I-Berlition 300 ikhombisa izakhiwo ze-hepatoprotective. Umphumela omuhle emzimbeni kungenxa yokuba khona kwe-antioxidant. Umuthi awunazo izinto ezinolaka. Ngenxa yalokhu, isilinganiso sokusetshenziswa kwaso siyanda.
I-ATX
I-A16AX01.
I-Berlition 300 ikhombisa izakhiwo ze-hepatoprotective.
Khipha amafomu nokwakheka
Ungathenga umuthi ngezinhlobo ezi-2: amaphilisi nesisombululo. Ithuluzi liyingxenye eyodwa - umphumela we-hepatoprotective emzimbeni une-thioctic acid. Ku-1 ithebhulethi, ukuqoqwa kwesithako esisebenzayo kungama-300 mg. Ukwakheka kwesisombululo sokuphathwa kwe-intravenous kuhlanganisa ne-thioctic acid. I-ampoule eyi-1 iqukethe u-388 mg wento esesimweni sikasawoti we-alpha lipoic acid. Leli nani lihambisana nama-PIECES angama-300 engxenye eyinhloko.
Amacwecwe ayatholakala emabhulashini, abekwe emaphaketheni ama-3, 6 no-10 ama-PC. Ama-Ampoules asemabhodini amakhadibhodi angama-5, 10 no-20 ama-PC. Umuthi uqukethe ezinye izinto. Isibonelo, ukwakheka kwesixazululo sengeza kufaka amanzi wokujova. Ukwakhiwa kwamathebhulethi:
- i-magnesium stearate;
- i-microcrystalline cellulose;
- i-povidone;
- i-croscarmellose sodium;
- i-lactose monohydrate;
- abicah dioxide hydrate.
Isenzo se-Pharmacological
Ingxenye esebenzayo (i-thioctic acid) iyinto efana nezakhiwo nokwakheka kwamavithamini. Amanye amagama alo: i-lipoic, i-alpha lipoic acid. Le ngxenye ikhombisa izakhiwo ze-antioxidant. Umphumela omuhle uyaqinisekiswa ngenxa yokuvinjwa komsebenzi wama-radicals wamahhala.
Ingxenye esebenzayo yesidakamizwa iyinto efana nezakhiwo nesakhiwo namavithamini.
Umsebenzi oyinhloko we-antioxidant ukunciphisa ijubane le-oxidation lezinto ezizuzisayo ezilethwa ngokudla noma ezikhiqizwa ngumzimba. Ngenxa yalokhu, ukusabela kwe-biochemical kuyabuyiselwa, umsebenzi wezitho zangaphakathi uyathuthuka.
I-Thioctic acid ikhiqizwa ngumzimba ngenxa yezinqubo zemvelo. Uma kwenzeka ukusabela kwe-metabolic kanye nokunye okuphilayo, inqubo yokukhiqiza ihamba kancane, okuholela ku-oxidation okusheshayo wamakhompiyutha ahlukahlukene. Ukukhiqizwa kwe-thioctic acid kwenzeka ngenxa ye-decarboxylation ye-alpha-keto acid. Ngenxa yengxenye esebenzayo yeBerlition, ukwehla kwezinga le-glucose ku-plasma yegazi kuyaphawulwa.
Ngaphezu kwalokho, i-lipoic acid ithinta umetabolism. Ngaphansi kwethonya lale ngxenye, impendulo yomzimba we-metabolic ezinhlotsheni ezahlukahlukene ze-insulin iyabuyiselwa. Ngenxa yalokhu, ukugcwala kwe-plasma kwe-insulin kuyancipha. I-Berlition isiza ukunqoba ukumelana ne-insulin. Lokhu kuqeda into engemihle ethinta izinqubo eziningi ze-metabolic emzimbeni (amaprotheni, amafutha), kuthuthukisa isimo sezangaphakathi zodonga lwemithambo yegazi.
Kanye nezinqubo ezichaziwe, izinga le-glycogen esibindini liyakhuphuka. Le yi-polysaccharide eyakhiwe ngenxa ye-glucose metabolism. Ngesikhathi sokwelashwa nge-ejenti ebhekwayo, ukwanda kwesilinganiso se-lipid metabolism kuyaphawulwa. I-Lipoic acid isebenzisa inqubo yokuguqulwa kwe-cholesterol. Ngenxa yalokhu, ubungozi bokuqhamuka nezinkinga ezihambisana nokungasebenzi kahle kohlelo lwezinhliziyo ziyancishiswa, ngokwelashwa okufanele, isisindo sincishisiwe.
Umuthi unciphisa ukuqina kokuvezwa kwezinto ezingezinhle ezithinta isibindi. Ikakhulu, i-lipoic acid ivikela lesi sitho etshwaleni, ubuthi bezinhlobo ezahlukahlukene, sinikeza imiphumela ye-lipid-lowing kanye ne-hypoglycemic.
I-Lipoic acid isebenzisa inqubo yokuguqulwa kwe-cholesterol.
Kodwa-ke, ngenxa yokuxineka okukhulu kwe-lipoic acid, ubungozi bokuqhamuka nemiphumela emibi ngesikhathi sokwelashwa nge-Berlition kukhuphuka. Uma isixazululo sifakwe emthanjeni, ubukhulu bokubonakaliswa kwemiphumela emibi buyancipha. Lokhu kungenxa yokuqukethwe kumalungiselelo we-lipoic acid ngendlela kasawoti.
I-Pharmacokinetics
Ithuluzi libonakaliswa yi-bioavailability ephansi (kufika ku-30%). Ngokushesha ngemuva kokungena, into esebenzayo iguqulwa ibe ukwakheka kwama-metabolites. Lokhu kungumphumela wezinqubo eziningi - i-oxidation ne-conjugation. Izinto ezikhishwe ngenxa ye-metabolism zivezwa ngesikhathi sokuchama. Ukuqedwa kwesigamu sempilo akudluli imizuzu engama-50. Umsebenzi ophakeme wesidakamizwa ufinyelelwa kungakadluli ihora eli-1.
Izinkomba zokusetshenziswa
Isidakamizwa sinconywa ukuthi sisetshenziswe kulezo zimo ze-pathological:
- ukulimala okuningana kwemizwa ye-etiologies ehlukahlukene, okuholela ekubonakaleni kwezimpawu ezithambile zokukhubazeka, umuthi ungasetjenziswa kwisifo sikashukela i-mellitus (diabetesic polyneuropathy) nasezimweni lapho kuvela lezo zimpawu ngenxa yokuchayeka kotshwala;
- ukuthuthukiswa kwezinqubo ze-dystrophic kwezicubu zesibindi ngokumelene nesizinda sokuqongelela kwamafutha ngamaseli awo;
- ukudakwa okungapheli;
- i-hepatitis, eyaqala ngenxa yokwephulwa kwezinqubo ze-biochemical kumaseli wesibindi.
Contraindication
Umuthi awukwazi ukusetshenziswa lapho kuboniswa ukusabela komuntu kunoma iyiphi ikhemikhali ekwakhekeni. Ayikho eminye imikhawulo lapho usebenzisa umuthi.
Amacwecwe asetshenziselwa i-glucose-galactose malabsorption syndrome, ukungabekezelelani kwe-lactose kanye nokuntuleka kwe-lactase. Lokhu kungenxa yokwakheka komkhiqizo.
Ungayithatha kanjani
Umuthi osefomini le-ketshezi uvinjelwe ngaphambili ngesisombululo se-sodium chloride (0.9%). Isilinganiso esinconyiwe: 12-24 ml wesidakamizwa uhlanganiswa no-250 ml we-NaCl. Isixazululo esiphelile singasetshenziswa emahoreni ayi-6 ngemuva kokulungiswa, kepha kufanele sivikeleke ekukhanyeni, i-foil ilungele lokhu. Kodwa-ke, kungcono ukusebenzisa umuthi ngokushesha ngemuva kokulungiselela - kuleli cala, amathuba okuthola imiphumela oyifunayo ngesikhathi sokwelashwa ayanda, ngoba izimo ezingalungile zokugcina zingadala ukwehla ekusebenzeni komuthi.
Kwabadala
Umuthi ngezindlela ezahlukahlukene usetshenziswa ngokwezinhlelo ezahlukahlukene. Imiyalo esetshenzisiwe:
- Izibhebhe: ama-1-2 ama-PC. ngosuku;
- ukumnika: 12-24 ml (umthamo wansuku zonke), into ewuketshezi ihanjiswa ngokudonsa ngamandla, ngaphakathi, ukufeza umphumela oyifunayo, umuthi uhanjiswa egazini kancane kancane (kungakapheli isigamu sehora).
Akunakwenzeka ukwedlula umthamo omkhulu wansuku zonke we-ejenti wokuphathwa kwe-intravenous (50 mg). Lapho wenza ama-infusions, inkambo yokwelashwa ikhawulelwe enyangeni eyi-1. Ekupheleni kwalesi sikhathi, kunconywa ukushintshela kumathebhulethi (300 mg ngosuku).
Akunakwenzeka ukwedlula umthamo omkhulu wansuku zonke we-ejenti wokuphathwa kwe-intravenous (50 mg).
Okwezingane
Ayabelwe.
Ukwelashwa kwesifo sikashukela
Umthamo onqunyelwe nsuku zonke ngu-600 mg. Inkambo yokwelashwa ihlala isikhathi esingaphezu kwamaviki ama-3. Ngama-polyneuropathy ozimele, ukwelashwa okude kwenziwa - izinyanga ezi-4. Umthamo uvamile.
Imiphumela emibi
Uma isixazululo sisetshenziselwa imijovo, okungukuthi, i-lipoic acid ekwakhiweni kwento ewuketshezi ihanjiswa egazini ngokushesha, umfutho wegazi ungakhuphuka kakhulu, okuthi kube nomthelela wokuthi umuzwa onzima ekhanda. Kwesinye isikhathi lesi simo se-pathological sihambisana nobunzima bokuphefumula.
Izitho zeHematopoietic
Kukhona ukwephulwa komsebenzi we-platelet. Amathuba okukhula kwe-purpura akhula.
Isistimu yezinzwa ephakathi
Mhlawumbe ukuthikamezeka okubukwayo, okubonakala ngokuhlukaniswa kwezinto. Amathuba okuxhuga ayanda, umbono wezinguquko zokunambitheka.
Ngasohlangothini lwe-metabolism
I-glucose emzimbeni iyancipha. Kwesinye isikhathi kuba nezimpawu zesimo se-hypoglycemic: ukukhanda ikhanda nesiyezi, ukujuluka okukhuphukayo kanye nombono ofiphele.
Kusuka emasosheni omzimba
Ukushaqeka kwe-Anaphylactic (akuvamile).
Allergies
I-Urticaria. Izimpawu: ukulunywa, ukuqubuka, ukuvuvukala. Ephuzwini lokufakwa kwenalithi ngesikhathi sokufakwa, ukuhlanganiswa, ukuvutha kwenzeka.
Imiyalo ekhethekile
Uma kutholakala isifo sikashukela, ukugxila koshukela egazini kubhekwa njalo. Lokhu kungenxa yengozi yokwehla okungazelelwe kokuqukethwe kwalesi zinto emzimbeni. Uma imiphumela emibi ivele esigabeni sokuqala sokwelashwa, irejimeni yokwelashwa iyabuyekezwa. Uma kunesidingo, umthamo we-insulin noma amanye ama-hypoglycemic agents, ovame ukubekwa kulesi simo se-pathological, uyancishiswa.
Ukuhambisana notshwala
Ngaphandle kokukwazi ukuqeda izimpawu ze-polyneuropathy yotshwala, umuthi akufanele uthathwe kanyekanye ne-ethanol - kulokhu, ukusebenza kwe-lipoic acid kuyancipha.
Uma kutholakala isifo sikashukela, ukugxila koshukela egazini kubhekwa njalo.
Umthelela ekhonweni lokulawula izindlela
Ucwaningo alwenziwe, kepha, kufanele kukhunjulwe ukuthi i-Berlition ibangela ukungaboni kahle futhi ingavusa ukubonakala kwesimo se-hypoglycemic.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Ayinqunyelwe, ngoba akukho mininingwane mayelana nethonya lemiphumela emibi ye-lipoic acid kwi-fetus.
Ukweqisa
Ngokukhula komthamo womuthi, kuzabonakala izimpawu ezilandelayo:
- isicanucanu
- ukuhlanza
- ikhanda.
Uma isiguli sithathe amaphilisi angaphezu kwama-20 we-300 mg kanye, kuvela ezinye izimpawu: ukwazi ukungasebenzi kahle, ukuquleka, ukukhathazeka ngokweqile, ukwehla okukhulu kwamazinga eglucose, kuyilapho kwenzeka isimo esihle, izinqubo ze-necrotic ezicutshini zikhula ngamandla, umsebenzi wamathambo ukhubazekile.
Ukuqeda ukubonakaliswa okungekuhle futhi okusongela impilo, ukwelashwa okubonakalayo kuyenziwa, asikho isidakamizwa esithile sokudakwa nge-lipoic acid.
Ukuxhumana nezinye izidakamizwa
Ungasebenzisi imikhiqizo yensimbi ne-calcium ne-Berlition ngasikhathi sinye. Ngenxa yesizathu esifanayo, imikhiqizo yobisi inconywa ukuba idliwe ngemuva kwasemini noma kusihlwa.
I-Cisplatin kanye nomuthi okukhulunywa ngawo awahlanganisiwe, ngoba Ukusebenzisana okusebenzayo kwe-lipoic acid enezinsimbi zensimbi kuyaphawulwa.
Ukusetshenziswa kwe-Berlition nezinye izidakamizwa ze-hypoglycemic kuholela ekwehlekeni okusheshayo kwamazinga kashukela egazini.
Ama-Analoggs we-Berlition 300
Ukufakwa esikhundleni okusebenzayo:
- UTogogma (Germany);
- I-Oktolipen (Russia);
- I-Thioctacid (Germany);
- I-Tiolipon (Russia).
Eyokuqala yamalungiselelo isesimweni samathebhulethi, isisombululo sokufakwa, kanye nokugxila, ongalungisa ngaso isisombululo. Ingxenye ekhombisa umsebenzi we-hepatoprotective yi-lipoic acid
kakhulu. Ukuhlushwa kwethebhulethi engu-1 ngu-600 mg. Leli nani lilingana nosuku.
I-Oktolipen ekwakhekeni nasekugxileni kwengxenye eyinhloko i-analogue eqondile yeBerlition. Kutholakala kumakhompiyutha, ngesimo sesisombululo kanye nento ehlanganisiwe esetshenziselwa ukulungisa umuthi owuketshezi. Enye i-analogue yesidakamizwa okukhulunywa ngaso (i-Thioctacid) ingathengwa kumathebulethi. Uqukethe i-lipoic acid, ngokuya ngomgomo wesenzo awufani ne-Berlition. Umthamo wesithako esisebenzayo kuthebhulethi engu-1 300 mg.
I-Thiolipone iqukethe i-thioctic acid. Kukhiqizwa kumathebhulethi ahlanganiswe nenethiwekhi ekhethekile. Ukuqoqwa kwento esebenzayo ku-1 pc. - 600 mg. Leli nani lilingana nosuku.
Imibandela yekhefu lekhemisi
Umuthi umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela
Cha.
Intengo
Izindleko ezijwayelekile ngama-ruble angama-600.
Izimo zokugcina ze-Berlition 300
Ibanga lokushisa elinconyelwe: kufika ku- + 25 ° ะก. Kubalulekile ukuvikela umkhiqizo ekuchayweni ngemisebe ye-ultraviolet.
Isikhathi sokuphelelwa yisikhathi
Amacwecwe agcina izakhiwo zawo zokwelapha iminyaka engu-2, isisombululo seminyaka emithathu.
Ukubuyekezwa kwe-Berlition 300
Odokotela
I-Dustov B.S., isazi sezinzwa, i-Perm
Lesi sidakamizwa sithokozwa kakhulu yibo bonke abangane bezempilo abasebenza nami. Isixazululo sika-Berlition ezimweni eziningi ngincoma iziguli ukuthi zingangeni isikhathi esingaphezu kweviki elilodwa. Ngemuva kwalokho ngihumushela ezibhebheni. Uketshezi luthambile
e, ukusabela okungekuhle kuleli cala kuyaqabukela kukhula.
I-Felbush A.A., isazi sezinzwa, uVladimir
Ithuluzi lisebenza kakhulu kuma-mono-and polyneuropathies. Ngiyinikeza njengengxenye yokwelapha okuyinkimbinkimbi. Ngenxa yokufakwa ngokushesha kwento esebenzayo, umphumela omuhle uyaqinisekiswa ngokushesha.
Ukuvela kwenicanucanu, ukugabha kuwuphawu lokusebenzisa ngokweqile umuthi i-Berlition.
Iziguli
UMarina, oneminyaka engama-34 ubudala, uNovomoskovsk
Wathatha umuthi nge-polyneuropathy ye-etiology engaziwa; irejimeni ejwayelekile yanqunywa. Cishe ngokushesha nje ngemuva kokuqala kokudakwa kwaba nezimpawu zokudakwa: izinga lokushisa lomzimba landa, ukubanda, ukuvela kwekhanda kwavela.
USvetlana, oneminyaka engama-39, uSamara
Isidakamizwa sithathwe sinoshukela omningi. Lingakapheli isonto ngibone izinguquko ezinhle. Izinga likashukela lehlile izikhathi ezi-2, kancane kancane isimo sathuthuka. Esigabeni sokuqala sokwelashwa, kuvela ikhanda, kepha kwadlula ngokushesha. Ngaphezu kwalokho, ngiqaphela umphumela wokunciphisa umzimba ngesikhathi sokwelashwa.
