I-Gliformin yesifo sikashukela - imiyalo, ukubuyekezwa, intengo

Eminyakeni engamashumi ambalwa edlule, amalungiselelo e-metformin abe yingxenye ebalulekile ekwelapheni isifo sikashukela sohlobo 2. Emhlabeni, kukhiqizwa izidakamizwa eziningana nge-metformin, eyodwa yazo yi-Russian Gliformin evela enkampanini i-Akrikhin. Kuyi-analogue yeGlucophage, isidakamizwa sokuqala saseFrance.

Isifo sikashukela, umphumela wazo emzimbeni ulingana, anciphisa ngokulinganayo ushukela wegazi. I-Gliformin ingasetshenziswa ngokuhlukile futhi njengengxenye yokwelashwa okuphelele ngokuhlangana namanye ama-antidiabetesic agents. Inkomba yokuqokwa komuthi ukumelana ne-insulin, okukhona cishe kulo lonke uhlobo lwesifo sikashukela.

Indlela amaphilisi we-Glyformin enza ngayo

Eminyakeni embalwa, umhlaba uzogubha iminyaka eyikhulu ye-metformin. Muva nje, inzalo kule nto ikhula ngokushesha. Njalo ngeminyaka wembula izakhiwo ezengeziwe ezimangazayo.

Ucwaningo selukhombe imiphumela ezuzisayo yezidakamizwa ene-metformin:

1. Ukunciphisa ushukela wegazi ngokuthuthukisa ukuzwela kwezicubu ku-insulin. Izibhebhe zeGliformin zisebenza kakhulu kwiziguli ezikhuluphele.
2. Ukwehla kukhiqizwa ushukela esibindini, okukuvumela ukuthi wenze ngokwejwayelekile i-glycemia esheshayo. Ngokwesilinganiso, ushukela wasekuseni wehliswa ngo-25%, imiphumela emihle kakhulu yibo abanesifo sikashukela abane-glycemia ephezulu.
3. Yehlisa ukufakwa kweglucose emgodini wokugaya ukudla, ngenxa yokuthi ukugxila kwalo egazini akufinyeleli amanani aphezulu.
4. Ukugqugquzela ukwakheka kwezindawo ezinoshukela ngendlela ye-glycogen. Ngenxa yedepho elinjalo kuma-diabetes, ingozi ye-hypoglycemia iyancishiswa.
5. Ukulungiswa kwephrofayili ye-lipid yegazi: ukwehla kwe-cholesterol ne-triglycerides.
6. Ukuvimbela izinkinga zesifo sikashukela enhliziyweni nemithambo yegazi.
7. Umphumela onenzuzo kwesisindo. Lapho kukhona khona ukumelana ne-insulin, iGliformin ingasetjenziswa ngempumelelo ekunciphiseni isisindo. Kuyatholakala ngokunciphisa i-insulin egazini, evimbela ukuwohloka kwamafutha.
8. IGlyformin inomphumela we-anorexigenic. I-Metformin, ihlangana ne-mucosa emathunjini, iholela ekwehleni kwesifiso sokudla kanye nokwehla kwesilinganiso sokudla okudliwayo. Ukubuyekezwa kokuncipha kwesisindo kukhombisa ukuthi i-Gliformin isiza hhayi wonke umuntu ukunciphisa umzimba. Ngokwe-metabolism ejwayelekile, la maphilisi awasebenzi.
9. Ukufa kwabantu abanesifo sikashukela abaphuza lo muthi kungamaphesenti angama-36% kunalezi ziguli ezithola olunye unyango.

Umphumela ongenhla wesidakamizwa usefakazelwe futhi ubonakala emiyalweni yokusetshenziswa. Ngaphezu kwalokho, kutholakala umphumela we-antitumor kaGliformin. Ngesifo sikashukela, ubungozi bomdlavuza wamathumbu, ama-pancreas, amabele bungaphezulu kwama-20-50%. Eqenjini labashukela abelashwa nge-metformin, izinga lomdlavuza laliphansi kunakwezinye iziguli. Kunobufakazi futhi bokuthi izibhebhe zeGliformin zilibazisa ukuqala kwezinguquko ezihlobene nobudala, kepha lokhu kufakazelwa kwengqondo akukakafakazelwa ngokwesayensi.

Isifo sikashukela nokucindezela kuzoba yinto yesikhathi esedlule

• Ukwehlela ushukela -95%
• Ukuqedwa kwe-vein thrombosis - 70%
• Ukuqedwa kokushaya kwenhliziyo okuqinile -90%
• Ukuqeda umfutho wegazi ophakeme - 92%
• Ukwanda kwamandla ngesikhathi sosuku, ngcono ukulala ebusuku -97%

Izinkomba zokuqokwa

Ngokusho kwemiyalo, uGliformin angabekwa:

• thayipha isifo sikashukela sababili, kubandakanya neziguli ezisukela eminyakeni eyi-10;
• ngesifo sohlobo 1, uma kunesidingo ukunciphisa ukumelana ne-insulin;
• iziguli ezinesifo se-metabolic syndrome kanye nezinye izinkinga ze-metabolic ezingase ziholele kushukela;
• Abantu abakhuluphele uma sebeqinisekisile ukumelana ne-insulin.

Ngokwezincomo zenhlangano yamazwe omhlaba yesifo sikashukela kanye noMnyango Wezempilo waseRussia, ngohlobo 2 lwesifo sikashukela, amaphilisi ane-metformin, kufaka phakathi noGliformin, afakiwe emgqeni wokuqala wezokwelapha. Lokhu kusho ukuthi banqunyelwe okokuqala, ngokushesha nje lapho kuvela ukuthi ukudla nokuzivocavoca akwanele ukukhokhela ushukela. Njengengxenye yokwelashwa okuhlanganiswa, i-Gliformin ithuthukisa ukusebenza kahle kokwelashwa futhi yehlisa imiphumela emibi yezinye izidakamizwa.

Ifomu lomthamo kanye nomthamo

IGliformin itholakala ngezindlela ezimbili. Ezibhebheni ze-metformin zendabuko, 250, 500, 850 noma 1000 mg. Intengo yokufakwa kwamathebhulethi angama-60 isuka kuma-ruble ayi-130 kuye kwangama-280. kuya ngomthamo.

Ifomu elithuthukisiwe ukulungiswa okulungisiwe kokukhishwa kweGlyformin Prolong. Ine-dosage ye-750 noma i-1000 mg, ihlukile kuneGlatinin ejwayelekile ekwakhiweni kwethebhulethi. Yenziwe ngendlela yokuthi i-metformin iwushiya ngokunensa futhi ngokulinganayo, ngakho-ke ukuhlangana okudingakalayo komuthi osegazini kuhlala usuku lonke ngemuva kokuwuthatha. I-Glyformin Prolong inciphisa imiphumela emibi futhi yenza ukuthi kungenzeka ukuthi uphuze umuthi kanye ngosuku. Ithebhulethi ingaphulwa ngesigamu ukwehlisa umthamo, kodwa ayikwazi ukuchobozwa ibe yimpuphu, ngoba izakhiwo ezinde zizolahleka.

Umyalo uncoma ukusuka ku-Gliformin ejwayelekile kuye ku-Glattin Prolong kuya kwabanesifo sikashukela lapho i-metformin inyusa imiphumela emibi. Awudingi ukulungisa umthamo. Uma isiguli sithatha i-Gliformin ngethamo eliphezulu, ngeke sishintshele kumuthi owandisiwe.

Imiyalo yokusebenzisa

Ukugwema imiphumela emibi, i-gliformin kuthathwe ngokudla, kugezwe ngamanzi. Ukwemukelwa kokuqala kusihlwa. Ngesikhathi esifanayo nesidlo sakusihlwa, thatha uGliformin kumthamo omncane kanye ne-Gliformin Prolong kunoma yiluphi umthamo. Uma kuthathwa isikhathi sokudla okubili, amaphilisi aphuzwa ngesidlo sasekuseni kanye nesidlo sasekuseni.

Umthamo wanda kancane kancane noma ngabe isiguli siyaziphuza yini ezinye izidakamizwa ezokwehlisa ushukela:

• amasonto amabili okuqala ngosuku baphuza ama-500 mg, ngokubekezelela okuhle - 750-850 mg. Okwamanje, ingozi yezinkinga zokugaya iphakeme kakhulu. Ngokusho kokubuyekezwa, imiphumela emibi imvamisa inomkhaba we-nausea ekuseni bese incipha kancane kancane njengoba umzimba uvumelana noGliformin;
• uma phakathi nalesi sikhathi ushukela engakafinyeleli okuvamile, umthamo unyuswa waba ngu-1000 mg, ngemuva kwamanye amasonto ama-2 - ufike ku-1500 mg. Umthamo onjalo ubhekwa njengongcono kakhulu, unikeza isilinganiso esihle kakhulu sengozi yemiphumela emibi kanye nokwehlisa ushukela;
• umthamo uvunyelwe ukukhushulwa ube ngu-3000 mg (weGlformin Prolong - kuze kufike kuma-2250 mg), kepha udinga ukulungela iqiniso lokuthi inani eliphindwe kabili le-metformin ngeke linikeze ukwehliswa ushukela okufanayo.

Imiphumela emibi yesidakamizwa

Imiphumela emibi ejwayelekile yesidakamizwa ifaka ama-upsets wokugaya ukudla. Ngaphezu kokuhlanza, isicanucanu, nohudo, iziguli zinambitha ukudabuka noma insimbi, ubuhlungu besisu emilonyeni yazo. Ukwehla kwesifiso sokudla kungenzeka, noma kunjalo, kwabaningi abanesifo sikashukela 2 lo mphumela awunakubizwa njengengathandeki. Ekuqaleni kokusetshenziswa kwesidakamizwa, imizwa engathandeki ivela ku-5-20% yeziguli. Ukuze wehlise, amaphilisi weGliformin adakwa kuphela ngokudla, aqale ngethamo elincane futhi alikhulise kancane kancane libe ngcono.

Inkinga ethile yokwelashwa ne-Gliformin yi-lactic acidosis. Lesi yisimo esingajwayelekile kakhulu, nemiyalo yokusebenzisa ubungozi ilinganiselwa ku-0,01%. Imbangela yayo yikhono le-metformin lokuqhakaza ukuqhekeka kwe-glucose ngaphansi kwezimo ze-anaerobic. Ukusetshenziswa kweGlformin kumthamo onconyiwe kungadala ukwanda okuncane ezingeni le-lactic acid. Izimo ezihambisana nezifo kanye "nezifo" zingadala "i-lactic acidosis: i-ketoacidosis ngenxa yesifo sikashukela esibucayiwe, isibindi, isifo sezinso, izicubu zomzimba, ukudakwa kotshwala.

Imiphumela emibi engafani yokusetshenziswa kwesidakamizwa isikhathi eside ifaka ukushoda kwamavithamini B12 kanye ne-B9. Kuyaqabukela, kunokungahambisani kahle ne-Gliformin - i-urticaria kanye nokulunywa.

Contraindication

Ukusetshenziswa kwe-Gliformin kuyenqatshelwa kulezi zimo ezilandelayo:

1. Nge-hypersensitivity ezingxenyeni zomuthi.
2. Uma isifo sikashukela sinobungozi obukhulu be-izicubu hypoxia ngenxa yesifo senhliziyo, i-anemia, ukwehluleka ukuphefumula.
3. Ngokulimazeka okukhulu kokusebenza kwezinso nezinso.
4. Uma ngaphambili isiguli sike saba ne-lactic acidosis okungenani kanye.
5. Kwabesifazane abakhulelwe.

IGlyformin kwisifo sikashukela ikhanselwa okwesikhashana amahora angama-48 ngaphambi kokulawulwa kwezinto ezine-radiopaque, imisebenzi ehlelelwe, isikhathi sokwelashwa kokulimala okungathi sína, izifo kanye nezinkinga ezinkulu zesifo sikashukela.

Ama-analog namagama

Ama-analoggs we-Glitterin ejwayelekile

I-Glyformin Prolong

Ngokusho kwesifo sikashukela, izidakamizwa ezidumile kakhulu ze-metformin yi-French Glucofage ne-Siofor yaseGerman. Yibo lapho ama-endocrinologists azama ukunquma. Okungaphansi kakhulu i-metformin yaseRussia. Intengo yamaphilisi asekhaya aphansi kunaleyo yezidakamizwa ezingenisiwe, imvamisa zithengwa izifunda ukuze zisatshalaliswe mahhala kwabanesifo sikashukela.

IGlatini noma iMetformin - okungcono

Bafunde ukuthi bangakhiqiza kanjani i-metformin esezingeni eliphakeme ngisho naseNdiya naseChina, ingasaphathwa eyaseRussia ngezidingo zayo eziphakeme zemithi. Abakhiqizi abaningi basekhaya bakhiqiza amafomu wesikhathi eside wesikhathi eside. Isakhiwo sethebhulethi esiyisisekelo esisha kumenyezelwa kuphela eGlucofage Long. Kodwa-ke, izibuyekezo zithi ekusetshenzisweni akukho mehluko nezinye izidakamizwa ezeluliwe, kufaka phakathi i-Gliformin.

Amatafula ane-metformin esebenzayo ngaphansi kwegama elifanayo lomkhiqizo akhiqizwa yiRafarma, iVertex, uGideon Richter, Atoll, Medisorb, Canonfarma, Izvarino Pharma, uPromomed, uBiosynthesis nabanye abaningi. Akukho neyodwa yalezi zidakamizwa okungashiwo ukuthi yimbi kakhulu noma ehamba phambili. Zonke zinokwakheka okufanayo futhi zidlule ngempumelelo ukulawulwa kwekhwalithi yokunikeza.

Ukubuyekezwa kwesifo sikashukela