Ubuningi besitho sohlelo lokugaya olunemisebenzi ye-endocrine secrete pancreatic juice, equkethe ama-enzyme. Njengomphumela wezimbangela ezithile, ukwanda kokuntuleka kwe-enzymatic pancreatic. Yiziphi izici zomsuka we-pathology emzimbeni? Yini edingekayo ukuze kubuyiselwe ukwakheka okuvamile kwezinto eziphilayo?
Amaqembu ama-enzyme nezenzo zawo
Isitho esincane sokugaya sitholakala ngezansi nje nangemuva kwesisu. Ama-pancreas asondele kakhulu emgogodleni ngezinga elithile - esifundeni se-lumbar vertebrae ephezulu. Isikhundla saso esidlulayo sifana nhlamvu oqondile "S". Ingabeka kuze kufike kumalitha ama-4 wejusi we-pancreatic ngosuku. Inqubo iqala ngokushesha ngemuva kokuthi umuntu athathe ukudla. Umsebenzi wezomfihlo uyaqhubeka amahora amaningi.
Ijusi le-pancreatic lingama-98% amanzi. Ingxenye encane esele iwela kuma-enzymes (ama-enzyme). Lezi zinto eziphilayo zingamaprotheni emvelweni. Basheshisa ukusabela okungamakhulu emzimbeni emzimbeni. Ngokwazo akufanele zichithwe futhi zichithwe. Kepha kunezizathu eziholela komunye umphumela - ukuntuleka kwama-enzyme noma ukungasebenzi kwawo. Isibonelo, ososayensi bezokwelapha baveze ukuthi ama-enzyme asebenza ngokujwayelekile ezindaweni ezigxile kakhulu ze-hydrogen ions kanye namakhulu ezinye izimo ziyabhekwa.
Kubonisa izakhiwo ezihlukile zama-enzyme nokukhetha kwawo. Ingxube ngayinye esebenza kakhulu igxile eqenjini layo lezinto:
- i-lipase iphula amafutha;
- trypsin (chymotrypsin) - amaprotheni;
- amylase - ama-carbohydrate.
Ama-enzymes asebenza kumakhemikhali ayinkimbinkimbi anesisindo esikhulu samangqamuzana ukuze awenze abe yizakhi ezilula: amaprotheni - kuma-amino acid, ama-carbohydrate - kuma-monosaccharides.
Izimbangela nezimpawu Zokungasebenzi kahle
Izidakamizwa ze-pancreaticIjusi yokugobhoza ihamba nge-duodenum iye emathunjini. Ngokushoda kwama-enzymes we-pancreatic, izakhi zokudla azithakwa, hlala ungaphazanyiswa. Lesi sifo singaba ngofuzo, sisuka kubazali sisiya ezinganeni. Kuyatholakala futhi nangesikhathi sokuphila, ngesimo sayo sokuqala - ngenxa yezinguquko ezihambisana nesitho sokugaya (okuhlobene nobudala, i-atrophy, ukulimala kwemishini - amatshe asezinduneni ze-pancreatic, izimila, izibazi).
Izinkinga ze-enzymatic zithola umlingiswa wesibili onomphumela ongaqondile esitho (i-atherossteosis, isifo sikashukela, ukukhuluphala, ukungondleki kahle okuhleliwe). Amasu wokuxilonga akuvumela ukuthi unqume ukusilela noma ukuphelela ngokuphelele kwama-enzyme emzimbeni.
Imvamisa izimpawu zokushoda kwe-enzymatic zibonakala njengezinkinga ze-pancreatitis e-acute kanye ne-pancreatitis engapheli.
Isiguli sisungula ukwephulwa kwe-pathological ngokwezimpawu ezilandelayo:
- ukunciphisa umzimba okuqhubekayo;
- ukuqhakaza njalo;
- isimo se-anemic;
- isifo sohudo esiwohlokayo (izitofu ezikhululekile).
Udokotela we-gastroenterologist osebenzisa izindlela zaselebhu zokutadisha ukutholakala kwangaphandle kwamanyikwe (ukuhlolwa kwe-probe, i-coprogram, enquma izinga lama-enzyme ezindundwini), izindlela zokwenza (i-ultrasound, i-MRI, i-CT, i-radiography) inquma izinga lokungakwazi kwe-enzymatic pancreatic.
Akuwona ama-molecule wamafutha aqukethe i-enzyme-cleave. Izinsikazi eziyindilinga:
- ukukhuphuka kwevolumu;
- ayakhiwe, ewuketshezi;
- unephunga le-fetid;
- ngumbala ompunga ompunga.
Ukwelashwa okubonakalayo kuhloswe ukuqeda ukubonakaliswa kokungalingani kwe-enzymatic. Lokhu kudinga ukukhuphuka okungu-100% kokuphuma kwe-secretory fluid. Ochwepheshe baphawula ukuthi ezigulini ezinesifo sikashukela i-mellitus, imiphumela yokuthuthuka ekwelashweni imvamisa ingamanga. Ukuhlolwa okuhle kokusebenza kwesitho esingasasebenzi.
Ukwelapha ukusiza umzimba ngenqubo yokugaya ukudla kanye nokumuncwa kokudla
Izimbangela Zokuzalwa Nokuthi Kutholakale Ukushoda Kwe-Enzyme
Isifo lapho i-pancreas ingakwazi ukukhipha ujusi wokugaya kusuka ezinsukwini zokuqala zempilo yengane ibizwa nge- hypoplasia. Kuvela ngokushesha. Kuvela ngenxa yokwakhiwa komzimba ngaphansi. Ingane ihlukunyezwa uphawu oluphambili nolusobala - shaya uhudo njalo. Ukuhudula kwenzeka ngenxa yokungabikho kwama-enzyme emathunjini.
Imvamisa i-pancreas engasebenzi kahle ayakhiqizi ama-hormone, okungukuthi, ayifezi ingxenye yesibili yezibopho zayo emzimbeni. Ngokuphikisana nesizinda sokungabikho noma inani elanele le-insulin, isifo sikashukela siyakhula.
Iziguli ezincishiswa amavithamini ancibilikayo amafutha nezinye izakhamzimba zithambekele ekugomeni okungenamandla. Imisebenzi yokuvikela umzimba ayikwazi ukubekezelela ukutheleleka (umkhuhlane, i-SARS, izifo zesikhumba). Ukwelapha i-pancreas engashitshi yenziwa ngamalungiselelo e-enzymatic. Ezinye izinto ezidingekayo zibuye zethulwe (i-insulin, amavithamini).
Esinye isifo lapho ujusi wokugaya ungahambi njengoba kuhlosiwe yingoba ngeke ikwazi ukuphuma kumashekhe amancane lapho akhiqizwa khona. I-pathology ye-cystic fibrosis ye-pancreas ingazalwa kabusha noma itholakale. Empilweni yonke, lokhu kwenzeka ngoba ijusi iba mnene kakhulu. Akakwazi ukudlula emiseleni emincane ye-bile futhi ayigoqele ndawonye.
Ama-Enzymes ahlanganisiwe
Ukuthathwa kwe-enzyme kuhlukile ngokuyisisekelo. Ngesikhathi se-pancreatitis eyingozi, isiguli sinqunywe ukuzila ukudla okunzima izinsuku eziningana, kwesinye isikhathi kuze kube ngamasonto ama-2. Ngalesi sikhathi, isiguli sifakwa ngezixazululo zezakhi emzimbeni. Kuyadingeka ukukhulula ukuvuvukala nokuvuvukala okuvela kumanyikwe. Faka izidakamizwa ezicindezela ukusebenza komfihlo komzimba (i-Mexicoidol, Pantripin, iSandostatin).
Kwi-pancreatitis engapheli, kusetshenziswa amalungiselelo e-enzymatic angenza ukuntuleka kwama-catalysts we-biochemical (accelerators):
- UMezim Forte
- Ikhoni
- I-Pancreatin
- Festal
- Enzistal.
Izidakamizwa zisetshenziselwa ukuphikisana nesizinda sokususwa ngokuphelele kotshwala nokunamathela ngokuqinile ekudleni okunokuqukethwe ngokulinganayo kwamaprotheni kokudla. Ukulondolozwa kwamaprotheni kuyadingeka njengezinto zokwakha izicubu ze-pancreatic ezonakalisiwe, kufaka phakathi.
Ukulungiselela okuhlanganisiwe kuqukethe ama-enzyme emvelo yezilwane ezincelisayo
Umthamo ofanele wezidakamizwa ukhethwa udokotela ngawodwana, ngokuya ngemiphumela yokuhlolwa, izimpawu zesiguli. Imininingwane ebalulekile ukuthi ama-enzyme asemaphaketheni noma ezibhebheni ahlanganiswa. Kuvikela ngokuphelele izidakamizwa ekubhujisweni esiswini. Ukugoqa akunakulimeka, ukuhlafuna ikhebula noma ithebhulethi. Ithuluzi lifinyelela imvelo esibelethweni, lilondoloze umsebenzi walo.
Izici zokuphuza izidakamizwa nazo ukuthi zisetshenziswa ngesikhathi sokudla noma, kwezinye izikhathi, ngokushesha emva kwazo. Ziyagezwa ngenani elikhulu loketshezi, kepha hhayi i-alkali (amanzi ajwayelekile noma amasiphu ezithelo ahlanjululwe). Ukuxabana kungafaka ukungabekezelelani ngakunye nomuthi, ukusabela komzimba engxenyeni yawo. Iziguli ezinesifo se-gastritis zinaka ukungakhululeki kwesisu ngesikhathi sokwelashwa.
Ukuvinjwa kwezifo ukubhema ukuqeda, zonke izinhlobo zalo (ezifashisayo, ezisebenzayo, ngesikhathi sokukhulelwa), utshwala obunamandla. I-pathology iba ngenxa yokufa kwengxenye ebalulekile yamangqamuzana akhiqiza ujusi we-pancreatic. Ukuxilongwa ngesikhathi kuyasiza esigabeni sokuqala sokukhula kokungalingani okutholwe ngokuphelele ukuze kubuyiswe ngokuphelele noma ingxenye yomsebenzi we-pancreas, abantu abanezifo zokuzala ukuze bathuthukise ikhwalithi yezempilo emzimbeni.
