IGlucophage Long ingenye yezinhlobo zomuthi owaziwa ngokuthi ushukela ophansi, osetshenziswa ngokuzikhandla ekwelashweni okuyinkimbinkimbi kokungezwani noshukela okungaxhomekeki ku-insulin.
Isandulelo Long sikhombisa ukuba khona kwesenzo sethebhulethi isikhathi eside, ngokungafani namalungiselelo ajwayelekile weGlucofage.
Zonke izidakamizwa ezikhona ezisetshenziselwa isifo sikashukela sohlobo 2 zingahlukaniswa ngamaqembu alandelayo:
- eminye yale mithi inomphumela onenzuzo ekusebenzeni kwamanyikwe, kuphoqa umzimba ukuthi ukhiqize i-insulin ethe xaxa;
- abanye banciphisa ukumelana okubonakalayo kwe-insulin esigulini, okwandisa ukuzwela kwamangqamuzana nezicubu kuyi-hormone.
Umuthi i-Glucofage Long (isenzo esenziwa isikhathi eside) usiza ukuguqula amazinga kashukela ngesikhathi sokuthuthukiswa kwesifo sikashukela futhi sisebenze njengendlela yokucindezela ukumelana ne-insulin.
Ngabe umuthi usebenza kanjani, ingabe ukudla kuyadingeka uma uwuphuza, futhi ngabe yi-Glucofage Long ebekiwe ezimweni ezingakanani?
Ukwakheka, ifomu lokukhulula, izimfanelo zemithi
Umuthi i-Glucofage Long iyingxenye yeqembu lezidakamizwa ze-Biguanide ezisetshenziselwa ukwelapha i-mellitus engavunyelwe yi-insulin.
Ummeleli weqembu lama-Biguanides - i-metformin hydrochloride isebenza njengesithako esikhulu esisebenzayo.
Umuthi umuthi onciphisa ushukela ovumela hhayi kuphela ukwenza amazinga kashukela ajwayelekile, kodwa futhi umise ukuthuthukiswa kwezinkinga ezahlukahlukene ezenzeka ngokuthuthukiswa kwesifo sikashukela.
Imiphumela enenzuzo yokuthatha amaphilisi akhululiwe akhululwa ngale ndlela elandelayo:
- Umphumela wayo ekunciphiseni ukumelana ne-insulin kubantu. I-Metformin hydrochloride iyakwazi ukukhulisa ukuzwela kwamaseli nezicubu ku-glucose ekhiqizwa ama-pancreas.
- Yehlisa ukubonakaliswa kwe-hyperglycemia, ngenkathi ayinikele ekwakhiweni kwe-hypoglycemia, ngisho nakubantu abaphilile. Inqubo yokwehlisa ushukela yenzeka emazingeni ajwayelekile futhi ayiqhubeki phambili. Kungakho, leli thuluzi lithola ukuthandwa kwalo phakathi kwawo wonke umuntu ofuna ukwehlisa isisindo, kungakhathalekile ukuthi kukhona ifomu lesifo elizimele le-insulin.
- Kwangathi kungakhombisa umsebenzi wokuzivikela mayelana nokusebenza kobuchopho ngokulwa nokuguga.
- Sithinta kahle isimo semithambo yegazi nemithambo yegazi. Ngakho-ke, ngosizo lwe-metformin, ukuthuthukiswa kwe-vasherticosis yemithambo yegazi, ukwehluleka kwenhliziyo, umfutho wegazi ophakeme, kanye nokubalwa kwemithambo kungavinjelwa. Yizinkinga ezifana nalezi ezivame ukukhula ezigulini ezinenkambo ende yesifo sikashukela.
- Yehlisa amathuba womdlavuza.
- Ikunciphisa ukuthuthukiswa kwamathambo kwabanesifo sikashukela. Ikakhulu kaningi, abesifazane bahlushwa amathambo ama-brittle ngemuva kokunqamuka kokuya esikhathini, ngoba kukhona ukwehla okukhulu kwama-hormone - estrogen.
- Kunomphumela omuhle ku-cholesterol, kunciphisa okubi futhi kukhula okuhle.
- Kuthinta kahle ukusebenza kwe-gland yegilo.
- Isiza ihlukanise inqubo ye-peroxidation yamafutha.
- Inomsebenzi wokuzivikela maqondana nohlelo lokuphefumula.
Umehluko omkhulu phakathi komuthi wethebhulethi iGlucofage Long ukubonakaliswa kwemiphumela efana:
- kukhona inqubo yokwenza kusebenze kanye ne-oxidation yamafutha omzimba;
- ama-carbohydrate angena emzimbeni kanye nokudla amuncwa odongeni lwepheshana lesisu ngesilinganiso esincane;
- kukhona ukuvusa kanye nokwenza kusebenze ukucubungula i-glucose ngama-izicubu zemisipha.
Umenzi walesi sidakamizwa yinkampani yezokwelapha iMerck, okuyizimpahla zayo eziseFrance naseJalimane. Kungakho, intengo yomuthi i-Glucophage Long ingahluka kakhulu emithini yasekhaya, enayo okufanayo neGlucophage Long.
Indlela ye-pharmacological yokukhishwa komuthi ulungiselela ithebhulethi egobolondweni. Ngaphezu kwe-metformin hydrochloride, ukwakhiwa komuthi nesiqalo Eside kufaka phakathi izakhi ezithile ezengeziwe ngesimo se-sodium carmellose, hypromellose, ne-magnesium stearate.
Imiyalo yokusebenzisa umuthi
Ukunquma ukuthi yisiphi isidakamizwa, nokuthi yisiphi isilinganiso esifanele isiguli kufanele sithathe udokotela waso kuphela.
Ngokuya ngemithamo udokotela obonayo anqume umuthi ngayo, uhlobo lomthamo luzoshintsha.
Kuze kube manje, kumakhemisi ungathenga umuthi ngemithamo emibili eyinhloko - ngenani lama-milligram angama-500 no-750 wengxenye esebenzayo.
Lapho uthatha i-glucophage yesenzo eside, ubude kanye nenqubo (ubude) bokuphathwa kanye nenani lemithamo kunqunywa uchwepheshe wezokwelapha ogcina umlando wezokwelapha weziguli.
Uma usebenzisa umuthi, kuyadingeka ukulandela izincomo ezinjalo (imiyalo yokusebenzisa iyakhombisa):
- thatha ngomlomo kanye ngosuku ngenani elincane lamanzi ngesikhathi sokudla kokugcina.
- uma kunesidingo, udokotela angakwazi ukuthola umuthi wezikhathi ezimbili.
- imithamo isetshenziswa ngayinye esigulini ngasinye esuselwa kuzinkomba zamazinga kashukela egazini.
- Njengomthetho, ukwelashwa kokuqala kuzoba yithebhulethi elilodwa elinenani elincane lempahla esebenzayo kusihlwa.
Kunezimo lapho isiguli siqala ukuthatha umuthi isikhathi esifushane sokuchithwa kwengxenye esebenzayo, okwathi ngemuva kwalokho wanikezwa ukwelashwa esebenzisa umuthi wezenzo ezinde. Lapho-ke ukuqala kokwelashwa kufanele kulingane nenani lomuthi owathathwa yisiguli ekuqaleni.
Ukwedluliswa kwemithamo ekhona kufanele kwenzeke kancane kancane, cishe njalo ezinsukwini eziyishumi ngegramu yesigamu yento esebenzayo. Ngokwesilinganiso, kusetshenziswa umthamo wamamiligremu ayi-1,500, kanti ukusetshenziswa okwedlulele komuthi kulingana namagremu amabili esakhi esisebenzayo.
Uma isiguli sinqume ukuyeka ukusebenzisa umuthi, udokotela ohambelayo kufanele aziswe ngalokhu.
Uma kuvela isimo lapho bekunokweqa khona ukuthatha ithebhulethi, asikho isidingo sokuphinda kabili umthamo olandelayo.
Ukusabela okungalungile lapho usebenzisa umuthi
Ukubonakaliswa kokungaphenduki okungekuhle kungabhekwa kuzigaba ezithile zeziguli. Kufanele kukhunjulwe ukuthi imiphumela enjalo emibi yenzeka ngokuvama okuhlukile kuye ngokuthi yiziphi izitho zangaphakathi eziphendule kabi ekuthambeni komuthi emzimbeni.
Ngokuvamile, kuba nemiphumela emibi engxenyeni yokugaya ukudla. Isiguli singazizwa sisondela ku-nausea, ehambisana nokuhlanza, ubuhlungu esifundeni sesisu. Ngaphezu kwalokho, imiphumela yesidakamizwa sethebhulethi ifaka ukwehla okulinganiselayo kwesifiso sokudla, ngokubonakaliswa kokungaphenduki okuhle, umuntu angazizwa elambile nakancane. Kwezinye izimo, abantu babika ukunambitheka okungathandeki kwensimbi emilonyeni yabo. Njengomthetho, izimpawu ezinjalo zivame ukukhula ezigabeni zokuqala zokwelashwa, emva kwalokho zincipha kancane kancane. Ukuze izitho zepheshana lesisu liphendule kabuhlungu ekuphuzeni umuthi, umthamo wazo kufanele ukhuphuke kancane kancane.
Kuyaqabukela, ukwanda kokuqina kwesibindi kanye nokwanda kwezifo ezahlukahlukene zezitho.
Ukusabela okwenziwa yi-allergic lapho uthatha umuthi kungaveza njengokukhanywa yisikhumba, ubomvu noma umuzwa ovuthayo.
Enye yokusabela okuyingozi okuyingozi kakhulu yi-lactic acidosis. Ngakho-ke, i-metabolism yesiguli, ekuthi isifo sikashukela sithinteke ngenxa yokuthuthuka kwenqubo ye-pathological, ingaphendula ekwelashweni okwelashwa. Ingozi yokubonakaliswa kwayo phambi kwe-renal pathologies esigulini iyanda. Izehlakalo ze-lactic acidosis zanda ngenxa yokudla okungafanele (ukudla okungenakulinganisela noma ukuzila ukudla), ukuphuza utshwala. Izimpawu eziphambili zalo mphumela ongemuhle kungaba umuzwa wobuthakathaka obujwayelekile bomzimba, ukulahlekelwa ukwazi, ukuqina kwemisipha, i-asthenia ne-hypothermia.
Ngaphezu kwalokho, kufanele kukhunjulwe ukuthi ukungahambisani nemithamo enconyiwe nakho kungasiza ekwakhiweni kwe-lactic acidosis. Lapho kunalesi simo, ukwelashwa kufanele kumiswe ngokushesha kanti isiguli kufanele silaliswe esibhedlela.
Njengokwelashwa kwe-overdose nokubonisa i-lactic acidosis, kunqunywa ukwelashwa okubonakalayo kanye ne-hemodialysis.
Kukweziphi izimo ukunqatshelwa kwemithi?
Kuyenqatshelwa ukuthi ngokuzimela uthathe isinqumo ngokwelashwa ngalo muthi.
Kufanele kukhunjulwe ukuthi amaphilisi we-Glucofage Long kufanele abhekiselwe abantu abatholakala nesifo sikashukela ukuze kubuywe ngokwejwayelekile inani likashukela egazini futhi andise ukuzwela kwe-insulin ekhishwe ezingeni lamaselula.
Umuthi unenombolo enkulu yokuphikisana ukuze usetshenziswe, kubalulekile ukuthi uzijwayeze ngaphambi kokuqala ukwelashwa.
Ukuphuza umuthi akuvunyelwe phambi kwalezi zinto ezilandelayo:
- Abesifazane ngesikhathi sokukhulelwa nokuqunjelwa, ngenxa yokuntuleka kwedatha eyenele ngomphumela womuthi ku-fetus nasenganeni. Ukuxilongwa okulinganiselwe okwenziwe akuzange kubonise umthelela omubi ekuthuthukisweni nasemsebenzini obalulekile wengane. Kodwa-ke, lolu lwazi alwanele ukucabanga ngokuthatha umuthi uphephile ezimweni ezinjalo.
- Uma kunezinga elikhulayo lokuzwela kwenye yezakhi zomuthi. Ukwehluleka ukuhambisana nalesi silinganiso kungadala ukuvela kokungezwani komzimba ngezindlela ezahlukahlukene.
- Uma isiguli sinezinkinga zokuphazamiseka kwezinso.
- Kukhona ubukhona be-ketoacidosis.
- Idlozi likashukela noma i-glycemic coma.
- Ukuxineka komzimba, okuhambisana nokuhlanza kakhulu noma uhudo, futhi kungaholela ekusebenzeni kokulimala kwe-renal.
- Lapho kukhona ukubonakaliswa kwezinqubo ezahlukahlukene ze-pathological ngamazinga ahlukahlukene wokuthuthuka, aba imbangela yohlobo lwethishu hypoxia.
- Ngesikhathi sokulimala okukhulu noma ukungenelela kokuhlinzwa.
- Izingane ezingaphansi kweminyaka yobudala obuningi.
Ngaphezu kwalokho, kufanele uphuze umuthi ngokucophelela neminye imithi. Kunokukhethwa lapho isithako esisebenzayo, esiyingxenye yesidakamizwa iGlucofage Long, singahambisani namaqembu athile emithi. Udokotela ohambelayo kufanele aziswe ngokusetshenziswa kwanoma yiziphi ezinye izidakamizwa ezingezekile.
Ama-analogues wezidakamizwa uGlyukofazh Long
Ukubuyekezwa kweGlucophage Long kubonakala emibonweni yeziguli nabasebenza kwezokwelapha. Njengomthetho, zibonisa ukubekezelela okujwayelekile komuthi, ukubiza kwawo kanye namazinga amahle kashukela wegazi ngesikhathi sokuphatha kwawo Ngasikhathi sinye, futhi kunesigaba seziguli, siphawula ukubonakala kwamathonya ahlukahlukene ahlukahlukene obunzima obuhlukahlukene.
Kuze kube manje, izindleko zethebhulethi yezidakamizwa ezinomphumela omude zikuluhlu lwama-ruble angama-270-300.
Kungenzeka kube nezimo lapho isiguli sidinga ukubheka okunye esikhundleni somuthi iGlucofage Long. Kulokhu, udokotela ohambelayo kufanele anikeze isiguli umuthi onomphumela ofanayo - isenzo esifushane noma eside. Njengomthetho, ukufakwa kwesidakamizwa kwenziwa ngokwe-INN etholakalayo, okungukuthi, ngento efanayo esebenzayo ekwakhiweni kwomuthi. Umehluko ungahle uhlangane nenani lezinto ezisizayo noma ziyehluka kumthamo.
Phakathi kwezidakamizwa ezihlobene ne-Glucophage Long, umuntu angabona imishanguzo efana ne-Glyformin Prolong, i-Diaformin OD, iForin Pliva.
Ungayisebenzisa kanjani iGlucophage yesifo sikashukela esizochazwa uchwepheshe kule vidiyo ekulesi sihloko.
