I-Liptonorm isidakamizwa esinciphisa i-lipid esingeqembu le-satins. Umphumela walo muthi ukuvimbela umsebenzi we-HMG-CoA reductase, i-enzyme ebanga ukuguqulwa kwe-HMG-CoA ibe yi-mevalonic acid. I-enzyme iyisici esigabeni sokuqala sokukhiqizwa kwe-cholesterol.
Ingxenye eyinhloko ivimbela ukukhiqizwa kwe-cholesterol, ngenxa yalokho ukwanda kwe-receptor ye-LDL (low density lipoproteins).
Le nqubo yenzeka izicubu ezengeziwe futhi ngqo ngaphakathi kwesibindi. Ngakho-ke, i-cholesterol esegazini incishiswa ngokubopha futhi kuyisuse ku-plasma.
Futhi, amaphilisi angaba nomphumela we-anti-atherosulinotic.
Izakhi zomuthi ziyakwazi ukuba nemiphumela elandelayo emzimbeni:
- kuvimbela umsebenzi wama-isoprenoids kanye nokuqamba kwawo;
- kuthuthukisa i-vasodilation;
- kwehlisa cholesterol, triglycerides, apoliproteins B, LDL;
- inyusa inani le-apoliprotein A ne-cholesterol "enenzuzo".
Izinyanga ezingama-50 ngemuva kokuqala kokwelashwa, ungaphawula ukuthambekela okuhle ngesikhathi sesifo. Ukufeza umphumela omkhulu, inkambo yanyanga zonke yokwelashwa okunjalo iyadingeka. Inkambo yokwelashwa inegalelo ekunciphiseni isisindo ngokunciphisa izinga le-cholesterol "embi".
Umuthi udakwe kahle, umphumela omkhulu wesidakamizwa ubonwa ngemuva kwamahora ama-2 ngemuva kokuwusebenzisa. Kwabesifazane, ukugcotshwa kwomuthi kaningi kuphakama ngama-20% kakhulu kunakubesilisa.
Umuthi udlulwa enkambweni yokusabela kwe-hepatic metabolism. Ukuhoxiswa kwenzeka kungakapheli amahora ayi-14, futhi umphumela womuthi ubonwa emahoreni angama-20 ngemuva kokuphatha. Ngesikhathi sokusebenza kwe-hemodialysis, ingxenye esebenzayo ayikhishwa emzimbeni. Umchamo wesiguli ungeqi ngaphezulu kwe-2% yomthamo othathwe.
Njengayo yonke imishanguzo, iLiptonorm inezincomo zayo zokusebenzisa.
Udokotela kuphela ongakunikeza umuthi, ngokususelwa ekuxilongeni nasezimpawu zomzimba.
Ukusetshenziswa kwomuthi inqubo yokwelapha ngokwakho kwenqatshelwe.
Amacwecwe amiselwe:
- IHomozygous ne-heterozygous lipocholesterolemia. Lesi sidakamizwa kwesinye isikhathi sihambisana nokwelashwa kokudla.
- Ihyperlipidemia exubekile.
- I-hyperlipidemia eyisisekelo.
Izici zalo muthi zingathinta kabi impilo lapho kunezinto ezithile. Ezimweni ezinjalo, awukwazi ukuzithatha.
Imibiko engafanele ibandakanya:
- ukwehluleka kwesibindi;
- i-cirrhosis yesibindi yemisuka ehlukahlukene;
- izifo zesibindi ezinamandla, kanye nezindlela ezingama-hepatitis ezingalapheki nezotshwala;
- ukuba khona komsebenzi owengeziwe we-hepatic transaminase yemvelaphi engaziwa;
- iziguli ezingaphansi kweminyaka engu-18;
- isikhathi sokuzala nengane;
- ukungabekezelelani ngakunye emzimbeni wezakhi zomuthi.
Kwezinye izimo, ukusetshenziswa komuthi kungenzeka kuphela ngaphansi kokuqondisa udokotela.
Ukuphulwa okuhlobene kufaka phakathi:
- Ukuba khona kwezifo zesibindi.
- Ukungalingani kwe-Electrolyte.
- Ukuphazamiseka kwesistimu ye-endocrine nezinqubo ze-metabolic.
- Uhlobo olungamahlalakhona lokuncika kotshwala.
- Ukuba khona kwezifo ezithathelwanayo ezinkulu.
- Ukuvela kokuhlaselwa okungalawulwa.
- Ukuba khona kokulimala kanzima.
- Ukuhlinzwa.
Ukwelapha ngomuthi onjalo kunqunywa kuphela uchwepheshe ofanele owazi izici zesimo sempilo sesiguli.
Umkhiqizo uyatholakala ngendlela yamaphilisi egobolondo. Ithebhulethi ngayinye iqukethe into esebenzayo, i-calcium atorvastatin. Amathebulethi atholakala ngo-20, noma u-10 mg. Amaphakeji angaqukatha amapuleti angu-1 kuye ku-4, ngalinye lawo lingaba amaphilisi ayi-7, 14 no-10.
Ngaphambi kokubeka leyo mithi, isiguli sishintshwa ukuze sikondleke, okuqinisekisa ukwehla kwamazinga we-lipid. Ukudla okunjalo kufanele kubhekwe kuyo yonke inkathi yokwelashwa.
Ngokusho kwemiyalo, kufanele uphuze amaphilisi kanye ngosuku, ukusetshenziswa kwomuthi akuxhomekile ekudleni kokudla. Udinga ukuphuza zonke izinsuku ngasikhathi sinye.
Okokuqala, udokotela ubeka umthamo - 10 mg. Ngaphezu kwalokho, umthamo ophelele unqunywa ngokubheka izici ngazinye - okuqukethwe kwe-LDL esegazini kanye nenkambo yesifo. Futhi, umthamo unqunywa ngokusekwe ekusebenzeni komuthi.
Isilinganiso esiphezulu ngu-80 mg. Uchwepheshe ofanele kufanele anikeze umthamo, kwenqatshelwe ngokuphelele ukusebenzisa lesi sidakamizwa inqubo yokuzilapha.
Kulelo phakethe ngalinye lesidakamizwa i-Liptonorm kunemiyalo yokusebenzisa. Intengo yesidakamizwa iyahlukahluka ngokuya ngendawo yokuthengisa umuthi. Imvamisa, izibuyekezo ezinhle zitholakala ngalesi sidakamizwa.
Intengo yesidakamizwa eRussia Federation isebangeni lama-ruble angama-275-319. Ukuthenga isidakamizwa kungenziwa kuphela ngencwadi kadokotela.
Imiphumela emibi yesidakamizwa
Lolu hlobo lomuthi alulungele wonke umuntu. Ngenxa yokusebenza kwayo okunamandla, inemiphumela emibi eminingana.
Umphumela wecala lomuthi emzimbeni uzibonakalisa ezinhlelweni ezihlukene zomzimba.
Ukusuka ohlangothini lwesistimu yezinzwa ephakathi nendawo, ukuphazamiseka kokulala nesiyezi kungabonakala kaningi, kungaphuzi kakhulu amaphupho amabi, ukukhathala, ukuphathwa ikhanda, ukulahlekelwa ukwazi, isimo sokudangala, ukukhumbula inkumbulo, ukukhubazeka kobuso bezinzwa, i-neuropathy kanye ne-lability yendawo engokomzwelo.
Engxenyeni yesistimu yemithambo yegazi, izinhlungu esifubeni, i-migraines, umfutho wegazi ophakeme, i-arrhythmia, i-angina pectoris, i-phlebitis kanye ne-palpitations yenhliziyo kuvame ukubonwa.
Engxenyeni yezitho zemizwa, kutholakala ukwephulwa komqondo wokunambitha nokuhogela, kungaba nezithulu ngokwengxenye, futhi kwesinye isikhathi kube nokukhubazeka kwe-glaucoma, ukopha kwamehlo kanye ne-amblyopia.
Engxenyeni yesistimu yokugaya ukudla, kutholakala umlomo owomile, i-stomatitis nezinsini zokuphuma kwegazi. Izilonda ezisesilungeni somlomo womlomo, ukushaya kwenhliziyo njalo, ukuthamba, izicubu ezikhathazayo, isicanucanu, isifiso sokulimala, ukuhlanza, i-esophagitis, i-melena, ulcer, i-pancreatitis, isibindi, i-jaundice ne-hepatitis kungavela.
Izitho zokuphefumula - i-bronchitis ne-rhinitis zivame ukubonwa. Okuncane kuvamile ukuphuma kwesikhala ekhaleni, i-asthma ye-bronchial kanye ne-pneumonia.
Isistimu ye-Musculoskeletal - isifo samathambo sivame ukuvela, kuyaqabukela ukuqhekeka, i-myositis, i-hypertonicity yemisipha ne-myalgia.
Kusukela ohlelweni lwe-hematopoietic, ukuthuthukiswa kwe-lymphadenopathy, i-thrombocytopenia kanye ne-anemia ku-mellitus yesifo sikashukela kungenzeka.
Uhlelo lwe-genitourinary - ukubonakaliswa kaningi kokutheleleka kwe-urogenital ne-edema yangaphakathi. Kancane kancane, imiphumela emibi ibonakaliswa ku-nephrourolithiasis, dysuria, hemorrhage sowesifazane, ukuqina, ukuncipha kwesifiso sobulili, i-nephritis, ukumiswa kwemizwa kanye ne-metrorrhagia.
Ukubonakaliswa kwe-Allergic ngendlela yokuqhuma kwesikhumba, ukulunywa kanzima kanye nesikhumba. Ukungaqapheleki okuvame kakhulu ukubonwa kwe-anaphylaxis, ukuvuvukala kobuso, i-urticaria, isifo seStevens-Johnson.
Ukubonakaliswa kwesikhumba kuvame kusimo se-alopecia, ukujuluka ngokweqile, i-eczema, i-xeroderma, i-petechiae.
Isisindo singabonakala, noma okuphambene nalokho, isiguli singase sehlise isisindo, i-gynecomastia kanye nokwanda kwe-gout kungaqhamuka uma isiguli sinakho.
Naphezu kwemiphumela emibi, amaphilisi asebenza kangcono futhi awekho ukubuyekeza owodwa omuhle ezigulini.
Nge-overdose, ezinye izinkomba ezimbalwa kungenzeka. Phakathi kwazo, ungabona izimpawu ezifana nemiphumela emibi, kuphela eshiwo.
Isiguli ngokweqile kufanele:
- vimbela ukuqhubeka kokufaka umuthi, ngokuthatha amalahle ocushiwe kanye nokugeza isisu;
- ukusekela umsebenzi wezitho ezibalulekile empilweni;
- susa izimpawu zokubonakaliswa.
Ukungasebenzi kwe-hemodialysis kuleli cala kuyaqinisekiswa.
Ngesikhathi sokwelashwa, isiguli sidinga ukwelashwa njalo. Kuyadingeka ukulawula umsebenzi wezitho nezinkomba zaselebhu. Uma kukhona ushintsho lwe-pathological, yeka noma wehlise umthamo womuthi.
Esigabeni sokuqala sokuphuza umuthi nangezikhathi zokwanda imithamo, udinga ukugcina umsebenzi wesibindi uqaphe. Ezinyangeni ezintathu zokuqala zokuphuza umuthi, kunokuphazamiseka okuncane emsebenzini womzimba. Uma kukhona ukwephulwa okubalulekile kokujwayelekile, kufanele umise inkambo yokwelashwa.
Uma isiguli sisebenzise i-myalgia noma ubuthakathaka bemisipha, umuthi kufanele uyekwe.
Uma kwenzeka wephula isibindi, kufanele uqaphele ukusithatha.
Ukuthatha umuthi kuphambene nezifo ezinjalo:
- ukuqina kwesibindi;
- isikhathi esisebenzayo sesifo sesibindi;
- ukwehluleka kwesibindi.
Ngesikhathi sokwelashwa, udinga ukulahla ukusetshenziswa kwejusi yamagilebhisi, kusiza ukwandisa ukuqoqwa kwe-atorvastatin egazini.
Uma iLiptonorm ithathwa ngokufana neCyclosporine, i-Erythromycin, nama-immunosuppressants, amazinga wegazi e-atorvastatin angakhuphuka, okuzoholela ekwenzekeni kwe-myopathy. Ukwemukelwa kwama-antacid kunciphisa ukuqoqwa kwengxenye eyinhloko yomuthi ngamaphesenti angama-35.
Imithi engathatha isikhundla seLiptonorm ine-contraindication efanayo, izinkomba kanye nemiphumela emibi. Bahluka ngentengo kuphela. Amathebulethi angashintshwa:
- I-Atorvastatin - izindleko eziseRussia zivela kuma-ruble ayi-126.
- I-Anvistatom - izindleko eziseRussia - kusuka kuma-ruble angama-210.
- I-Atoris - izindleko eziseRussia - kusuka kuma-ruble angama-426.
- I-Liprimar iyi-analogue ebiza kakhulu nezindleko eRussia kusuka kuma-ruble angama-2500.
- I-Torvakard - inani lentengo eRussia lisuka kuma-ruble angama-499.
Umuthi ngamunye ungabekwa uchwepheshe ofanele kuphela, ngoba izinto ezinomthelela onamandla emzimbeni futhi, uma zichazwe ngokungafanele, zingadala izinkinga eziningi.
Ukuthi wehlise kanjani amazinga we-cholesterol echazwe kwi-video kulesi sihloko.
