Ungayisebenzisa kanjani isidakamizwa i-Glyformin Prolong?

IGlatini Prolong umuthi osetshenziselwa ukwelapha isifo sikashukela sohlobo 2.

Igama Lezwe elingafanele

I-Metformin.

I-ATX

Ikhodi ye-ATX: A10BA02.

IGlatini Prolong umuthi osetshenziselwa ukwelapha isifo sikashukela sohlobo 2.

Khipha amafomu nokwakheka

Umuthi usesimweni samacwecwe. Amakhebuli ahlanganiswa amafilimu futhi abe nomphumela wesikhathi eside.

Umbala wegobolondo uyahluka kusuka ophuzi kuya kokuphuzi okukhanyayo. Okuqukethwe ngaphakathi kumhlophe ngombala omncane ophuzi. Ithebhulethi inesimo se-oval biconvex.

Isithako esikhulu esisebenzayo yi-metformin hydrochloride. Umuthi uqukethe izingxenye ezisizayo:

• i-methyl acrylate ne-ethyl acrylate njengama-Copolymers;
• i-hypromellose;
• i-microcrystalline cellulose;
• i-silicon dioxide.

Ukwakheka kwegobolondo kufaka i-talc, glycerol, imibala yokudla. Amacwecwe agcwele emithini yamapulasitiki noma emabhodleleni ama-30 noma angama-60 ama-PC. Ukufakwa kwangaphandle okwenziwe ngekhadibhodi.

Umuthi usesimweni samacwecwe. Amakhebuli ahlanganiswa amafilimu futhi abe nomphumela wesikhathi eside.

Isithako esikhulu esisebenzayo yi-metformin hydrochloride.

I-Glyformin isiza ukunciphisa ukunciphisa i-glucose egazini le-plasma yegazi.

Isenzo se-Pharmacological

Ingxenye eyinhloko ivimbela i-gluconeogeneis futhi ivimbele ukwakheka kwamafutha acid. Amandla we-lipid peroxidation ancishisiwe. Isiza ekunciphiseni ukugxilisa i-plasma glucose.

Ukuzwela kwe-peripheral insulin receptors kuyanda kanye nomuthi.

Akuthinti ukuvikelwa kwe-insulin. Isakhi esiyinhloko siguqula ama-pharmacodynamics we-insulin yamahhala, futhi sithuthukisa namandla okuhamba kwezitho zamangqamuzana.

I-Metformin ithuthukisa ukwakheka kwe-glycogen ngenkathi inciphisa ukumuncwa kwe-glucose emathunjini.

Isithako esisebenzayo sithuthukisa izakhiwo ze-fibrinolytic zegazi.

Inani lama-triglycerides, ama-asidi e-saturated and unsaturated ancishisiwe.

Ngokuphikisana nesizinda sokuthatha umuthi, isisindo sesiguli siyazinza futhi siqala ukuncipha kancane.

I-Pharmacokinetics

Lapho ungenile, umuthi udonswa usuka emathunjini kancane. Ukuhlushwa okuphezulu kutholakala emahoreni angama-2-3 ngemuva kokuthatha iphilisi. I-Bioavailability ingama-60%. Into esebenzayo ayibanjwanga yi-albhamu ye-plasma futhi idonswa amaseli omzimba ngokushesha. Umuthi ugcotshwa kakhulu ngenkani ezicutshini zezinso, isibindi kanye nezindlala zamathe.

Ayikhiqizwanga esibindini. Kuboniswa kungashintshiwe ngohlelo lwe-excretory. Isikhathi sokuphila se-glyformin isikhathi eside sisuka emahoreni amabili kuya kwayisithupha.

Izinkomba zokusetshenziswa

I-Metformin ibekelwa ukwelashwa kwe-mellitus engavikelekile nge-insulin ngokudla okunganele nokuzivocavoca kwiziguli ezikhuluphele.

Kubantu abadala, isetshenziswa ngokuhlukile futhi ngokuhlanganiswa namanye ama-hypoglycemic agents.

Ngenkathi uthatha umuthi, isisindo sesiguli siyazinza futhi siqala ukuncipha kancane.

Lapho ungenile, umuthi udonswa usuka emathunjini kancane. Ukuhlushwa okuphezulu kutholakala emahoreni angama-2-3 ngemuva kokuphathwa.

Kubantu abadala, isidakamizwa sisetshenziswa bobabili ngokwehlukana futhi sihlanganiswa namanye ama-hypoglycemic agents.

Ezinganeni ezingaphezulu kweminyaka engu-10 ubudala, iGlatiniin lingasetshenziswa lodwa noma lihlanganiswe ne-insulin.

Ezinganeni ezingaphezulu kweminyaka engu-10 ubudala, zingasetshenziswa ngokuhlukile futhi ngokuhlanganiswa ne-insulin.

Contraindication

Ukuxhunyaniswa ngomuthi kukhonjisiwe kwimiyalo yokusebenzisa:

• i-acute noma i-acidosis engamahlalakhona;
• isifo sikashukela sikashukela;
• isifo sikashukela noma isimo sokuqaqamba;
• izifo ezinzima;
• umkhuhlane
• ukuphelelwa amandla emzimbeni noma ukukhathala komzimba;
• ukungasebenzi kahle kwe-renal ngokwehla kwezinga lokuhlunga kwe-renal liye kuma-60 ml ngomzuzu noma ngaphansi;
• ukuhluleka kwenhliziyo noma i-myocardial infarction;
• ezinye izifo ezihambisana nokubulawa yindlala kwamaseli;
• ubuthi be-ethanol acute;
• uphuzo oludakayo;
• Ukusetshenziswa kokuqukatha okuqukethe iodine we-radiogra noma i-compact tomography yemithambo yegazi, isimangalo senyongo kanye nepheshana lomchamo.
• hypersensitivity yomuntu ngamunye ezingxenyeni eziyinhloko noma ezisizayo zomuthi.

Ngokunakekela

Iziguli ezineminyaka engaphezu kwengama-60 ezithola ukuzikhandla ngokomzimba zinobungozi obukhulu bokuhlakulela i-lactic acidosis.

Ngokuphikisana nomuthi, kuvezwa i-acidosis noma i-acidosis engalapheki.

UGliformin wenqatshelwe ukwehluleka kwenhliziyo.

Ngomkhuhlane, ukuphuza umuthi akunconywa.

Lapho uthatha umuthi ezigulini ezineminyaka engaphezu kwengu-60 ubudala, ubhekana nokuzivocavoca okuphezulu komzimba, ingozi ye-lactic acidosis iphakeme.

Ngesikhathi sokuqunjelwa, ungasebenzisa umuthi ngaphansi kokuqondisa udokotela.

Ngesikhathi sokuqunjelwa, ungasebenzisa umuthi ngaphansi kokuqondisa udokotela.

Ungayithatha kanjani i-Glyformin Prolong

Izibhebhe zithathwa ngomlomo ngesikhathi noma ngemuva kokudla ngenani elincane lamanzi.

Ngoshukela

Ngesikhathi se-monotherapy kubantu abadala, umthamo wokuqala wesidakamizwa wokuphathwa komlomo owodwa ngu-500 mg. Inani lokwamukelwa ngosuku lisuka ku-1 liye ku-3.

Umthamo omkhulu ovunyelwe yi-2 g ngosuku. Inani losuku lomuthi lihlukaniswe ngemithamo engu-2-3.

Umthamo ukhuphuka kancane kancane emavikini ambalwa.

Inani le-glucose egazini liqashelwa kusetshenziswa izivivinyo, kususelwa enkombeni, umthamo uguqulwa.

Izibhebhe zithathwa ngomlomo ngesikhathi noma ngemuva kokudla ngenani elincane lamanzi.

Imiphumela emibi

Ezinganeni nakubantu abadala, imiphumela efanayo emibi yenzeka lapho usebenzisa umuthi.

Amapheshana wesisu

Imiphumela emibi evela emgodini wesisu ibonwa phakathi neviki lokuqala lokwelashwa, bese wedlula. Kungakhula:

• isicanucanu
• ukushisa kwenhliziyo;
• ukuthopha;
• ukugabha noma isifo sohudo;
• Ubuhlungu besisu.

Ezimweni ezingavamile, i-hepatitis yezidakamizwa iye yabonwa.

Izitho zeHematopoietic

I-anemopablastic anemia ehambisana nokungasebenzi kahle kwe-vitamin b12 metabolism ingakhula.

Imiphumela emibi evela emgodini wesisu (ngokwesibonelo, isicanucanu) ibonwa ngeviki lokuqala lokwelashwa, bese idlula emhlabeni.

Ngokusetshenziswa isikhathi eside kweGliformin, ukuntuleka kwevithamini b12 kungakhula.

Umphumela ongaba khona womuthi yi-hypoglycemia, obangelwa ukusetshenziswa komuthi ongalungile nomuthi.

Ngasohlangothini lwe-metabolism

Kukhona ubungozi be-lactic acidosis. Ngokusetshenziswa isikhathi eside, ukuntuleka kwevithamini b12 kungakhula.

Kusuka ohlelweni lwezitho zofuzo

Kusuka emiphumeleni emibi yohlelo ayimisiwe.

Uhlelo lwe-Endocrine

I-Hypoglycemia ebangelwa ukusetshenziswa komuthi ongalungile wesidakamizwa.

Allergies

Imvamisa, kuphenduka khona isikhumba: ubomvu, ukuqubuka, ukulunywa, i-dermatitis ye-allergic.

Umthelela ekhonweni lokulawula izindlela

Umuthi awuthinti uhlelo lwezinzwa. Ukushayela kuvunyelwe ngesikhathi sokwelashwa.

Imvamisa, lapho uthatha umuthi, ukuvela kwesikhumba kukhula ngendlela yokulunywa.

Ngesikhathi sokulashwa, ukushayela kuvunyelwe.

Ngesikhathi sokukhulelwa, umuthi awunconywa.

Imiyalo ekhethekile

Umthamo ulungiswa njengoba ungadingeki isikhathi esinge-1 ngeviki. Lapho kuhlangene ne-insulin ezinganeni, kuyanda ukwelashwa okulawulwa ngudokotela ukuze ugweme i-hypoglycemia.

Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba

Isifo sikashukela esiwohlokile sithinta ukuthuthukiswa kokuphazamiseka kwemvelo ku-fetus. Ngesikhathi sokukhulelwa, umuthi awunconywa. Ngesikhathi sokuncelisa, i-ejenti ye-hypoglycemic inqunywa ngokuqapha.

Ukunquma ukwandisa isikhathi se-glyformin ezinganeni

Ayisetshenziswanga ukuphatha izingane ezingaphansi kweminyaka eyi-10.

Sebenzisa ebudaleni

Iziguli ezineminyaka engaphezulu kweminyaka engama-60 zisengozini ephezulu yokuhlakulela i-acidosis, ngenxa yalokho, ukuqashwa kukadokotela kuyadingeka.

Isicelo sokusebenza kokulimala kwezinso

Uma isiguli sinokuhluleka okungapheli kwe-renal, umuthi awusetshenziswa.

Uma isiguli sinokuhluleka okungapheli kwe-renal, umuthi awusetshenziswa.

Sebenzisa umsebenzi wesibindi okhubazekile

Ngokuhluleka kwesibindi, kuvunyelwe ukusetshenziswa ngokuqapha, ngoba isakhi esiyinhloko asenziwa ngamaseli wesibindi.

Ukweqisa

Ngomthamo ojwayelekile owedlulele, umuthi unqwabelana ezinso. I-lactic acidosis iyakhula. Umphumela we-Lethal kungenzeka. Izimpawu ezilandelayo ziyaphawulwa:

• ukwehla okukhulu kokushisa komzimba;
• ukuhlanza
• Ubuhlungu esiswini;
• imisipha nobuhlungu obuhlangene;
• i-arterial hypotension ngokuhambisana nokwehla kwesilinganiso senhliziyo;
• ukuphefumula ngokushesha.

Ngokukhuphuka kwe-lactic acid egazini, isiyezi, ukufiphala, nethala kuyabonakala.

Uma kusolwa i-overdose, ukwelashwa kwezidakamizwa kuyakhanselwa. Isiguli kufanele siyiswe esikhungweni sezokwelapha ngokushesha okukhulu.

Ngemithamo ejwayelekile yomuthi, i-lactic acidosis iyakhula. Ukwehluleka kungenzeka.

Uma kwenzeka kwe-overdose, i-hypotension ye-arterial ibonwa ngokuhambisana nokwehla kwesilinganiso senhliziyo.

Uma usola ngokweqile isiguli, kufanele uyiswe esikhungweni sezokwelapha ngokushesha okukhulu.

I-Hemodialysis kanye nokwelashwa okubonakalayo kuyenziwa.

Ukuxhumana nezinye izidakamizwa

Ngokuphathwa kanyekanye ne-insulin, i-sulfonamides, umphumela wesidakamizwa we-hypoglycemic uyathuthukiswa, okungaholela ekwakhiweni kwe-hypoglycemia.

Ngokusetshenziswa kanye kanye nezindlela zokuvimbela inzalo zama-hormonal, ama-hormone wezindlala ze-adrenal noma i-yegland yegilo, umphumela wezidakamizwa uyancipha.

I-Loop diuretics isheshisa ukugcotshwa kwengxenye eyinhloko, okunciphisa umphumela okhiqizwayo.

Izivuseleli ze-B2-adrenergic zandisa ushukela wegazi.

I-Cimetidine inyusa inani le-lactic acid. Ngokuhlanganiswa kwezidakamizwa, ubungozi be-acidosis buphakeme.

I-Nifedipine inyusa ukumunca umuthi.

Ngokusetshenziswa ngasikhathi sinye kweGliformin ngezindlela zokuvimbela inzalo zama-hormonal, umphumela wezidakamizwa uyancipha.

I-Cimetidine inyusa inani le-lactic acid. Ngokuhlanganiswa kwezidakamizwa, ubungozi be-acidosis buphakeme.

Kuyenqatshelwe ngokuphelele ukuphuza utshwala ngesikhathi sokwelashwa.

Isakhi esiyinhloko sokwenza buthaka umphumela wezidakamizwa ze-anticoagulation.

Ukuhambisana notshwala

Ukuphuza utshwala kanyekanye nomuthi kukhulisa ubungozi be-lactic acidosis. Kuyenqatshelwe ngokuphelele ukuphuza utshwala ngesikhathi sokwelashwa.

Ama-Analog

Ukufana kwezidakamizwa yilezi:

• IFommetin;
• I-Glucophage ende;
• UGliformin Berlin Chemie;
• I-Ssiofor 1000;
• I-Bagomet;
• I-Metfogama.

Uyini umehluko phakathi kukaGliformin noGlattin Prolong

I-Gliformin iyi-analogue yesidakamizwa nesikhathi esifushane sokusebenza. Isigamu sempilo sisuka emahoreni ayi-1.5 kuye kwayi-4.

Ukwakheka okufanayo kufomu le-formmetin.

Enye indlela, ungakhetha i-Glucofage Long.

I-Gliformin iyi-analogue yesidakamizwa nesikhathi esifushane sokusebenza.

Imibandela yokusetshenziswa kweGlyformin Prolong Z Pharmacy

Umuthi usatshalaliswa kuphela ngomuthi odingekayo.

Intengo Yokwandisa i-Glyformin

E-Russia, izindleko zomuthi ziqala kusuka kuma-ruble angama-200.

Izimo zokugcina zomuthi

Umuthi ungoweqembu B. Kuvunyelwe ukugcina umuthi endaweni emnyama neyomile endaweni yokushisa engeqi ngama-25 ° C. Gwema kude nezingane.

Isikhathi sokuphelelwa yisikhathi

Umuthi uvunyelwe ukugcinwa iminyaka emi-2. Usuku lokukhiqiza lukhonjisiwe kwiphakheji.

Umkhiqizi we-Gliformin Prolong

Umuthi ukhiqizwa yiPlant of Medicines in the Republic of Belarus.

Ukubuyekezwa mayelana nokunwebeka kwe-Gliformin

Umuthi uthandwa ngabodokotela kanye neziguli zombili.

Odokotela

U-Olga Belyshova, udokotela wezokwelapha, eMoscow: "Umuthi unikeza ukwehla okuzinzile ushukela wegazi futhi kuthuthukisa isimo samaseli."

U-Egor Smirnov, i-endocrinologist, uSochi: "Umuthi awunconywa ukuthi usetshenziswe ngasikhathi sinye namalungiselelo e-thyroid, ngoba kuleli cala umphumela wazo zombili izidakamizwa uncishisiwe."

Iziguli

U-Elena, oneminyaka engama-48 ubudala, uSt. Petersburg "Ukuthatha lesi sidakamizwa kunikeza ukwehla okuzinzile ushukela wegazi."

U-Oleg, oneminyaka engama-35, uSyzran: "Ngiqale ukuphuza lesi sidakamizwa ngonyaka owedlule. Izinga likashukela lihlala lisesimweni esejwayelekile."

Ukulahlekelwa isisindo

U-Ekaterina, oneminyaka engama-39: "Ngisebenzisa amaphilisi ngaphezu kokudla. Ezinyangeni ezi-3 ngilahlekelwe ngamakhilogremu ayi-8. Isisindo asibuyi futhi sisalokhu sisezingeni."

U-Alexandra, oneminyaka engama-28 ubudala: "Ngokuhlanganiswa kwezokwelapha, ukudla nokuzivocavoca, wehlise isisindo sisuka ku-72 kuye kuma-65 kg."