Amaphilisi weSiofor ajwayele ukusetshenziswa emithini yesimanje yesifo sikashukela sohlobo 2.
Ngokuhambisana neSiofor, kunconywa ukuthatha iLosartan neThioctacid. ILosartan isiza ukuvikela izinso uma ngabe i-proteinuria ikhona, futhi ngaphezu kwalokho, i-losartan inciphisa ingozi yokuhlaselwa yisifo sohlangothi kanye nesifo senhliziyo. I-Thioctacid yohlobo 2 sikashukela i-mellitus ilawula i-lipid ne-carbohydrate metabolism, ngaphezu kwalokho, iThioctacid inomphumela we-antioxidant.
Kuze kube manje, amaqembu alandelayo wezidakamizwa zohlobo lwesifo sikashukela 2 asetshenziswa ngumkhuba wezwe:
- Izidakamizwa ezitholakala sulfonylurea. Inzuzo yabo eyinhloko ukubekezelela kalula umuthi yiziguli eziningi. Lesi isidakamizwa sokuqala esisetshenziswe ngentshiseko ekwelapheni isifo sikashukela.
- Imikhiqizo yezokwelapha eqenjini le-Biguanide. Umphumela wazo uhlose ukunciphisa isidingo soku secretion se-insulin.
- Imithi etholakala ku-thiazolidinol isiza ukwehlisa ushukela wegazi futhi ibe nomphumela omuhle ekuvumelaneni kwephrofayili ye-lipid.
- Ama -retretins.
Ngaphezu kwalokho, izifundo zokwelapha zokwelapha njengamanje zakhiwa manje ezigxila ekusetshenzisweni kwezidakamizwa ezimbili noma ngaphezulu zesifo sikashukela.
Ukusetshenziswa kwanoma imaphi amadivaysi ezokwelapha kufanele kwenziwe ngaphansi kokuqashwa kedokotela onguchwepheshe; ukuzelapha, kulokhu, kuvinjelwe ngokuphelele.
Izici eziphambili ze-pharmacological
Enye yezidakamizwa ezidume kakhulu eqenjini le-Biguanide yi-Siofor (isithombe), etholakala ngethebulethi. Imithamo yento esebenzayo ingahluka futhi ithengiswe njengo:
- I-Siofor 500 iqukethe ama-milligram angama-500 wesithako esisebenzayo (uma kunesidingo, ukunciphisa umthamo ukuya ku-250 mg, ungasebenzisa uhhafu wethebhulethi);
- umuthi uSiofor 850;
- siofor 100
Isithako esikhulu esisebenzayo somuthi yi-metformin hydrochloride; i-silicon dioxide, i-povidone, i-magnesium stearate, ne-macrogol asetshenziswa njengezakhi ezisizayo.
I-Siofor yesifo sikashukela isetshenziselwa ukwehlisa ushukela wegazi. Ngaso leso sikhathi, ukwehla kwezinkomba kwenzeka hhayi kuphela ngemuva kokudla okuyinhloko, kodwa futhi kukuvumela ukuthi wehlise izinga lesisekelo.
Isithako esikhulu esisebenzayo eSiofor sikuvumela ukuthi ulawule ukukhiqizwa kwe-insulin ngama-pancreas, athinta umzimba kahle futhi ungavumeli ukuthuthukiswa kwe-hypoglycemia. Ngaphezu kwalokho, phakathi kwemiphumela emihle ifaka:
- ukungathathi hlangothi kwe-hyperinsulinomy;
- kunomthelela ekunciphiseni isisindo;
- kunciphisa ubungozi bokuthola izifo zohlelo lwethambo nenhliziyo;
- ithinta kahle i-lipid metabolism emzimbeni;
- kunciphisa amazinga aphakeme e-cholesterol embi;
- kunciphisa ama-triglycerides.
Isigaba sesibili sithi umuthi uyasiza ekwenzeni umzimba ube ngokwejwayelekile. Kunombono wokuthi ucindezela umuzwa wokulamba futhi, ngakho-ke, ukuvumela ukuthi wehlise isisindo futhi ube nesincane. Eqinisweni, iSiofor ekwakhiweni kwesifo sikashukela kwezinye izimo kusiza ukwehlisa isisindo, kepha ukudla kuphela nendlela yokuphila esebenzayo okufanele kube izinkomba eziphambili zesiguli.
Umuthi weSiofor - izinkomba zokusetshenziswa - kwehlise izinga le-glucose emzimbeni ngesifo sikashukela sohlobo 2 kanye nokungabikho kokulashwa kwe-insulin ekwelashweni. Isenzo sikaSiofor sibuye sikhonjiswe kahle ngokungabikho komphumela wokwelashwa kokudla. Ngokuthuthukiswa kohlobo lwesibili sikashukela emzimbeni, uSiofor ungomunye wemithi ephumelela kakhulu.
Isakhi esisebenzayo, esiyingxenye yokwakhiwa kweSiofor, sizibonakalisa sinciphisa ukumuncwa kwe-glucose emathunjini amancane, siphazamisa ukukhiqizwa kwawo ngamaseli wesibindi.
Imiyalo yokusebenzisa umuthi
Ukusetshenziswa kwe-Siofor yesifo sikashukela kunqunywe udokotela ohambelayo. Kumele kwaziwe ukuthi lesi sidakamizwa sikhishwa kusokhemisi kuphela uma kunikezwa incwadi kadokotela ebekiwe.
I-Siofor ibekelwa isifo sikashukela emithanjeni esekelwe esithombeni somtholampilo esivamile salesi sifo kanye nezimpawu zomzimba womuntu ogulayo. Isikhombisi esiyinhloko okufanele usinake lapho ukhetha umthamo izinga le-glucose esegazini.
Imiyalo yokusebenzisa umuthi ithi amaphilisi enzelwe ukuphathwa ngomlomo ngamanzi amaningi. Kulokhu, umthamo ungaba kanje:
- Kumathebhulethi anezinto ezingama-500 mg zento esebenzayo, iphilisi elilodwa kuqala limiselwe kanye ngosuku. Kancane kancane, inani lamathebulethi lingakhushulelwa libe kathathu noma ngaphezulu (kodwa hhayi ngaphezu kwamaphilisi ayisithupha ngosuku). Kufanele kukhunjulwe ukuthi umthamo owodwa awukwazi ukudlula ku-500 mg wengxenye esebenzayo, okungukuthi, ithebhulethi eyodwa. Isikhathi sokwamukelwa kufanele sinikezwe kuphela uchwepheshe wezokwelapha. Ngaphezu kwalokho, kwenqatshelwe ngokuzimela ukwandisa umthamo ngaphandle kwemvume kadokotela.
- Kumathebhulethi anama-850 mg wesithako esisebenzayo, umuthi uqala ngethebhulethi elilodwa futhi, uma kunesidingo, uyanda kancane kancane. Umthamo omkhulu wansuku zonke ngamaphilisi amathathu.
- Ama-Siofor 100 aqala ukuthatha ithebhulethi eyodwa ngokukhuphuka kancane kancane. Udokotela ososayensi angalukhulisa umthamo womuthi, kepha kungamathebulethi amathathu ngosuku. Umthamo onjalo ubhekwa njengongaphezu kwamandla. Ezimweni ezimbi kakhulu, ukuthatha iSiofor 100 kuhlanganiswa ne-insulin.
Uma, ngenxa yezimo ezithile, umuthi ulahlekile, asikho isidingo sokuwunxephezela ngokwandisa umthamo olandelayo.
Lapho uthatha umuthi, kuyadingeka ukuthi ucabangele inkambo ejwayelekile yezinqubo ze-metabolic nempilo enhle, njengoba kunobungozi obandayo be-lactic acidosis.
Ukusetshenziswa kwe-Siofor 100 ekwakheni i-polycystic ovary kungenzeka kuphela ngemuva kokubonisana nodokotela wakho.
Yikuphi ukuphambana kokusetshenziswa okukhona?
Naphezu kweqiniso lokuthi iSiofor 100 inomphumela omuhle empilweni yesiguli futhi isiza ukulawula izinga le-glucose egazini, kunezindlela eziningi zokuphikisana nokusetshenziswa kwayo.
Umsebenzi wezokwelapha ukhomba lezi zinto ezilandelayo ezenqatshelwe ukuthatha lo muthi:
- thayipha i-1 isifo sikashukela;
- uma umzimba uyeka ukukhiqiza ngokuzimela i-insulin, futhi umuntu uye ancike esidingweni sokwethulwa kwaleli hormone;
- ukuthuthukiswa kwezifo ezinjenge-ketoacidosis yesifo sikashukela, idumela noma ukhokho wohlobo lwesifo sikashukela;
- i-pathologies sina yesibindi noma izinso;
- i-bronchitis;
- izifo zesistimu yenhliziyo, ukwehluleka kwenhliziyo noma ukufakelwa kwenhliziyo;
- izinqubo ze-pathological ezenzeka emaphashini, ukwenzeka kobunzima bokuphefumula;
- ukubonakaliswa kwezifo ezithathelwanayo;
- ukuhlinzwa nokulimala kwakamuva;
- i-lactic acidosis;
- ukungabekezeleli noma i-hypersensitivity engxenyeni eyodwa noma eziningi zomuthi;
- uma kukhona ukomisa;
- utshwala.
Ngaphezu kwalokho, akufanele usebenzise ithuluzi elandulela ucwaningo lokuxilonga (i-radiography noma i-radioisotropic diagnostic) usebenzisa i-ejenti ehlukile ngokuqukethwe kwe-iodine. Yekani ukusebenzisa umuthi ezinsukwini ezimbili ngaphambi kwenqubo nezinsuku ezimbili ezizayo.
Amantombazane akhulelwe awakwazi ukuthatha umuthi ukuze ungalimazi ukukhula okujwayelekile nempilo yengane. Ngaphezu kwalokho, umuthi nawo uvunyelwe ngenkathi uncelisa ibele. Kukholakala ukuthi ingane engaphansi kweminyaka eyi-14 akufanele usebenzise lo muthi.
Izingane nabantu abaphilile abangahlushwa yisifo sikashukela abakwazi ukuthatha lo muthi ngisho nakumithamo emincane noma nge-prophylaxis (ngokwesibonelo, ngenhloso yokunciphisa umzimba).
Kuyaqapheleka ukuthi ukwephulwa okungathi sína kungavela uma uhlanganisa isidakamizwa nokudla okuphansi kwekhalori (ngaphansi kwama-kilometri ayinkulungwane ngosuku).
Imiphumela emibi nemiphumela emibi engaba khona
Umuthi uSiofora, nokubuyekezwa kodokotela neziguli kukhombisa lokhu, kungenye yezidakamizwa ezisebenza ngempumelelo ekwelapheni isifo sikashukela.
Kulokhu, kufanele unake ukuthi ukwamukelwa kwalomenzeli nokukhethwa komthamo kufanele kwenziwe ngokucophelela. Kunohlu olukhulu lwe-contraindication ukusetshenziswa kwayo, noma ngabe umuthi unomphumela omuhle.
Ngaphezu kwalokho, uma umthamo ukhethwe ngokungalungile noma izincomo zikadokotela zingalandelwa, imiphumela emibi elandelayo ingaqhamuka:
- izinkinga zokugaya ukudla, okungahle kuhambisane nokubumbana, izinhlungu esiswini noma uhudo;
- isicanucanu nokuhlanza
- ukuntuleka kwamaqembu athile wamavithamini;
- ukubonakaliswa kokungafani komzimba engxenyeni eyodwa noma eziningi zomuthi;
- ukuthuthukiswa kwe-lactic acidosis;
- i-megaloblastic anemia.
Eminye yemiphumela emibi ejwayelekile evela ekusetshenzisweni komuthi yi-lactic acidosis. Lesi simo sihambisana nezimpawu ezinjengokwehla kokuqina, ukuqina kwemisipha, ukwehla kwezinga lokushisa lomzimba nomfutho wegazi, nobunzima bokuphefumula.
Njengomthetho, ukusetshenziswa komuthi kuthatha isikhathi esingaphezu konyaka. Ngakho-ke, ngaphambi kokuthatha, kanye nazo zonke izinyanga eziyisithupha (ngokwesibonelo, ubusika-ehlobo), kwenziwa izifundo ngokusebenza okujwayelekile kwesibindi nezinso.
Njenge-prophylaxis, ukusetshenziswa kwamacwecwe e-lozartan ne-thioctacid kuvunyelwe. Umbuzo wokusetshenziswa kwephrophylactic wezidakamizwa iLosartan neThioctacid kufanele unqunywe ngokukhethekile ngudokotela ohambelayo.
Ukuhambisana neminye imithi
Omunye wemiphumela emibi kakhulu kungaba "ukuhambisana" kwamathebulethi kaSiofor neziphuzo zotshwala. Ukusetshenziswa kwalezi zinto ezimbili kungaholela ekwakhiweni kwe-lactic acidosis.
Ukuxhumana kwesidakamizwa nezinye izidakamizwa ngale ndlela elandelayo:
- Umuthi ungaholela ekunciphiseni imiphumela ye-anticoagulants engaqondile.
- Uma uthatha umuthi ngemithi yokuvimbela inzalo yomlomo, i-epinephrine, i-glucagon noma imishanguzo ye-hormonal yegland yegland, kungahle kwehle imiphumela ye-hypoglycemic.
Ukwanda okwengeziwe komphumela we-hypoglycemic wesidakamizwa kungatholakala ngokuhlanganisa ukuphathwa kwawo ne-insulin, okuphuma ku-sulfonylurea, izidakamizwa ezingezona ze-steroidal anti-inflammatory, noma i-clofibrate derivatives.
Ingabe zikhona izifanekiso zomkhiqizo wezokwelapha?
Namuhla, kunezinguqulo eziningi zalo muthi. Malini uSiofor? Intengo yeSiofor kumakhemisi isukela kuma-ruble angama-250 kuya kwangama-350 ngephakethe ngalinye, kuya ngomenzi, amaphilisi angahluka.
Ngaphezu kwalokho, eSiofor, intengo emakhemisi ingaba ngaphezulu noma ephansi, okungahle kuncike esifundeni sezwe. Kukhona ama-analogues anendleko ephansi noma ephezulu.
Izidakamizwa eziphambili ze-analogue ezine-metformin esebenzayo, ezitholakala emakethe:
- I-Glucophage yisidakamizwa sethebhulethi esinezakhiwo ze-hypoglycemic. Kutholakala kwimithamo ye-500, 850 ne-1000 mg yesithako esisebenzayo. Intengo ejwayelekile ingafika kuma-ruble angama-200.
- I-Bagomet - isidakamizwa esiqukethe izinto ezimbili ezisebenzayo - i-metformin ne-glibenclamide. Le nhlanganisela isetshenziselwa ukwelapha uhlobo II lwesifo sikashukela i-mellitus. Intengo ephakathi yesidakamizwa ama-ruble angama-210.
- Langerine.
- Siofor analogue m Nova wahlangana.
Lapho ukhetha umuthi ofanele, udokotela kuphela ongakwazi ukuthi yini efanelekile isiguli futhi angakhetha ama-analogues adingekayo. Namuhla, kunokuningi ongakukhetha kukho, ngoba isayensi yemithi yesimanjemanje inikezela ngemithi ebanzi kakhulu. Ividiyo ekulesi sihloko izonikeza ukukhetha kwezidakamizwa eziningana zabanesifo sikashukela.
