Ungasisebenzisa kanjani isidakamizwa i-Ofloxin 400?

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I-Ofloxin 400 isidakamizwa eqenjini le-fluoroquinolone. Inomphumela we-antimicrobial.

Igama Lezwe elingafanele

INN - Ofloxacin.

I-Ofloxin 400 isidakamizwa eqenjini le-fluoroquinolone.

Ath

J01MA01.

Khipha amafomu nokwakheka

Umuthi ukhiqizwa ngezindlela ezahlukahlukene: amaphilisi, okokugcoba, amakhompiyutha, amaconsi nesisombululo. Into esebenzayo kuzo zonke izinhlobo yi -loloacacin, i-quinolone yesizukulwane sesibili.

Amaphilisi

Avikelwe igobolondo futhi aqukethe isithako esisebenzayo kumthamo we-400 mg no-200 mg. Izithako ezingeziwe:

  • ushukela wobisi;
  • isitashi sommbila;
  • i-talc;
  • hypromellose 2910/5.

Igcwele amaphilisi we-10 ama-PC. ezimangeni.

Amaconsi

Khiqiza izinhlobo ezi-2 zamaconsi: iso nezindlebe. Umuthi uvezwa ngendlela yesisombululo esicacile, ku-1 ml oqukethe:

  • I-3 mg ye -loxacin;
  • isisombululo se-saline;
  • i-benzalkonium chloride;
  • i-hydrogen chloride;
  • amanzi alungiselelwe.

Umuthi osefomini eluketshezi uthelwa emabhodleleni epulasitiki. Amathangi afakwe i-dropper.

Khiqiza izinhlobo ezi-2 zamaconsi: iso nezindlebe.

Powder

Le ndlela yokukhishwa kwe -loxacin ayikho.

Isixazululo

Isixazululo senzelwe ukumnika. Inombala ogqamile ophuzi ophuzi. Umuthi uthelwa ezimpondweni ngesilinganiso esingu-100 ml. Ngaphezu kwento esebenzayo, kunezingxenye ezengeziwe:

  • isisombululo se-saline;
  • Trilon B;
  • i-hydrogen chloride;
  • amanzi ahlanziwe.

Amakhandlela

Le ndlela yesidakamizwa ivezwa ngendlela yamaphilisi we-gelatin aphuzi. Ukwakheka:

  • i-ofloxacin - 200 mg;
  • i-hypromellose;
  • i-sodium lauryl sulfate;
  • ushukela wobisi;
  • calcium phosphate bisubstituted i-anhydrous;
  • i-talcum powder.

Umuthi ubuye wethulwe ngesimo samaphilisi we-gelatin aphuzi.

Amafutha

Umuthi ukhiqizwa ngendlela yokugcotshwa kwezinhlobo ezi-2: ekwelapheni amanxeba nokwelashwa kwezifo zamehlo. I-Ofloxacin, okuhloselwe ukusetshenziswa esikhunjeni, ithengiswa kumashubhu angama-15 noma ama-30 g. Umuthi uqukethe izinto ezilandelayo:

  • I-1 mg ye -loxacin;
  • I-30 mg lidocaine hydrochloride;
  • propylene glycol;
  • ipoloxamer;
  • macrogol 400, 1500, 6000.

Amafutha wamehlo atholakala kumashubhu ka-3 no-5 g.

  • i-ofloxacin - 0,3 g;
  • i-nipagin;
  • nipazole;
  • i-petroleum jelly.

Amakhandlela

Ngaphansi kwamagama ahlukahlukene okuhweba, kukhiqizwa ama-suppositories wesitho sangasese sowesifazane.

Isenzo se-Pharmacological

Umuthi unezinto ezingama-bactericidal ezibangelwa ukuvinjwa kwe-DNA gyrase (yilezi enzymes ezibhekele ukwakheka kwe-DNA kumaseli we-pathogenic microflora nokukhiqizwa kwawo, futhi ibuye ihlanganyele nezinqubo ezibaluleke kakhulu: ukusontelana kokuqina kanye nokuqinisekisa ukuqina kwawo).

Umuthi unezinto ezinamagciwane azibangelwa ukuvimbela i-DNA-gyrase.

I-Fluoroquinolone ibhubhisa igobolondo le-microflora ye-pathogenic, ukuze ukuthi amathuba okuthuthuka kwamafomu amelana nawo alincane. Umuthi ukhombisa ukusebenza okuphezulu kakhulu maqondana nama-bacterium angenalo gamu. I-Ofloxacin, uma iqhathaniswa ne-antibiotic Ciprofloxacin, ihlala isebenza lapho ihlanganiswa nokusetshenziswa kwama-inhibitors we-RNA polymerase synthesis.

Into esebenzayo yesidakamizwa icekela phansi ukuxhumana phakathi kwezinsiza ze-DNA, ngenxa yokuthi iseli le-micorganism liyafa. Ngenxa yalesi senzo salo muthi, sisetshenziselwa ukulwa nezinhlobo zamagciwane ahlangabezana nezinye izinhlobo zama-antibhidal kanye nama-sulfonamides.

I-Pharmacokinetics

Umuthi usheshe futhi ugcwale ngokuphelele emathunjini, ukugcwala okukhulu kwe-Ofloxacin ku-plasma yegazi kuyabonakala ngemuva kwamahora ama-1-3. Ukuqedwa kwesigamu sempilo kungamahora angama-5 ukuya kwengama-10, ngenxa yalokho umuthi unganikezwa khona izikhathi eziyi-1-2 ngosuku. Cishe i-75-90% yezidakamizwa ishiya umzimba ngomchamo.

I-Fluoroquinolones - Izindlela Zokusebenza Nokumelana
Ama-antibiotic ayazuza futhi alimaza umzimba

Izinkomba zokusetshenziswa

I-Ofloxacin isetshenziselwa ukwelapha izinqubo zokutheleleka:

  • uhlelo lomchamo;
  • izitho zangasese zowesifazane nowesilisa;
  • STI
  • amathumbu;
  • isisu sesibeletho kanye nepheshana lesibeletho;
  • uhlelo lwebhiliary;
  • nosocomial kanye ne-postoperative;
  • ipheshana lokuphefumula;
  • i-septicemia ne-bacteremia;
  • Isistimu yezinzwa ephakathi;
  • isifo sofuba, uchoko.

Amafutha akhonjiswa ekwelapheni isikhumba, izifo zamazinyo kanye namanxeba athelelekile.

I-Ofloxacin isetshenziselwa ukwelapha izifo zohlelo lokuchama.
I-Ofloxacin isetshenziselwa ukwelapha ukutheleleka kwezitho zangasese zowesifazane nowesilisa.
I-Ofloxacin isetshenziselwa ukwelapha ukutheleleka nge-STI.
I-Ofloxacin isetshenziselwa ukwelapha izinqubo zamathumbu ezingapheli.
I-Ofloxacin isetshenziselwa ukwelapha izifo zokuphefumula.
I-Ofloxacin isetshenziselwa ukwelapha izifo zohlelo lwe-biliary.
I-Ofloxacin isetshenziselwa ukwelapha izifo ze-CNS.

Contraindication

Umuthi unokuphikisana okulandelayo:

  • hypersensitivity kuzakhi;
  • ukukhulelwa kanye ne-hepatitis B;
  • izingane ezingaphansi kweminyaka engu-18;
  • isithuthwane nokuhlaselwa kokuzala (ngemuva kokuhlukumezeka kwe-craniocerebral kanye nesifo sohlangothi);
  • okuqukethwe okuphezulu kwe-urea;
  • ukulimala kwama-tendon okwenzeka ngenkathi kuthatha i-fluoroquinolones;
  • ukuntuleka kwe-encyme ye-cytosolic (G6FD).

Ngokunakekela

Imiyalo esetshenzisiwe ikhombisa ukuthi lapho kunqunywa umuthi, kufanele kuqashelwe iziguli ezinama-pathologies alandelayo:

  • i-arrososososis yobuchopho;
  • ukuphazamiseka kokujikeleza kobuchopho;
  • umsebenzi wokuphazamiseka wezinso (ngokucaciswa kwe-creatinine ka-50-20 ml / min);
  • ukhubazeka kwentuthuko kanye nesimo sohlelo lwezinzwa oluphakathi;
  • ukuhluleka kwenhliziyo nokuhlala isikhathi eside kwe-QT.
It is contraindicated kwabesifazane abakhulelwe.
Umuthi une-contraindication elandelayo - ukubanjwa kwesithuthwane nokuqunjelwa kwezitho zomzimba.
Umuthi une-contraindication elandelayo - ukulimala kwama-tendon okwenzeka ngenkathi kuthatha i-fluoroquinolones.
Thatha ngokuqapha kubantu abane-cerebral arteriosulinosis.
Thatha ngokuqapha kubantu abanokulimala kokusebenza kwezintso.
Sebenzisa ngokuqapha kubantu abanezinkinga zesigqi senhliziyo.
Thatha ngokuqapha kubantu abanezifo zobuchopho bokujikeleza kwengqondo.

Ungayithatha kanjani i-Ofloxin 400

Ezigulini zabantu abadala, umthamo wesidakamizwa ngu-200-600 mg. Ukwemukelwa kokuhola kungakapheli izinsuku ezingama-7-10. Umuthi osethweni lama-400 mg ungathathwa kanye. Izibhebhe azikwazi ukuhlafunwa, kufanele zigwazwe ziphelele, zigezwe ngenani lamanzi adingekayo. Endabeni yokutheleleka okukhulu nokukhuluphala, umthamo ukhuphuka ufike ku-800 mg ngosuku.

Ekwelashweni kwe-pathologies yokuvuvukala yezingxenye ezingezansi zesistimu ye-urine yefomu elula, bathathwa ngama-200 mg kanye ngosuku, isifundo sithatha izinsuku ezingama-3-5. Ukwelashwa kwe-gonorrhea, umuthi udakwa kanye ngomthamo we-400 mg.

Uma weqa umthamo

Uma ngesizathu esithile isiguli singakwazanga ukuphuza umuthi, ungawuphuza masisha lapho umuntu ekhumbula lokhu.

Ngoshukela

Iziguli ezinesifo sikashukela ngesikhathi sokwelashwa nge-Ofloxin zidinga ukuqapha ukuhlangana kweglucose egazini, ngoba ukuphathwa ngokubambisana kwesidakamizwa ngezidakamizwa ezinciphisa ushukela, i-insulin ne-fluoroquinolones kungaholela ekwakhiweni kwe-hypo- noma hyperglycemia.

Iziguli ezinesifo sikashukela ngesikhathi sokwelashwa ne-Ofloxin kufanele ziqaphele ukugcwala kweglucose egazini.

Imiphumela emibi ye -loxine 400

Futhi yize imiphumela emibi ingenzeki kakhulu, uma itholakele, isiguli kufanele sibonane nodokotela.

Amapheshana wesisu

Izimpawu ezilandelayo zenzeka:

  • Ubuhlungu nokungaphatheki kahle esiswini;
  • ukuphazamiseka kwe-dyspeptic;
  • gastralgia;
  • dysbiosis;
  • isifiso sokudla;
  • ihepatitis.

Izitho zeHematopoietic

Kubonwe:

  • i-anemia
  • i-leukopenia;
  • i-pancytopenia;
  • hemorrhages;
  • thrombocytopenia.
Imiphumela emibi ye -loxine 400 -dyspeptic ukuphazamiseka.
Imiphumela emibi ye -loxine 400 gastralgia.
Imiphumela emibi ye -loloin 400 - dysbiosis.
Imiphumela emibi ye -loloine 400 - i-hepatitis.
Imiphumela emibi ye -loxine 400 - i-anemia.
Imiphumela emibi ye-heloxine hemorrhage engu-400.
Imiphumela emibi ye -loloxine 400 - thrombocytopenia.

Isistimu yezinzwa ephakathi

Izimpawu eziseceleni ezinokulimazeka kwesistimu yezinzwa

  • Isiyezi
  • i-migraine
  • Ukukhathazeka
  • ukuphazamiseka kokulala;
  • i-psychosis ne-phobias;
  • ukukhuphuka kwengcindezi ye-intracranial;
  • imibono;
  • isimo sokudangala.

Kusuka ohlelweni lwe-musculoskeletal

Kubonwe:

  • i-tendonitis;
  • ukuwohloka kwemisipha;
  • inqubo yokuvuvukala kuzinto ezihlanganayo ze-ligamentous;
  • ubuthakathaka bemisipha nobuhlungu.

Kusuka ohlelweni lokuphefumula

Abekho.

Engxenyeni yesikhumba

Kubhekwe: i-petychia, ukuqubuka kanye nesikhumba.

Imiphumela emibi ye -loloin 400 - isiyezi.
Imiphumela emibi ye -loloxine 400 - i-migraine.
Imiphumela emibi ye -loloxine 400 - i-psychosis ne-phobias.
Imiphumela emibi ye-Ofloxin 400 - ukuphazamiseka kokulala.
Imiphumela emibi ye -loloin 400 - i-tendonitis.
Imiphumela emibi ye -loloxine 400 - inqubo yokuvuvukala kuhlelo lokusebenza oluhlanganyelwe lwe-ligamentous
Imiphumela emibi ye-Ofloxin 400 iyabonakala: i-petichia, ukuqubuka kanye nesikhumba.

Kusuka ohlelweni lwezitho zofuzo

Imiphumela enjalo emibi ayiveli:

  • i-hypercreatininemia;
  • i-jade;
  • ukwanda kwe-urea.

Kusuka ohlelweni lwezinhliziyo

Iziguli zingakhula:

  • ukuphazamiseka kwesigqi senhliziyo;
  • ukuncipha kwengcindezi yegazi;
  • i-tachycardia;
  • ukuvuvukala kwemithambo;
  • ukuwa kwentuthuko.

Uhlelo lwe-Endocrine

Abekho.

Allergies

Ukusabela komzimba kukhonjiswa yizimpawu ezilandelayo:

  • imishayo;
  • ukulunywa
  • ukuphefumula
  • i-allergic nephritis;
  • ukuvuvukala ebusweni nasentanyeni;
  • i-allergic pneumonitis;
  • I-edema kaQuincke;
  • ukwethuka kwe-anaphylactic.
Kuqabukela kakhulu lapho uthatha umuthi i-nephritis ongawukhulisa.
Lapho uthatha umuthi, umfutho wegazi ungancipha.
Ukubonakaliswa kokuphendula komzimba ngendlela yokuqunjaza kanye nokulunywa kungenzeka.
Ukusabela komzimba wonke ngendlela yokuphefumula kungenzeka.
Lapho uthatha umuthi, i-edema kaQuincke ingaqhamuka.

Umthelela ekhonweni lokulawula izindlela

Ngesikhathi sokulashwa nge-Ofloxin, kwenqatshelwe ukushayela imoto nezinqubo eziyinkimbinkimbi.

Imiyalo ekhethekile

Umuthi uzobe ungasebenzi ekwelapheni i-pathologies, ukuthuthukiswa kwayo okuthonywe yi-pneumococci noma i-mycoplasmas: uhlobo olungamahlalakhona lwe-bronchitis ne-pneumonia.

Endabeni yokwakheka kwezimpawu zokwaliwa, ukusabela okungekuhle maqondana nohlelo oluphambili lwezinzwa, kubalulekile ukukhansela umuthi.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Umuthi awuvunyelwe ukusetshenziswa ngabesifazane ngesikhathi sokuzala nengane ngenxa yokuqalwa kwe-pathologies yamalunga nama-ligaments enganeni.

Umuthi we-inloxine wezingane ezingama-400

Iziguli ezingaphansi kweminyaka engu-18 ubudala azinqunyelwe umuthi, ngoba udinga ukulinda ukuqeda ukukhula kanye nokwakhiwa kohlelo lwe-musculoskeletal. Kepha uma kunesidingo, nangaphansi kokuhlolwa ngudokotela, i-Ofloxacin ingabekwa kumthamo ka-7.5 mg nge-1 kg yesisindo. Isilinganiso esivumelekile esiphezulu yi-15 mg / kg.

Iziguli ezingaphansi kweminyaka engu-18 ubudala azinqunyelwe umuthi, ngoba udinga ukulinda ukuqeda ukukhula kanye nokwakhiwa kohlelo lwe-musculoskeletal.

Sebenzisa ebudaleni

Sebenzisa i-antibiotic ngokuqapha ngenxa yezinguquko ezihlobene nobudala kanye nengozi yokuphendula okungalungile.

Isicelo sokusebenza kokulimala kwezinso

Ukulungiswa komthamo kuyadingeka, futhi ukwelashwa kwenziwa ngaphansi kokuqondisa kukadokotela.

Sebenzisa umsebenzi wesibindi okhubazekile

Isidakamizwa sisetshenziswa ngaphansi kwesimo sokuthi isiguli sizokuhlola njalo ukugcwala kwe-biliburin, futhi uma ukwanda kombala we-bile, khona-ke umthamo uyalungiswa noma umuthi ukhanseliwe ngokuphelele.

I-Ofloxin 400 okweqile

Izimpawu ezilandelayo zokudakwa zingakhula:

  • ukuphazamiseka kwe-dyspeptic;
  • umfutho wegazi ophakeme
  • ukudideka.

Uma kutholakala i-overdose, umuthi uyamiswa, isiguli sigezwa esiswini esibhedlela. Uma kudakwa kakhulu, i-hemodialysis ingabekwa.

I-overdose ye-Ofloxin 400 iboniswa ngesimo sokuphazamiseka kwengqondo kwe-dyspeptic.
I-overdose ye-Ofloxin 400 iboniswa ngesimo sehypertension.
I-overdose ye-Ofloxin 400 iboniswa ngesimo sokudideka.

Ukuxhumana nezinye izidakamizwa

Umuthi uxhumana ngokuhlukile nezinye izidakamizwa.

Inhlanganisela ehlanganisiwe

Ukuphathwa kanyekanye kwe-ejenti yokulinganisa nezidakamizwa ezilandelayo akuvunyelwe:

  • Ama-NSAIDs - umkhawulo wokubanjwa kwenhliziyo kungancipha;
  • ama-quinolones nezidakamizwa ezine-metabolic e-renal - kukhuphuka izinga le -lolo futhi isikhathi sayo sokukhuphuka sihlala isikhathi eside;
  • izidakamizwa ze-antihypertensive, ama-barbiturates - umfutho wegazi ungakhula kakhulu;
  • i-glucocorticoids - ingozi eyengeziwe ye-tendonitis;
  • ama-anthocyanins - ukwehla komuthi kuncishisiwe.

Akuhlanganisiwe ukuhlanganisa

Ukuhambisana kwe-Ofloxacin nezidakamizwa ezilandelayo akuvunyelwe:

  • Abaphikisana ne-Vitamin K - ukwanda kwegazi kungakhula;
  • I-Glibenkamid - izinga le-serum Glibenkamide lingakhuphuka;
  • ngesikhathi sokuxilongwa, ngenxa ye-antibiotic, kungahle kube nomphumela ongemuhle kuma-opiate nama-porphyrins kumchamo.

Inhlanganisela edinga ukuqashelwa

Ngokusetshenziswa okuhlangene kwe-Ofloxacin ngama-anticoagulants omlomo, ukwanda komsebenzi wokugcina kungenzeka.

Ngokuhlanganiswa kwama-antibhiliya nezidakamizwa ezephula isigqi se-sinus, kuyadingeka ukulawula i-ECG.

Ukuhambisana notshwala

Umuthi awusetshenziswa notshwala.

Ama-Analog

I-Ofloxacin inamagama alandelayo:

  • Ofaxin;
  • Oflo;
  • Phloxane;
  • I-Oftagel;
  • Ofor.
Umuntu obambele lesi sidakamizwa ngu-Oflo.
Esikhundleni salesi sidakamizwa uPhloxan.
Esikhundleni somuthi yi-Oftagel.
Esikhundleni salo muthi ngu-Ofor.

Imibandela yekhefu lekhemisi

Ngokusebenzisa umuthi.

Ngingakwazi ukuthenga ngaphandle kadokotela

Cha.

Intengo ye-Ofloxin 400

Ungathenga umuthi e-Ukraine ngentengo ka-133.38-188 UAH., Futhi eRussia - ama-ruble ayi-160-180.

Izimo zokugcina zomuthi

Gcina i-antibiotic endaweni eyomile futhi emnyama lapho izingane zingafinyeleleki khona. Ukushisa akufanele kudlule i-25 ° C.

Isikhathi sokuphelelwa yisikhathi

Akudluli iminyaka emithathu.

Umkhiqizi

I-republic yaseCzech.

Ukubuyekezwa kwe-Ofloxin 400

Odokotela

UMaxim, eMoscow: "Emsebenzini wami wezokwelapha, ngisebenzisa i-fluoroquinolones ukwelapha iziguli. I-Ofloxacin, ngiyibheka njengomuthi osebenzayo. Unikeza imiphumela esheshayo nevumayo, ngaphandle kwemiphumela emibi."

UGalina, eSt.

Lapho uthatha umuthi, ukuvuvukala kwemithambo kungakhula.

Iziguli

U-Ana, oneminyaka engama-38, u-Omsk: "Lesi sidakamizwa sisize ekwelapheni i-cystitis enzima. Ngemuva kwezinsuku ezingama-2-3 zokuthatha, isimo sathuthuka, ngoba izimpawu zalesi sifo zanyamalala. Kwakungekho miphumela emibi, ngisho ne-thrush ngemuva kokulashwa kwe-antibiotic."

U-Yuri, oneminyaka engu-29 ubudala, uKrasnodar: "Ngonyaka owedlule ngathola umkhuhlane omubi emsebenzini, obudale nezinkinga zokuchama. Udokotela wanquma lesi sidakamizwa, engasithatha isonto lonke.Amaphilisi asebenza ngokushesha, ngoba ngemuva kwezinsuku ezintathu izimpawu zaqala ukunyamalala "

UTatyana, oneminyaka engama-45, uVoronezh: "Udokotela ngemuva kokuhlolwa uveze ukuthi kukhona izifo ezifihliwe kimi. Kwaqokwa i-Ofloxacin, engayithatha izinsuku eziyi-10. Ngemuva kokuhlolwa kwesibili, umphumela waba mubi."

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