I-Atomax isetshenziselwa ukwelapha iziguli ngokuxilongwa kwe-hypercholesterolemia, hyperlipidemia, dysbetalipoproteinemia. I-ejenti yomlomo ye-hypoglycemic ikuvumela ukuthi uzinzise izinga le-lipids, izinkomba ze-cholesterol ephelele, i-triglycerides ngokungasebenzi kahle kokudla kokudla kanye nomsebenzi owengeziwe womzimba. Ukusetshenziswa isikhathi eside kwesidakamizwa kunciphisa amathuba okushintshwa kwe-atherosulinotic ku-vascular endothelium ne-cholesterol plaques.
Igama Lezwe elingafanele
Atorvastatin.
I-ATX
C10AA05.
Khipha amafomu nokwakheka
Umuthi wenziwa ngesimo samathebulethi okuphatha ngomlomo. Utho ngalunye lwesidakamizwa luqukethe i-10 noma 20 mg ye-atorvastatin calcium trihydrate njengesithako esisebenzayo. Umongo uphinde ufake izithako ezengeziwe ezidingekayo ukwenza ngcono i-bioavailability kanye nokufakwa kwento esebenzayo emathunjini:
- i-silicon dioxide e-dehydrate;
- ushukela wobisi;
- isitashi;
- unxantin;
- i-magnesium stearate;
- i-povidone;
- crodarmellose sodium.
Umuthi wenziwa ngendlela yamathebulethi okusetshenziswa ngomlomo, iyunithi ngalinye lesidakamizwa liqukethe i-10 noma 20 mg ye-atorvastatin calcium trihydrate.
Amathebulethi amhlophe ajikelezayo ahlanganiswa nefilimu le-enteric eliqukethe i-titanium dioxide, talc, crospovidone, hypromellose.
Isenzo se-Pharmacological
Indlela yokusebenza yomuthi okwehlisa i-lipid isuselwa ku-atorvastatin, okuyi-blocker ye-HMG-CoA reductase. Le enzyme iyadingeka ekwakhekeni kwe-mevalonic acid, eyandulelayo ye-cholesterol. Lapho umsebenzi wokusebenza we-HMG-CoA reductase uvinjelwe, i-atorvastatin ingamisa ukwakheka kwe-cholesterol, i-low density lipoproteins (LDL) ne-triglycerides esibindini.
Umuthi ukhulisa inani lama-receptor we-LDL kulwelwesi lwamaseli kwezicubu, okukhuphula ukuthathwa kanye nokudla kwama-lipoproteins. Ngokuphikisana nesizinda sokwehla kokuxineka kwe-LDL, kukhuphuka inani labantu abaphakeme kakhulu be-lipoproteins (HDL).
I-Pharmacokinetics
Uma ingena emzimbeni, isakhi esisebenzayo siqala ukudonswa ngenkuthalo ezindongeni zesisu esincane. I-Bioavailability ingu-100%. Uma ingena egazini, i-atorvastatin ibhekana ne-beta-oxidation kumaseli wesibindi ngokwakhiwa kwemikhiqizo ye-metabolic enomphumela wokunciphisa we-lipid. Umuthi ubizwa ngokuthi i-biotransformed phambi kwe-P450 isoenzyme. Umphumela wokwelapha utholakala ngo-70% ngenxa yama-metabolites asebenzayo.
I-Atomax isetshenziselwa ukwelapha iziguli ngokuxilongwa kwe-hypercholesterolemia, hyperlipidemia, dysbetalipoproteinemia.
I-Atorvastatin ingama-95% ibophele amaprotheni e-plasma. Umuthi osebenzayo kanye nemikhiqizo ye-metabolic ishiya umzimba ikakhulukazi ngepheshana elisebenzayo ngemuva kokuqina kwe-hepatic. Cishe i-2% yezidakamizwa ezisesimweni sayo sokuqala ikhishwa emchameni. Isigamu sempilo singamahora ayi-14.
Izinkomba zokusetshenziswa
Umuthi usetshenziselwa ukwehlisa i-cholesterol ephezulu, i-triglycerides ne-LDL. Umuthi uyasebenza ezigulini ezine:
- ifa noma i-hypercholesterolemia eyindalo;
- dysbetalipoproteinemia ngokwehluleka kokudla;
- i-hyperlipidemia ehlangene;
- i-serum triglycerides ephezulu.
Ukuthola umphumela ophelele we-hypolipidemic kungenzeka kuphela ngokuhlangana nokwelashwa okukhethekile kokwehlisa i-cholesterol ephezulu.
Contraindication
Umuthi uphambaniswe emacaleni alandelayo:
- ukwanda kokuthikamezeka kwezinto ezakha umuthi;
- umsebenzi owandayo wama-transpases we-hepatic ku-serum wedlula okwejwayelekile okungenani izikhathi ezi-3 ngenxa yezizathu ezingaziwa;
- izifo ezinzima zesibindi;
- abesifazane abakhulelwe nabancelayo;
- ebuntwaneni nasebusheni bokufika eminyakeni eyi-18.
Ukuqapha kufanele kusetshenziswe lapho uthatha amaphilisi abantu abanenkinga ye-endocrine.
Ukuqapha kufanele kusetshenziswe lapho uthatha amaphilisi wabantu abane:
- i-pathologies yesibindi sobunzima obukhulu noma obulinganiselayo:
- ukuhoxiswa kotshwala;
- ukwephulwa okukhulu kwe-metabolic kasawoti wamanzi;
- ukuphazamiseka kwesistimu ye-endocrine;
- ukubanjwa isifo sokuwa.
Ungayithatha kanjani i-Atomax
Ngaphambi kokuqala ukwelashwa kwe-Atomax, isiguli sinqunywe ukudla okwehlisa i-lipid.
Umthamo wabantu abadala esigabeni sokuqala sokwelashwa ngu-10 mg ngokusetshenziswa okukodwa. Ukwandisa umphumela wokwelapha, umthamo wokwehlisa i-lipid, ngokubekezelela okuhle, ungakhuphuka ube ngu-80 mg. Ukuphindaphindwa kokwamukelwa - isikhathi esingu-1 ngosuku.
Njalo ezinsukwini eziyi-14-28, udinga ukuthatha izivivinyo zokuhlushwa kwe-lipidma ye-lipids. Ngokusekelwe kudatha etholakele, umthamo uguqulwa udokotela ohambelayo.
Nge-hyperlipidemia ehlangene ne-hypercholesterolemia, umthamo ojwayelekile ngu-10 mg ngosuku. Umphumela wokwelapha ubonwa zingakapheli izinsuku eziyi-14, umphumela ophansi kakhulu we-lipid uboniswa emavikini ama-4 ngemuva kokuqala kokwelashwa. Ngokusebenzisa isikhathi eside i-Atomax, umphumela wokwelapha uyaphikelela.
Ngoshukela
Umuthi awukwazi ukuthinta ukuhlangana kwe-glucose emzimbeni futhi awunobuthi kumaseli we-beta wamanyikwe. Ngesikhathi sokulashwa, kuyadingeka ukuthi uqaphe njalo izinga le-glucose. Uma kwenzeka ushintsho olukhulu, thintana nodokotela oyi-endocrinologist mayelana nokulungiswa kwenqubo yemithi yemithi ye-hypoglycemic.
Imiphumela emibi ye-Atomax
Imiphumela emibi iba khona ezimeni eziningi ngokusetshenziswa okungafanele kwe-ejenti yehlise i-lipid.
Engxenyeni yesitho sombono
I-Conjunctiva eyomile, i-hemorrhage ku-eyeball, ukwanda kwengcindezi ye-intraocular.
Kusuka ezicutshini zemisipha
Ngokuphulwa kohlelo lwe-musculoskeletal, ukuthuthukiswa kwamathambo, imisipha imisipha, izinhlungu emalungeni nasemisipha kungenzeka. Ezimweni ezihlukile, i-rhabdomyolysis, i-myopathy iyakhula.
Amapheshana wesisu
Ukuphazamiseka kokugaya ukudla kuphawuleka ngokwenzeka:
- isicanucanu
- ukushisa kwenhliziyo;
- isifo sohudo
- ukuthatheka, ukuqunjelwa;
- i-stomatitis, i-glossitis;
- izilonda eziwohloka esiswini kanye ne-duodenum;
- ukuvuvukala kwamanyikwe;
- ukukhuphuka kwe-hepatic aminotransferases;
- Melena;
- ukopha okungunxande.
Izitho zeHematopoietic
Ngokuphula i-hematopoiesis yamathambo, inani lamaseli egazi abunjiwe liyancipha.
Isistimu yezinzwa ephakathi
Ukuphazamiseka kwesistimu yezinzwa kuhambisana nokukhula kwesiyezi nekhanda, izinkinga zokulala, i-peropheral neuropathy, ukulahleka kokulawula okungokomzwelo kanye nokuvela kwesimo sokucindezela.
Kusuka ohlelweni lomchamo
Kunengozi ye-edema yangaphandle, izifo ezithinta umchamo, i-dysuria, ukuvuvukala kwezinso, i-hematuria, ukopha kanye ne-urolithiasis.
Kusuka ohlelweni lokuphefumula
Mhlawumbe ukuthuthukiswa kwezinqubo zokuvuvukala ku-bronchi, sinuses paranasal, ukwehluleka ukuphefumula.
Engxenyeni yesikhumba
Kumadoda, izinwele zingaphuma. Kukhona ukwanda kokujuluka, ukubukeka kwe-dandruff, eczema.
Kusuka ohlelweni lwezitho zofuzo
Ngokuphulwa kohlelo lokuzala, i-libido iyancipha, ukungasebenzi kahle kwe-erectile kanye ne-ejaculation disorder.
Kusuka ohlelweni lwezinhliziyo
Kukhona izinhlungu esifubeni, i-arrhythmia, vasodilation, phlebitis kanye ne-arterial hypotension.
Ngasohlangothini lwe-metabolism
Ngokuphazamiseka kwemetabolism ejwayelekile, ukwanda kweqoqo le-serum ye -ineine phosphokinase kungenzeka. Ukulahleka kokulawulwa kwe-glycemic, ukuthuthukiswa kwe-albhamuinuria kanye nomsebenzi owandayo we-ALT, AST akunqunyelwe. Kwezinye izimo, ukwanda kwesisindo, ukwanda kwezimpawu ze-gout, hyperthermia kuyabonakala.
Allergies
Ukuvela kwe-allergic kwenzeka ezigulini ngokubekezelela okungafaniyo kwezakhi ze-Atomax zokwakheka. Umzimba womzimba ubonakala ngokuthuthukiswa kwama-rashes, ukulunywa kanye nokuhlangana kwesikhumba. Ezimweni ezingavamile, i-angioedema, i-hypersensitivity to light, shock anaphylactic, uStevens-Johnson noLyell isifo kungenzeka.
Umthelela ekhonweni lokulawula izindlela
Umuthi awuchaphazeli kabi umsebenzi wezinsizakalo zokuphathelene nethambo kanye nokungaphakathi futhi awuphindeki, ngakho-ke ngesikhathi sokwelashwa nge-Atomax uvunyelwe ukulawula izindlela eziyinkimbinkimbi nokushayela imoto.
Imiyalo ekhethekile
I-HMG-CoA reductase inhibitors ihola ushintsho emsebenzini we-biochemical of hepatocytes. Ngakho-ke, ngaphambi kokuqala ukwelashwa, emavikini ayisithupha nayi-12 ngemuva kokuqokwa kwe-Atomax, kuyadingeka ukuqapha ukusebenza kwesibindi. Ngokubekezelela okuhle nama-enzyme ajwayelekile wesibindi, ukuhlolwa kokusebenza kwesibindi kwenziwa ngokwanda komthamo wansuku zonke futhi njalo ezinyangeni eziyisithupha.
Iziguli ezikhuluphele kufanele zizame ukuqinisa i-cholesterol yazo ngaphambi kokuqala ukwelashwa.
Kubalulekile ukukhumbula ukuthi ukuthatha i-atorvastatin kungaholela ku-myopathy. Kuyadingeka ukwazisa udokotela ngokubonakala kobuhlungu nobuthakathaka emisipha, ikakhulukazi ngokuthuthukiswa komkhuhlane kanye ne-malaise ejwayelekile. Uma i-myalgia yenzeka, kunconywa ukuthi uyeke ukuthatha i-Atomax. Uma imiphumela yokuhlolwa kwegazi kukhombisa ukwanda komsebenzi we-creatine phosphokinase, okudlula okujwayelekile ngezikhathi eziyishumi noma ngaphezulu, ukwelashwa nge-atorvastatin kukhanseliwe.
Ngesikhathi sokulashwa kwezidakamizwa, kukhona ubungozi be-myoglobinuria. Ngokuphikisana nesizinda senqubo ye-pathological, i-rhabdomyolysis kanye ne-renal dysfunction kungenzeka. Uma kuvela izimpawu ze-myopathy noma ukwehluleka kwezinso, yeka ukwelashwa nge-Atomax.
Iziguli ezikhuluphele ngaphambi kokuqala ukwelashwa kufanele zizame ukuqinisa amazinga azo e-cholesterol zisebenzisa ukwelashwa kokudla, ukukhulisa ukusebenza komzimba nezinye izindlela zokunciphisa isisindo somzimba.
Sebenzisa ebudaleni
Lapho ufinyelela eminyakeni engaphezu kwengu-65, kunconywa ukulandela irejimeni yemithamo ejwayelekile futhi ulandele izincomo zochwepheshe bezokwelapha.
Isabelo sezingane
Kwenqatshelwe ukuthatha lesi sidakamizwa ezinganeni ezingaphansi kweminyaka engu-18. Ayikho imininingwane ngomthelela we-atorvastatin ekukhuleni nasekuthuthukisweni kwezicubu zomzimba omncane.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi uphambaniswe nabesifazane ngesikhathi sokukhulelwa ngenxa yokuntuleka kwemininingwane ku-phytotoxicity ye-Atomax. I-Atorvastatin ayaziwa ukuthi ingena obisini lwebele, ngakho-ke, kunconywa ukuthi udlulise ingane ukuyondla ngemingxube yokufakelwa ngesikhathi sokulashwa.
Isicelo sokusebenza kokulimala kwezinso
Ama-pathologies wezinso awathinti izinga lokukhuphuka kwe-atorvastatin nokuqukethwe kwalo egazini, ngakho-ke kunconywe ukuthatha umthamo ojwayelekile wezifo zezinso.
Sebenzisa umsebenzi wesibindi okhubazekile
Iziguli ezinesifo sesibindi kufanele zisebenzise lo muthi ngaphansi kokuqashwa ngudokotela okuqinile. Okuhlukile ngabantu abanomsebenzi owandayo we-hepatic aminotransferases, wedlula okwejwayelekile izikhathi ezi-3 noma ngaphezulu. Kulokhu, umenzeli wokuncishiswa kwe-lipid uvunyelwe ukusetshenziswa.
Ukweqisa kwe-Atomax
Emsebenzini wokuthengisa ngemuva, azange kube namacala okweqa ngokweqile. Uma isilinganiso esiphezulu esivumelekile sama-80 mg sidlulwa, kungenzeka ukwandisa noma ukwandisa amathuba emiphumela emibi. Ngenxa yokuntuleka kwedatha, i-antidote ethile ayikakhiwa. Ukwelashwa okubonakalayo kusetshenziselwa ukususa imiphumela emibi. I-Hemodialysis yokuqedwa okusheshisiwe kwalo muthi ayisebenzi.
Ukuxhumana nezinye izidakamizwa
Kukhona ubungozi bokuhlakulela i-myopathy ngokuphathwa kanyekanye kwama-atomax antifungal agents eqenjini lama-azoles, ama-cyclosporin antibiotic, uNiacin, i-fibroic acid derivatives, i-Erythromycin.
Ngokusetshenziswa kanye kanyekanye kokumiswa okuqukethe usawoti we-aluminium ne-magnesium, ukugcwala kwe-plasma kwe-atorvastatin kuncishiswa ngo-35%, kanti izinga le-LDL-cholesterol complex aliguquki. Ingxenye esebenzayo ye-Atomax ayithinti i-pharmacokinetics ye-Antipyrine, Azithromycin. Uma usebenzisa i-80 mg ye-Digoxin, kungenzeka ukwandisa izinga layo le-serum ngama-20%. Iziguli ezinalolu shintsho ekuhlushwa kweDigoxin zingaphansi kokuqashwa ngudokotela.
I-Atorvastatin inyusa i-AUC ye-ethylene estradiol-based control control ngo-20%.
I-Colestipol ingadala ukwehla kwamazinga e-atorvastatin plasma ngo-25%. Kulokhu, kukhona ukwanda kwesenzo sokunciphisa i-lipid.
Ukuhambisana notshwala
Ngesikhathi sokulashwa, akunconywa ukuphuza iziphuzo ezidakayo nezidakamizwa eziqukethe i-ethanol. I-ethyl alcohol idala ukudakwa, iplatelet kanye nokuhlangana kwegazi elibomvu, okuthinta kabi isimo sohlelo lwezinhliziyo. Ukuwohloka kwomphumela wokwelapha kanye nokuwohloka kwama-pathologies wohlelo lokujikeleza kwempilo kuyabonakala.
Ama-Analog
Uma kungekho umphumela wokunciphisa we-lipid, amaphilisi e-Atomax angathathelwa indawo ngomuthi owodwa olandelayo:
- I-Liprimar;
- Atoris;
- I-Liptonorm;
- Tulip;
- IVazotor;
- Atorvastatin-SZ.
Imibandela yekhefu lekhemisi
Umuthi uthengiswa ngomuthi kadokotela.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ukuthengiswa kwamahhala kwesidakamizwa esinciphisa i-lipid kukhawulelwe ngenxa yengozi ephezulu yemiphumela emibi uma isetshenziswe ngendlela engafanele.
Intengo
Izindleko ezijwayelekile ze-Atomax ngama-ruble angama-400-500.
Izimo zokugcina zomuthi
Gcina amaphilisi ehlukanisiwe nelanga endaweni enomswakama ophansi. Kunconywa ukuthi uqukethe umuthi ngokushisa kwe + 8 ... + 25 ° C.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-2
Umkhiqizi
I-CJSC MAKIZ-PHARMA, eRussia.
Uma kungekho umphumela wehlise i-lipid, amaphilisi e-Atomax angathathelwa indawo nge-Liprimar.
Ukubuyekezwa
U-Eduard Petukhov, oneminyaka engama-38, uRostov-on-Don
Ngicabanga ukuthi umuthi uyindlela ephumelelayo yokulwa ne-cholesterol. Ezinyangeni ezi-6 ezedlule, banqunywe ukuthi baphuze amaphilisi nge-cholesterol engu-7.5 mmol. Ukuhlolwa kwegazi kokugcina emasontweni amabili edlule kuveze ukwehla kwaba ngu-6 mmol. Ngiyaqhubeka nokwelashwa. Akubanga khona ukusabela komzimba kuyo yonke inkathi yokwelashwa.
UVasily Zafiraki, udokotela wezifo zenhliziyo, eSt
Ekuhambeni kwezifundo zokulingana okwelashwa kwe-Atomax neLipirimar, amazinga we-triglyceride kanye nokusebenza kokusebenza kwe-vasotine endothelium kuqhathaniswa nokusetshenziswa isikhathi eside kwezidakamizwa ezi-2. Ucwaningo selukhombisile izinzuzo ze-Atomax. Abanye abakhiqizi be-atorvastatin abenzi izivivinyo ezifanayo futhi banikeze inani eliphansi lamaphilisi, okusenza sicabange ngokusebenza kwezidakamizwa zabo. Ngithanda ukuthi i-Atomax ine-dosages ehlukahlukene.
