I-Flemoklav Solutab iqukethe inhlanganisela ye-ejenti elwa namagciwane kanye ne-enzyme inhibitor. Lesi sidakamizwa sakwantu sonke ekwelapheni izifo ezithathelwanayo zesimo segciwane.
I-ATX
J01CR02
Khipha amafomu nokwakheka
Ifomu lomthamo ngendlela yamathebulethi ahlakazekile likhiqizwa linezimpawu ezilandelayo:
- ijamo oblong;
- umbala omhlophe onamabala ansundu;
- ilebuli ehlobene nethamo;
- ingxenye yelogo yomenzi.
Izinto ezisebenzayo zifakwe emigodini, okunyusa ukumuncwa, i-bioavailability yomuthi.
Ifomu lomthamo lisesimweni samathebulethi ahlakazekile.
Ithebhulethi ngayinye inokwakhiwa kwayo:
- i-amoxicillin trihydrate;
- potasium clavulanate;
- ababukeli.
Akuqukethe i-glucose, izingxenye ze-allergenic, nezinye izinto eziyingozi.
Ukumaka kufakelwe imithamo. Kubonisa okuqukethwe kwento ngayinye esebenzayo. I-Amoxicillin + clavulanic acid esecebeni esingu-1 siyabekwa:
- "421" ihambelana nomthamo we-125 mg + 31.25 mg;
- "422" kukhonjiswa ngomthamo we-250 mg + 62,5 mg;
- "424" ufake isicelo somuthi ka-500 mg + 125 mg;
- I- "425" ihambelana nomthamo we-875 mg + 125 mg.
Ipakwe emabhulashini ama-4 ama-pcs. ngokumaka "421", "422", "424". Ama-7 ama-PC. - kumakwe "425". Kutholakala ekhadini lekhadibhodi lezinhlamvu ezi-2 no-5.
Ipakwe emabhulashini ama-4 ama-pcs. ngokumaka "421", "422", "424".
Indlela yokusebenza
Uhla lwezenzo zamakhemikhali ezinhlobonhlobo zinikeza ukuxhumana kwe-ejenti ye-antibacterial ene-enzyme inhibitor ye-ejenti ethelelekayo.
Njengomphumela wokuvinjwa kokuhlanganiswa kwe-beta-lactamases, ukuthuthukiswa nokukhula kwamaseli we-microorganism kuyaphazamiseka. Ngendlela ye-monotherapy ayisetshenziswa.
Ngokubambisana ne-antibiotic kuhlinzeka umphumela onamandla we-bactericidal ngokumelene nenqwaba yezinhlobo zamagciwane we-pathogenic.
Ukuhlanganiswa kwezinto ezimbili kunikeza umphumela owanele wokwelapha, ozibonakalisa ngesimo se:
- khuphula ukungatheleleki kwe-antibacterial;
- ukuthuthukisa umsebenzi we-antimicrobial;
- ukunwebisa umthamo wesenzo.
Ububanzi besicelo banda ngenxa yokwakhiwa kokugxila kokuthize kwento ezindaweni ezahlukahlukene nezicubu zomzimba.
Ukuhlanganiswa kwezinto ezimbili kuhlinzeka ngomphumela owanele wokwelapha, ozibonakalisa ngesimo sokungavikeleki kwe-antibacterial.
I-Pharmacokinetics
Zombili izakhi zomuthi zinokuncipha okukhulu, azivezi emiphumeleni eyonakalisayo yemvelo ene-acid esiswini. I-Absorption izimele ngokudla ukudla.
Ukukhishwa kwama-granules ngezinto ezisebenzayo kwenzeka kancane kancane. Izingxenye zihlukaniswe ngokuphelele kusihlungi se-duodenum.
I-bioavailability ephezulu yesidakamizwa iqinisekiswa ifomu leSolutab, noma ngabe iyiphi indlela yokuphatha. I-bioavailability ye-amoxicillin ingama-94%. Okokuvimbela ama-enzyme angamagciwane, lesi sibalo sifinyelela kuma-60%.
Zombili izakhi zomuthi zinokuncipha okukhulu, azivezi emiphumeleni eyonakalisayo yemvelo ene-acid esiswini.
Ibopha amaprotheni e-plasma ama-20% ento esebenzayo. Ukuphathwa ngomlomo kuvumela ukunakekelwa kwegazi okuphezulu ngemuva kwamahora ama-2. Izinkomba zohlobo ngalunye lokukhululwa zivezwa emiyalweni yokusetshenziswa.
Inani elincane likhishwa nge-bile. Ukuphila kwesigamu kuya ngethamo lomuthi kanye nokusebenza kokusebenza kwezinso.
Ngakho-ke, ngemuva kokuphathwa ngomlomo ku-doses of 375 no-625 mg we-amoxicillin, impilo yesigamu iyhora eli-1 kanye namahora ayi-1.3, ngokulandelana. Yabelwe izinso.
Inqoba kalula isithiyo se-placental, inani elincane likhishwa kubisi lwebele.
Izinkomba zokusetshenziswa
Yakhelwe ukwelashwa kwezifo zemvelo esithathelwanayo.
Izifo ezelapheka kahle zokuphefumula, izifo zesikhumba.
Isetshenziswa kabanzi ekwelapheni i-sinusitis, i-otitis media, i-tonsillitis.
Iphumelela ezifweni zokuvuvukala zomkhakha wezitho zofuzo.
Imithamo emikhulu yezidakamizwa inesizathu ekwelapheni i-osteomyelitis, i-articular pathology.
Ifomu elikhethekile nokuba khona kwezihlanganisi ezimbili ezisebenzayo kuvumela ukusetshenziswa komuthi, noma ngabe bunjani bokusaphazeka kwenqubo yokutheleleka.
Contraindication
Akubeki phambi komzimba ezintweni ezisebenzayo.
Ihlanganiswe ku-mononucleosis ethelelekayo.
Ukusetshenziswa kwesidakamizwa kukhawulelwe ngeziqephu ezedlule ze-cholestatic jaundice.
Kuyenqatshelwa kumthamo omkhulu wezingane ezingaphansi kweminyaka eyi-12 abanesisindo esingaphansi.
I-Lymphocytic leukemia kuwukuphikisana nokusetshenziswa komuthi.
Ngokunakekela
UFlemoklav ubizwa ngokuqapha ezifweni ezinzima zesibindi, isisu, amathumbu.
Dose ngawodwana. Kwi-pathology enzima ye-renal, kuvunyelwe ukuphatha umuthi ngaphambi nangemva kokudayipha kokuthathwa komthamo owodwa.
Akubeki phambi komzimba ezintweni ezisebenzayo.
Ungayithatha kanjani
Kubantu abadala nezingane ezindadlana, umuthi ohlangene we-antibacterial unqunywa kumithamo ephakathi evame ukuphathwa imvamisa yokuphatha engekho ngaphezulu kwezikhathi ezi-3 ngosuku. Amafomu abekiwe avumelekile:
- chitha ku-50 ml wamanzi, uvuse ngokuphelele kuze kube yilapho uchithe ngokuphelele;
- ginya lonke ngamanzi;
- chaza emthanjeni womlomo.
Endabeni yenkambo ebucayi yenqubo yokutheleleka, ngokubuye kube njalo kwezifo ezingamahlalakhona, ukuphindaphinda umthamo kuvunyelwe.
Kubantu abadala nezingane ezindadlana, umuthi ohlangene we-antibacterial unqunywa kumithamo ephakathi evame ukuphathwa imvamisa yokuphatha engekho ngaphezulu kwezikhathi ezi-3 ngosuku.
Ngaphambi noma ngemuva kokudla
Ukudla akukuthinti i-kinetics yesidakamizwa. Ukuvimbela imiphumela emibi esiswini namathumbu, kungcono ukuthatha imithamo enqunyelwe ngokushesha ngaphambi kokudla.
Le ndlela inomphumela omncane ocasulayo kulwelwesi lwama-mucous lwendlela yokugaya ukudla.
Zingaki izinsuku zokuphuza
Isikhathi sokwamukelwa sincike ekujuleni kwesimo, iminyaka, ukukhula kwemiphumela emibi. Isikhathi sokwelashwa kufanele singabi ngaphezu kwezinsuku eziyi-14. Akunakwenzeka ukwedlula imigomo yokusebenzisa umuthi.
Isikhathi sokuphatha sincike ekujuleni kwesimo, iminyaka, ukuthuthukiswa kwemicimbi engemihle, isikhathi sokwelashwa akufanele sibe ngaphezulu kwezinsuku eziyi-14.
Kungenzeka yini ukuthi uphuze umuthi onesifo sikashukela
Inzuzo yezindlela zethebhulethi ukungabikho kokuqanjwa kwazo kwe-gluten, glucose, allergener ehlukahlukene. Ukutholakala kwamakhompiyutha asebenzayo awuthinti i-glycemia. Lokhu kwenza ukuthi sikwazi ukusebenzisa umuthi ekwelapheni izifo ezibangelwa amagciwane ezigulini ezinesifo sikashukela mellitus.
Imiphumela emibi
Ukuvela kokungathandeki okuhle kokunye okuhambisana nokuhambisana nokungabekezeleleki kwezakhi ezisebenzayo, ukuqokwa komthamo omkhulu. Imiphumela emibi iyaphenduka.
IHepatitis akuvamile ukuba ikhule. Ukwanda kwama-hepatic transaminases kuvame ukubonwa kakhulu. Ezimweni ezingazodwa, ukuphazamiseka kohlelo lwe-hepatobiliary bekuyinkimbinkimbi ukwehluleka kwesibindi.
Ungasebenzisa ithuluzi ekwelapheni izifo ezibangelwa amagciwane ezigulini ezinesifo sikashukela.
Amapheshana wesisu
Kungakhathalekile iminyaka yobudala, ukuthatha umuthi kuhambisana nohudo, ukugabha. Izimpawu ezinjalo zenzeka kaningi lapho usebenzisa imithamo emikhulu. Zadlula kwesikhashana, azifani ngokuqina okuveziwe.
Isifo sohudo esiqhubekayo siholela ekukhuleni kwe-membranous colitis. Ezimweni ezingavamile, i-candidiasis yamathumbu, i-hemorrhagic colitis, i-gastritis, ne-stomatitis kukhula.
Izitho zeHematopoietic
Ukuphendula kwesistimu ye-hematopoietic ngesimo se-leukopenia, thrombocytopenia, agranulocytosis akuvamile ukwenzeka. Ukunwetshwa okungenzeka kwesikhathi sokuhlanganiswa kwegazi. Lokhu kusabela kuguqukele emuva.
Kungakhathalekile iminyaka yobudala, ukuthatha umuthi kuhambisana nohudo, ukugabha.
Isistimu yezinzwa ephakathi
Umphumela wesidakamizwa esihlangene se-antibacterial ungavela:
- umuzwa wokukhathazeka;
- Ukukhathazeka
- isiyezi
- ushintsho ekuziphatheni kokuziphatha.
Kukhula imvuthuluka engavamile. Ngemuva kokususwa kokudakwa, konke ukubonakala okungathandeki kunyamalale.
Umphumela wesidakamizwa esihlanganisiwe se-antibacterial ungavezwa umuzwa wokukhathazeka.
Kusuka ohlelweni lomchamo
Akuvamile. Kuhlotshaniswa nokusetshenziswa okuhlangene kwe-diuretics, umsebenzi wezinso okhona. Kubonakaliswa ukuthuthukiswa kwe-hematuria, ukukhishwa kwamakristali kasawoti, izimpawu ze-nephritis ezihlangene.
Allergies
Ukuvela kokulunywa, i-urticaria, i-erythroderma kuwukubonakaliswa kokungafani komzimba nomuthi. Impendulo yamasosha omzimba ibonakaliswa ukukhula kwe-anaphylactic shock, hemorrhagic vasculitis. Mhlawumbe ukuthuthukiswa kwe-dermatitis ye-allergic, edema kaQuincke. Amacala omkhuhlane wezidakamizwa, i-erythema exudative, ne-edema laryngeal. Ukuphendula ngokushesha kudinga ukuyekiswa komuthi nokunakekelwa okukhulu.
Ukuvela kokulunywa, i-urticaria, i-erythroderma kuwukubonakaliswa kokungafani komzimba nomuthi.
Imiyalo ekhethekile
Amandla omuthi wokuthonya ama-coagulation indices wegazi adinga ukusetshenziswa ngokucophelela kanye nama-anticoagulants.
Ukuba khona kwe-pathology yepheshana lesisu ngokuhuda, isicanucanu, nokuhlanza kungumkhawulo wokuyalela ukwelashwa ngama-anti-antibiotic. Kulesi simo, kuqubuka imishanguzo yesidakamizwa. Kunqunywe ngemuva kokuqedwa kwezimpawu zesifo. I-Pseudomembranous colitis yisizathu sokuqedwa kwe-antibiotic.
Izinkinga ngokusebenza okujwayelekile kwama-enzyme wesibindi anciphisa isikhathi sesifundo, zidinga ukubhekwa njalo.
Ukuqhuba i-diuresis ephoqelelwe kunomthelela ekususeni ngokushesha kwezinto ezisebenzayo.
Misa ukuthatha lo muthi futhi wenze ukwelashwa okukhulu kuyadingeka ngokuthuthukiswa kokuphendula kwe-anaphylactic.
Ukuba khona kwe-pathology yepheshana lesisu ngokuhuda, isicanucanu, nokuhlanza kungumkhawulo wokuyalela ukwelashwa ngama-antibiotic.
Ukuhambisana notshwala
Awukwazi ukuhlanganisa imishanguzo notshwala. Iziphuzo zotshwala zivimbela isenzo sama-enzyme. Ukusebenzisana kotshwala kanye ne-ejenti elwa namagciwane kubangela ukusabela okunzima, kudala ukudakwa.
Umthelela ekhonweni lokulawula izindlela
Izimpawu zokuphazamiseka kwesistimu yezinzwa ezihambisana nokuphuza umuthi zenza kube nzima ukwenza umsebenzi onzima, ukushayela imoto. Isiyezi, ubuthakathaka, kanye nokushintsha kokungazi kahle kuthinta kabi umsebenzi odinga ukunakwa okwengeziwe.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Kunqunywa kuphela ngudokotela oholayo, kucatshangelwa izingozi ezingaba khona.
Akunamphumela we-teratogenic ku-fetus.
Uma kunesidingo, imithamo emincane evunyelwe ibekwe ku-trimester yokuqala yokukhulelwa. Ukusetshenziswa okunye kwesidakamizwa kuvunyelwe ngokuya ngemiyalo.
Ukwembiwa ngobisi lwebele akuyona ukwephulwa kwemithi yokwelashwa ngesikhathi sokuqunjelwa. Isimo sikamama nengane kufanele sibhekwe.
Ukuvela kosanda kuzalwa kwezimpawu zokwephulwa kwemisebenzi ye-emathunjini emathunjini, ukuthuthukiswa kwe-candidiasis kudinga ukuhoxiswa kwalo muthi.
I-Flemoklav Solutab inqunywa kuphela ngudokotela oholayo onaka izingozi ezingaba khona, ayivezi imiphumela ye-teratogenic kwi-fetus.
Ungayinikeza kanjani uFlemoklav Solutab ezinganeni
Imithamo kanye nemvamisa yokuphatha yezingane kunqunywa ngeminyaka. Ukubalwa kwenziwa nge-1 kg yesisindo somzimba ngosuku.
Izinhlobo ezibhebhekile zomuthi ezinomthamo omncane zibekelwe izingane ezingaphansi kweminyaka engu-7. Ngesisindo somzimba esingaphansi kwamakhilogremu ayi-14, umuthi awubekiwe ngenxa yokungakwazi ukwenziwa kwe-dosing efanele.
Izingane ezineminyaka engaphezu kwengu-7 ubudala zingaphuza umuthi obhalwe ukuthi "422" kabili ngosuku. Izingane ezingaphansi kweminyaka engu-12 ubudala zinikezwa imithamo ephansi.
Imithamo ye- "424" inikezwa ingane endala enesisindo esijwayelekile. Ukuphindaphindwa kokwamukelwa kuvunyelwe amahlandla ama-3 ngosuku.
Ngesisindo somzimba wengane esingaphansi kwamakhilogremu ayi-14, lesi sidakamizwa asinqunyelwe ngenxa yokungakwazi ukwenza i-dosing eyiyo.
Ukuze ugweme ukukhula kwezenzo ezingathandeki engxenyeni yokugaya ukudla, kungcono ukuthi izingane zinikeze umuthi ngokudla.
Uma kunesidingo, umthamo ungaphindwa kabili, kepha ungabi ngaphezu kwama-60 mg + 15 mg nge-1 kg yesisindo ngosuku.
Ukuvama kokuphathwa, umthamo, ukubalwa kwazo zonke izingozi ezingaba khona kufanele kunqunywe ngudokotela oya kuye.
Ngeke uyeke ukuzithatha ngokwakho, awukwazi ukwandisa isikhathi sokwelashwa.
Umthamo ekugugeni
Ukusetshenziswa kwesidakamizwa esihlanganisiwe seqembu le-penicillin ngaphandle kokulungiswa kwamthamo kuyamukeleka kwabadala.
Uhlelo lwe-hepatobiliary luphendula ngemiphumela emibi emavikini ambalwa ngemuva kokuphela kokwelashwa. Imiphumela enjalo engafuneki ihlala yenzeka ekugugeni. Isimo sidinga ukubheka isikhathi esifushane kakhulu sokwelashwa, hhayi ukunquma ukuphathwa kanyekanye kwezidakamizwa nemiphumela ye-hepatotoxic.
Imikhawulo yokwelashwa ekugugeni isethelwe abantu abanokungasebenzi kahle kwe-renal.
Imikhawulo yokwelashwa ekugugeni isethelwe abantu abanokungasebenzi kahle kwe-renal. Umthamo we-1000 mg awunqunyelwe emananini wokuhlunga kwama-glomerular ngaphansi kwama-30 ml / min.
Ukweqisa
I-overdose ibangela ukuthuthukiswa okusheshayo kokuphendula okungathí sina. Ukubonakala kokuhlanza, isifo sohudo kuzoholela ekuphanjukeni komzimba, ukuphazamiseka kwe-electrolyte. Ukudideka kukhula, i-convulsive syndrome.
I-overdose idinga ukuqothulwa komuthi, ukulungiswa okukhulu kwe-electrolyte ukuphazamiseka, ukukhipha emzimbeni okusebenzayo. Ekwehlulekeni okukhulu kwe-renal kuguqukela ku-hemodialysis.
Ukuxhumana nezinye izidakamizwa
Ukuphathwa okuhlanganayo nge-glycosides kuholela ekwandeni kokuxineka kwabo egazini, imiphumela eyengeziwe enobuthi.
Ungasebenzisi nge-disulfiram.
Imicimbi yokuphikisana nokwaziwa yaphawulwa nokuphathwa kanyekanye kwama-bacteriostats kwamanye amaqembu ekhemisi.
I-Flemoklav Solutab ayikwazi ukusetshenziswa ne-Disulfiram.
Ingozi yokopha ikhona lapho isetshenziswa ndawonye nama-anticoagulants.
Ukwemukelwa kwe-Allopurinol kucasula ukuvela kwesikhumba.
Izidakamizwa ezingezona ezibangelwa ukuvuvukala zivimbela ukumbiwa kwe-amoxicillin yizinso.
Ukuphathwa kanyekanye kwe-methotrexate kudala ukwanda komphumela wayo onobuthi.
Ukusebenza kwezindlela zokuvimbela inzalo kuncipha lapho kuthathwa ndawonye ne-ejenti elwa namagciwane.
Ama-Analog
Ama-analoggs wesidakamizwa sokuqala aqukethe izithako ezifanayo ezisebenzayo. Hlukanisa kuzindleko, okuqukethwe kwabokutholwayo.
Izincazelo ezinconyelwe futhi ezisetshenziswa njalo:
- Panklav;
- Flemoxin Solutab;
- Augmentin;
- I-Amoxicillin;
- I-Ecoclave;
- I-Amoxiclav.
I-analogue enconyelwe futhi esetshenziswa kaningi ye-flexamine solutab yi-Augmentin.
Udokotela kufanele akhethe i-analogue yokwelashwa. Kutholakala ngesimo sokumiswa kanye ne-powders kulungele ukusetshenziswa ekuzijwayezeni kwezingane.
Imibandela yekhefu lekhemisi
Ikhishwe ngumbhalo.
Intengo Flemoklav Solyutab
Izindleko zincike kumthamo womuthi. Intengo isukela kuma-ruble angama-298 kuya kwangama-468. ukupakisha.
Izimo zokugcina zesidakamizwa Flemoklav Solutab
Gcina emazingeni okushisa aze afike ku- + 25 ° C endaweni engafinyeleleki ezinganeni.
Impilo yeshelf umuthi
Kuboniswa kwiphakheji.
Kwisidakamizwa esibhalwe ukuthi "425" yiminyaka emi-2. Amacwecwe ahlakazekile kumithamo emincane agcinwa iminyaka emithathu.
Ngemuva kosuku lokuphelelwa yisikhathi alikwazi ukusetshenziswa.
Ukubuyekezwa kweFlemoklava Solutab
UCreola, oneminyaka engama-26, eMoscow
Umuthi uyasebenza. Imiphumela emibi ayibangelwa. Umphimbo wami ubuhlungu isikhathi eside. I-Sinusitis iye yathuthuka. Udokotela wanquma uFlemoklav. Thatha kabili ngosuku. Kuhlakazwe emanzini. Ngemuva kwezinsuku ezi-5, ukululama kwafika.
U-Amita, oneminyaka engama-23 ubudala, eMoscow
Ingane yayinemithombo yezindaba ezimbili ze-otitis. Ukushisa okuphezulu. Udokotela ubeke lo muthi ku-250 mg + 62,5 mg. I-Otitis yelashwa ezinsukwini eziyi-10. Azange kube nemiphumela emibi.
UVella, oneminyaka engama-31, eMoscow
Indodakazi yami yayinomphimbo obuhlungu onomkhuhlane ophakeme. Kuthathwe njengokuyalelwa udokotela. Ukululama kwafika ngezinsuku eziyi-6.
