Ungayisebenzisa kanjani i-Tritace Plus yezidakamizwa?

Ukusebenza kweTraceace Plus kususelwa emiphumeleni ye-ramipril ne-hydrochlorothiazide. Zombili izakhi zivimbela ukuguqulwa kwe-angiotensin I zibe uhlobo lwe-angiotensin II, ngaleyo ndlela kufezekiswe umphumela we-antihypertensive. Kulokhu, umuthi awuvamile ukubekwa emtholampilo njenge-monotherapy. Iziguli zithola i-ejenti ye-hypotensive njengengxenye yokwelashwa okuyinkimbinkimbi kwe-arterial hypertension ukufezekisa amazinga azinzileyo egazi.

Igama Lezwe elingafanele

IHydrochlorothiazide + Ramipril.

I-ATX

C09BA05.

Ukusebenza kweTraceace Plus kususelwa emiphumeleni ye-ramipril ne-hydrochlorothiazide.

Khipha amafomu nokwakheka

Umuthi uyatholakala ngesimo sethebulethi. Ithebhulethi eyi-1 ihlanganisa amakhompiyutha ama-2 asebenzayo - i-ramipril ne-hydrochlorothiazide.

Ukwenza ngcono amapharamitha we-pharmacokinetic, kusetshenziswa izithako ezingeziwe:

• i-sodium stearyl fumarate;
• i-iron oxide, enikeza izibhebhe umbala ngamunye ngokuya ngenqwaba yezinto ezisebenzayo;
• isitashi sommbila we-gelatinized;
• i-microcrystalline cellulose;
• hypromellose.

Izibhebhe ze-Oblong, ezinomugqa wokuhlukanisa ezinhlangothini zombili.

Isidakamizwa akuvamile ukuba sinikezwe kumtholampilo njenge-monotherapy.

Isenzo se-Pharmacological

I-Tritace ihlanganisa i-angiotensin eguqula i-enzyme (ACE) inhibitor - i-ramipril, ne-thiazide diuretic hydrochlorothiazide. Ukuhlanganiswa kwezakhi ezisebenzayo kunomthelela oqinile we-antihypertensive. I-ACE blocker ivimbela ukwakheka kwe-angiotensin II, okudingekile ukunciphisa izicubu ezibushelelezi ze-vasotine endothelium.

URamipril uvimbela ukuvela komphumela we-vasoconstrictor futhi uvimbele ukuwohloka kwe-bradykinin, into yokwanda okungokwemvelo kwemithambo yegazi. I-Hydrochlorothiazide ithuthukisa i-vasodilation, ngenxa yokuthi izikebhe zinwebisa okuningi. Kubalulekile ukugcina umthamo ojwayelekile wokujikeleza kwegazi ukuze ugweme ukuthuthukiswa kwe-bradycardia ne-arterial hypotension.

Umphumela omkhulu wokwelapha ubonwa ngemuva kwamahora angama-3-6 ngemuva kwesicelo futhi uphikelela usuku. Umphumela we-diuretic we-thiazide diuretic uhlala amahora angama-6 kuya kwayi-12.

I-Pharmacokinetics

I-Ramipril ne-hydrochlorothiazide zidonswa ngokushesha kwi-projimal ye-projimal, kusuka lapho zingena khona ekujikelezweni kwe-systemic. I-bioavailability ye-hydrochlorothiazide ingama-70%. Egazini, zombili izinhlanganisela zamakhemikhali zifinyelela ekuhlushweni okuphezulu kungakapheli amahora angama-2-4. URamipril unesilinganiso esiphakeme sokubopha amaprotheni e-plasma - 73%, kuyilapho amaphesenti angama-40 kuphela we-hydrochlorothiazide enza i-albhamu ne-albhamuin.

Ukuphila kwesigamu salezi zinto zombili kufinyelela emahoreni angama-5-6. URamipril ukhishwe ku-60% ngokuhlangana nomchamo. IHydrochlorothiazide ishiya umzimba ngohlobo lwayo lwangempela ngama-95% ezinsweni kungakapheli amahora angama-24.

Izinkomba zokusetshenziswa

Umuthi uyadingeka ukwehlisa umfutho wegazi ophakeme.

Umuthi uyadingeka ukwehlisa umfutho wegazi ophakeme.

Contraindication

Umuthi uphulwe kubantu abane:

• i-hypersensitivity ku-hydrochlorothiazide, i-ramipril nezinye izinto ezihlelekile ze-Tritace;
• isethulo ekuthuthukisweni kwe-Quincke edema;
• ukungasebenzi kahle kwezinso;
• ushintsho kuma-electrolyte e-plasma: potassium, magnesium, calcium;
• izifo ezinzima zesibindi;
• hypotension enkulu ye-arterial.

Ngokunakekela

Kuyadingeka ukulawula inhlalakahle jikelele ngesikhathi sokulashwa kwezidakamizwa phambi kwe-pathologies elandelayo:

• ukwehluleka kwenhliziyo okukhulu;
• ukuphazamiseka ku-ventricle yesobunxele, ebonakaliswa izinguquko ze-hypertrophic;
• i-stenosis yomgogodla oyinhloko, wemithambo yegazi, umgogodla noma imithambo yegazi;
• ukuphazamiseka kwe-metabolic-electrolyte metabolism;
• ngokukhishwa kwe-creatinine ka-30-60 ml / min;
• isikhathi sokuvuselelwa ngemuva kokufakelwa kwezinso;
• isifo sesibindi
• ukulimala kwezicubu ezixhunywayo - i-scleroderma, lupus erythematosus;
• ukucindezelwa kokujikeleza kwezitho zomzimba.

Iziguli ezake zathatha i-diuretics kudingeka zilawule isimo sebhalansi kasawoti wamanzi.

Contraindication ozosebenzisa ukungasebenzi kwezinso.

Kwezifo ezinzima zesibindi, umuthi uvunyelwe.

Ukuqapha kufanele kusetshenziswe ekuhlulekeni kwenhliziyo.

Ungayithatha kanjani i-Tritace Plus

Umuthi awunqunyelwe njengokwelashwa kokuqala kwe-antihypertensive. Amacwecwe enzelwe ukusetshenziswa ngomlomo. Ukuphuza umuthi ekuseni kuyanconywa. Umthamo unqunywa ngudokotela osezingeni eliphezulu ngokuya ngezinkomba zokucindezela kwegazi (BP) kanye nobunzima begazi lomfutho.

Umthamo ojwayelekile ekuqaleni kokwelashwa kwezidakamizwa ngu-2,5 mg we-ramipril ngokuhlanganiswa ne-12,5 mg we-hydrochlorothiazide. Ngokubekezelela okuhle, ukwandisa umphumela we-hypotensive, umthamo ungakhuphuka ngemuva kwamaviki ama-2-3.

Ngoshukela

Umuthi ungaholela ekutheni u-hypoglycemia asetshenziswe ngendlela efanayo nezidakamizwa ze-hypoglycemic noma i-insulin, lapho kulashwa ngomuthi olwa ne-antihypertensive, kubalulekile ukulungisa umthamo wemithi elwa namagciwane. Iziguli ezinesifo sikashukela kudingeka ziqaphele njalo amazinga kashukela wazo.

Imiphumela emibi ye-Tritace Plus

Ezimweni eziningi, i-dosing engafanele ye-Tritace iholela ekukhathaleni okungapheli kanye nemfiva.

Amapheshana wesisu

Ukuphazamiseka kwendlela yokugaya ukudla kubonakaliswa ukuthuthukiswa kokuvuvukala kolwelwesi lwama-mucous, ukubonakala kwe-gingivitis, ikhalipha ekhaliphile, kanye nokuqunjelwa. Mhlawumbe ukuthuthukiswa kwe-gastritis, ukungakhululeki esiswini.

Ngezifo zesisu, i-gastritis ingakhula njengomphumela omubi.

Izitho zeHematopoietic

Ngokuncipha kwe-hematopoiesis yomongo wethambo, inani lamaseli egazi abunjiwe liyancipha.

Isistimu yezinzwa ephakathi

Ngokulahleka kokulawulwa ngokomzwelo kwengqondo, isiguli sinokucindezeleka, ukukhathazeka, kanye nokukhubazeka kokulala. Ngokuphikisana nesizinda sokudangala kohlelo lwezinzwa, kukhona ukulahleka kokuma esikhaleni, ikhanda, umuzwa ovuthayo, ukulahleka noma ukunambitheka okucasulayo.

Kusuka ohlelweni lomchamo

Mhlawumbe ukwanda kwenani lomchamo okhishwe kanye nokuthuthukiswa kokwehluleka kwezinso okukhulu kakhulu.

Kusuka ohlelweni lokuphefumula

Esikhathini esiningi, ngenxa yokwanda kwezinga le-bradykinin, kungahlehlela ukukhwehlela, kwezinye iziguli - ukucinana kwamakhala nokuvuvukala kwezono.

Engxenyeni yesikhumba

Kukhona ingozi yokuhlakulela i-angioedema, engaholela ku-asphyxia kwezinye izimo. Izimpawu ezinjenge-Psoriasis, ukujuluka okuthe xaxa, ukuqubuka, ukulunywa nokugcwala kwe-etiology ehlukahlukene kungenzeka.

Ngenxa yokuthatha umuthi, i-erythema ye-etiologies ehlukahlukene ingakhula.

Kusuka ohlelweni lwezitho zofuzo

Emadodeni, ukuncipha kokukhula nokwanda kwezinduna ezincelisayo kungenzeka.

Kusuka ohlelweni lwezinhliziyo

Mhlawumbe ukwehla okubukhali kwengcindezi yegazi, i-thrombosis ngenxa yokuphelelwa ngamandla, ukuqina kwe-stenosis yemikhumbi eyinhloko, ukuvimbela ukuhamba kwegazi, ukuvuvukala kodonga lwe-vascular kanye neRaynaud's syndrome.

Uhlelo lwe-Endocrine

Kungenzeka ukuthi ukwandise ukukhiqizwa kwe-antidiuretic hormone.

Engxenyeni yesibindi ne-biliary

Ezimweni ezihlukile, ukuvuvukala kwesibindi kwe-cytolytic kuba nemiphumela ebulalayo. Kukhona ukwanda kwezinga le-bilirubin egazini nokuvela kwe-cholecystitis engabaleki.

Allergies

Ukuphazamiseka kwe-allergic kubonakaliswa ukubonakala kokuphendula kwesikhumba.

Ukuphazamiseka kwe-allergic kubonakaliswa ukubonakala kokuphendula kwesikhumba.

Kusuka ohlelweni lwe-musculoskeletal kanye nezicubu ezithintekayo

Umuntu uyakwazi ukuzwa izinhlungu nobuthakathaka emisipha.

Ngasohlangothini lwe-metabolism

Ezimweni ezikhethekile, kukhona ukwehla kokubekezelelana kwezicubu ku-glucose, ngenxa yokuthi ikhuphuka kanjani ushukela wegazi. Ngokuphula i-metabolism ejwayelekile, okuqukethwe kwe-urea ku-plasma yegazi kuyanda, ukwanda kwe-gout kanye nokukhula kwe-anorexia. Ezimweni ezingavamile, i-hypokalemia ne-metabolic acidosis ziyakhula.

Kusuka emasosheni omzimba

Mhlawumbe ukuthuthukiswa kokuphendula kwe-anaphylactic maqondana nokwanda kwe-titer ye-antiinodar antibodies. I-Recept Tritace ingavusa i-angioedema yobuso, amathumbu amancane, izinyawo nolimi.

Umthelela ekhonweni lokulawula izindlela

Ngenxa yokwehla okungenzeka kwe-acuity ebonakalayo kanye nokulahlekelwa ukwazi, isiguli kufanele siqaphele lapho sishayela amadivaysi ayinkimbinkimbi noma izimoto ezidinga ijubane eliphezulu lokuphendula kwe-psychomotor kanye nokuqina okunyukayo.

Ngenxa yokwehla okungenzeka kwe-acuity ebonakalayo kanye nokulahlekelwa ukwazi, isiguli sidinga ukuqaphela lapho ushayela amadivaysi noma izimoto ezinzima.

Imiyalo ekhethekile

Ngaphambi kokungenelela okuhleliwe kokuhlinzwa, kubalulekile ukuxwayisa udokotela ohlinzayo nodokotela obulala izinzwa osesemsebenzini mayelana nokwelashwa nge-ACE inhibitor. Lokhu kuyadingeka ukuvikela ukwehla kwengcindezi yegazi ngesikhathi sokuhlinzwa.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Ngenxa yemiphumela enokwenzeka ye-teratogenic ne-fetotoxic, lesi sidakamizwa asinqunyelwe abesifazane abakhulelwe. Kukhona ubungozi bokulimazeka kwe-intrauterine esibelethweni.

Ngesikhathi sokulashwa, kufanele uyeke ukuncelisa ibele.

Ukuqokwa kwe-Tritace Plus yezingane

Ngenxa yokuntuleka kwemininingwane ngomthelela we-Tritace emzimbeni womuntu phakathi nesikhathi sokuthuthuka, lesi sidakamizwa sibekwa ezinganeni ezingaphansi kweminyaka engu-18 ubudala.

Sebenzisa ebudaleni

Abantu asebekhulile abadingi ukwenza izinguquko kwimodeli yokwelapha.

Abantu asebekhulile abadingi ukwenza izinguquko kwimodeli yokwelapha.

Isicelo sokusebenza kokulimala kwezinso

Iziguli ezihlushwa yisifo sezinso ezinobumnene kuya kokulinganisela kufanele ziqaphele ukusebenza kokusebenza kwezitho zomzimba ngesikhathi sokwelashwa.

Sebenzisa umsebenzi wesibindi okhubazekile

Umuthi awuvunyelwe ukusetshenziswa ngabantu abane-dysfunction yesibindi.

I-Overdose yeTraceace

Isimo somtholampilo sowesilisa ngokweqile sibonisa ukuhlukunyezwa kwe-ejenti eyi-hypotensive futhi sibonisa ngokubonakala kwezimpawu ezilandelayo:

• i-polyuria, ezigulini ezine-benign prostatic adenoma noma okunye ukuphuma komchamo okukhinyabeza ukuthuthukiswa kokuqina kokuchama ngokubona kwesigaxa;
• i-bradycardia, i-arrhythmia;
• i-vasodilation ye-peripheral;
• ukwephulwa kwe-metabolic-electrolyte metabolism;
• ukudideka nokulahlekelwa ukwazi ngokuthuthuka okwalandela;
• izicubu zomsipha;
• ukungasebenzi kahle kwamathumbu emathunjini.

Uma kudlule imizuzu engaphansi kwengama-30-90 selokhu kwathathwa lelo pilisi, khona-ke kuyadingeka ukuba ohlukunyeziwe ahlanzeke futhi ahlambe isisu. Ngemuva kwenqubo, isiguli kufanele sithathe i-adsorbent ukubambezela ukumuncwa kwezinto ezisebenzayo. Nge-bradycardia enzima, kuyadingeka ukwethula ngaphakathi kwe-1-2 mg ye-adrenaline noma ukusungula i-pacemaker yesikhashana. Uma kwenzeka kweqa ngokweqile, kuyadingeka ukulawula izinga le-serum creatinine nomfutho wegazi ngesikhathi sokwelashwa okubonakalayo.

Nge-overdose yesidakamizwa, kungenzeka kuqubuke imisipha.

Ukuxhumana nezinye izidakamizwa

Ngokuphathwa kanyekanye kweTraceace nge-thiazides, ukugcwala kwe-cholesterol ku-serum yegazi kungakhuphuka.

Inhlanganisela ehlanganisiwe

Ukungahambelani kwemithi kuyabonakala ngokusetshenziswa okufanayo kwe-aliskiren kanye ne-angiotensin II receptor antagonists. Endabeni yokugcina, ukuphathwa kugqilazwa kwiziguli ezine-polyneuropathy yesifo sikashukela. I-Aliskiren ayinqunyelwe ukuthi kube nokulinganisela okwehlulekile kakhulu kwezinso.

Akuhlanganisiwe ukuhlanganisa

I-ejenti ehlanganisiwe ye-antihypertensive ngamaphilisi okulala, usawoti we-lithium, i-tacrolimus nge-sulfamethoxazole akufanele ichazwe.

Inhlanganisela edinga ukuqashelwa

Kuyadingeka ukubheka izindlela zokuphepha lapho uqashwa ngokufana:

• ama-anticepressants ama-tricyclic;
• ezinye izidakamizwa ze-antihypertensive;
• okuvela ku-barbituric acid;
• imali yokuhlanza izinzwa ngokujwayelekile;
• isodium chloride solution;
• izidakamizwa ze-diuretic;
• vasopressor sympathomimetics;
• i-allopurinol, ama-immunomodulatory agents, ama-glucocorticosteroids, ama-cytostatics;
• i-estramustine, i-heparin, i-vildagliptin;
• ama-hypoglycemic agents.

Ngesikhathi sokulashwa, amalungiselelo e-ethanol aqukethe nemikhiqizo yotshwala akufanele isetshenziswe.

Kuyadingeka ukuyeka ukuthatha i-ethanol.

Ukuhambisana notshwala

Ngesikhathi sokulashwa, amalungiselelo e-ethanol aqukethe nemikhiqizo yotshwala akufanele isetshenziswe. Lapho uthatha i-Tritace ene-ethanol ngokufana, kunengozi yokuwa.

Ama-Analog

Ukushintshela kwesinye isidakamizwa se-antihypertensive kwenziwa ngaphansi kokuqashwa kukadokotela, ongase anikeze omunye walemithi elandelayo njengezindlela zokwelapha ezithathe indawo:

• IHartil-D;
• I-Amprilan NL;
• Amprilan ND;
• Wazolong H;
• URamazid H.

Ama-Analogs atholakala kakhulu ebangeni lentengo - ama-ruble angama-210- 358.

Imibandela yekhefu lekhemisi

Kuthengiswe ngezizathu zokwelashwa.

Ngingakwazi ukuthenga ngaphandle kadokotela

Umuthi ungadala hypotension ye-orthostatic uma isetshenziswe ngendlela engafanele. Ngokuphepha kweziguli emakhemisi, umuthi ungathengwa kuphela ngokubhaliwe.

Intengo ku-Tritac Plus

Intengo ephakathi yamaphilisi ama-5 mg ama-ruble angama-954-1212, ngomthamo wama-ruble ayi-10 mg - 1537.

Izimo zokugcina zomuthi

Amathebhulethi avunyelwe ukugcinwa emazingeni okushisa we- + 8 ... + 30 ° C endaweni eqhelelene nokukhanya kwelanga.

Isikhathi sokuphelelwa yisikhathi

Iminyaka emithathu

Umkhiqizi

ISanofi Aventis, e-Italy.

Ukubuyekezwa kweTracac

Ukubuyekezwa okuhle mayelana nomuthi kukhombisa ukuthi umuthi usuziqinisile emakethe yemithi.

Odokotela

USvetlana Gorbacheva, udokotela wezifo zenhliziyo, uRyazan

Yisitha esisebenzayo esisebenzisa i-hydrochlorothiazide. Amakhemikhali aqhakambisa umphumela we-antihypertensive. Nginikeza umuthi ezigulini zami kuphela nge-hypertension ye-arterial yedosi elilodwa ngosuku. Isikhathi sokwelashwa singesomuntu ngamunye esiguli ngasinye. Akukho miphumela emibi eye yabonwa. Abantu abalimele kakhulu izinso abavunyelwe ukuthatha umuthi.

Iziguli

U-Alexey Lebedev, oneminyaka engama-30, uYaroslavl

Umama waqala ukubonisa umfutho wegazi ophakeme ngeminyaka. Ngenxa yomfutho wegazi ophakeme, izidakamizwa ze-antihypertensive kufanele zithathwe nsuku zonke. Ezinsukwini ezimbalwa ezedlule, iTritace ibe lusizo lwesikhathi eside. Amathebulethi enza ngokwejwayelekile umfutho wegazi futhi awubangeli imiphumela emibi. Ngokusetshenziswa isikhathi eside, udinga ukuthatha ikhefu noma ukwandise umthamo, ngoba umzimba uyeka ukubona umphumela wamathebulethi. Ukuphela kwento ukunambitheka okumunyu.

U-Elena Shashkina, oneminyaka engama-42, uVladivostok

UTraceace udedelwe kunina ngemuva kokugwazwa ngenxa yomfutho wegazi ophakeme. Isidakamizwa sisizile - umama uzizwa engcono, ukuguquguquka kwengcindezi okunamandla sekuyekile. Umama uthatha isilinganiso esincane ukuze umuthi uhlale isikhathi eside. Ngokwezincomo zikadokotela, ngemuva kwenyanga yokwamukelwa njalo, uyeka ukuyisebenzisa amaviki angu-1-2. Lokhu kuyadingeka ukuze kungabikho miphumela emibi nokulutha.