Umuthi i-Vozulim: imiyalelo yokusetshenziswa

Lokhu kuyi-insulin yabantu eyenziwe ngonjiniyela bezakhi zofuzo. Isetshenziselwa ukwelapha isifo sikashukela sohlobo 1 noma 2.

Igama Lezwe elingafanele

Insulin yobunjiniyela boluntu.

IVozulim iyi-insulin yomuntu eyenziwe ngonjiniyela bezakhi zofuzo, esetshenziselwa ukwelapha isifo sikashukela sohlobo 1 noma uhlobo 2.

I-ATX

A10AB01.

Khipha amafomu nokwakheka

Kutholakala ngesimo sesisombululo somjovo (ukumiswa kokuphathwa kwe-subcutaneous). I-1 ml iqukethe i-100 IU yento esebenzayo ye-insulin. Ebhodleleni - 10 ml yesisombululo. Kuyi-syringe pen elahlekayo - 3 ml yesisombululo kwikhabhathi.

Isenzo se-Pharmacological

I-ejenti ye-hypoglycemic yesikhathi esiphakathi. Ifana ngokuphelele ne-insulin yomuntu, yize yadalwa ngonjiniyela bezakhi zofuzo. Isebenzisana nama-receptors of ulwelwesi lwangaphandle lweseli futhi yakha inkimbinkimbi ezinzile nayo.

Ithuthukisa ukuvela kwe-cyclic AMP kumaseli wamafutha nesibindi. Iyakwazi ukungena ezicutshini zemisipha. Kuthuthukisa ukwakheka kwe-pyruvate kinase, i-hexokinase, i-glycogen synthetase esezingeni le-intracellular.

Ngenxa yokwenza kusebenze izinqubo zokuhambisa ushukela, inkomba yalesi sikhathi egazini iyancipha. Ishukumisa ukwakheka kwamafutha, i-glycogen, amaprotheni. Yehlisa isilinganiso sokukhiqizwa koshukela kwezicubu zesibindi.

Ama-metabolites amaningi esidakamizwa adalulwa izinso.

I-Pharmacokinetics

Ukuqala kokusebenza kwale nto kuncike kwindlela (s / c noma i-IM) kanye nesayithi lomjovo, kanye nevolumu yento efakiwe. Sisatshalaliswa ngokungalingani ezicutshini, asisakazeki kuwo wonke umgoqo we-placental kanye nobisi lwebele.

I-Metabolism yenzeka ngosizo lwe-enzyme insulinase ezinso nasezibindini. Iningi lama-metabolites adalulwa yizinso.

Izinkomba zokusetshenziswa

Kubhekiselwe ukwelashwa:

• uhlobo lwe-1 yesifo sikashukela esincike ku-insulin;
• Uhlobo 2 isifo sikashukela;
• ukumelana nokuphikelela komzimba ezidakamizweni ezinciphisa ushukela, kanye nokumelana nakho kancane, inqobo nje uma ukwelashwa okuyinkimbinkimbi kwenziwa;
• izifo ezithathanayo.

Contraindication

Umuthi uphambaniswe ne-hypoglycemia. Akunconyelwe ukuzwela okwedlulele komzimba ku-insulin nezinye izingxenye zesisombululo.

Ungayithatha kanjani i-Vulim?

Ngokuzenzakalelayo, cishe isigamu sehora ngaphambi kokudla kwasekuseni. Indawo yomjovo kufanele iguqulwe ngaso sonke isikhathi. Ezimweni ezikhethekile, ukuphathwa kwe-intramuscular kunqunyelwe. Kunqatshelwe ngokuphelele ukunikeza imijovo ye-Vezulim engena ngaphakathi.

I-Vozulim isetshenziswa ngokunqenqemeni, cishe isigamu sehora ngaphambi kokudla kwasekuseni.

Ukudluliselwa kwesiguli kwenye i-insulin kuhambisana nokulawulwa kwenani le-glucose egazini.

Umphumela ojwayelekile kakhulu wokuphathwa kwe-insulin yi-hypoglycemia.

Umthamo ukhethwa kuphela ngawodwana, kucatshangelwa izici zomzimba nezidingo ze-insulin. Kwethulwe amayunithi angama-8- 24 ngosuku.

Uma umthamo udlula ama-0.6 PIECES ngekhilogremu ngayinye yesisindo, lapho-ke udinga ukunitha imijovo emi-2 ezingxenyeni ezihlukene zomzimba. Uma iziguli zithola i-insulin engaphezu kwe-100 ye-insulin, lapho-ke ukuyiguqula, kuyadingeka ukuthi ulaliswe esibhedlela. Ukudlulisela kwenye i-insulin kuhambisana nokulawulwa ngokucophelela kwenani le-glucose esegazini.

Imiphumela emibi yeVozulima

Umphumela ojwayelekile kakhulu wokuphathwa kwe-insulin yi-hypoglycemia. Ngokungafani ne-hyperglycemia, iba ngokungazelelwe, futhi izimpawu zayo zanda ngokushesha. Iziguli ezithintekayo:

• ukukhuphuka kokujuluka;
• izibuko
• indlala yesikhumba;
• ikhanda elinzima;
• ukudideka;
• umkhuhlane
• iminwe ethuthumela;
• umuzwa wokuxineka ebusweni;
• umuzwa obukhali wendlala;
• igxuma ekucindezelweni kwegazi.

Uma isiguli singasizwa, i-hypoglycemia izokwanda kuphela. Isimo esikhulu se-hypoglycemic siholela ekuthuthukisweni komthambo.

I-Anaphylactoid kanye nokunye ukusabela komzimba akuvamile kakhulu. Phakathi kokuphendula kwasendaweni - izinhlungu nokuvuvukala endaweni yomjovo, ukuvuvukala. Ukusetshenziswa isikhathi eside kubangela ukwenzeka kwe-lipodystrophy.

Imiphumela emibi yesidakamizwa ifaka ukugxuma ekucindezelweni kwegazi.

IVozulim ingadala ukujuluka ngokweqile.

Ngesikhathi sokwelashwa ngezidakamizwa, izinga lokushaya kwenhliziyo liyaphawulwa.

Ngemuva kokusebenzisa umuthi, kuvame ukuvela ikhanda, okuwuphawu lomphumela wecala.

Isimo esikhulu se-hypoglycemic siholela ekuthuthukisweni komthambo.

Ngokuphikisana nesizinda sokuthatha umuthi, ukudideka kungenzeka.

Ukuthatha umuthi kungahle kuhambisane neminwe ethuthumela.

Eminye imiphumela emibi ifaka ushintsho oluncane nolwesikhashana kwesichasiso. Lokhu kuvame kakhulu ekuqaleni kwenkambo yokwelashwa.

Umthelela ekhonweni lokulawula izindlela

Ngoba I-hypoglycemia kungenzeka, ke abantu abathambekele ekwakhiweni kwesimo esinjalo kufanele bayenqabe ukushayela imoto futhi basebenze ngamasu ayinkimbinkimbi.

Imiyalo ekhethekile

Umthamo uhlala ukhethwa ngokuqapha ezigulini ezinenkinga yokujikeleza okunamandla kanye ne-ischemic pathologies.

Ukulungiswa kwe-dose kuyadingeka kuma-pathologies athathekayo, ukungasebenzi kwe-adrenal gland dysfunction (isifo se-Addison), i-dys- noma i-hypopituitarism, ukwehluleka kwezinso okungamahlalakhona, izifo ze-thyroid. Ngama-pathologies anjalo, kuyadingeka ukuthi kwenziwe izivivinyo zokwelashwa ngezikhathi ezithile.

I-Hypoglycemia yenzeka ngokweqile kwe-insulin, ukuhlanza, uhudo, ukukhulisa ukuzikhandla komzimba. Kwesinye isikhathi ngisho nokushintsha indawo yomjovo kuholela ekunciphiseni okwashiwo ushukela wegazi.

Umthamo ongafanele ezigulini ezinesifo sikashukela sohlobo lokuqala kuholela ekuthuthukisweni kwe-hyperglycemia. Kuboniswa ukoma, isicanucanu, ukuqina kwesifiso, ukulahlekelwa kwesifiso sokudla, kanye nokushibilika kwesikhumba. Ezigulini kuvela iphunga le-acetone. I-Hyperglycemia ingadala i-ketoacidosis esisongela impilo.

I-Hyperglycemia ingadala i-ketoacidosis esisongela impilo.

Ukulungiswa komthamo we-Vozulima kuyadingeka ekwehlulekeni kwezinso okungamahlalakhona.

Ukuqunjelwa kungaholela ekunciphiseni okumakwe kushukela wegazi.

Kwezifo ze-gland yegilo, kuyadingeka ukulungisa umthamo womuthi.

Ukwanda kokuzivocavoca umzimba kuholela ku-hypoglycemia.

Iziguli ezingaphezu kweminyaka engama-65 kufanele zikhethe ngokucophelela umthamo womuthi.

Izingane azivinjelwe ukuqoka iWozulim.

Sebenzisa ebudaleni

Iziguli ezingaphezulu kweminyaka engama-65 kufanele zikhethe ngokucophelela umthamo futhi ziqaphe isimo sezempilo ngesikhathi sokwelashwa.

Isabelo sezingane

Izingane azivunyelwe ukunquma lo muthi. Ngesikhathi sokwelashwa, isimo sezempilo kanye ne-glycemia ziqashwa njalo.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ukusetshenziswa kwale insulin kuvunyelwe uma isiguli sikhulelwe. Kuyadingeka ukuthi unake izinguquko ezidingweni ze-insulin ngezikhathi ezahlukahlukene zokuthinta: ukwehla kwethilitha yokuqala nokwenyuka okuncane kwezinye izinkathi. Isidingo saso sincipha ngaphambi kokuzalwa uqobo nangemva kokuzalwa kwengane.

Ngesikhathi sokuncelisa, owesifazane kufanele abonwe izinyanga eziningana, kuyadingeka ukufezekisa ukuzinza kwesidingo se-insulin.

Isicelo sokusebenza kokulimala kwezinso

Nge-pathologies yezinso, isidingo somzimba se-insulin singashintsha.

Sebenzisa umsebenzi wesibindi okhubazekile

Ngama-pathologies wesibindi, ukwehla kwesidingo somzimba sehomoni kungenzeka. Uma uqhubeka nokusikisela ngemithamo efanayo, isiguli singaba ne-hypoglycemia enkulu, iphenduka ihlombe.

Ukweqisa kweVozulim

Nge-overdose, i-hypoglycemia iyakhula. Ukuthuthuka okusheshayo kwale nto kuyinto ebonakalisayo. Kwesinye isikhathi isiguli singalahlekelwa yimizwa emizuzwini embalwa.

Ukusetshenziswa kweVozulima kuvunyelwe uma isiguli sikhulelwe.

Isiguli kufanele siphathe ushukela uma kwenzeka sizwa izimpawu zokuqala zokwehla koshukela okubukhali.

Ngokukhula komqondo we-hypoglycemic coma, isixazululo se-dextrose siphathwa ngaphakathi kwesiguli.

Wonke umuntu onesifo sikashukela uyaziswa ngengozi yokuba ne-hypoglycemia kanye nezimpawu zokuqala zokukhula kwayo. Udinga ukuphatha ushukela uma ezwa izimpawu zokuqala zokuwohloka okubukhali ushukela.

I-hypoglycemia ye-acute yelashwa esibhedlela. Uma ukwazi kwesiguli kugcinwa, khona-ke i-dextrose inikezwa kuye (ngomlomo, ngokungenamahloni, ngomlomo noma ngomzimba). Imijovo yeGlucagon yenziwa. Ngokukhula komqondo we-hypoglycemic coma, isixazululo se-dextrose sifakwa jet futhi ngomjovo. Isikhathi sokwethulwa kuze kufike lapho umuntu ebuyela ekuqwashweni.

Ukuxhumana nezinye izidakamizwa

Umphumela we-hypoglycemic uma uhlanganiswa nezidakamizwa ezithile ungakhuphuka noma wehliswe.

Ukuqina kwesenzo kubangelwa:

• izidakamizwa ze-sulfa;
• I-MAO, i-ACE inhibitors;
• okususwayo kwe-salicylic acid;
• ama-steroid;
• Bromocriptine;
• imishanguzo ye-tetracycline;
• I-Ketoconazole;
• Clofibrate;
• I-Fenfluramine;
• I-Pyridoxine;
• I-Quinidine;
• IQuinine neChloroquinine;
• wonke amalungiselelo aqukethe i-ethanol.

Ngokuhlanganiswa kweKetoconazole neVozulima, umphumela we-hypoglycemic wokugcina uyanda.

IMorphine inciphisa umphumela we-hypoglycemic weVozulim.

INicotine yehlisa umphumela we-insogulin.

Yehlisa umphumela we:

• I-Glucagon;
• Ukukhula kwehomoni;
• yonke indlela yokuvimbela inzalo yomlomo;
• i-loop ne-thiazide diuretics;
• Bromocriptine;
• i-heparin;
• amalungiselelo - Abamelene ne-calcium tubule;
• i-morphine;
• I-Diazoxide.

Iziguli zokubhema kudingeka zikhumbule ukuthi i-nicotine yehlisa umphumela we-insogulin. Ama-Thiazolidinediones akhulisa ukuzwela kwamangqamuzana ku-insulin.

Ukuhambisana notshwala

Iziguli ezithola i-insulin zinokuncipha kokubekezelelwa kwe-ethanol. Utshwala buvusa ukukhula kwe-hypoglycemia.

Ama-Analog

• I-Biosulin;
• IGansulin;
• IGensulin;
• I-Insuman;
• I-Insuran;
• I-Protafan;
• I-Rinsulin;
• I-Humulin;
• IPen Royal;
• Asibuse ama-30 70.

Imibandela yekhefu lekhemisi

Ikhishwa ngomuthi kuphela.

Ngingakwazi ukuthenga ngaphandle kadokotela?

Cha.

Intengo

Izindleko zebhodlela lika-10 ml zingama-ruble angama-600. Izindleko zepeni yesirinji cishe ama-ruble angama-990.

Izimo zokugcina zomuthi

Umuthi kufanele ugcinwe endaweni epholile (lokushisa - kusuka ku- +2 kuya ku- + 8ºC). Ibhodlela elivulekile noma ipeni lesirinji ligcinwa ekushiseni kwegumbi. Kufanele zisetshenziswe emavikini ama-4.

Isikhathi sokuphelelwa yisikhathi

Umuthi ulungele ukusetshenziswa kungakapheli iminyaka emi-2 kusukela ngosuku lokukhiqizwa. Kuyenqatshelwa ukufaka isicelo ngemuva kwalesi sikhathi.

Umkhiqizi

Ikhiqizwa ebhizinisini i-Wokhard Towers, iBandra Kurla Complex, iBandra (East), iMumbai.

IHumulin inomphumela ofanayo emzimbeni.

Ukwakheka okufanayo iBiosulin.

I-Rinsulin isidakamizwa esifanayo.

Ungabuyisela umuthi umuthi onjengeProtafan.

Ukubuyekezwa

U-Irina, oneminyaka engama-35, eMoscow: "Lokhu yi-insulin, esiza ukugcina amazinga eglucose ejwayelekile. Ukufakwa kwangaphansi okubangelwa yi-hypoglycemia, kwesinye isikhathi umbono uyawohloka. Ukufakwa kwe-Uzulim akubangeli imiphumela emibi, ukuvuvukala esizeni somjovo. phatha ukulawula amanani eglucose futhi ungeqi ama-6 mmol. "

UPavel, oneminyaka engama-55 ubudala, uNizhny Novgorod: "Lesi sidakamizwa sinciphisa ngempumelelo ukugcwala kwe-glucose futhi asikuvumeli ukweqa kwawo okungazelelwe. Izidakamizwa zangaphambili azizange zinikeze umphumela onjalo. Isimo sami sempilo sithuthuke kakhulu, futhi akubanga nokuxhuma ushukela izinyanga ezimbalwa. Ngabona ukuthi manje sengithuthukile kancane. "Ngilandela nokudla nendlela ejwayelekile yansuku zonke, ngakho-ke ushukela wami awukweqeki."

UNatalia, oneminyaka engama-49 ubudala, eSt. kungenzeka ukulawula isikhathi sikashukela futhi uvikele ukuthuthukiswa kwezinkinga ezinzima. "