Njengoba sekushiwo ngenhla, leli thuluzi lingumuthi omuhle kakhulu we-antidiabetic, futhi linomphumela omuhle ekwehlisweni kwesisindo ngokweqile, esivame kakhulu ukuthinta iziguli ezitholakala zinhlobo lwe-2 isifo sikashukela.
Lokhu kungenzeka ngenxa yokuthi ukungena egazini lesiguli, umkhiqizo ukhulisa kakhulu inani lama-peptides aqukethe emzimbeni wanoma yimuphi umuntu. Yilesi senzo esisiza ukuguqula ama-pancreas futhi kusebenze inqubo yokukhiqizwa kwe-insulin.
Ngenxa yale nqubo, inani loshukela eliqukethwe egazini lesiguli lincishiswa laya ezingeni olifunayo. Ngokufanelekile, zonke izinto eziwusizo ezingena emzimbeni wesiguli kanye nokudla zimunca kahle. Impela, ngenxa yalokho, isisindo sesiguli sijwayelekile futhi kuthambekele kwehla kakhulu.
Kepha, njengawo wonke omunye umuthi, i-Liraglutid kumele ithathwe ngokuqinile njengokusho kwodokotela oholayo. Ake sithi kufanele ungayisebenzisi kuphela ngenhloso yokunciphisa isisindo. Isixazululo esisebenza kahle kunazo zonke ukusebenzisa umuthi lapho kukhona isifo sikashukela sohlobo 2, esihambisana nokukhuluphala ngokweqile.
Umuthi iLiraglutide ungathathwa uma udinga ukubuyisela inkomba ye-glycemic.
Kepha odokotela baphinde bahlukanise lezo zimpawu ezikhombisa ukuthi isiguli asinconywa ngokwezinga elithile ukunquma ikhambi elishiwo ngenhla. Lokhu:
- ukusabela komzimba kunoma yiziphi izingxenye zomuthi;
- ukuxilongwa kwesifo sikashukela sohlobo lokuqala;
- noma yikuphi ukugula okungapheli kwesibindi noma izinso;
- ukwehluleka kwenhliziyo kwe degree lesithathu noma lesine;
- izinqubo zokuvuvukala emathunjini;
- ukuba khona kwe-neoplasm ku-gland yegilo;
- ukuba khona kwe-neoplasia eminingi ye-endocrine;
- isikhathi sokukhulelwa kowesifazane, kanye nokuncelisa ibele.
Kufanele futhi ukhumbule ukuthi lesi sidakamizwa asikwazi ukuphuzwa ngemijovo ye-insulin noma nangomunye umuthi oqukethe izinto ezifanayo. Odokotela abasakhuthazi ukusebenzisa umuthi ezigulini ezineminyaka engaphezu kwengu-75, kanye nakulabo abatholakala bethola i-pancreatitis.
Imiphumela emibi evela ekusebenziseni umuthi
Mayelana nolwazi olungenhla, kuyacaca ukuthi ngaphambi kokuqala ukwelashwa nalesi sidakamizwa, udinga ukucacisa ukuthi ngabe lesi sidakamizwa siyayilimaza yini impilo yesiguli. Isibonelo, uma kunezinkinga ngohlelo lwezinhliziyo, khona-ke lokhu kuxilonga nakho kungukuphikisana nokusetshenziswa kwomuthi.
Akumelwe sikhohlwe ukuthi ukusetshenziswa kwezindlela eziningi zokunciphisa umzimba kuvinjelwe ngokuphelele. Izingane ezingaphansi kweminyaka engu-18 nazo zisengozini; nazo zihambisana nemithi yokwelashwa ngalo muthi.
Kunomyalo wokusebenzisa umuthi, lapho kukhonjiswa yonke le mininingwane.
Uma sikhuluma ngokuqondile ukuthi yimiphi imiphumela emibi evame kakhulu evela ekusetshenzisweni kwalesi sidakamizwa, khona-ke yilezi zingqinamba ezisobala zomgudu wesisu. Cishe isigamu samacala lapho isiguli sibhekana nokubi okungafani naso, siqala ukuzizwela isicanucanu futhi sihlaselwe ingqondo.
Isiguli sesihlanu ngasinye eselashwa ngomuthi sikhononda ngokugayeka, ikakhulukazi, isifo sohudo noma, ngokweqile, ukuqunjelwa kanzima.
Imiphumela emibi ifaka phakathi ukubonakala kwemizwa yokukhathala okungapheli noma ukukhathala.
Kumele kuqashelwe ukuthi kwesinye isikhathi izimo zivela lapho, ngemuva kokuthatha umthamo omkhulu kakhulu womuthi, ushukela wegazi wesiguli wehla kakhulu.
Kulokhu, uju uzomsiza. Empeleni isipuni soju noshukela wegazi kujwayelekile.
Imiyalo yokusebenzisa umuthi
Iziguli eziningi zinesithakazelo embuzweni wokuthi isebenza kanjani iLyraglutide.
Kulokhu, konke kuncike kumthamo othathwa yisiguli, uma ukhethwe kahle, khona-ke ukusebenza komuthi kuzoba ngaphezulu.
Isibonelo, uma sikhuluma ngomuthi othengiswa ngohlobo lwe-Saxenda, umthamo ungasukela ku-0,6 mg uye ku-3.
Kulokhu, akunandaba ukuthi umuthi uthathwe ngasiphi isikhathi, ukusebenza kwawo akukuguquki kulokhu.
Ekuqaleni, umthamo ungaba ngu-zero ophantse ube yizishumi eziyisithupha ze-mg, futhi umthamo ngamunye olandelayo uyanda. Cishe ngesonto lesihlanu, isiguli sinconywa ukuthatha i-3 mg yomuthi wezidakamizwa, umthamo onjalo uyagcinwa kuze kuphele inkambo yokwelashwa.
Uma sikhuluma ngohlobo lomuthi olubandakanya ukwethulwa kwemijovo yento, khona-ke umuthi ufakwa entangeni, esiswini noma ehlombe.
Kumele kuqashelwe ukuthi umthamo ngqo kanye nesikhathi sokwelashwa esinconyiwe singachazwa kuphela ngudokotela. Ukusetshenziswa okuzimele kwalo muthi kungadala ingozi enkulu kakhulu empilweni yeziguli.
Kwezinye izikhathi kungavela izimo lapho i-hypoglycemia ingaqala kumuntu kusuka ekusebenzeni isikhathi eside kwe-liraglutide. Kulokhu, kufanele usebenzise uju ngokushesha.
Ama-analog kanye nezindleko
Ngenxa yokuthi lo muthi uphethwe i-insulin ezigulini ezithembela ku-insulin, abanye odokotela batusa ukuthi kubhekwe izifaniso zezidakamizwa. Isibonelo, kulokhu, i-Reduxine izosebenza ngokuphelele.
Lawa makhompiyutha asebenza kakhulu ekwehliseni isisindo, futhi futhi kuyimfashini ukuwaphuza ukwelashwa kohlobo lwe-2 yesifo sikashukela kanye nesifo esincike kwinsulin. By the way, yilezi zifo ezivame ukuhambisana nokukhuluphala. Enye futhi umuthi izindleko zayo ezinengqondo; ayidluli ama-ruble angamakhulu amabili.
I-lipase inhibitor nayo isetshenziswa kaningi. Uhlu lwezidakamizwa eziqukethe into enjalo luhlanganisa amaphilisi ahlukahlukene, isibonelo, i-Orsogen noma i-Xenical. Banazo cishe zonke izakhiwo ezifanayo ezazichazwe ngenhla.
Kumele kwaziwe ukuthi ama-analogues awanakukhethwa ngokwawo. Udokotela oholayo kuphela onganquma ukuthi kungenzeka yini ukuthi anikeze isiguli esinye isiguli noma ukuthi kungcono yini ukugxila kumuthi owawukhethwe ekuqaleni.
Kukhona ezinye, ama-analogues ezingasetshenziswa futhi ukulwa nesisindo eseqile esivela kwisifo sikashukela. Isibonelo, iNovonorm, iBaeta noma i-Liksumiya. Uma sikhuluma ngezindleko zalezi zimali, ke umuthi wokuqala ushibhile, ubiza cishe ama-ruble angama-250.
Ukubuyekezwa Kwezokwelapha
Njengoba kushiwo ngenhla, iziguli eziningi ziphawula ukusebenza kahle kwalesi sidakamizwa, esisetshenziselwa isifo sikashukela, esihambisana nokukhuluphala ngokweqile. Lesi sibalo cishe singama-80% wabo bonke abasebenzise lo muthi.
Ezinye iziguli, zabelana ngesipiliyoni sazo sokwelashwa, zabonisa ukuthi kwesinye isikhathi zazinezimpawu zokuqala ze-hypoglycemia. Lokhu kuvame ukwenzeka lapho umthamo womuthi owathathwa yisiguli wawuphezulu kakhulu kunenconywa udokotela. Kulokhu, uju noma uswidi ojwayelekile kakhulu kuzosiza. Kepha, iqiniso, uju lunempilo kakhulu.
Kepha akunandaba ukuthi lo muthi unikela muphi umphumela, awukwazi ukuphuzwa ngokuqhubekayo.
Kunendlela ethile yokwelashwa engahluka esigulini ngasinye. Kungalesi simo lapho uzokwazi ukuqeda ngokuphelele izinkinga nge-ngokweqile futhi wehlise ngempumelelo amazinga aphezulu eglucose egazini.
Ngokusekelwe olwazini olwethuliwe ngenhla, kuyacaca ukuthi ukusetshenziswa kwalesi sakhi sokwelapha kufanele kwenziwe kuphela ngemuva kokubonisana nodokotela ngaphambili futhi, ngokuncoma kwakhe kuphela.
Yimaphi amaphilisi okukhuluphala kwesifo sikashukela asasetshenziswa azotshela ividiyo ekulesi sihloko.
