I-Espa-Lipon 600 isidakamizwa esitholakala ngendlela yamaphilisi noma ngomjovo. Indlela yokusebenza nezakhiwo zamakhemikhali kuncike kumphumela we-alpha-lipoic acid, oyingxenye yomuthi. Umuthi usetshenziswa njengengxenye yokwelapha yokwelapha ekwelapheni isifo sikashukela noma i-alcoholne polyneuropathy. I-Thioctic acid ayinqunyelwe izingane noma abesifazane abakhulelwe, ngoba abukho ubufakazi bomphumela ongemuhle wento esebenzayo ekuthuthukisweni komzimba.
Igama Lezwe elingafanele
I-Thioctic acid.
Igama le-Espa-Lipon elejwayelekile emhlabeni jikelele yi-Thioctic acid.
I-ATX
I-A05BA.
Khipha amafomu nokwakheka
I-ejenti ye-metabolic yenziwa ngendlela yesisombululo somjovo nangefomu lethebhulethi. Esimweni sokugcina, amayunithi wokulungiselela ambozwe ngefilimu emincane ye-enteric equkethe i-hypromellose, macrogol 6000, titanium dioxide ne-talc. Engxenyeni yethebhulethi ingu-600 mg wekhompiyutha esebenzayo - i-alpha-lipoic noma i-thioctic acid. Ukuze uthuthukise ukumunyaniswa kwengxenye esebenzayo futhi usebenze ukubola kwipheshana lamathumbu, ifomu lethebhulethi lihambisana nezinto ezisizayo, njengoku:
- i-microcrystalline cellulose powder;
- i-povidone;
- ushukela wobisi;
- i-silicon dioxide colloidal enamanzi;
- isitashi se-sodium carboxymethyl;
- i-magnesium stearate.
Amathebulethi aphambili anesimo se-biconvex. I-membrane yefilimu ngombala ophuzi ngenxa yokuba khona kodayi be-quinoline womthunzi ohambisanayo.
Isixazululo se-Espa-Lipon somjovo sise-ampoules yengilazi, ngalinye liqukethe u-600 mg we-ethylene bis usawoti we-alpha lipoic acid.
Isixazululo somjovo sise-ampoules yengilazi, ngalinye liqukethe u-600 mg we-ethylene bis usawoti we-alpha lipoic acid. Amanzi angcolile asetshenziswa njenge-solvent.
Isenzo se-Pharmacological
I-Alpha lipoic acid ithuthukisa imetabolism. Ingxenye esebenzayo ivuselela i-metabolism emzimbeni ngenxa ye-oxidation ye-pyruvic acid kanye ne-alpha-keto acid. Ngamapharamitha we-biochemical, i-thioctic acid ifana nesenzo samavithamini we-B.
Into esebenzayo ingeyama-antioxidants endo native. Ithatha iqhaza kuma-carbohydrate metabolism. I-Alpha-lipoic acid ine-lipid-yehlisa umphumela, inciphisa i-cholesterol ye-plasma, ithuthukisa ukusebenza kwesibindi futhi ikhuthaza ukuqeda okusheshayo kobuthi emzimbeni. Umuthi ubuyekeza amangqamuzana ezinzwa ayizidumbu.
I-Pharmacokinetics
Lapho kuthathwa ngomlomo, i-alpha lipoic acid imunzwa ngokushesha emgudleni wamathumbu. Ukudla ngokulinganayo kwamathebulethi ngokudla kunciphisa ukumuncwa kwe-thioctic acid. I-Bioavailability ingama-30-60%. Izinga eliphansi lokufakelwa kwento esebenzayo kungenxa yesigaba sokuqala somuthi ngokusebenzisa i-hepatocytes, lapho ikhemikhali elingaphansi lifakwa khona inguquko.
Ingxenye esebenzayo ifinyelela ekujuleni kwe-serum ephezulu egazini ngemuva kwemizuzu engama-25-60. Ukuqedwa kwesigamu sempilo kwenza imizuzu engama-20-50. I-Alfa-lipoic acid ishiya umzimba ngohlelo lwe-urine ngama-80-90%.
Ingxenye esebenzayo ye-Espa-Lipon ifinyelela ekugxileni kwayo okuphezulu egazini ngemuva kwemizuzu engama-25-60.
Izinkomba zokusetshenziswa
Isidakamizwa sisetshenziswa kwezokwelapha ukuze kuqedwe i-alcoholic kanye nesifo sikashukela. Imijovo ye-Intravenous ingasetshenziselwa ukwelapha izinqubo ze-pathological esibindini: i-cirrhosis, ukuvuvukala okungapheli (i-hepatitis), ukudakwa kwezidakwa noma izidakamizwa kwe-hepatocytes. I-Alfa-lipoic acid ingadambisa isimo sesiguli futhi isize ukususa izinto ezinobuthi uma kungenzeka ukuthi inoshevu ngosawoti osindayo, amakhowe noma amakhemikhali.
Kwezinye izimo, i-Espa-Lipon isetshenziswa njengomuthi okwehlisa i-lipid ngokumelene nesizinda se-vascular atherossteosis kanye nokwehlisa i-cholesterol. Lokhu kokugcina kuyimbangela yokwakheka kwamathafa e-atherosselotic ezindongeni zemithambo yemithambo yegazi eyinhloko nethambekele.
Contraindication
Umuthi uphambaniswe nobukhona be-hypersensitivity ezintweni ezihlelekile ze-Espa-Lipon, ngokubekezelela kwe-lactose.
Ngokunakekela
Umuthi kufanele unikezwe ngokuqapha uma kwenzeka ukwehluleka kwesibindi nokulimala kwezinso.
U-Espa-Lipon 600 kufanele anqunywe ngokuqapha uma kungaphumeleli isibindi.
Ungayithatha kanjani i-Espa-Lipon 600
Ukuphathwa ngomlomo kwesidakamizwa kwenziwa kanye ngosuku, ukuphuza ithebhulethi eyi-1 (600 mg) esiswini esingenalutho. Akunconyelwe ukusebenzisa ithebhulethi eyonakele, ngoba ukwephula ngomshini kokubandakanyeka kwe-enteric kunciphisa ukumuncwa kanye nomphumela wokwelapha we-alpha lipoic acid. Amacwecwe asetshenziswa njengezinyathelo zokuvimbela noma ngemuva kokuphela kokuphathwa kwabazali ngomuthi, inkambo yawo owathatha amasonto angama-2-4.
Ukwelapha ngamathebulethi akukho ngaphezulu kwezinyanga ezi-3. Ezimweni ezihlukile, kungenzeka ukwanda kokuqhubeka kwesikhathi kokwelashwa kungenzeka. Isikhathi sokwelashwa sinqunywa nguchwepheshe wezokwelapha osuselwa kudatha esilinganisweni sokuvuselelwa kwezicubu futhi ngokuya ngesithombe somtholampilo se-pathology.
Ukuphathwa kwe-Intravenous kwenziwa ngendlela ye-infusions. I-dropper ibekwa isikhathi esingu-1 ngosuku ngesisu esingenalutho. Ukugxila noma isixazululo kufakwa kwisisombululo se-0.9% saline sodium chloride. Kwi-polyneuropathy enzima, i-24 ml ye-Espa-Lipon ihlanjululwe ku-250 ml yesisombululo se-0.9% sodium chloride. I-dropper ibekwe imizuzu engama-50.
Ukuthatha umuthi wesifo sikashukela
Iziguli ezinesifo sikashukela zidinga ukulawulwa kwe-plasma glucose zisebenzisa umthamo ojwayelekile we-Espa-Lipon.
Imiphumela emibi
Ngokusetshenziswa kahle kwesidakamizwa ngokuya ngemiyalo yokusetshenziswa, ubungozi bemiphumela emibi buyancishiswa. Ezimweni ezingavamile, lokhu kusabela okulandelayo kwenzeka:
- ukwehla kokuhlushwa ushukela we-plasma;
- ukungezwani komzimba okubonakalayo esikhumbeni ngesimo se-eczema noma i-urticaria;
- ukukhuphuka kokujuluka;
- ukuthuthukiswa kokuthuthumela kwe-anaphylactic kanye nokuvela kwama-hematomas.
Ngezinga elikhulu lokuphathwa kwezidakamizwa, izicubu zomsipha, idiplopia, ikhanda, ukusindeka emathempelini, ukuphefumula okunobunzima kungenzeka.
Ezimweni eziningi, imiphumela emibi ihamba yodwa.
Umthelela ekhonweni lokulawula izindlela
Umuthi awunawo umphumela wokuvimbela umsebenzi wokusebenza kohlelo lwezinzwa oluyinhloko noluzungezile. Ngokubheka ukukhula okungaba khona kokuphendula okungekuhle (ukwethuka, isiyezi), ukunakekelwa kufanele kuthathwe lapho ushayela amadivaysi ayinkimbinkimbi nemoto, ngoba umsebenzi onjalo udinga ukuphendula okusheshayo nokuxineka.
Imiyalo ekhethekile
Kuyadingeka ukwazisa isiguli ngokwenzeka kwe-paresthesia - ukuphazamiseka kwemizwa. Inqubo yesikhashana ye-pathological iba ngokuphikisana nesizinda sokuvuselelwa kwezicubu zezinzwa ekwelapheni i-polyneuropathy nge-alpha lipoic acid. Isiguli singazizwa "ngama-goosebumps."
Iziguli ezithambekele kokuvela kokuphendula kwe-anaphylactoid kufanele zinikezwe ukuhlolwa kwe-allergic ngaphambi kokulawulwa kwe-intravenous. Ngokwazisa u-2 ml wesidakamizwa ngaphansi kwesikhumba, ukubekezelela umuthi emzimbeni kungatholwa. Endabeni yokumiswa, isicanucanu kanye nokungaphatheki kahle, ukwelashwa ngezidakamizwa kumele kumiswe ngokushesha. Uma kwenzeka i-angioedema ne-anaphylactic shock, ama-glucocorticosteroids ayadingeka.
Ngenkathi uthatha i-Espa-Lipon 600, ukuncelisa akukanconywa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi ubekwa ngesikhathi sokukhulelwa kuphela ezimweni ezimbi kakhulu lapho umphumela omuhle we-alpha-lipoic acid emzimbeni womama udlula khona ingozi yezinkinga zokuthuthuka kwe-intrauterine embungwini. Ukuhlolwa okunjalo kwezokwelapha kuyadingeka ngoba akukho datha emtholampilo ekhonweni le-thioctic acid ukungena emgoqweni we-hematoplacental.
Ngesikhathi sokulashwa kwezidakamizwa, ukuncelisa akukanconywa.
Umuthi ka-Espa-Lipon Wezingane ezingama-600
Izifundo zokwelashwa ngemiphumela yomuthi ekukhuleni nasekukhuleni komzimba ebuntwaneni nasebusheni bezingakaqhutshwa. Njengesilinganiso sokuphepha, ukuphathwa noma ukuphathwa kwe-alpha lipoic acid akunconywa kuze kube seminyakeni engu-18.
Sebenzisa ebudaleni
Ebantwini abangaphezulu kweminyaka engama-50, amapharamitha we-pharmacokinetic we-thioctic acid awazange abonwe lapho athathwa ngefomu lethebhulethi, ngakho-ke iziguli esezikhulile azidingi ukuguqula umthamo. Ukuphathwa kwe-Intravenous kwenziwa kuphela ezimeni zokuma ngaphansi kokuqondisa kukadokotela.
Ukweqisa
Lapho uthatha umuthi ongu-10-40 g wesidakamizwa, kuphazamiseka ukuphazamiseka kwegazi okuqhamukayo, ukuqina kwe-hypoglycemic kukhula, bese ibhalansi ye-acid emzimbeni iyaphazamiseka. Ukudakwa okukhulu kuyaqala. Isisulu sidinga ukulaliswa esibhedlela ngokushesha.
Isisulu sidinga ukulaliswa esibhedlela ngokushesha uma kunokweqisa kwe-Espa-Lipon 600.
Ukuxhumana nezinye izidakamizwa
Ngesikhathi kuqhubeka izifundo zokumaketha nokuthengisa ngemuva kokusebenzisa okufanayo kwe-Espa-Lipon neminye imithi, lokhu kuxhumana kwalandelwa:
- Umuthi wenza buthaka ukusebenza kwe-cisplatin.
- Kuyadingeka ukubheka njalo ukugcwala kwe-plasma ye-glucose ngokuhlanganiswa kwe-alpha-lipoic acid ene-insulin noma ezinye izidakamizwa ze-hypoglycemic. I-Espa-Lipon iyakwazi ukuthuthukisa ukuzwela kwezicubu ezixakile ku-hormone yamaseli we-beta wamanyikwe. Ngokuya ngomphumela othole, kunconywa ukuthi uguqule umthamo wezimali ezidingekayo ukufezekisa ukulawulwa kwe-glycemic.
- I-Thioctic acid iyakwazi ukuhlangana nama-ionic irones complexes kanye nokwakheka kwamangqamuzana ama-saccharides, kufaka phakathi i-levulose, ukwakha izakhiwo eziyinkimbinkimbi. Ngakho-ke, ukusetshenziswa okufanayo kwesidakamizwa ngezithasiselo zokudla, imikhiqizo yobisi (ngenxa yobukhona be-calcium ion) noma ama-ejenti aqukethe usawoti we-iron ne-magnesium akuvunyelwe. Ngesikhathi sokulashwa kwezidakamizwa, kunconywa ukuthi kugcinwe isikhathi phakathi kokuthatha i-Espa-Lipon nokudla amahora angama-2-4.
- Ukungahambisani kwemithi kubhekwa lapho kufakwa i-thioctic acid ngendlela yesisombululo ku-5% dextrose, isixazululo sika-Ringer.
Umuthi ungakhuthaza umphumela wokulwa nokuvuvukala we-glucocorticosteroids.
Ukuhambisana notshwala
Ngesikhathi sokwelashwa ngezidakamizwa, ukusetshenziswa kweziphuzo, izidakamizwa nemikhiqizo yokudla equkethe i-ethyl alcohol akuvunyelwe ngokuphelele. Ngokusetshenziswa okufana kotshwala ne-Espa-Lipon, ukuwohloka kwemphumela yokwelapha kuyabonakala.
Ngesikhathi sokuphuza i-Espa-Lipon 600, ukusetshenziswa kotshwala akuvunyelwe ngokuphelele.
I-ethyl alcohol kanye nemikhiqizo yayo ye-metabolic ingavusa ukuvela kwe-polyneuropathy ephindaphindekayo lapho uthatha i-Espa-Lipon njenge-prophylactic.
Ama-Analog
Le mishanguzo elandelayo ingeyokufanekisa okuyisakhiwo kanye nokufakwa esikhundleni sendlela efanayo yokusebenza ye-Espa-Lipon:
- I-Oktolipen;
- I-Thioctacid BV;
- I-Berlition 600;
- I-Thiogma;
- I-Thiolipone;
- I-Lipoic acid;
- Neuroleipone.
Ukushintsha umuthi akuhambisani nokwehla kancane kancane komthamo phakathi nesonto, ngoba i-Espa-Lipon ayizibangeli zimpawu zokuhoxa.
Izimo zeholide u-Espa Lipona 600 ovela ekhemisi
Umuthi uthengiswa emakhemisi ngokunikezwa umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Ngohlobo olungalungile lomthamo, kusabela okungahle kube khona, ngakho-ke ukuthengiswa kwamahhala kwalo muthi ngaphandle kwezinkomba eziqondile zezokwelapha kunomkhawulo.
Intengo ye-espa lipon 600
Izindleko ezijwayelekile zomuthi ezitolo eziqinisekisiwe zezitolo ziyahlukahluka kusuka kuma-ruble angama-656 kuya kwangama-787.
Izimo zokugcina zomuthi
Ithebhulethi nesixazululo somjovo zivunyelwe ukulondolozwa ekushiseni kwe + 15 ... + 25 ° C. Ukulungiswa kwamafomu omthamo, izimo ezinomswakama ophansi nokuntuleka kokukhanya kwelanga kuyadingeka.
Isikhathi sokuphelelwa yisikhathi
Iminyaka emi-2
Umkhiqizi u-Espa Lipona 600
Siegfried Hamelin GmbH, Germany.
Amathebulethi e-Espa-Lipon nesixazululo sokuvunyelwa ayavunyelwa ukuba agcinwe ekushiseni kwe + 15 ... + 25 ° C.
Ukubuyekezwa ku-Espa Lipone 600
Ukususwa ngokuphelele kwe-polyneuropathy yesifo sikashukela noma yotshwala, i-Espa-Lipon monotherapy ayanele, ngoba ezinhlanganweni zezithintana ze-Inthanethi iziguli zibona umphumela ojwayelekile wokulapha.
Odokotela
U-Olga Iskorostinskova, i-endocrinologist, iRostov-on-Don
Ngicabanga ukuthi i-Espa-Lipon isidakamizwa eseqophelweni eliphezulu esekelwe ku-thioctic acid. Ngisebenzisa isidakamizwa ukuphatha i-intravenous, elandelwa ukuguqulwa kokuthatha ifomu lethebhulethi. Ngibona umphumela we-lipotropic ekusebenzeni ngokomtholampilo. Umuthi usiza ukunciphisa ukudakwa komzimba. Okuwukuphela kwento ekhokhwayo izindleko eziphezulu zazo zombili isixazululo namathebulethi. Umuthi ubekelwe iziguli njengendlela yokwelapha i-antioxidant ye-polyneuropathies yesifo sikashukela.
U-Elena Mayatnikova, isazi sezinzwa, eSt
I-Espa-Lipon iyikhambi elisebenzayo eluselwa esenzweni se-thioctic acid, umkhiqizo okhiqizwa ekhaya. Ngisebenzisa umuthi ekwelapheni i-polyneuropathy ye-diabetes noma i-alcoholic alcohol, kanye nomonakalo ohlelweni lwezinzwa oluyindilinga ngemuva kwesizinda somhubhe. Abantu abanesifo sikashukela badinga ukuphuza i-alpha-lipoic acid ngendlela yamaphilisi izikhathi ezi-2 ngonyaka ukuvimbela ukwenzeka kwe-polyneuropathy. Ezigulini eziningi, umuthi ubekezeleleke kahle, futhi awubonanga noma yimiphi imiphumela emibi ekusetshenzisweni kwawo.
Iziguli
UMalvina Terentyeva, oneminyaka engama-23, uVladivostok
Ngenelisekile ngomphumela ngemuva kwenkambo ephelele yokwelashwa ne-Espa-Lipon. Udokotela ubeke amaphilisi ngenxa yokuba khona kwezimpawu zokushintshwa kwe-degenerative-dystrophic emgogodleni we-lumbar. Inqubo ye-pathological yabonakaliswa ngesimo se-osteochondrosis sedigri yokuqala. Umzimba usabele kahle kulo muthi, isimo sempilo sithuthukile, nomuthi awuzange ube nemiphumela emibi. Lapho unikela ngegazi ukuze lihlaziywe, kwavela ukuthi i-cholesterol iyancipha: yayingama-7.5 mmol, yaba yi-6.
U-Evgenia Knyazeva, oneminyaka engama-27, uTomsk
Ngisebenzisa umuthi kuphela ngenhloso yokuvimbela. Ekwelashweni kwe-polyneuropathy, imiphumela yesidakamizwa, kanye nokuphathwa kwe-intravenous kanye nokusebenzisa amaphilisi, ayiphawulwanga. U-Espa-Lipon ubenganele ukuthuthukisa isithombe sezempilo. Odokotela bathuthukisa umphumela nezinye izidakamizwa, okwalandela ngemuva kwalokho baqoka i-Espa-Lipon njengesinyathelo sokuvimbela. Ngikholwa ukuthi izici ezinhle zisezingeni elithengiswayo.
