Imiphumela Yesifo Sikashukela sePentoxifylline

Ekwelashweni okuyinkimbinkimbi kwezifo ezihambisana nokuphazamiseka esimisweni sokujikeleza kwegazi, kuboniswa ukusetshenziswa kwama-vasodilators, kufaka phakathi iPentoxifylline.

Lapho usebenzisa umuthi, imiyalo enamathiselwe kufanele ibhekwe ngokuqinile.

I-ATX

C04AD03.

Amalungiselelo we-Pentoxifylline anconyelwa ngokusemthethweni ukuthi asetshenziswe ekwelapheni izilonda ezikhuluphayo, i-gangrene, angiopathy kanye nokuphambuka ohlelweni olubonakalayo ezigulini ezinesifo sikashukela.

Khipha amafomu nokwakheka

Umuthi wenziwa ngesimo samathebhulethi, ama-dragees kanye nesixazululo esenzelwe i-infravenous infusions (amaconsi), imijovo kanye nokuphathwa kwemithambo.

Kungakhathalekile ukuthi hlobo luni lokukhululwa, umuthi uqukethe isithako esiyisisekelo esisebenzayo - i-pentoxifylline (ngesiLatin - Pentoxyphyllinum).

Kulokhu, umthamo wengxenye esebenzayo ungahluka.

Amaphilisi

Amathebulethi e-enteric afakiwe aqukethe i-100 mg ye-pentoxifylline.

Umuthi ungoweqembu lama-vasodilators (vasodilators).

Isixazululo

Isixazululo esisetshenziselwe umjovo siqukethe ama-20 mg wezithako ezisebenzayo nge-1 ml. Umuthi uthengiswa ngama-ampoules we-1, 2, 5 ml.

Ubhontshisi weJelly

Ama-Dragees (retard) angamakhompiyutha anolwelwesi lwamafilimu apinki. Ku-1 ithebhulethi kuqukethe i-400 mg yento esebenzayo.

Indlela yokusebenza

Umuthi ungoweqembu lama-vasodilators (vasodilators).

Umphumela wemithi yesidakamizwa ihloselwe ukujikeleza kwegazi okujwayelekile nokwenza ngcono izakhiwo zegazi.

Lo muthi unomphumela olandelayo emzimbeni wesiguli:

• kunciphisa ukubukeka kwegazi, kunciphisa amathuba okuqhekeka kwegazi;
• ivuselela imithambo yegazi (ngokulinganisa), isusa izinkinga nge-microcirculation yegazi;
• ikhuthaza ukugcotshwa kwezicubu ezinomoya-mpilo, ukuvimbela ukukhula kwe-hypoxia (ngenxa yokwanda kwemikhumbi ye-pulmonary and inhliziyo);
• kwandisa ithoni yesiphambano, izicubu zokuphefumula;
• umphumela onenzuzo emsebenzini wohlelo lwezinzwa;
• Isiza ukuqeda ama-cramps kanye nobuhlungu emisipha yethole ehambisana nokuphazamiseka kokujikeleza emilenzeni.

Umuthi unciphisa ukuvela kwegazi, wehlise amathuba okuqhekeka kwegazi.

I-Pharmacokinetics

Izinto ezisebenzayo zomuthi zidonswa kahle egazini zisuka emgodini wokugaya ukudla futhi zithambisa kancane esibindini. Izakhi zemithi zikhishwa emzimbeni phakathi nosuku zingena ezinso (ngomchamo) kanye namathumbu (anezindunduma).

Okusizayo

Umuthi usetshenziswa ekwelapheni ama-pathologies alandelayo:

• ukwephulwa kokuhlinzekwa kwegazi okungezona ezandleni nasezinyaweni (isifo sikaRaynaud);
• ukulimala kwezicubu ngenxa yokulimala kwe-microcirculation yegazi emithanjeni nasemithanjeni (izilonda zesikhumba ezindexekile, isifo se-posthlebotic, gangrene);
• ukulimala kokubuka nokuzwa okuhambisana nokuntuleka kokujikeleza kwegazi;
• i-ischemia yobuchopho yobuchopho;
• Isifo sikaBuerger (i-thromboangiitis obliterans);
• ukungakwazi okubangelwa ukunikezwa kwegazi okunganele ezithweni zokuzala;
• isifo sokuqina kwemizwa;
• i-arterial hypertension;
• angiopathy ezigulini ezinesifo sikashukela i-mellitus;
• isifo senhliziyo;
• i-vegetovascular dystonia;
• encephalopathy yama-etiologies ahlukahlukene.

Umuthi usetshenziswa ekwelapheni iRaynaud's syndrome.

Umuthi uyasebenza kwi-ischemia ye-cerebral.

I-Pentoxifylline isetshenziselwa ukungabinamandla okubangelwa ukunikezwa kwegazi okunganele kwizitho zokuzala.

Ithuluzi lisetshenziselwa ukwelapha umfutho wegazi ophakeme.

I-Pentoxifylline isetshenziswa ekwelapheni i-angiopathy ezigulini ezinesifo sikashukela i-mellitus.

I-Pentoxifylline imiselwe i-vegetovascular dystonia.

Ithuluzi libuye lusetshenziswe ekwelapheni i-osteochondrosis njenge-vasodilator esekelayo.

Contraindication

Uhlu lwe-contraindication ekusebenziseni umuthi lubandakanya:

• isifo se-porphyrin;
• i-infarction ye-myocardial eyingozi kakhulu;
• i-retinal hemorrhage;
• ukopha kakhulu.

Isixazululo asisetshenziselwa i-atherosulinosis yemithambo yobuchopho nenhliziyo kanye ne-hypotension enzima.

Ukusetshenziswa kwe-Pentoxifylline akufakwanga ezigulini ezine-hypersensitivity engxenyeni esebenzayo yesidakamizwa, ama-excipients afakiwe ekwakhiweni kwawo, noma eminye imithi eqenjini le-xanthine.

Nge-atherosclerosis yemithambo yobuchopho nenhliziyo, ungasebenzisi umuthi ngendlela yesisombululo.

Ungayithatha kanjani

Umuthi, otholakala ngesimo se-dragees kanye namathebulethi, uhloselwe ukuphathwa ngomlomo. Sebenzisa umuthi ngemuva kokudla. Awukwazi ukuhlafuna amaphilisi. Kufanele zigezwe ngamanzi amancane.

Udokotela unquma isilinganiso esifanele somuthi ngamunye esigulini ngasinye, kucatshangelwa izici zomzimba wakhe futhi kususelwa kwimininingwane evela esithombeni somtholampilo walesi sifo. I-standard dimage regimen ingu-600 mg ngosuku (200 mg izikhathi ezi-3 ngosuku). Ngemuva kwamaviki angu-1-2, lapho izimpawu zokuphazamiseka zivela kancane, umthamo wansuku zonke wehliswa ube ngu-300 mg (100 mg izikhathi ezi-3 ngosuku). Ungathathi okungaphezulu kwenani eliphakanyisiwe lomuthi ngosuku (1200 mg).

Isikhathi sokwelashwa nge-pentoxifylline kumathebhulethi singamaviki ama-4 ukuya kwele-12.

Isixazululo singalawulwa ngokubandakanyeka, ngokomzimba nangaphakathi emithanjeni. Umthamo unqunywa ngawodwana, kucatshangelwa ubunzima bokuphazamiseka kwemithambo yegazi. Imiyalo yokusebenzisa umuthi ithi udinga ukusebenzisa ikhambi kanjena:

1. Ngendlela ye-droppers - i-0,0 g yesidakamizwa esixutshwe ne-250-500 ml kasawoti noma isisombululo se-5% kashukela. Kuyadingeka ukuphatha umuthi kancane, kungakapheli amahora angama-1.5 ukuya kwayi-8.
2. Imijovo (intravenous) - esigabeni sokuqala sokwelashwa, kunqunywe umuthi ongu-0,1 g (kuxutshwe ku-20-50 ml we-sodium chloride), khona-ke umthamo uyandiswa ube ngu-0-0-0.3 g (uhlanganiswe no-30-50 ml we-solvent). Umuthi kufanele uphathwe kancane (0.1 g imizuzu eyi-10).
3. Nge-intramuscularly, umuthi ubhalwa kumthamo we-200-300 mg izikhathi ezingama-2-3 ngosuku.

I-standard dimage regimen ingu-600 mg ngosuku (200 mg izikhathi ezi-3 ngosuku).

Ukusetshenziswa kwekhambi kungahlanganiswa nokuphathwa ngomlomo kwefomu lepilisi lomuthi.

Ngoshukela

Amalungiselelo we-Pentoxifylline anconyelwa ngokusemthethweni ukuthi asetshenziswe ekwelapheni izilonda ezikhuluphayo, i-gangrene, angiopathy kanye nokuphambuka ohlelweni olubonakalayo ezigulini ezinesifo sikashukela. Kodwa-ke, ungasiphuza lesi sidakamizwa kuphela njengoba kushiwo udokotela, obeka umthamo ngamunye futhi uyaqiniseka ukusilungisa uma isiguli sisebenzisa izidakamizwa ze-hypoglycemic. Ukuzilapha okwenziwe nge-pentoxifylline kulesi simo akwemukeleki, ngoba uhlobo lokwelashwa olukhethwe ngokungeyikho lungaholela ekwakhiweni kwemiphumela engathandeki (kufaka phakathi i-hypoglycemic coma).

I-Pentoxifylline ekwakheni umzimba

Ukusetshenziswa kwePentoxifylline kungaba wusizo hhayi ekwelapheni ama-pathologies ajikelezayo kuphela, kodwa futhi nakwezemidlalo, ngoba umuthi uyakwazi ukukhulisa ukusebenza kahle kokuqeqesha, ukhuphule ukukhuthazela, usheshise ukufezekiswa komphumela owufunayo ngenxa yemiphumela emihle emzimbeni.

I-Pentoxifylline iyakwazi ukukhulisa ukusebenza kahle kokuqeqeshwa, ikhulise ukukhuthazela, isheshise ukufezekiswa komphumela oyifunayo.

Abadlali kanye nabakhi bomzimba bayelulekwa ukuthi basebenzise leli khambi ngale ndlela elandelayo:

1. Kuyadingeka ukuqala ngomthamo omncane - 200 mg izikhathi ezi-2 ngosuku. Phuza amaphilisi ngemuva kokudla.
2. Uma ungekho imiphumela emibi nokubekezelela okuhle komuthi, ungakhulisa umthamo wansuku zonke uye ku-1200 mg (400 mg izikhathi ezi-3 ngosuku).
3. Ukuthola umphumela omuhle kakhulu, kunconywa ukuthatha umuthi imizuzu engama-30 ngaphambi kokuzivocavoca kanye namahora ambalwa ngemuva kokuqedwa kwawo.
4. Isikhathi sokusebenzisa umuthi singamaviki angama-3-4. Ngemuva kwesifundo, udinga ukuthatha ikhefu izinyanga ezingama-2-3.

Imiphumela emibi

Lapho uthatha umuthi, ukuvela kokungaphenduki okuhle kwezitho zangaphakathi nezinhlelo ezibalulekile akunqunyelwe.

Amapheshana wesisu

Umuthi ungadala ukuvuvukala kwesibindi, kuhambisane nobunzima bokuphuma kwesifo se-bile, ukwanda kwesifo sokuvuvukala kwe-gallbladder, ukuwohloka kokuqina kwamathumbu, ukuncipha kokudla, kanye nomuzwa wokuqina komgodi womlomo. Ezimweni ezingavamile, ukopha kwamathumbu kuyabonakala.

Ithuluzi lingadala ukuvuvukala kwesibindi, kuhambisane nobunzima ekuphumeni kweziqubu ze-bile.

Izitho zeHematopoietic

Ukusabela okulandelayo okungekuhle kusuka ohlelweni lokujikeleza igazi kungenzeka:

• ukwehla kwamazinga e-platelet egazini;
• ukwehla kwengcindezi yegazi;
• izinhlungu zenhliziyo
• ukuphazamiseka kwesigqi senhliziyo.

Isistimu yezinzwa ephakathi

Ukuqubuka, ikhanda, isiyezi, nokulala kabi kungenzeka.

Isiguli esithatha umuthi sivame ukungacasuki futhi sihlushwa ukukhathazeka ngokweqile.

Allergies

Lapho usebenzisa umuthi, ukusabela okwenziwa yisikhumba (ukulunywa, i-urticaria) kanye ne-anaphylactic shock kungenzeka.

Okunye ukusabela

Kungabakhona ukuwohloka kwesimo sezinwele, izinzipho, ukuvuvukala, ubomvu besikhumba (“amalangabi” egazi ebusweni nase esifubeni).

Lapho usebenzisa umuthi, ukuvela komzimba wesikhumba kanye ne-anaphylactic shock kungaqala ukwanda.

Ukwephulwa komqondo obonakalayo kanye nokuthuthukiswa kwama-scotomas wamehlo awafakwa ngaphandle.

Imiyalo ekhethekile

Ukwelashwa kwe-pentoxifylline kwenziwa ngokucophelela okukhulu kubantu abaphethwe yi-peptic ulcer yesisu kanye ne-duodenum, i-pathologies yezinso nesibindi, ukuhluleka kwenhliziyo, futhi bathambekele ekucindezelweni kwegazi eliphansi. Kulezi zigaba zeziguli, ukulungiswa komthamo ophoqelekile kanye nokulawulwa okuqinile kwezokwelapha kuyo yonke inkambo yokwelashwa kuyadingeka.

Ukuhambisana notshwala

Odokotela batusa ngokuqinile ukuthi iziguli eziphuza umuthi osuselwa kuPentoxifylline zingabandakanyi ukuphuza utshwala ngaphambi kokuqeda ukwelashwa.

Kunconywe ukuthi kuqedwe utshwala ngaphambi kokuthi kuqedwe ukwelashwa ngePentoxifylline.

I-Ethyl alcohol iyakwazi ukubopha kumamolekyulu ento yomuthi, iwahlukanise noma iqinise isenzo sezinto ezisebenzayo, okungaholela ekwehleni kokusebenza kwomuthi noma kubangele ubunzima.

Umthelela ekhonweni lokulawula izindlela

Umuthi awuthinti ngqo ikhono lokulawula izindlela eziyinkimbinkimbi, kufaka phakathi izimoto, noma kunjalo, uma imiphumela emibi (isiyezi, ukuphazamiseka kokulala, njll.) Kwenzeka, ukunaka kokunaka kwesiguli kungahle kume. Lokhu kunganciphisa ikhwalithi yokushayela nezinye izimoto.

Ngesikhathi sokukhulelwa nokuqunjelwa

Lapho uncelisa ibele nangesikhathi sokukhulelwa, ukusetshenziswa komuthi akuvunyelwe. Uma owesifazane onkulisa engakwazi ukugwema ukuphuza umuthi, kufanele ayeke ukuncelisa ibele ngaphambi kokuqeda ukwelashwa.

Yini ebekelwe izingane

Ukusebenza kahle nokuphepha kwalo muthi ebuntwaneni akufundiswanga, ngakho abakhiqizi bePentoxifylline abaphakamisi ukunquma lo muthi ezigulini ezingaphansi kweminyaka engu-18 ubudala.

I-Pentoxifylline ayinconywa kwiziguli ezingaphansi kweminyaka engu-18.

Kodwa-ke, ekusebenzeni, uma kunesidingo ngokuphelele, odokotela bangayinikeza lo muthi ingane engaphezu kweminyaka eyi-12. Imvamisa lokhu kubangelwa ukuphazamiseka okujikeleza kakhulu kwegazi nokungasebenzi kahle kwezinye izindlela zokwelapha.

Umthamo ekugugeni

Ebudaleni, ukuqedwa kwesidakamizwa kunciphisa, ngakho-ke kunconywa ukusebenzisa imithamo yomuthi encishisiwe.

Ukweqisa

Ngokusetshenziswa isikhathi eside kwemithamo ephezulu yemithi, kungavela lezi zimpawu ezilandelayo zokweqisa:

• isicanucanu, ukuhlanza "izizinda zekhofi" (kukhombisa ukuthuthukiswa kokopha kwesisu);
• Isiyezi
• ubuthakathaka
• iminyakazo.

Ezimweni ezimbi kakhulu zokweqisa kwezidakamizwa, ukufiphala, ukucindezelwa kokuphefumula, i-anaphylaxis kuyabonakala.

Ezimweni ezinzima kakhulu, ukuhoxa, ukucindezelwa kokuphefumula, i-anaphylaxis kuyabhekwa.

Ukuxhumana nezinye izidakamizwa

Umuthi ungakhuphula umphumela wezidakamizwa ezilandelayo:

• ama-anticoagulants;
• i-thrombolytics;
• izidakamizwa ezisehlisa umfutho wegazi;
• imithi elwa namagciwane
• izidakamizwa eziqukethe i-insulin ne-hypoglycemic;
• amalungiselelo we-valproic acid-based.

Ukusetshenziswa kanyekanye kwePentoxifylline nemithi equkethe i-cimetidine kwandisa ubungozi bemiphumela emibi. Ukulungiselela okususelwa ku-ketorolac naseMexico akuhambelani nePentoxifylline, ngoba uma bexhumana nomuthi, bakhulisa amathuba okuba nokopha kwangaphakathi.

Ungathenga umkhiqizo kuphela uma unemithi efanelekile enqunywe udokotela wakho.

Akunconyelwe ukuhlanganisa ukusetshenziswa komuthi nokusetshenziswa kwamanye ama-xanthines, ngoba lokhu kungadala ukweqiwa kwemizwa okweqile.

Ama-Analog

Ekwelashweni kwe-pathologies ebangelwa ukuphazamiseka kokujikeleza, asetshenziswa ama-analogues alandelayo wePentoxifylline:

• UCavinton;
• Trental;
• I-Pentoxifylline-NAS;
• I-Piracetam
• Pentilin;
• IMexidol;
• I-Fluxital;
• I-Latren;
• i-nicotinic acid.

Ukunquma ukuthi imuphi umuthi osetshenziselwa kangcono isifo esithile sokujikeleza kwegazi, kufanele uthintane nodokotela wakho.

Umkhiqizi

Umuthi okhiqizwa eRussia ukhiqizwa yizinkampani ezenza amakhambi i-Organika (Novokuznetsk) ne-Akrikhin (eMosos). Imithi efanayo yenziwa amafemu amaCzech (Zentiva) nama-Israeli (Teva).

Imibandela yekhefu lekhemisi

Ungathenga umkhiqizo kuphela uma unemithi efanelekile enqunywe udokotela wakho.

Intengo yePentoxifylline

Izidakamizwa ezikhiqizwe eRussia zinentengo ephansi - kusuka kuma-ruble angama-40 kuye kwangama-150. Izidakamizwa ezingeniswa ngaphandle kwePentoxifylline zibiza izikhathi ezi-2 ngaphezulu.

Izimo zokugcina

Ukuze ugcine endaweni evikelwe ezinganeni, ngamazinga okushisa komoya angadluli ku- + 25 ° C.

Izidakamizwa ezikhiqizwe eRussia zinentengo ephansi - kusuka kuma-ruble angama-40 kuye kwangama-150.

I-Pentoxifylline

Ithuluzi lingasetshenziswa kungakapheli iminyaka emithathu kusukela ngosuku lokukhiqizwa.

Ukubuyekezwa kwePentoxifylline

Iningi labodokotela neziguli baphendula kahle ngokusetshenziswa kwePentoxifylline.

Odokotela

E. G. Polyakov, i-neurosurgeon, iKrasnoyarsk

Umuthi unomphumela omuhle ekuphanjukisweni okuhlukahlukene kokujikeleza okuphakathi nokuphathelene nethambo. Ithuluzi lingekhwalithi ephezulu futhi lentengo ephansi, ngakho-ke liyatholakala kuzo zonke izigaba zeziguli. Okubi kwesidakamizwa kufaka nomphumela obuthakathaka kuma-angiopathies.

Iziguli

ULily, oneminyaka engama-31 ubudala, u-Astrakhan

Ngaphambi kwalokho, ngangivame ukuhlaselwa ukuhlaselwa i-vegetative-vascular dystonia, okwayithonya kakhulu inhlala-kahle yami. Manje sengelashwa ngePentoxifylline. Ngokuhlasela okulandelayo, ngiqala ukuthatha leli khambi enkambweni (zingakapheli izinsuku eziyi-10). Ukukhululeka kwenzeka ezinsukwini zokuqala zokwelashwa, futhi ngemuva kwezinsuku eziyi-10 zonke izimpawu zihamba ngokuphelele. Ukunakwa okukhethekile kukhokhelwa ngentengo yesidakamizwa: iphansi kakhulu kangangokuba ekuqaleni iyesabisa ngisho. Kodwa ikhwalithi ye-Pentoxifylline yaseRussia ayisiyibi kangako kunaleyo esetshenziswe kwamanye amazwe, ebiza 2, noma ngisho nentengo ephindwe kathathu.

U-Igor, oneminyaka engama-29 ubudala, uVolgograd

Ukwenza ngcono i-microcirculation yegazi ezinso, kufanele kuthathwe ama-vasodilators.UCurantil wayevele abekiwe ngaphambili, kepha ikhanda lakhe laba buhlungu kakhulu, ngakho-ke kwadingeka ngishintshele kuTrental. Lawa amaphilisi amahle, kepha abiza kakhulu, ngakho-ke nginqume ukuwafaka esikhundleni sePentoxifylline eyenziwe ngeRussia. Angibonanga mehluko (ngaphandle kwentengo). Basebenza futhi, ababangeli ukusabela okubi, benza umsebenzi wabo kahle.