ILoapap ne-Amlodipine izindlela zanamuhla zokunciphisa ingcindezi. Zithinta umzimba ngezindlela ezihlukile, kepha zingasetshenziswa ngokuhlangana. Thatha ngesifo senhliziyo kufanele kube ngokwemiyalo. Ukubuyekezwa kodokotela neziguli ngokusetshenziswa okuhlangene kulungile, yize kwezinye izimo kunemiphumela engemihle.
ILoapap kanye ne-Amlodipine kuyindlela yokunciphisa ingcindezi.
Isimilo se-Lozap
I-Losartan iyinto esebenzayo yalesi sidakamizwa. Kutholakala kumthamo ka-12,5, 50 noma 100 mg. Inomphumela we-antihypertensive. Ngemuva kokungena, ama-angiotensin 2 receptors avinjelwe. Umenzeli usebenza kuphela kuma-receptors e-AT1 subtype futhi akuyona i-ACE inhibitor. Kungakapheli amahora ayi-6, ingcindezi nokumelana nokugeleza kwegazi ohlelweni lwe-vascular emzimbeni kuncipha. ILosartan isusa ne-uric acid emzimbeni, ivimbela ukukhishwa kwe-aldosterone futhi inciphise nengozi yokuqhamuka nezinkinga zenhliziyo.
ILosartan iyinto esebenzayo yeLozap.
Ukwenza kanjani Amlodipine
Umuthi uqukethe into efanayo esebenzayo nomthamo we-5 mg noma we-10 mg. Ithuluzi livimba iziteshi ze-calcium, lithuthukisa ukuhamba kwegazi liye enhliziyweni futhi lisiza ukugcwalisa i-myocardium nge-oxygen. Ngenxa yalokhu, i-potassium ayingeni kumaseli enhliziyo, bese kwenzeka i-vasodilation. Ngemuva kokuthatha umuthi, ukugeleza kwegazi kuvamile, umfutho wegazi uyancipha, nomthwalo osemisipha yenhliziyo uyancipha. Inhliziyo iqala ukusebenza kangcono, futhi ubungozi be-angina pectoris nezinye izinkinga kuncishisiwe. Ikhambi liqala ukusebenza kungakapheli amahora angama-6- 10.
Umphumela ohlanganayo weLozapa ne-Amlodipine
Zombili lezi zidakamizwa zinomphumela we-hypotensive. I-Amlodipine igxilisa imithambo yegazi futhi inciphise ukumelana okuphelele kwengxenye yemithambo yegazi. I-Lozap ivimbela ukwanda kwengcindezi futhi ivimbele ukuthuthukiswa kwezinkinga ezinzima zenhliziyo. Ukuphathwa okuhlanganisiwe kwezidakamizwa kukuvumela ukuthi usheshe futhi isikhathi eside ukunciphisa ingcindezi.
Ukuphathwa okuhlanganisiwe kwezidakamizwa kukuvumela ukuthi usheshe futhi isikhathi eside ukunciphisa ingcindezi.
Izinkomba zokusetshenziswa ngasikhathi sinye
Yabela ngokwanda okuqhubekayo kwengcindezi. Ukuphathwa okuhlanganyelwe kwezidakamizwa kuzovumela isikhashana ukuthi kuzinze isimo somfutho wegazi ophakeme futhi kunciphise nengozi yezinkinga ezinzima.
Contraindication ku-Lozap nase-Amlodipine
Ukuphathwa ngokubambisana kwamathebulethi kuyaphikiswa kwezinye izifo nemibandela ethile, njengoku:
- ukukhulelwa
- isikhathi sokuncelisa;
- ukungezwani komzimba kuma-losartan noma ama-amlodipine;
- ukungasebenzi kahle kwesihlungu sezinso noma kwesibindi;
- i-cardiomyopathy engapheli;
- amapharamitha we-hemodynamic angazinzile ngemuva kokufakelwa kwe-myocardial;
- isimo sokushaqeka;
- ukusetshenziswa kwezidakamizwa eziqukethe i-aliskiren;
- ukungakwazi komzimba ukugaya nokufaka ushukela obisini;
- ukuntuleka kwe-lactase;
- ukuntuleka kokufakwa kweglucose ne-galactose;
- izingane nentsha;
- ukukhuphuka kwe-potassium ku-plasma yegazi.
Kwenqatshelwe ukuqala ukwelashwa ngokubambisana ne-hemodialysis kanye nokuphuza utshwala. Ukuqapha kufanele kusetshenziswe lapho kunciphisa ukukhishwa kwemithambo ye-renal, isifo senhliziyo se-coronary, isifo se-cerebrovascular, umlando we-edema kaQuincke, ukomisa kanye nomfutho wegazi ophansi. Ezigulini esezikhulile kanye ne-hyperkalemia, umuthi kufanele unqunywe ngudokotela.
Ungayithatha kanjani iLozap ne-Amlodipine
Kuyadingeka ukuthatha izidakamizwa zombili ngemuva kokubonana nodokotela. Umthamo onconyiwe uthathwa ngaphandle kokudla futhi ugezwe ngamanzi. Kuyadingeka ukwandisa umthamo kancane kancane ukuze ufinyelele umphumela owufunayo wokwelapha.
Ukusuka ekucindezelweni
Nge-hypertension ye-arterial, umthamo wokuqala ngosuku ngu-5 mg we-Amlodipine no-50 mg we-Lozap. Umthamo ungandiswa ube ngu-10 mg + 100 mg. Uma ukusebenza kwesibindi kukhubazekile futhi isilinganiso segazi elijikelezayo sincishisiwe, umthamo we-losartan kufanele wehliselwe ku-25 mg ngosuku. Nge-hypertension ye-arterial, isidakamizwa asinqunyelwe.
Isifo senhliziyo
Umthamo ophakanyisiwe wansuku zonke wesifo senhliziyo ngu-5 mg we-Amlodipine no-12,5 mg weLozap. Ngokubekezelela okuhle, umthamo ungakhuphukela ku-10 mg + 100 mg. Ukwehluleka kwenhliziyo, sebenzisa ngokuqapha.
Imiphumela emibi
Ngokusebenzisa ngasikhathi sinye, ukusabela okungahle kwenzeke kungenzeka:
- Isiyezi
- ukuphazamiseka kokulala;
- ukukhathala;
- i-migraine
- ukuzindla kwenhliziyo;
- ukuqunjelwa
- ukuthopha;
- ubunzima bokuphefumula
- isikhumba esikhanyayo;
- ukuchama njalo;
- I-edema kaQuincke;
- anaphylaxis.
Izimpawu ziyanyamalala ngemuva kokuhoxiswa noma ukuncishiswa komthamo.
Umbono wodokotela
U-Alexey Viktorovich, udokotela wezifo zenhliziyo
Ngokusho kwezifundo, zombili lezi zidakamizwa zisebenza kahle ngokubambisana futhi zinikeza umphumela ophakeme kakhulu kune-placebo. I-Amlodipine isiza ukuphumula izicubu ezibushelelezi zemithambo yegazi, futhi i-losartan ivimbela ukwanda kwengcindezi. Ngokuhlanganiswa, zisiza ukuvikela ezinye izifo zenhliziyo nezemithambo. Ingcindezi iyancipha ngaphandle kwesikhundla somzimba. Lapho isetshenziswa ngokufanele, ubungozi bemiphumela emibi buyancishiswa. Ukwamkelwa akuholeli ekwakhiweni kwe-tachycardia.
Elena Anatolyevna, udokotela wezokwelapha
ILoapap ne-Amlodipine zidonswa ngokushesha. Ama-metabolites asebenzayo enza i-biotransformation esibindini. Uma kwenzeka ukungasebenzi kahle kwesibindi nokuqoqeka kwe-creatinine okungaphansi kwama-20 ml / min, ukwelashwa akufanele kuqale. Le mishanguzo ihlangana kahle, futhi umphumela wokubusa ngokubambisana uphakeme kakhulu kunalowo we-monotherapy. Ukuqapha kufanele kusetshenziswe ekugugeni nasekuguleni kwezifo ezinzima zesistimu yezinhliziyo ene-hemodynamics engazinzile.
Ukubuyekezwa kweziguli
Anastasia, iminyaka engu-34
Kungazelelwe kube nezinkinga zokucindezela. Kwakunokwenzeka ukwenza isimo sibe ngokwejwayelekile ngokusebenzisa inhlanganisela yezidakamizwa ezimbili. I-Act losartan ne-amlodipine ene-hypertension iqala kungakapheli ihora. Kancane kancane, ukungezwani endaweni yekhanda kuyanyamalala, izinhlungu emathempelini ziyayeka, ukushaya kwenhliziyo kuvamile. Ngokusho kokubukwa kungakapheli amasonto ama-3, lesi simo siyathuthuka, futhi ukwelashwa kungaqedwa. Ayikho imiphumela emibi. Izintengo ezinengqondo nemiphumela emihle.
