Isifo sikashukela yisidakamizwa esisebenza ngohlobo 2 sikashukela. Isakhi sayo esisebenzayo yi-gliclazide. Umuthi ubonakala ngokukhishwa okusheshayo kanye nentengo ephezulu, iziguli eziningi zifuna izithonjana ezingabizi kakhulu zikaDiabetes. Ukuzenzisa esikhundleni somuthi akuvunyelwe: izeluleko zochwepheshe ziyadingeka.
Incazelo Yomkhiqizo
I-Diabeteson yi-ejenti ye-hypoglycemic futhi esuselwa ku-β-sulfonylurea, ethathwa ngomlomo. Umehluko wawo kusuka kuma-synonyms ubukhona bendandatho ene-heterocyclic eyi-N ene-endocyclic bond. Umuthi uvuselela ukukhiqizwa kwe-insulin ngama-β-cell ama-islets ama-Langerhans futhi wehlise okuqukethwe kwe-glucose egazini.
Ngemuva kweminyaka emibili yokwelashwa, ukwanda kwesamba se-C-peptide ne-postprandial insulin kusale. Ingxenye esebenzayo ikhombisa imiphumela ye-hemovascular futhi ithinta i-carbohydrate metabolism. Ngohlobo 2 sikashukela, sikhulisa isigaba sesibili sokukhishwa kwe-insulin futhi sibuyise inani eliphakeme lokukhuphuka kwalo ekuphuzeni i-glucose. Lezi zinqubo zibhekwa ikakhulukazi ngesingeniso saso kanye nangempendulo yokukhuthaza, okubangelwa ukungena kokudla.
Umuthi unciphisa ubungozi be-thrombosis encane yegazi kanye nokuthuthukiswa kwezinkinga ezivela kwisifo sikashukela. Ngemuva kosuku lokusetshenziswa okukodwa kwalo muthi, ukuqoqwa kwama-metabolites asebenzayo kanye ne-pioglitazone ku-serum yegazi kuhlala kusezingeni eliphakeme kunalokho.
Imiyalo yokusebenzisa
Isichasiselo sikhombisa imingcele ekuphuzeni umuthi. Contraindication yayo eyinhloko imibandela elandelayo:
isifo sikashukela nesifo sikashukela;- isikhathi sokukhulelwa nokuzala ingane;
- ukwehluleka okukhulu kwe-hepatic ne-reso;
- okuqukethwe okuphezulu kwemizimba ye-ketone kanye noshukela wegazi;
- ukungabekezeleli i-lactose, i-sulfanilamide, i-gliclazide.
isifo sikashukela nesifo sikashukela;Umuthi ubekelwe iziguli zabantu abadala kuphela. Ithebhulethi kumele ithathwe kanye ngosuku ngesikhathi sokudla. Isilinganiso esiphezulu sansuku zonke singu-120 mg. Umuthi awunakachotshozwa futhi uhlafunwe, kufanele ugezwe ngamanzi angenalutho. Uma weqa lo muthi, awusetshenziswa umthamo ophindwe kabili.
Esigabeni sokuqala sokwelashwa, umthamo ngu-30 mg. Uma kunesidingo, inyuswa nguchwepheshe kungakapheli izinsuku ezingama-40 kuqokwe owedlule. Iziguli ezingaphezu kweminyaka engama-65 ubudala azidingi ukulungiswa komthamo. Ngesikhathi sokulashwa, isikhathi sokuhoxiswa kwemithi yangaphambilini kufanele sibhekwe. Lapho uthatha umuthi, kungahle kube nemiphumela engemihle. Lokhu kufaka phakathi:
ukulahleka kwengqondo;- ukozela noma ukuqwasha;
- injabulo yenjabulo;
- ukungaphatheki kahle kwezizathu;
- ukugoba nobuthakathaka obujwayelekile;
- ukubona okulimazayo, isiyezi.
ukulahleka kwengqondo;Analogs kanye esikhundleni somuthi
Umuthi unezindleko eziphakeme impela. Ama-analog kanye nezindawo ezinesifo sikashukela zimelelwa yile mithi elandelayo:
- Diabetesalong;
- I-Gliclazide;
- UGlidiab;
- I-Diabefarm MV;
- Predian;
- I-Glucostabil;
- I-Piroglar.
Diabetesalong - I-analogue eshibhile ye-Diabeteson, isichazamazwi esandisa ukukhiqizwa kwe-insulin, umuzwa wezicubu zepherishi futhi sinciphise inani le-glucose egazini. Hhayi umlutha ngisho nangemva kweminyaka emi-3 yokusetshenziswa. Umuthi wehlisela i-postprandial hyperglycemia, ubuyisela inani eliphakeme ekuqaleni kokukhiqizwa kwe-insulin, unciphisa isikhathi sokuphumula phakathi kokudla nokuvikelwa kwe-insulin. Esibindi, umuthi unciphisa ukwakheka kwe-glucose futhi wenze ukusebenza kwawo kube okujwayelekile.
Into esebenzayo ithuthukisa i-microcirculation kanye ne-carbohydrate metabolism, inciphisa ingozi ye-thrombosis futhi ibuyise umsebenzi we-activ plasminogen activator.
I-Gliclazide - Lolu uhlobo lwesidakamizwa oluchazwe ngaphakathi. Kufaka indandatho ye-heterocyclic nge-endocyclic bond. Umuthi uvuselela ukukhiqizwa kwe-insulin futhi unciphise inani le-glucose. Ngemuva kweminyaka emithathu yokwelashwa, ukwanda kokuhlushwa kwe-C-peptide kanye ne-postprandial insulin kuhlala. Isakhi esisebenzayo sikhombisa umsebenzi we-hemovascular futhi sithinta kahle i-carbohydrate metabolism. Sebenzisa umuthi kwehlisa ingozi yezinkinga zesifo sikashukela.
UGlidiab umuthi osuselwa kwizidakamizwa ezimbili we-sulfonylurea. Kuthuthukisa umsebenzi we-glucose insulin-secretory, ukuzwela kwezicubu ezithintekayo futhi kunomthelela omuhle ekusindisweni kwe-insulin, kuvuselela isenzo se-intracellular kwemisipha ye-glycogen synthetase enzymes, futhi kunciphise inani eliphakeme le-hyperglycemia ngemuva kokudla. Ukusetshenziswa kwomuthi kufanele kuqalwe ngokumelene nesizinda sokudla okunekhalori ephansi nokuqukethwe okuphansi kwama-carbohydrate.
Kunconywa ukubheka njalo amazinga kashukela egazini ngemuva kokudla nasesiswini esingenalutho. Umthamo ulungiswa ngokuxineka ngokomzwelo noma ngokomzimba.
I-Diabefarm MV - Lesi i-analogue ye-Diabeteson 60, okuyisidakamizwa se-hypoglycemic futhi esihlobene nesizukulwane sesi-2 sokutholwa kwe-sulfonylurea. Isebenzisa ukukhiqizwa kwe-insulin ngamaseli e-pancreas kanye nesenzo sama-enzyme angama-intracellular. Umuthi usebenza ngempumelelo kakhulu kuhlobo lwesifo sikashukela esinga-insulin esinezimpawu zempilo ezinesifo sikashukela kanye ne-prophylactic yezinkinga ze-microcirculation.
Predian - Umuthi wemvelaphi yokwenziwa. Ingathengwa ngohlobo lwamathebulethi ngomthamo ongu-0,08 g, opakwe ebhokisini lekhadibhodi. Umuthi osebenzayo wehlisa ukuqina kwegazi futhi wehlise inani loshukela. Umuthi kumele uqalwe ngengxenye yepilisi. Umuthi awukwazi ukuhlanganiswa ne-acetylsalicylic acid, i-butadione, i-amidopyrine ngenxa yokusongela i-hypoglycemia.
I-Glucostabil kuthuthukisa umsebenzi we-fibrinolytic vascular, kunciphisa ukuthuthukiswa kwe-parietal thrombus, ukuhlanganiswa kweplatelet kanye nokunamathela. Umuthi ukhulisa i-microcirculation, inani le-HDL-C, yehlisa i-cholesterol ephelele, ukuzwela kwemithambo yegazi ku-adrenaline futhi kuvimbela ukukhula kwe-atherosclerosis ne-micothrombosis. Ukwehla isikhathi eside kwe-proteinuria kuphawulwa ngemuva kwesizinda sokusetshenziswa gliclazide isikhathi eside ku-nephropathy yesifo sikashukela.
I-pioglar - Umuthi we-hypoglycemic womlomo kanye ne-agonist ekhethekile ye-gamma receptor enamandla Isakhi esisebenzayo sibonisa ukuguqulwa kwezakhi zofuzo ezibandakanyekile ekuqhekekeni kwe-lipid nokulawulwa kweglucose. Esiswini nasezithanjeni eziphelele, kunciphisa ukumelana ne-insulin. Ngohlobo 2 sikashukela i-mellitus lowers glycated hemoglobin ne-insulin ku-plasma.
Ungathola ukuthi yini i-Diabeteson engayithatha esikhundleni nodokotela wakho. Akunconywa ukusebenzisa umuthi uwedwa, ngoba lokhu kungaholela emiphumeleni emibi eyingozi.
