I-C-peptide yesifo sikashukela - ungahlolwa kanjani futhi ngani

Ukwanda kwamaglucose ekuhlolweni kwegazi kwelebhu kusivumela ukuba sahlulele ukuthi i-carbohydrate metabolism ikhubazekile, ngezinga eliphakeme kakhulu, ngenxa yesifo sikashukela mellitus. Ukuqonda ukuthi kungani ushukela ukhule, kudingeka i-C-peptide test. Ngosizo lwayo, kungenzeka ukuthi kuhlolwe ukusebenza kwamanyikwe, futhi ukuthembeka kwemiphumela yokuhlolwa akuthinteki yi-insulin injake noma ama-antibodies akhiqizwa emzimbeni.

Ukunqunywa kwezinga le-C-peptide kuyadingeka ukusungula uhlobo lwesifo sikashukela, ukuhlola ukusebenza okusele kwama-pancreas ngesifo sohlobo 2. Lokhu kucubungula kuzophinde kube wusizo ekuboneni izimbangela ze-hypoglycemia kubantu abangenaso isifo sikashukela.

I-C-peptide - iyini?

Ama-peptide ayizinto eziyizintambo zezinsalela zamaqembu wama-amino. Amaqembu ahlukahlukene alezi zinto abandakanyeka ezinqubweni eziningi ezenzeka emzimbeni womuntu. I-C-peptide, noma i-peptide ebophayo, yakheka kumanyikwe kanye ne-insulin, ngenxa yalokho, ngezinga lokuqalwa kwayo, umuntu angahlulela ukungena kwe-insulin yeguli uqobo egazini.

Isifo sikashukela nokucindezela kuzoba yinto yesikhathi esedlule

• Ukwehlela ushukela -95%
• Ukuqedwa kwe-vein thrombosis - 70%
• Ukuqedwa kokushaya kwenhliziyo okuqinile -90%
• Ukuqeda umfutho wegazi ophakeme - 92%
• Ukwanda kwamandla ngesikhathi sosuku, ngcono ukulala ebusuku -97%

I-insulin yenziwe ngamaseli e-beta ngokusebenzisa ukusabela kwamakhemikhali okulandelanayo okuningana. Uma ukhuphuka isinyathelo esisodwa ukuthola i-molecule yayo, sizobona i-proinsulin. Le yinto engasebenzi ehlanganisa i-insulin ne-C-peptide. Ama-pancreas angawugcina ngohlobo lwesitoko, hhayi ukuthi awuphonse ngokushesha egazini. Ukuqala ukusebenza ekudluliseleni ushukela emangqamuzaneni, ama-proinsulin ahlukaniswa ngemolekyuli ye-insulin ne-C-peptide, ngokuhlangene alingana angena egazini futhi athwalwa esiteshini. Into yokuqala abayenzayo ukungena esibindini. Ngokungasebenzi kahle kwesibindi, i-insulin ingafakelwa amandla kuyo, kodwa i-C-peptide idlula ngokukhululeka, ngoba yenziwa kuphela yizinso. Ngakho-ke, ukugxilwa kwayo egazini kukhombisa ngokunembile ukwakheka kwe-hormone kumanyikwe.

Isigamu se-insulin esegazini siphuka ngemuva kwemizuzu emi-4 ngemuva kokukhiqizwa, kanti impilo ye-C-peptide yinde kakhulu - cishe imizuzu engama-20. Ukuhlaziywa ku-C-peptide ukuhlola ukusebenza kwama-pancreas kunembe kakhudlwana, ngoba ukuguquguquka kwayo kuncane. Ngenxa yesikhathi sokuphila esihlukile, izinga le-C-peptide esegazini liphindwe kahlanu inani le-insulin.

Lapho kuqala isifo sikashukela sohlobo 1 egazini, amasosha omzimba abulala i-insulin avame ukuba khona. Ngakho-ke, ukwakheka kwawo ngalesi sikhathi akukwazi ukulinganiselwa ngokunembile. Kepha la ma-antibodies awanaki ukunakwa okuncane kwe-C-peptide, ngakho-ke, ukucubungula kuwona kuyithuba kuphela ngalesi sikhathi lokuhlola ukulahleka kwamaseli we-beta.

Akunakwenzeka ukucacisa ngokuqondile izinga lokuhlanganiswa kwe-hormone ngamanyikwe ngisho noma kusetshenziswa ukwelashwa kwe-insulin, ngoba elabhoratri akunakwenzeka ukuhlukanisa i-insulin ngaphakathi kokulimazeka kokunye nokungaphandle. Ukuzimisela kwe-C-peptide kuleli cala kuyindlela kuphela, ngoba i-C-peptide ayifakiwe kumalungiselelo we-insulin anikezwe iziguli ezinesifo sikashukela i-mellitus.

Kuze kube muva nje, bekukholelwa ukuthi ama-C-peptides awasebenzi ngokomzimba. Ucwaningo lwakamuva luveze iqhaza labo lokuvikela ekuvimbeleni i-angiopathy ne-neuropathy. Indlela yokusebenza ye-C-peptides iyafundwa. Kungenzeka ukuthi ngokuzayo kuzongezwa kwezilungiselelo ze-insulin.

Isidingo sokuhlaziywa kwe-C-peptide

Ucwaningo lokuqukethwe kwe-C-peptide esegazini livame ukunqunyelwa uma ngemuva kokuthola isifo sikashukela, kunzima ukuthola uhlobo lwaso. Isifo sikashukela sohlobo loku-1 siqala ngenxa yokubhujiswa kwamaseli we-beta ngama-antibodies, izimpawu zokuqala ziyavela lapho iningi lamaseli lithinteka. Ngenxa yalokhu, amazinga we-insulin asevele ancishisiwe ngesikhathi kutholwa isifo sokuqala. Amaseli weBeta angafa kancane, ikakhulukazi kwiziguli ezisencane, futhi uma ukwelashwa kwaqala masinyane. Njengomthetho, iziguli ezinemisebenzi ye-pancreatic eseleyo zizizwa zingcono, kamuva iba nezinkinga. Ngakho-ke, kubalulekile ukugcina amaseli we-beta ngangokunokwenzeka, okudinga ukubhekwa njalo kukhiqizwa kwe-insulin. Ngonyango lwe-insulin, lokhu kungenzeka kuphela ngosizo lwe-C-peptide assows.

Uhlobo 2 sikashukela esigabeni sokuqala lubonakala ngokuhlanganiswa okwanele kwe-insulin. Ushukela ukhuphuka ngenxa yokuthi ukusetshenziswa kwawo yizicubu kuyaphazamiseka. Ukuhlaziywa kwe-C-peptide kukhombisa okujwayelekile noma ukweqisa kwayo, ngoba amanyikwe akhulisa ukukhipha kwe-hormone ukuze kuqedwe ushukela omningi. Naphezu kokukhiqizwa okwandisiwe, ushukela wokuya isilinganiso se-insulin uzoba mkhulu kunabantu abaphilile. Ngokuhamba kwesikhathi, ngesifo sikashukela sohlobo 2, ama-pancreas ayaphela, ukuvela kwe-proinsulin kuyancipha kancane kancane, ngakho-ke i-C-peptide yehla ngokujwayelekile futhi ngaphansi kwayo.

Futhi, ukuhlaziywa kubekelwe izizathu ezilandelayo:

1. Ngemuva kokuphindwa kabusha kwamanyikwe, ukuthola ukuthi ingakanani ingxenye esele esele ekwazi ukukhiqiza, nokuthi kudingeka yini ukwelashwa kwe-insulin.
2. Uma i-hypoglycemia ngezikhathi ezithile kwenzeka, uma isifo sikashukela singatholakali futhi, ngenxa yalokho, ukwelashwa akwenziwa. Uma izidakamizwa ezinciphisa ushukela zingasetshenziswa, izinga le-glucose lingase lehle ngenxa yesimila esikhiqiza i-insulin (insulinoma - funda ngakho lapha //diabetiya.ru/oslozhneniya/insulinoma.html).
3. Ukubhekana nesidingo sokushintshwa kwemijovo ye-insulin enohlobo 2 lwesifo sikashukela. Ngokwezinga le-C-peptide, umuntu angahlulela ukulondolozwa kwamanyikwe futhi abikezele ukuwohloka okuthe xaxa.
4. Uma usola uhlobo lokufakelwa lwe-hypoglycemia. Abantu abazibulalayo noma abagula ngengqondo bangakwazi ukuphatha i-insulin ngaphandle kokuthola udokotela. Ukweqisa okubukhali kwehomoni ngaphezulu kwe-C-peptide kukhombisa ukuthi i-hormone yajova.
5. Ngezifo zesibindi, ukuhlola izinga lokuqongelelwa kwe-insulin kuyo. I-hepatitis engapheli kanye ne-cirrhosis kuholela ekwehlekeni kwamazinga e-insulin, kepha akunakuphazamisa ukusebenza kwe-C-peptide.
6. Ukukhonjwa kokuqala nesikhathi sokuxolelwa kwisifo sikashukela sentsha lapho amanyikwe eqala ukuzihlanganisa okwakhe ukuphendula ekwelashweni ngemijovo ye-insulin.
7. Ngokwe-polycystic nangokuzala. Ukhushulwa okwandisiwe kwe-insulin kungaba imbangela yalezi zifo, ngoba ukukhiqizwa kwe-androgens kuyathuthukiswa ekuphenduleni kukho. Futhi, kuyaphazamisa ukuthuthukiswa kwama-follicle futhi kuvimbele i-ovulation.

Kuhlaziywa kanjani i-C-peptide

Kuma-pancreas, ukukhiqizwa kwe-proinsulin kwenzeka njalo ngewashi, ngomjovo weglucose egazini, kushesha kakhulu. Ngakho-ke, imiphumela enembile, futhi ezinzile inikezwa ngocwaningo ngesisu esingenalutho. Kuyadingeka ukuthi kusukela ngomzuzu wokudla wokugcina uye ekunikelweni kwegazi okungenani amahora ayi-6, kudlule amahora angama-8.

Kuyadingeka futhi ukukhipha kusengaphambili ithonya kuma-pancreas wezinto ezingasusa ukwakheka okuvamile kwe-insulin:

• usuku ungaphuzi utshwala;
• khansela uqeqesho olwake lwazolo;
• Imizuzu engama-30 ngaphambi kokuba umnikelo wegazi ungakhathali emzimbeni, zama ukungakhathazeki;
• ungabhemi ekuseni njalo kuze kuhlaziywe;
• Ungaphuzi umuthi. Uma ungeke ukwazi ukwenza ngaphandle kwabo, xwayisa udokotela wakho.

Ngemuva kokuvuka nangaphambi kokunikela ngegazi, kuvunyelwe kuphela amanzi ahlanzekile ngaphandle kwegesi noshukela.

Igazi lokuhlaziywa lithathwa emthanjeni liye kwi -hubhu ekhethekile yokuhlola equkethe umuthi wokugada. I-centrifuge ihlukanisa i-plasma nezinto zegazi, bese kusetshenziswa ama-reagents ukuthola inani le-C-peptide. Ukuhlaziywa kulula, kuthatha amahora angaphezu kuka-2. Kumalabhoratri ezentengiso, imiphumela imvamisa ilungele usuku olulandelayo.

Yiziphi izinkomba ezijwayelekile

I-C-peptide esiswini esingenalutho kubantu abaphilile isuka kuma-260 kuya ku-1730 picomoles kwilitha le-serum yegazi. Kwamanye ama-laboratories, amanye amayunithi asetshenziswa: ama-millimitha ilitha noma ama-nanigremu nge-millilitha ngayinye.

Isimo se-C-peptide kumayunithi ahlukene:

Amanani angahluka phakathi kwelebhu uma kusetshenziswa amakhithi we-reagent avela kwabanye abakhiqizi. Izinombolo eziqondile zojwayelekile zibonisa njalo ekhasini lokuphetha kukholamu "yamanani okusebenza".

Iliphi izinga elikhulayo

Ukwanda kwe-C-peptide uma kuqhathaniswa nokujwayelekile kusho ukweqile kwe-insulin - i-hyperinsulinemia. Kungenzeka ngokuphulwa okulandelayo:

1. I-Hypertrophy yamaseli we-beta ophoqelelwa ukuba avumelane nama-hormone amaningi ukwehlisa ushukela oshukela.
2. I-Metabolic syndrome emelana ne-insulin uma ushukela wokuzila usondele kwesejwayelekile.
3. I-Insulinoma iyi-beta-cell neoplasm ekwazi ukuzimela i-insulin ngokuzimele.
4. Ngemuva kokuhlinzwa ngokuhlinzwa kwe-insulinomas, ukwanda kwe-metastasis noma ukubuyiselwa kwesimila.
5. I-Somatotropinoma yisimila esisendaweni ye-pituitary gland ekhiqiza ama-hormone okukhula, okuyi-insulin antagonist. Ukuba khona kwalesi simila kubangela ukuthi ama-pancreas asebenze kakhulu.
6. Ukuba khona kwama-antibodies kuma-insulin. Imvamisa, ukubonakala kwama-antibodies kusho ukudalwa kwesifo sikashukela sohlobo 1, okuvame kakhulu yisifo sikaHirat kanye ne-polyglandular insufficiency syndrome.
7. Ukwehluleka kwangempela uma i-hormone kuyinto evamile futhi i-C-peptide iphakanyisiwe. Imbangela yayo ingaba yi-nephropathy.
8. Amaphutha ekudluliseleni ukuhlaziya: ukungenisa ukudla noma izidakamizwa, imvamisa i-hormonal.

Kusho ukuthini izinga eliphansi?

Uma ukuhlaziya kukhombise ukwehla kwezinga le-C-peptide, lokhu kungakhombisa izimo ezifana:

• ushukela othembele ku-insulin - uhlobo 1 noma uhlobo 2 olusezingeni eliphezulu;
• ukusetshenziswa kwe-insulin engaphandle;
• wehlise ushukela ngenxa yokudakwa kotshwala;
• ukucindezelwa kwakamuva;
• ukuhlinzwa kwe-pancreatic ngokulahlekelwa okuyingxenye komsebenzi wayo.

I-C-peptide kancane ngaphansi kwamanani wesethenjwa kungenzeka njengokuhlukahluka kwento ejwayelekile ezinganeni nakubantu abadala abasebancane. Ukuhlolwa kwe-glucose ne-glucose ukubekezelela kuleli cala kuzonikeza imiphumela emihle. Uma i-C-peptide ijwayelekile noma iphansi kancane, futhi ushukela iphakanyisiwe, kungaba zombili izinhlobo ezinesifo sikashukela esingu-1 (isifo sikashukela se-LADA) nokuqala kokubuyiselwa kwe-beta-cell ngohlobo 2.

Ukunquma isidingo sokwelashwa kwe-insulin sikashukela, kuhlaziywa okwenziwe. I-Glycemia kufanele yenziwe ibe ngejwayelekile ezinsukwini ezimbalwa ngaphambi kokunikela ngegazi, ngaphandle kwalokho imiphumela izoba ngethembekile ngenxa yemiphumela enobuthi yoshukela kumaseli we-beta.

Ukufakwa komjovo we-1 mg we-glucagon ukukhuthaza ukukhiqizwa kwe-insulin. Izinga le-C-peptide linqunywa ngaphambi komjovo nemizuzu engu-6 ngemuva.

Inketho elula ukusebenzisa ama-unit amabili esinkwa emahoreni ama-2 ngaphambi kokuhlaziywa kwama-carbohydrate, ngokwesibonelo, itiye elinoshukela nocezu lwesinkwa. Izinga lokusebenza kwe-pancreatic lanele uma i-C-peptide ngemuva kokuvusa okujwayelekile. Uma kuncane kakhulu - ukwelashwa kwe-insulin kuyadingeka.

Funda futhi:

• Imithetho eyisisekelo yokunikela ngegazi ushukela - //diabetiya.ru/analizy/analiz-krovi-na-sahar.html