Izinkinga zokucindezelwa kwegazi, odokotela banquma imishanguzo efanele ukusiza ukwenze kube okujwayelekile. Imvamisa, uDiroton noLisinopril babekelwe le nhloso. Izidakamizwa ezinjalo zinokufana okuningi, kepha kukhona umehluko. Awukwazi ukubathatha ngaphandle kokuqokwa udokotela.
Isimilo sikaDiroton
Lesi sidakamizwa siyi-ACE inhibitor esebenzayo esehlisa umfutho wegazi futhi sinciphise imithambo yegazi. Into yayo esebenzayo yi-lisinopril, ehlisa umthamo we-aldosterone ne-angiotensin ku-plasma. Ngenxa yalokhu, kukhona ukwehla kokumelana kokuqina kwemithambo yegazi nokukhuphuka kwe umthamo wegazi odlula enhliziyweni ngomzuzu. Lokhu akubangeli ukungasebenzi kahle kwesigqi senhliziyo.
Izinkinga zokucindezelwa kwegazi, odokotela banquma imishanguzo efanele ukusiza ukwenze kube okujwayelekile. Imvamisa, uDiroton noLisinopril babekelwe le nhloso.
Ukukhishwa ifomu - amaphilisi. I-lisinopril ephezulu kakhulu egazini ivela ngemuva kwamahora angama-6-7.
Izinkomba zokusetshenziswa kwe-Diroton:
- i-arterial hypertension;
- i-infarction ye-myocardial eyingozi kakhulu;
- isifo sikashukela se-nephropathy;
- ukwehluleka kwenhliziyo okungapheli.
Kwenqatshelwe ukuphuza umuthi ezimeni ezinjengokuthi:
- ukungabekezelelani kwezakhi;
- ukuncipha kwe-lumen yemithambo ye-renal;
- isifiso sokuthola ifa ku-edema kaQuincke;
- ushintsho kumakhemikhali egazi we-biochemical;
- i-stenosis ye-aortic orifice;
- i-aldosteronism eyinhloko;
- iminyaka engu-16.
I-Diroton ayivunyelwe ngesikhathi sokuzala kwengane, ngoba izingxenye zayo zingena kwi-placenta. Ukusetshenziswa kwe-ACE inhibitors ku-trimester yokugcina kuthinta kabi i-fetus ekhulayo, okuholela ekufeni kwe-fetus. Umuthi awuthathwa ngesikhathi sokuqunjelwa.
Ukusetshenziswa kwomuthi kuholela ekuphendukeni okuhlukahlukene okuvela ezinhlakeni eziningi zomzimba:
- ukuphefumula: i-bronchospasm, ukuphefumula, ukukhwehlela ngaphandle kwesikhohlela;
- inhliziyo: infarction ye-myocardial, izinhlungu zesternum, ukwehla kwesilinganiso senhliziyo, ukwanda kwenhliziyo;
- i-urogenital: i-uremia, ukuncishiswa kocansi okunciphile, umsebenzi we-renal ophazamisekile;
- ukujikeleza kwegazi: amazinga aphansi we-hemoglobin, i-anemia, i-neutropenia;
- imizwa ephakathi: ukushuba, ukukhathala okukhulu, ukozela, ukuguquguquka kwemizwelo, ukungakwazi ukugxila kunoma yini;
- Ukugaya ukudla: ukuvuvukala kwe-pancreatic, i-hepatitis, ukunambitheka kokudabukisa, isifo sohudo, ukuhlaselwa kabuhlungu kobuhlungu esiswini, umlomo owomile, ukuhlanza;
- Isikhumba: ukulunywa, impandla, ukuqubuka, ukujuluka ngokweqile.
Umenzi walo muthi nguGideon Richter OJSC, eBudapest, eHungary.
Isimo seLisinopril
ILisinopril iyi-inhibitor ye-ACE. Isakhi saso esikhulu i-lisinopril (ngesimo se-dihydrate). Umuthi wehlisela ngokuphumelelayo umfutho wegazi, unwebeka imithambo, ulungise ukusebenza kwe-myocardial, futhi ususe nosawoti we-sodium. Ngokusetshenziswa isikhathi eside komuthi, izindonga ze-myocardium nemithambo yegazi ziyaqina, ukujikeleza kwegazi kuvamile. Kukhululwa umuthi ngesimo samathebulethi.
ILisinopril inezinkomba ezinjalo ezisetshenziswa njenge:
- i-infarction ye-myocardial eyingozi kakhulu;
- isifo sikashukela se-nephropathy;
- ukwehluleka kwenhliziyo okungapheli;
- umfutho wegazi ophakeme.
Umuthi uphambaniswe emacaleni afana nalawa:
- i-mitral stenosis;
- i-hypertrophic cardiomyopathy;
- hemodynamic aortic stenosis;
- i-idiopathic angioedema;
- ukungabekezeleli kanye nokushoda kwe-lactose;
- ukungabekezeleli izinto ezakha umkhiqizo;
- iminyaka efinyelela eminyakeni eyi-18;
- ukukhulelwa nokukhipha umunyu.
Ukwelashwa kuvame ukuhambisana nokukhula kwe-hyperkalemia. Izici zobungozi zokuvela kwayo zifaka phakathi: isifo sikashukela, iminyaka engaphezu kweminyaka engama-70, umsebenzi wezinso ongalimazi.
ILisinopril yehlisa ngempumelelo umfutho wegazi ophakeme, kepha ingadala inani elikhulu lemiphumela emibi. Kungaba:
- ukukhwehlela okune-sputum engahlukaniseki, ukukhathala, isicanucanu, isiyezi, isisu, ikhanda;
- i-palpitations, izinhlungu ku-sternum, tachycardia, infarction ye-myocardial;
- ukuncipha ukunakwa, ukuqina kwemisipha emilenzeni nasezingalweni;
- dyspnea, bronchospasm;
- ukuvuvukala kwama-pancreas nesibindi, i-jaundice, ushintsho ekunambithekeni, izinhlungu esiswini, umlomo owomile, i-anorexia;
- isikhumba esikhanyayo, ukukhiqizwa ngokweqile kwesithukuthuku, impandla;
- i-uremia, ukwehluleka kwe-renal acute, i-oliguria, i-anuria, ukungasebenzi kahle kwezinso;
- isifo samathambo, i-myalgia, i-vasculitis.
Ukusuka ohlelweni lwe-hemopoietic, i-anemia, i-thrombocytopenia kwenzeka. I-allergy ikhula ngendlela ye-angioedema yemikhawulo kanye ne-anaphylactic edema ye-larynx. Imvamisa kuba nokuqubuka esikhunjeni, i-urticaria, umkhuhlane, i-leukocytosis.
Ngokusebenzisa kanyekanye i-lisinopril ne-sodium aurothiomalate, kungavela lezi zimpawu ezilandelayo: umfutho we-arterial hypertension, isicanucanu, ukubomvu kwesikhumba sobuso. Ukuthatha umuthi kusho ukungafakwa komthamo womzimba, ngoba ukuphuma komzimba kungaqala ukwenzeka. ILisinopril ehlangene ne-diuretics isusa i-potassium emzimbeni.
Umenzi walo muthi yi-CJSC Skopinsky Pharm.zavod, eRussia.
Ukuqhathanisa kukaDiroton noLisinopril
Zombili lezi zidakamizwa zinokufana kakhulu, kodwa kunomehluko phakathi kwazo.
Okujwayelekile
I-Diroton neLisinopril izidakamizwa ze-antihypertensive futhi ziqukethe isakhi esifanayo esisebenzayo - i-lisinopril. Babekelwe umfutho wegazi ophakeme, ngoba banomphumela ofanayo. Kuyatholakala ngesimo sethebhulethi. Umphumela omkhulu lapho uzithatha ubonwa ngemuva kwamasonto angama-2-4.
Izidakamizwa akufanele zithathwe ngesikhathi sokukhulelwa ngenkathi uncelisa ibele. Ngemuva kokuzithatha, imiphumela eminingi emibi ingakhula.
Uyini umehluko
Umehluko omkhulu phakathi kukaDiroton noLisinopril ukuthi umuthi wokuqala awunakuthathwa yiziguli ezinesifiso sokuthola ifa ku-edema kaQuincke, nesesibili - ezigulini ezingabekezeleli i-lactose. Kunokwehluka kwemithamo. I-Diroton kufanele ithathwe ngesilinganiso se-10 mg kanye ngosuku, futhi uLisinopril - kuphela u-5 mg. Banabakhiqizi abahlukile.
Yikuphi okushibhile
Intengo yezidakamizwa imi ngalendlela elandelayo:
- I-Diroton - ama-ruble angama-360.
- I-Lisinopril - ama-ruble ayi-101.
Yikuphi okungcono - Diroton noma Lisinopril
Lapho ukhetha ukuthi yisiphi isidakamizwa esingcono - i-Diroton noma uLisinopril, udokotela unaka amaphuzu amaningi:
- isifo seziguli;
- contraindication
- izindleko zomuthi.
Ukubuyekezwa kochwepheshe bezokwelapha
U-Olga, udokotela wenhliziyo, oneminyaka engu-56, eMoscow: "Ngokuvamile i-Diroton inqunyelwa iziguli ezinokwehluleka kwenhliziyo okuhlala njalo kanye nomfutho wegazi ophakeme. Ngikhetha umthamo ngamunye. Isikhathi sokwelashwa sincike esimweni. Ukusabela okuhlukile akwenzeki."
USergey, udokotela wezokwelapha, oneminyaka engama-44, uSyzran: "Ngivame ukunquma umuthi uLisinopril kwiziguli ezinomfutho wegazi ophakeme. Usheshe wehlise umfutho wegazi. Kepha ku-monotherapy, umuthi awusizi wonke umuntu, ngakho-ke kufanele uhlanganiswe nezinye izidakamizwa."
Ukubuyekezwa kweziguli mayelana ne-Diroton neLisinopril
UVera, oneminyaka engama-44, u-Omsk: "Ingcindezi yaqala ukukhuphuka njalo isukela eminyakeni engu-40 ubudala. Inani eliphezulu lafika ku-150. Udokotela wamisa uLisinopril. Umphumela awutholi ngokushesha njengoba besingathanda. Ingcindezi esuka ku-150 yehle yaya ku-120 ngemuva kwamahora angama-8 kuphela. Umphumela wesidakamizwa. eyengeziwe - uma isikhathi eside uyithatha, yilapho ingcindezi iqinisa khona. Ngifuna ukubabaza nokukhathala ngemiphumela emibi. Kufanele ngikubekezelele lokhu, ngoba umuthi akufanele ukhanselwe futhi udakwe. "
U-Oksana, oneminyaka engama-52, uMinsk: "Ngithatha uDiroton njengokuyalelwa udokotela ngokwehluleka kwenhliziyo. Uma kuqhathaniswa neminye izidakamizwa, kusebenza kakhulu futhi kuphephile. UDiroton unemiphumela emibi embalwa: umlomo owomile, isiyezi, isicanucanu. Kepha umphumela uyashesha, ukunciphisa ingcindezi ngehora. "
