I-Gliclazide MV: incazelo yesidakamizwa, izibuyekezo ukusetshenziswa, intengo

I-Gliclazide MB ukulungiswa komlomo kwe-hypoglycemic okuhlobene nokutholwa kwesulfonylurea kwesizukulwane sesi-2. Umuthi:

1. ivuselela ukukhiqizwa kwe-insulin ye-hormone;
2. kuthuthukisa umphumela we-insulin-secretory we-glucose;
3. kwehlisa ushukela wegazi;
4. kwandisa ukuzwela kwe-insulin kwezicubu ze-peripheral .;
5. iguqula izinga lokuzila ukudla kweglycemia;
6. kunciphisa ukukhiqizwa koshukela ngesibindi;
7. ngaphezu kokuthinta i-carbohydrate metabolism, isidakamizwa sithuthukisa i-microcirculation.

IGlyclazide inciphisa ingozi yokuqhekeka kwegazi emithanjeni emincane, okuthinta kanyekanye izindlela ezimbili ezibambe iqhaza ekwakheni izinkinga zesifo sikashukela i-mellitus:

• ukuvimbela okuyingxenye kokunamathela kwe-platelet nokuhlangana;
• ukuthola;
• ukunciphisa izinto ezenziwa ngokusebenza kwe-platelet (i-thromboxane B_2, i-beta-thromboglobulin).

Imiyalo yokusetshenziswa nezinkomba

I-Gliclazide ehambisana nokwelashwa kokudla imiselwe isifo sikashukela sohlobo 2, uma ukudla nokuvivinya kungakhange kube nomphumela omuhle.

Contraindication

• Uhlobo 1 sikashukela;
• ukuzwela okuphezulu kwe-Glyclazide noma ezingxenyeni zomuthi (sulfonamides, to sulfonylurea derivatives);
• ukukhulelwa nokuqunjelwa;
• ukwehluleka okukhulu kwe-hepatic noma i-renal;
• ukuthatha i-miconazole;
• isifo sikashukela;
• isifo sikashukela;
• isifo sikashukela sikashukela;
• iminyaka efinyelela eminyakeni eyi-18;
• ukuntuleka kwe-lactase;
• ukungabekezelelani kokuzala kwe-lactose;
• i-glucose-galactose malabsorption. Odokotela abakukhuthazi ukusetshenziswa kwesidakamizwa esifanayo kanyekanye ne-danazol noma i-phenylbutazone.

Uzothathwa nini ngokuqapha

IGliclazide ayikwazi ukusetshenziswa ngaphandle kwemithi kadokotela, ngoba umuthi awulungele wonke umuntu. Nalu uhlu lwezimo lapho kumele lusetshenziswe ngokuqapha:

1. ukungondleki noma ukungahambi kahle;
2. ubudala
3. i-hypothyroidism;
4. ukungapheleli kwepituational noma adrenal;
5. izifo ezinzima zesistimu yezinhliziyo (isifo sokuqina kwemithambo yegazi, isifo senhliziyo);
6. i-hypopituitarism;
7. i-glucocorticosteroid yesikhathi eside yokwelashwa;
8. ukwehluleka kwesibindi noma kwezinso;
9. ukusweleka kwe-glucose-6-phosphate dehydrogenase;
10. utshwala.

Nakani! Umuthi ubekelwe abantu abadala kuphela!

Ungathatha kanjani ngesikhathi sokukhulelwa nokuncelisa

Ayikho imininingwane ngokusetshenziswa kwesidakamizwa ngesikhathi sokukhulelwa. Imininingwane yokusetshenziswa kwezinye izinto eziphuma sulfonylurea ngesikhathi sokukhulelwa ilinganiselwe.

Ocwaningweni lwelabho yezilwane, imiphumela ye-teratogenic yomuthi ayitholakalanga. Ukunciphisa ubungozi bokukhubazeka kokuzalwa, udinga ukulawula okucacile kwesifo sikashukela i-mellitus (ukwelashwa okufanele).

Kubalulekile! Izidakamizwa zomlomo ze-Hypoglycemic ngesikhathi sokukhulelwa azinqunyelwe. Ukwelashwa kwesifo sikashukela ngesikhathi sokukhulelwa, kukhethwe i-insulin yezidakamizwa. Ukwemukelwa kwezidakamizwa ze-hypoglycemic kunconywa ukuthi kuthathelwe indawo nge-insulin therapy.

Ngaphezu kwalokho, lo mthetho uyasebenza esimweni lapho ukukhulelwa kwenzeka ngesikhathi sokuphuza umuthi, futhi uma ukukhulelwa kufakwa kuphela ezinhlelweni zowesifazane.

Ngokukhishwa kweqiniso lokuthi akukho datha ekuthweni kwesidakamizwa obisini lwebele, ubungozi bokukhula kwe-fetog hypoglycemia abukhishwa. Ngokuvumelana nalokho, ukusetshenziswa kwe-Gliclazide ngesikhathi sokuncelisa ibelekisiwe.

Imiyalo nomthamo

Ama-30 mg amaphilisi wokukhipha modified kufanele athathwe isikhathi esingu-1 ngosuku ngesikhathi sasekuseni. Uma isiguli sithola lokhu kwelashwa okokuqala, umthamo wokuqala kufanele ube ngu-30 mg, lokhu kuyasebenza nakubantu abaneminyaka engaphezu kwengama-65 ubudala. Kancane kancane shintsha umthamo kuze kube yilapho kudingeka umphumela wokwelapha.

Ukukhethwa komthamo kunconywa ngokuya ngezinga likashukela egazini ngemuva kokuqala kokwelashwa. Noma yikuphi ukuguqulwa komthamo okulandelayo kungenziwa kuphela ngemuva kwesikhathi samasonto amabili.

I-Glyclazide MB ingashintshwa namathebulethi we-Glyclazide ngokukhululwa okujwayelekile (80 mg) ngethamo lansuku zonke lezingcezu ze-1-4. Uma ngesizathu esithile isiguli siphuthelwa umuthi, umthamo olandelayo akufanele ube mkhulu.

Uma amaphilisi we-Glyclazide MB 30 mg esetshenziselwa ukufaka omunye umuthi we-hypoglycemic, isikhathi sokushintsha asidingeki kuleli cala. Kuyadingeka kuphela ukuqeda ukuthola nsuku zonke isidakamizwa esedlule futhi ngosuku olulandelayo kuphela ukuthatha i-Gliclazide MB.

Kubalulekile! Uma isiguli sake saphathwa nge-sulfonylureas isikhathi eside sempilo, ukuqapha ngokucophelela ukugxila kwe-glucose egazini kuyadingeka amasonto ama-2.

Lokhu kuyadingeka ukuze ugweme ukuthuthukiswa kwe-hypoglycemia, engahle ibonakale ingemuva kwemiphumela eseleyo yokwelashwa okwedlule.

Umuthi ungahlanganiswa ne-alpha-glucosidase inhibitors, i-biguanides noma i-insulin. Iziguli ezinokwehluleka okuncane noma okulinganiselayo kwe-renal, i-Gliclazide MB ichazwa kumthamo ofanayo neziguli ezinomsebenzi omuhle wezinso. Umuthi ubhekene ne-contraindication ekwehlulekeni okukhulu kwe-renal.

Iziguli ezisengozini ye-hypoglycemia

Iziguli zisengozini yokuba ne-hypoglycemia:

1. nokungalingani noma ukungondleki;
2. nokukhubazeka okungahambi kahle noma i-endocrine enobunzima (i-hypothyroidism, ukungasebenzi kahle kwe-adrenal ne-pituitary);
3. nokuqedwa kwama-ejenti we-hypoglycemic ngemuva kokusetshenziswa kwawo isikhathi eside;
4. ngezindlela eziyingozi ze-inhliziyo ye-inhliziyo (isifo sokuqina kwamathambo), isifo sokuqina kwenhliziyo (carotid arteriosclerosis, isifo senhliziyo)

Ezigulini ezinjalo, umuthi iGlyclazide MB unqunyelwe ngemithamo emincane (30 mg).

Imiphumela emibi

Umuthi ungadala i-glycemia, ebonakaliswa yizimpawu ezilandelayo:

• umuzwa wendlala;
• ukukhathala, ubuthakathaka obukhulu;
• ikhanda, isiyezi;
• ukukhuphuka kokujuluka, ukuthuthumela, i-paresis;
• arrhythmia, palpitations, bradycardia;
• ukwanda kwengcindezi yegazi;
• ukuqwasha, ukozela;
• ukungaphatheki kahle, ukukhathazeka, ulaka, ukudangala;
• ukuyaluza;
• ukunaka kokuphazamiseka kwengqondo;
• ukusabela okuhamba kancane nokungakwazi ukugxila;
• ukuphazamiseka kwemizwa;
• ukungaboni kahle
• i-aphasia;
• ukulahlekelwa ukuzithiba;
• umuzwa wokungakwazi ukusiza;
• ukuphefumula okungashonile;
• iminyakazo
• delirium;
• ukulahlekelwa ukwazi.

Ukuphendula komzimba:

1. i-erythema;
2. ukuqhuma kwesikhumba;
3. i-urticaria;
4. ukulunywa kwesikhumba.

Kunemiphumela emibi evela emgodini wokugaya ukudla:

• Ubuhlungu besisu;
• ukuqunjelwa yisifo sohudo;
• isicanucanu, ukuhlanza
• akuvamile ukuba i-cholestice jaundice hepatitis, kepha idinga ukuhoxiswa ngokushesha komuthi.

Ukweqa ngokweqile kanye nokuxhumana

Ngomthamo onganele, amathuba okuba nesimo esibi se-hypoglycemic, angahle ahambisane nokuphazamiseka kwemizwa, ukuqaqanjelwa, ukoma kuphezulu. Ekubukeni kokuqala kwalezi zibonakaliso, isiguli sidinga ukulaliswa esibhedlela ngokuphuthumayo.

Uma i-hypoglycemic coma isolwa noma itholakala, isisombululo se-40-50% dextrose siphathwa ngokuqondile esigulini. Ngemuva kwalokho, babeka i-dropper nekhambi le-5% dextrose, okudingekayo ukugcina ukuhlangana okujwayelekile kweglucose egazini.

Ngemuva kokuthi isiguli siphinde siqaphele, ukuze sigweme ukuphindaphindwa kwe-hypoglycemia, kufanele sinikezwe ukudla okune-carbohydrate egaya kalula ukudla. Lokhu kulandelwa ukuqapha ngokucophelela amazinga kashukela wegazi nokuqashwa njalo kwesiguli emahoreni angama-48 alandelayo.

Izenzo ezengeziwe, ngokuya ngesimo sesiguli, zinqunywa udokotela oholayo. Ngenxa yokubopha isidakamizwa kumaphrotheni e-plasma, ukudayela kungasebenzi.

I-Glyclazide ithuthukisa ukusebenza kwama-anticoagulants (warfarin), okuwukuphela kwesimo ukuthi ungadinga ukulungisa umthamo we-anticoagulant.

UDanazole kanye noGliclazide wumphumela wesifo sikashukela. Kokubili ngesikhathi sokusetshenziswa kwe-danazol nangemva kokuhoxiswa kwayo, ukulawulwa kweshukela kanye nokulungiswa komthamo kwe-glycazide kuyadingeka.

Ukuphathwa kwamasistimu kwe-phenylbutazone kuthuthukisa umphumela we-Goglazide (yehlisa ijubane emzimbeni, kususwa ekuxhumaneni namaprotheni egazi). Ukuhlolwa komthamo we-Glyclazide kanye nokuqapha ushukela wegazi kuyadingeka. Kokubili ngesikhathi sokuthatha i-phenylbutazone, nangemva kokuhoxiswa kwayo.

Ngokuphathwa okuhleliwe kwe-Miconazole futhi uma usebenzisa ijeli emgodleni womlomo, kuthuthukisa umphumela we-hypoglycemic womuthi, kuze kube sekuthuthukisweni komthambo.

I-Ethanol kanye nokuphuma kwayo kuthuthukisa i-hypoglycemia, kungaholela ekwakhiweni kwe-hypoglycemic coma.

Lapho isetshenziswa ngokuhlanganiswa nezinye izidakamizwa ze-hypoglycemic (biguanides, acarbose, insulin), i-fluconazole, i-beta-blockers, i-H2-histamine receptor blockers (cimetidine), i-angiotensin-converting enzyme inhibitors (enalapril, Captoprilamide antioxidants, non-steroidal sulfide inhibitors umphumela we-hypoglycemic, ngokulandelana, ubungozi be-hypoglycemia.

I-Chlorpromazine kwimithamo emikhulu (ngaphezu kwe-100 mg / ngosuku) ikhulisa ukugcwala kweglucose egazini, kuvimbela ukucashelwa kwe-insulin. Kokubili ngesikhathi sokusebenzisa i-chlorpromazine, futhi ngemuva kokuhoxiswa kwayo, ukulawulwa kweshukela kanye noshintsho kumthamo we-Glyclazide kuyadingeka.

I-GCS (i-rectal, yangaphandle, i-intraarticular, ukusetshenziswa kwe-systemic) inyusa ushukela wegazi ngokuthuthukiswa kwe-ketoacidosis. Kokubili ngesikhathi sokusetshenziswa kwe-GCS nangemva kokuhoxa kwabo, ukulawulwa kweshukela kanye noshintsho kumthamo we-Gliclazide kuyadingeka.

I-Terbutaline salbutamol, i-ritodrin ngaphakathi - yandisa ushukela wegazi. Ukulawulwa kwe-glucose egazini kuyadingeka futhi, uma kunesidingo, ukushintshela ekwelashweni kwe-insulin.

Izincomo ezikhethekile nefomu lokukhulula

I-Gliclazide MB yezidakamizwa isebenza kuphela ngokuhlanganiswa nokudla okunekhalori ephansi, equkethe inani elincane lama-carbohydrate. Ukuqashwa njalo kokuhlushwa kwe-glucose, kokubili esiswini esingenalutho nangemva kokudla, kuyadingeka. Lokhu kubaluleke kakhulu esigabeni sokuqala sokwelashwa.

Ngesikhathi sokulashwa nomuthi, ukuze uvikele ukulimala nezingozi emgwaqweni, kunconyelwa ukugwema ukushayela izimoto nokusebenza ngamasu ayingozi adinga ukunakwa okukhulu nokushesha kokuphendula.

Izibhebhe ezingama-30 mg, zifakwe ezinhlamvwini zezingcezu eziyi-10.

Impilo yeshelufu leGliclazide yiminyaka emi-3, ngemuva kwalokho angeke isetshenziswe. Umuthi kufanele ugcinwe endaweni eyomile, emnyama futhi epholile, engatholakali ezinganeni.

Ezifundeni ezihlukene zezwe, intengo yesidakamizwa iyahlukahluka kusuka kuma-ruble ayi-120 kuye kwangama-150. Sikhuluma ngamaphakeji aqukethe amaphilisi angama-60. Kukhona okufakayo emathini wamapholima. Imbiza eyodwa noma u-1 kuya ku-6 amabhulukwe afakwa ebhokisini lekhadibhodi.

Umehluko ngentengo uncike ezintweni ezahlukahlukene: umenzi, isifunda, isimo sokhemisi.