Akukenzeki njalo ukulawula uhlobo lwe-2 yesifo sikashukela kuphela ngosizo lokudla okuphansi kwe-carb nemithwalo yemisipha ebunjiwe. Futhi kuyadingeka ukulwa ne-hyperglycemia, ngoba ukwelashwa okungafundi kuholela ezinkingeni ezinkulu.
Ezinye zezingozi eziyingozi kakhulu zenhliziyo. I-Diabetesalong (Latin Diabetalong), isidakamizwa se-hypoglycemic ngokukhishwa isikhathi eside noma okuguquliwe, kuzosiza ukunciphisa ingozi yokuthola i-CVD.
Amathuba wemithi
Izici ze-antidiabetesic zomuthi zibangelwa i-gliclazide esetshenziswayo. Amacwecwe aqukethe i-30 noma i-60 mg yezithako eziyisisekelo kanye nokutholwa: i-calcium stearate, hypromellose, talc, lactose monohydrate, colloidal silicon dioxide.
I-Diabetalong ingumuthi wesigaba sesibili sulfonylurea. Uma ingena egazini, i-gliclazide ivuselela ukwakheka kwe-endo native hormone ngama-β-cell of pancreas, isheshise ukusetshenziswa kwe-glucose (isheshisa umsebenzi we-misuli glycogen synthase). Ezinsukwini ezimbalwa kusukela kuqale isifundo, iphrofayili ye-glycemic isezingeni elifanele. Isikhathi sokuphuma kokufakwa kokudla endaweni yokugaya ukudla kuya ekunciphiseni kwe-insulin yendlala siyancishiswa, futhi izinkomba ze-glycemic ezishukunyiswa ukudla ziyancishiswa.
Kuyamangaza ukuthi eminyakeni emibili ngemuva kokuthatha umuthi, ukugcinwa kwe-insprandial insulin ne-C-peptide kugcinwa. Umthelela emzimbeni weDiabetesalong uyinkimbinkimbi:
- Ilawula umsoco we-carbohydrate;
- Inomphumela we-antioxidant ohlelekile;
- Kukhuthaza ukuvikelwa kwe-insulin;
- Inomphumela we-hemovascular (suppress platelet aggregation).
Lapho ushukela ungena egazini, i-gliclazide iyasebenza ngokushesha ukukhiqizwa kwe-insulin. Ngokulashwa njalo, umuthi uyaxwayisa:
Izinkinga ze-Microvascular - retinopathy (inqubo yokuvuvukala ku-retina) kanye nephropathy (ukungasebenzi kahle kwezinso);- Imiphumela yemiphumela emisha - imivimbo, ukushaya kwenhliziyo.
Izinkinga ze-Microvascular - retinopathy (inqubo yokuvuvukala ku-retina) kanye nephropathy (ukungasebenzi kahle kwezinso);Izici ze-Pharmacokinetic
Ukusuka esiswini, umuthi udonswa ngokugcwele. Okuqukethwe okuphezulu okusegazini kufinyelelwa ngemuva kwamahora angama-2-6, nakumathebhulethi anamahora we-MV - amahora ayi-6 kuya kwayi-12.
Umphumela wokwelapha uthatha amahora angama-24, amaprotheni egazi i-glycazide abopha aze afike ku-85-99%. Esibindini, umkhiqizo webhayoloji uguqulwa ube ngama-metabolites, omunye wawo unomthelela omuhle ku-microcirculation. Ukuphila kwesigamu kungamahora angama-8 kuya kwele-12, kumathebulethi ane-MB - amahora ayi-12-16. Umuthi ukhishwa ngamaphesenti angama-65 ngomchamo, ngo-12% ngomquba.
Uboniswa ngubani lo muthi
Isizathu sokuqokwa kweDiabetesalong isifo sikashukela sohlobo 2, kokubili njenge-monotherapy futhi sihlanganiswa nemithi ye-insulin noma efanayo ye-antidiabetes.
Contraindication kanye nemikhawulo
- Uhlobo 1 sikashukela;
- I-Hypersensitivity;
- I-Pathology yesibindi;
- Ukungasebenzi kahle kwesixongo;
- I-ketoacidosis;
- I-Hypo- ne-hyperthyroidism;
- Isifo sikashukela noma i-hyperosmolar;
- Ukukhulelwa nokuncelisa ibele
- Ukulimala okungathi sína nokushiswa.
I-Diabetesalong i-contraindication kwabesifazane abakhulelwe, uma ingeke ikhansulwe ngenkathi incelisa ibele, ingane idluliselwa kokudla okungelona okwenziwe emzimbeni.
Ukusetshenziswa kwe-glycoside akuvunyelwe uma kuthathwa kanyekanye ne-miconazole.
Imiphumela emibi
Imiphumela engathandeki yipheshana lesisu ingaba yizingqinamba zesifo ngendlela yokuhlaselwa isicanucanu, ukugabha, nobuhlungu besisu. Kusukela ohlangothini lwe-metabolism, i-hypoglycemia kungenzeka, ohlelweni lokujikeleza - i-eosinophilia, cytopenia, anemia. Engxenyeni yesikhumba, i-allergy kanye ne-photosensitization kungenzeka. Kusukela ezithweni zezinzwa kukhona ukuphazamiseka kokunambitha, ukukhanda ikhanda, ukulahleka kokuxhumana, ukulahleka kwamandla.
Ukusebenzelana kwezidakamizwa
Ukusebenza kwe-glycoside kuthuthukiswa ukusetshenziswa okuhlanganiswe ne-anabolic steroid, ACE inhibitors, β-blockers, cimetidine, fluoxetine, salicylates, MAO inhibitors, Flucanazole, Pentoxifylline, Miconazole, Theophylline, Tetracycline.
Amathuba we-glycoside ayenziwa buthaka lapho asetshenziswa ngokubambisana nama-barbiturates, ama-glucocorticoids, ama-sympathomimetics, ama-saluretics, ama-rifampicin, amaphilisi okulawula ukuzala, ama-estrogens.
Ungasifaka kanjani isicelo
I-Glycloside kufanele ithathwe ngokudla kokudla. Ithebhulethi ligwinyiwe ligcwele, ligezwe ngamanzi ekushiseni kwegumbi. I-endocrinologist ikhetha imithamo kanye namarejimthi wokwelashwa ngawodwana, kucatshangelwa isigaba sesifo kanye nokusabela kwesifo sikashukela emuthini. Ngomuthi i-Diabetesalong, imiyalo yokusebenzisa itusa umkhuba wokuqala wama-30 mg nokulungiswa okwengeziwe endaweni yokwanda (uma kunesidingo).
Ukufeza umphumela omkhulu wokwelapha, kubalulekile ukulandela imithetho elula.
- Yonke imithamo yansuku zonke ithathwa kanye, okuhle kunakho konke - ekuseni;
- Inani lomuthi lingashintshwa ngaphakathi kwe-30 -120 mg / ngosuku;
- Uma isikhathi sokwamukelwa siphuthelwe, okujwayelekile akufanele kuphindwe kabili ngomnqamulajuqu olandelayo;
- Lapho ubala umthamo, udokotela unaka ukufundwa kwemitha neHbAlc.
Ngokusebenza okunganele, kuvamile ukwanda (ngemuva kwesivumelwano nodokotela), kepha hhayi ngaphambi kwenyanga ngemuva kokuba kuthathwe umthamo wokuqala we-glycoside. Njalo emavikini ama-2, ngesinxephezelo esiphelele se-glycemia, ungandisa umthamo.
Kubalulekile ukubheka ukuthi ithebhulethi eyi-1 ye-Diabetalong PV iqukethe ama-60 mg we-glyclazide, lokhu kuhambelana namathebulethi amabili e-Diabetalong MV 30 mg lilinye.
Lapho udlulisela isifo sikashukela ku-gliclazide kusuka kwezinye izidakamizwa ze-hypoglycemic, ikhefu aludingekile, ngaphandle kokuphuma kokunye kwe-sulfonylurea. Umthamo wokuqala kuleli cala usejwayelekile - 30 mg, uma ngabe i-endocrinologist ingabekanga uhlelo lwakhe.
Ekwelashweni okuyinkimbinkimbi, iDiabetesalong isetshenziswa ndawonye nezinhlobo ezihlukile zama-insulin, ama-biagudins, ama-cy-glucosidase inhibitors. Ngokuqapha, umuthi unqunyelwa kwabanesifo sikashukela eqenjini elibeka engcupheni i-hypoglycemic (ukuphuza kabi utshwala, ukusebenza kanzima ngokomzimba noma ezemidlalo, ukubulawa yindlala, isizinda esiphakeme kakhulu esicindezelayo). Imisebenzi yeHematopoietic iphazamiseka ngokwakhiwa kwe-anemia, i-thrombocytopenia, i-leukopenia, i-granulocytopenia.
Ukuphepha kokuphepha
Ukuze ugweme i-hypoglycemia, kubalulekile ukubeka isikhathi ukusetshenziswa komuthi wokudla, ukuvimbela ikhefu elikhulu ekudleni, ukuqeda ngokuphelele ukuphuza kotshwala. Ukulawulwa okufanayo kwe-β-blockers kungahlanekezela izimpawu ze-hypoglycemia.
Isimo se-hypoglycemic singabonwa wukugula kwekhanda, ukuphazamiseka kokuhlangana, ukuhlaselwa okungalawulwa kwendlala, ukudangala, ukufeyila, ukubona okungalunganga, ukuphazamiseka kwengqondo. Ukusabela kwe-Adrenergic nakho kuyabonakala: ukukhathazeka, ukujuluka, amaconsi emfuthweni wegazi, isifo senhliziyo somoya, ukuphazamiseka kwesigqi senhliziyo. Ukuphazamiseka kwengqondo kwe-dyspeptic, ukuphazamiseka kusigqi sokuzila, nokuphendula kwesikhumba (ukuqubuka, ukungajabuli, i-erythema, i-urticaria, i-edema yeQuincke) kuyimpawu.
Ukwelapha okuphumelelayo akwenzeki ngaphandle kokudla okuphansi kwe-carb. Ngenxa yobungozi bemiphumela emibi, abashayeli kufanele basebenzise umuthi ngokuqapha. Izincomo ezifanayo zisebenza kubamele abamele ubuchwepheshe obuhambisana namazinga wokuphendula aphezulu nokuhlushwa.
Ama-pathologies wesibindi ne-bile ducts akhuthaza i-hepatitis, ukwanda komsebenzi we-enzyme.
Uma ohlukunyeziwe ekwazi, kudingeka adle uswidi, aphuze ingilazi yetiye noma okunye okuphakeme kuma-carbohydrate. Ngemuva kokuba lesi simo sithuthuka, udokotela obambele udinga ukubonisana ukuze alungise umthamo noma atshintshe umuthi.
Ukufana kwezidakamizwa
Ngokusho kwengxenye esebenzayo yeDiabetesalong, i-analogue kuzoba isidakamizwa uGlidiab esibiza ama-ruble ayi-140. Odokotela banikeza izidakamizwa zeDiabeteson neDiabeteson MV ngesilinganiso esiphakeme ngamanani asukela kuma-ruble angama-286 kuya kwangama-318. Kumalungiselelo afanayo, i-Glyclada nayo inganconywa.
Ukulungiselela okunomphumela ofanayo we-hypoglycemic njenge-Amaril, Glimepiride, Glemaz, Glyurenorm kuzoba kuhle kakhulu ekwakhiweni. Babekelwe i-hypersensitivity noma okunye ukuphambana kwe-glycoside.
Ukukhishwa ifomu, izimo zokugcina
Amathebhulethi e-Diabetesalong akhiqizwa yi-Synthesis OJSC ne-MS-Vita LLC akhiqizwa emaphaketheni okulimaza. Amabhola afakwa ebhokisini lekhadibhodi.
Umuthi ungagcinwa iminyaka emithathu ekushiseni kwegumbi, ngaphandle kokuthola ukukhanya kwelanga okuqondile nezingane. Emakhemisi, iDiabetesalong iyatholakala ukuthi inikezwe umuthi ngentengo yama-ruble angama-98-127. amaphilisi angama-60 ama-30 mg.
Ukubuyekezwa kwesifo sikashukela
Abanesifo sikashukela abaye babona imiphumela ye-Diabetesolong, kuzibuyekezo baphawula izinzuzo zayo:
- Ukuthuthuka kancane kancane kwezinkomba ze-glucometer;
- Ukuhambisana okuhle neminye imithi;
- Izindleko ezingabizi zemithi;
- Amandla okunciphisa isisindo ngesikhathi sokwelashwa.
Akuwona wonke umuntu oweneliseka ngesidingo sokulawulwa kwe-glycemic njalo (kuze kube ka-5 ngosuku), kepha ngokuqhubeka kwesikhathi izinkomba zayo ziyaqina futhi nesidingo sokuzibamba esithuthukisiwe siyancipha.
Ngokuvamile, i-Diabetesalong iyisidakamizwa esithembekile se-antidiabetic esenza ukuthi iphrofayili ye-glycemic ihlale kahle. Uma isetshenziswa kahle, iyakwazi ukuvimbela izehlakalo zenhliziyo nezinye izinkinga ezinkulu zesifo sikashukela sohlobo 2.
