I-Siofor 500 - izindlela zokulwa nesifo sikashukela

ISiofor 500 isetshenziselwa ukwehlisa ushukela wegazi. Iphinde isetshenziswe ezimweni lapho kudingekile khona ukuzinza nokunciphisa umzimba. Ukusebenza okuphezulu kwesidakamizwa kungenxa yomphumela oyinkimbinkimbi: izinqubo eziningi ze-biochemical zenziwa zenziwe ngokwejwayelekile ngesikhathi sokwelashwa.

Igama Lezwe elingafanele

I-Metformin

ISiofor 500 isetshenziselwa ukwehlisa ushukela wegazi.

I-ATX

A10BA02

Khipha amafomu nokwakheka

Kumakhemisi, ungathola umuthi kuphela ngesimo samathebulethi. Ngokubizwa kwesidakamizwa okukhulunywa ngaso, umthamo wento eyinhloko (metformin hydrochloride) ubethelwe - 500 mg. Kunezinye izinhlobo zemithi ezihlukile enanini lale nto: 850 no-1000 mg.

Umuthi ukhiqizwa emaphaketheni amaseli aqukethe amaphilisi ayi-10 no-15. Inani eliphelele lamabhuloksi emabhokisini amakhadibhodi: 2, 3, 4, 6, 8, 12.

Isenzo se-Pharmacological

I-Siofor ingeyeqembu lama-hypoglycemic agents. Umuthi ungowama-Biguanides. Kusetshenziswa kaningi ngokuhlangana nezinye izindlela. Ngaphezu kwalokho, umuthi unqunyelwa kuphela isifo sikashukela esinga-insulin. Ngokuqondile umuthi awuthinti isizinda se-hormonal, kutholakala kuphela umphumela ongaqondile. Ngakho-ke, ngesikhathi sokwelashwa ngeSiofor, ubukhulu bokukhiqizwa kwe-insulin ngamaseli e-pancreatic awukhuphuki. Kodwa-ke, kukhona ukwanda kokuzwela komzimba ngale hormone.

Indlela yokusebenza ye-metformin isuselwe ekubuyiselweni kwezinqubo eziningi ze-biochemical:

• izinga lokusebenzisa ushukela okhuphukayo, ngenxa yalokho, i-glycemia incipha kancane;
• ukuqina kwenqubo yokungenisa ama-carbohydrate yizitho zendlela yokugaya ukudla kuyancipha;
• ukukhiqizwa kweshukela kusibindi kuyancipha;
• ukuqina kokungasebenzi kwe-insulin nakho kuyancipha.

Ngenxa yomthelela oyinkimbinkimbi ochungechungeni lwezinqubo ezifaka isandla ekwakhekeni nasekusetshenzisweni kweglucose, kuyehla ukuncipha kokuxineka kwaso ngeplanethi yegazi. Ngaphezu kwalokhu, isakhi esisebenzayo seSiofor sithinta ukwenziwa kwe-glycogen. Ngaso leso sikhathi, umthamo wokuhamba wamaprotheni we-glucose membrane uyanda.

I-Siofor ingeyeqembu lama-hypoglycemic agents.

Naphezu kokungabikho komphumela oqondile kwinqubo yokukhiqizwa kwe-insulin, ukwehla kwesilinganiso se-insulin okuboshelwe mahhala kuyaphawulwa. Kanye nalokhu, kukhona ukwanda kwesilinganiso se-insulin kuma-proinsulin. Ngenxa yezinqubo ezinjalo, ukuzwela kwezicubu kuleli hormone kuyanda.

Kodwa-ke, umuthi unomphumela we-lipid metabolism. Kule nqubo, ukukhiqizwa kwamafutha acid yamahhala kukhula kancane kakhulu. Amafutha oxidation anciphisa ijubane. Ngenxa yalokhu, umfutho wenqubo ye-fat metabolism uyancipha, osiza ekuqiniseni isisindo. Ukuqoqwa kwe-cholesterol (okuphelele kanye ne-LDL), kanye ne-triglycerides, nakho kuyancishiswa. Ngenxa yalokhu, inqubo yokufakwa emzimbeni kwamafutha iyaphazamiseka. Ngenxa yalokhu, isisindo sincishiswa ngemuva kwesizinda sokudla nokugcina umfutho owanele womzimba womzimba.

Enye into ye-metformin yikhono lokuthonya inqubo ye-thrombosis. Le mpahla ibonakaliswa buthaka. Ngibonga yena, uSiofor ukhuthaza ukuhlanganiswa kabusha kwamagumbi.

I-Pharmacokinetics

Ingxenye esebenzayo ingena egazini ivela emgodini wokugaya ukudla, lapho i-mucosa ingeniswa khona ngokushesha. Izibhebhe ziphelele emafilimu. Le nto inomthelela ekukhishweni kwento esebenzayo kuphela emathunjini. I-plasma okuhlushwa kakhulu ye-metformin ifinyelelwa ngemuva kwamahora ayi-2,5. Ukudla kufaka isandla ekutholeni umuthi kancane.

I-Metformin ivame ukusabalala emzimbeni wonke. Kodwa-ke, ngokwezinga elikhudlwana, le ngxenye ibambezeleka kuphela ezithweni ezithile (isibindi, izinso), nasezindongeni ezithambile. I-bioavailability yesidakamizwa emzimbeni onempilo ifinyelela kuma-60%. Ama-Siofor ahlukile kuma-analogues lapho kungekho khona amandla okubopha kumaphrotheni e-plasma.

Into esebenzayo iSiofor 500 ayihambi inguquko.

Into esebenzayo ayisebenzi inguquko. Lapho isuswa emzimbeni, izinso ziyahileleka. Isigamu sempilo singamahora ayi-6.5. Kuyaphawuleka ukuthi uma kwenzeka umsebenzi wezinso ongasebenzi kahle, kanye nokwehla kokuxineka kwe-creatinine, izinga lokususwa kwe-metformin emzimbeni liyancipha. Ngenxa yalokhu, inani lezinto ezisebenzayo ku-plasma landa ngokushesha.

Kubekelwe ini?

Inkomba enkulu yokusetshenziswa kweSiofor nge-metformin 500 mg ukuphathwa kweziguli ezinesifo sikashukela sohlobo 2. Isibonakaliso sokusetshenziswa kwalesi sidakamizwa ukwanda kwe-glucose yegazi. Kodwa-ke, umuthi ungabekelwa kuphela isifo sikashukela esinga-insulin. Lokhu kungenxa yokuthi iSiofor yandisa ukuzwela kwezicubu kuyi-insulin. Ngakho-ke, ukwanda kokufakelwa kokuqukethwe kwaleli hormone kungaholela ezinkingeni.

Umuthi okukhulunywa ngawo unconyelwe ukusetshenziselwa ukukhuluphala, okwavela ngemuva kwesizinda sikashukela. Kodwa-ke, kuyalulekwa ukusebenzisa iSiofor kanye nokwelashwa kokudla kanye nokuzivocavoca okulinganiselayo. Leli khambi linqunyelwe kanye neminye imithi. Kakhulu kaningi (kuma-5-10% wamacala), kunconyelwa ukusetshenziswa njengezinyathelo zokwelapha ezizimele.

Isibonakaliso sokusetshenziswa kwalesi sidakamizwa ukwanda kwe-glucose yegazi.

Contraindication

Akufanele ukunquma umuthi ezimweni ezinjalo:

• thayipha i-1 isifo sikashukela;
• ukusabela komuntu kwesimo esingesihle kokuthile okusebenzayo noma okusebenzayo ekwakhiweni kweSiofor;
• ukonakala kwe-carbohydrate metabolism ngemuva kwesifo sikashukela;
• isimo sokugula okwandulele ukoma;
• izifo kanye nezici ezimbalwa ezingezinhle ezifaka isandla ekusebenzeni kahle kwesibindi, lokhu kubandakanya izifo ezinzima, ukuphuma komzimba;
• i-pathologies eholela ekuthuthukisweni kwe-hypoxia: ukusebenza okungahambi kahle kwenhliziyo, uhlelo lokuphefumula, ukufakwa kwe-myocardial, isimo sokushaqeka;
• ukwanda okubucayi kokuqukethwe kwe-lactate, okuhambisana nokuphulwa kwe-pH yegazi nokubonakaliswa kokungalingani kwe-electrolyte;
• ubuthi be-ethanol, uphuzo oludakayo;
• ukwelashwa kokudla, inqobo nje uma inani lansuku zonke lwamakhalori lilingana noma lingaphansi kuka-1000.

Ngokunakekela

Kudingeka ukunakekelwa okukhethekile lapho uphatha izingane kusuka eminyakeni eyi-10 kuye kweyi-12. Ngaphezu kwalokho, ukunakekelwa kumele kuthathwe lapho uphuza umuthi esegugile (kusuka eminyakeni engama-60 noma ngaphezulu), inqobo nje uma isiguli sivelelwa ukuzikhandla okukhulu ngokomzimba. Kulokhu, amathuba okukhula kwe-lactic acidosis, ehambisana nokungalingani kwe-electrolyte, ukwanda kokuqukethwe kwe-lactate kanye nokwephulwa kwe-pH yegazi, kuyanda.

Ungayithatha kanjani iSiofor 500?

Umuthi ubekwa lapho udla noma ngemuva kokudla. Isikhathi sokwelashwa sinqunywa ngawodwana. Qala inkambo yokwelashwa ngethamo elincane. Kancane kancane, inani le-metformin lenyuka. Ngaphezu kwalokho, umthamo wayo kufanele ukhuphuke njalo ngesonto. Ngenxa yalokhu, umzimba uvumelana kangcono nento yamakhemikhali.

Umuthi ubekwa lapho udla noma ngemuva kokudla.

Ukwelashwa kwesifo sikashukela

Esigabeni sokuqala, i-500-1000 mg yesidakamizwa kumele ithathwe. Kancane kancane, inani eliphakeme lomuthi nsuku zonke lifinyelelwa - 3000 mg (ezigulini zabantu abadala). Umthamo ochaziwe uhlukaniswe ngemithamo emithathu.

Ukwelashwa kwezingane kwenziwa ngokwemiyalo efanayo, kepha ngomehluko omncane: phakathi namasonto amabili okuqala, ama-500 mg ngosuku kufanele athathwe. Ngemuva kwalokho umthamo omkhulu wansuku zonke weSiofor ufinyelelwa kancane kancane - 2000 mg (weziguli ezisukela eminyakeni eyi-10 kuye kweli-18).

Ukwehla kwesisindo

Ngokuthi umuthi ungabekelwa kuphela abantu abanesifo sikashukela esiqinisekisiwe, ukuze wehlise isisindo somzimba, kuvunyelwe ukusebenzisa irejimeni yokwelashwa ejwayelekile. Ngaphezu kwalokho, ukudla kanye nokuzivocavoca okulinganiselayo kunqunyelwe. Umuthi okukhulunywa ngawo awukwazi ukumiselela lezi zinyathelo.

Imiphumela emibi

I-Lactic acidosis iyakhula, ukumuncwa kwe-vithamini B12 kuyaphazamiseka.

Isicanucanu, ukuhlanza - imiphumela emibi yesidakamizwa uSiofor.

ISiofor ingadala isifo sohudo.

Umphumela wecala lomuthi uSiofor ukubukeka kobuhlungu esiswini.

ISiofor ingadala ukulunywa.

I-Urticaria ingumphumela wesidakamizwa.

Amapheshana wesisu

Kukhona ukulahlekelwa ukunambitheka, isicanucanu kuvela, kuncane kakhulu - ukugabha. Ukuhudula kungenzeka. Kwesinye isikhathi kuba nobuhlungu esiswini. Isifiso sokuphazamiseka siyaphazamiseka, futhi ngasikhathi sinye kukhona inqwaba yensimbi emlonyeni. Lezi zimpawu zinganyamalala zodwa uma ukwelashwa kuyaqhubeka, ukuphuza umuthi amahlandla ama-2 ngosuku. Ingozi yokuqhamuka nemiphumela emibi inyuka esigabeni sokuqala sokwelashwa. Kulokhu, umzimba awukakavumeli i-metformin.

Izitho zeHematopoietic

I-Anemia

Engxenyeni yesikhumba

Ukulunywa, i-hyperemia, ukuqubuka.

Allergies

I-Urticaria.

Imiyalo ekhethekile

I-Metformin ivame ukunqwabelana emzimbeni ngenkathi ilashwa neSiofor. Ngokungasebenzi kahle kwesibindi noma kwezinso, lo mphumela unamandla. Ngenxa yokwanda kokuhlushwa kwe-metformin, inani le-lactic acid egazini liyanda. Ngenxa yalokho, i-lactic acidosis iyakhula. Kulokhu, kuyadingeka ukumisa ngokushesha inkambo yokwelashwa. Ukulaliswa esibhedlela kwesiguli kuyadingeka.

Ukuhlanganiswa kwe-metformin neziphuzo eziqukethe utshwala kuyimbangela yezinkinga ezinzima.

Ukuvimbela ukuthuthukiswa kwe-lactic acidosis, zonke izici zobungozi zinqunywa futhi, uma kunokwenzeka, zingabandakanywa ngesikhathi sokwelashwa. Izimbangela zezimpawu zalesi simo se-pathological:

• ukuphuza utshwala
• ukwehluleka kwesibindi;
• ukuzila ukudla;
• i-hypoxia.

Ngaphambi kokuthatha uSiofor, kuyadingeka ukuthola inani le-creatinine. Lokhu kungenxa yokuthi into esebenzayo ikhishwa yizinso.

Kuyadingeka ukuthatha ikhefu ngokuthatha lesi sidakamizwa okukhulunywa ngaso ngaphambi kokuqhuba isifundo usebenzisa ama-iodine aqukethe i-iodine agents. Inkambo yokwelashwa iphazanyiswa ezinsukwini ezi-2 ngaphambi kosuku olumisiwe bese kuqhubeka izinsuku ezingama-2 ngemuva kokuhlolwa.

Ukuhambisana notshwala

Ukuhlanganiswa kwe-metformin neziphuzo eziqukethe utshwala kuyimbangela yezinkinga ezinzima.

Umthelela ekhonweni lokulawula izindlela

ISiofor ayinikele ekunciphiseni okukhulu kwe-glycemia, ngakho-ke, akukho mkhawulo lapho ushayela izimoto ngesikhathi sokwelashwa ngaleli thuluzi. Kodwa-ke, kufanele kuqashelwe ngenkathi ushayela.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ungasebenzisi ekwelashweni kweziguli kulezi zimo, ngoba alukho ulwazi olwanele ngokuphepha komuthi.

Akunconyelwe ukuthatha leli thuluzi leziguli ezingaphansi kweminyaka eyi-10.

Ukuqokwa kukaSiofor ezinganeni ezingama-500

Akunconyelwe ukuthatha leli thuluzi leziguli ezingaphansi kweminyaka eyi-10.

Sebenzisa ebudaleni

Umuthi uvunyelwe ukusetshenziswa.

Isicelo sokusebenza kokulimala kwezinso

Ukulimala okukhulu kwalesi sitho yisizathu sokuvinjelwa kokusetshenziswa kweSiofor ukuze kubuyiswe izinga le-glycemia ku-mellitus yesifo sikashukela. Isilinganiselo esinqunayo ukuncipha kokuhlushwa kwe-creatinine ku-60 ml ngomzuzu.

Sebenzisa umsebenzi wesibindi okhubazekile

Kwezifo ezinzima zalesi sitho, iSiofor ayinconywa.

Ukweqisa

Uma kuthathwe umthamo we-metformin 85 g, imiphumela emibi ayikhuli. Lapho inani lezinto likhuphuka kakhulu, ingozi yezimpawu ze-lactic acidosis iyanda. Kulokhu, ukungena esibhedlela kuyadingeka. Yehlisa ukugcwala kwe-lactic acid ne-metformin egazini usebenzisa i-hemodialysis.

Ukuxhumana nezinye izidakamizwa

Inhlanganisela ehlanganisiwe

Ukuhambisana kwama-ejenti aqukethe iodine aqukethe i-iodine ne-Siofor akwamukeleki. Kulesi simo, ingozi yokwanda ukwehluleka kwezinso inyuka, lapho kuvela khona izimpawu ze-lactic acidosis.

Ukuhambisana kwama-ejenti aqukethe iodine aqukethe i-iodine ne-Siofor akwamukeleki.

Akuhlanganisiwe ukuhlanganisa

Ungabuphuzi utshwala ngesikhathi sokwelashwa nomuthi okukhulunywa ngawo. Ngaso leso sikhathi, ubungozi bokuhlakulela i-lactic acidosis nabo buyanda. Umphumela ofanayo unikeza inhlanganisela yezidakamizwa eziqukethe i-metformin ne-ethanol.

Inhlanganisela edinga ukuqashelwa

UDanazole usiza ukukhulisa i-glycemia. Uma kunesidingo esiphuthumayo sokuphuza lo muthi, ukulungiswa kwamthamo kuyadingeka.

Izinga le-glucose nalo likhuphuka ngokuhlanganiswa kwama-ejenti alandelayo, izinto:

• izindlela zokuvimbela inzalo ngomlomo;
• ama-hormone egilo;
• I-Epinephrine;
• i-nicotinic acid;
• i-glucagon;
• okususelwa ku-phenothiazine.

Iqoqo le-Siofor landa kakhulu nge-Nifedipine therapy. I-Morphine nezinye izidakamizwa ze-cationic zinikeza umphumela ofanayo.

Ama-Derivatives we-sulfonylureas, i-insulin - le mishanguzo ivusa ukwanda kwesenzo se-metformin.

Umuthi okukhulunywa ngawo usiza ukunciphisa ukusebenza kwe-anticoagulants engaqondile (i-aspirin, njll).

Ama-Analog

Izikhundla ezingabakhona zeSiofor:

• I-Diaformin;
• Glyformin;
• IGlucophage Long;
• IFommetin;
• Metformin nabanye

Izimo zeholide Siofora 500 ezivela emakhemisi

Umuthi umuthi.

Ngingakwazi ukuthenga ngaphandle kadokotela?

Cha, ungathenga umuthi kuphela njengoba uyalelwe udokotela wakho.

Intengo

Izindleko ezijwayelekile ngama-ruble angama-250.

Izimo zokugcina zeSiofor 500

Izinga lokushisa eliphakeme kakhulu yi-+25 ° C.

Isikhathi sokuphelelwa yisikhathi

Umuthi ugcina izakhiwo zeminyaka engu-3 kusukela ngosuku lokukhululwa.

Umkhiqizi

Berlin - Chemie AG (Germany).

I-Diaformin iyi-analogue yeSiofor.

UGlatiniin uthathwa njenge-analogue kaSiofor.

IFommetin - umuthi we-analogue uSiofor.

I-Metformin ithathwa njenge-analogue yeSiofor.

I-Analogue Siofor - I-Glucofage Long.

Ukubuyekezwa mayelana neSiofor 500

Odokotela

UVorontsova M.A., oneminyaka engama-45 ubudala, udokotela wobuchopho, uKaluga

Nginikeza umuthi ngokumelana ne-insulin okufakazelwe. Phakathi kweziguli zami kukhona nezingane ezisencane. Umuthi ubekezelelwa kahle, ukubonakaliswa okungekuhle kwenzeka kaningi futhi ikakhulukazi kusuka emgudwini wesisu. Ngaphezu kwalokho, inani lentengo liphansi, uma liqhathaniswa ne-analogues.

I-Lisker A.V., eneminyaka engama-40, i-Therapist, eMoscow

Umuthi usebenza ngokushesha, usebenza kakhulu. Ngalesi sizathu, ingasetshenziswa ekwelapheni i-hyperglycemia futhi ngenhloso yokunciphisa umzimba kuphela ngemuva kokubonana nodokotela. ISiofor igqame ezinhlwini eziningi zezimpawu zokuthi kungaba nomthelela ekuguquguqukeni kwesimo nge-polycystic ovary. Kulokhu, abesifazane banezimpawu ezihlukile: izinwele emzimbeni nasebusweni, isisindo sanda. Umuthi unomphumela olinganiselayo ngemuva kwesizinda se-hormonal, ukususwa kwezinwele emzimbeni kubhekwa, isisindo sincishisiwe.

Iziguli

UVeronika, oneminyaka engama-33, uSamara

Uthathe umuthi nge-hyperglycemia. USiofor uthathe isinyathelo ngokushesha. Futhi angibonanga umthelela omubi kimi.

U-Ana, oneminyaka engama-45, uSochi

Umuthi awubizi futhi uyasebenza. Isifo sikashukela i-mellitus sitholakale isikhathi eside, kumina kunzima ukukhetha imishanguzo ye-hypoglycemic, umzimba uvame ukungaziboni. Kepha iSiofor imnene ngokunene.

Ukulahlekelwa isisindo

U-Olga, oneminyaka engama-35, idolobha laseKerch

Angizange nginciphise isisindo ngenkathi ngithatha lo makhambi. Benginethemba lokuthi ama-kilogramu ambalwa azohamba. Isisindo sisamile, kepha okungenani asikhuphuki, nakho okuhle.

UMarina, oneminyaka engama-39, uKirov

Wayezibandakanya kwezemidlalo kakhulu (ngangokunokwenzeka ngesifo sikashukela), kunokudla okulinganiselayo. Umphumela awunamandla - isisindo cishe asiphumlanga. Kepha ngilandela irejimeni yokwelashwa isikhashana, mhlawumbe leli yiphuzu.