I-Carbamazepine Retard isetshenziselwa ukunciphisa ubukhulu kanye nokuvimbela ukuqala kwezimpawu zesifo sokuwa. Umuthi uyasebenza uma ubanjwa. Ububanzi bokusetshenziswa kwayo banzi, kepha kukhona inani le-contraindication, ngakho-ke awukwazi ukusebenzisa ithuluzi ngokubona kwakho.
Igama Lezwe elingafanele
Carbamazepine
I-Carbamazepine Retard isetshenziselwa ukunciphisa ubukhulu kanye nokuvimbela ukuqala kwezimpawu zesifo sokuwa.
I-ATX
N03AF01
Khipha amafomu nokwakheka
Ungathenga umuthi ezibhebheni. Ku-1 pc I-200 noma i-400 mg yento esebenzayo ingaqukathwa, okuyi-complication yegama elifanayo (i-carbamazepine). Ukuqanjwa kufaka phakathi izinto ezingakhombisi umsebenzi we-antiepileptic, ngenxa yabo bathola ukungaguquguquki okudingakalayo komuthi:
- i-microcrystalline cellulose;
- i-magnesium stearate;
- i-silicon dioxide colloidal;
- i-carbomer;
- isitashi se-sodium carboxymethyl.
Umuthi uyatholakala emaphaketheni amaphilisi ayi-10 nangu-50. Ibhokisi lekhadibhodi liqukethe amanxeba (1 noma ama-5 ama-pcs.). Ngaphezu kwalokho, amaphilisi kungenzeka atholakale embizeni. Umehluko omkhulu phakathi kweCarbamazepine Retard nama-analogues yikhono lezinto ezisebenzayo ukuthi likhishwe isikhathi eside, elenziwa ukuba khona kwegobolondo elikhethekile.
Ithebhulethi eyi-1 ingaqukatha u-200 noma u-400 mg wento esebenzayo, okuyi-complication yegama elifanayo (i-carbamazepine).
Isenzo se-Pharmacological
Umuthi ungowama-anticonvulsants. Isetshenziselwa ukwelashwa kwe-antiepileptic kanye nezinye izifo ezihambisana nokuxhuga. Ngaphezu kwalokho, i-carbamazepine ikhombisa ezinye izakhiwo:
- analgesic elinganiselayo;
- antipsychotic;
- i-standardotymic;
- i-timoleptic.
Umphumela wokuthoba wesidakamizwa kungenxa yamandla ayo wokuvimba umsebenzi wamashaneli e-sodium amangqamuzana ezinzwa, abonakala ngomsebenzi owandayo. Ngaphezu kwalokho, kukhona ukucindezela kwe-glutamate, i-aspartate. Lawa ma-amino acid anomthelela othokozisayo. Ngenxa ye-carbamazepine, ukuqina kokusebenzisana nama-adenosine receptors kuyancipha. Le nto isiza ukucindezela umsebenzi we-norepinephrine ne-dopamine, ngaleyo ndlela isuse ukubonakaliswa kokuziphatha kobuntu.
Umuthi uphumelela ikakhulukazi ekwelapheni kwezingane, nasezigulini lapho usakhula, lapho kutholakala njengokujwayelekile indlela yokuziphatha kanye nesimo sengqondo: ulaka, ukungabekezeleleki, ukudangala, kanye nokukhathazeka okungenangqondo kuqedwa. I-Carbamazepine isiza ngokuhlaselwa okubanzi nokugxile. Ngiyabonga kuye, lesi simo senziwa ngendlela ejwayelekile kanye nokwephulwa kwemvelo ye-neuralgic yezinzwa ye-trigeminal nerve. Kulesi simo, ubukhulu bezinhlungu buyancipha.
Umuthi uphumelela ikakhulukazi ekwelapheni kwezingane, lapho kusebenza okuvamile nesimo sokusebenza kwengqondo.
Ngokulashwa kwezimpawu zokuqeda utshwala, ukubonakaliswa kuba yize. Kudlula ukuhlasela, ukweqile, i-gait iyabuyiselwa. I-Carbamazepine isetshenziswa njengesijobelelo ekuphazamisekeni kokuphefumula, i-psychososis yengqondo.
I-Pharmacokinetics
Umuthi ubonakala ngezinga lokutholwa eliphansi, ngakho-ke imiphumela emihle ayitholwa ngokushesha. I-Carbamazepine igxile ngokuphelele. Ukudla okudliwayo akukuthinti isilinganiso sokufakwa komkhiqizo.
Umthamo ophakeme wento esebenzayo eplasma yegazi ufinyelelwa phakathi kwamahora ayi-12-24 ngemuva kokuthatha umuthi wokuqala womuthi.
Iqoqo lokulinganisa kwento ku-plasma liba ngemuva kwezinsuku eziyi-7-14. Ijubane lale nqubo lincike ezintweni ezimbalwa zangaphakathi, ikakhulukazi isibindi kanye nesidingo sezinye izidakamizwa. Amandla omuthi wokubopha amaprotheni egazi ahlukile. Emzimbeni wezingane, le nkomba ayidluli kuma-59%, kubantu abadala ifinyelela kuma-80%.
I-Carbamazepine iguqulwa esibindini. Kulokhu, kukhululwa ama-metabolites amaningana. Lezi zinqubo ziqhubeka nokubamba iqhaza kwama-enzymes we-cytochrome P450, kanye ne-UGT2B7 isoenzymes. Isikhathi sesikhathi lapho ukwehla kokuxakaniseka kwento esebenzayo kuya ngesilinganiso somuthi, imvamisa yokuphatha kwawo futhi kungamahora ayi-16 kuye kwayi-8. Kuyaphawuleka ukuthi ngokusetshenziswa njalo kwesidakamizwa, izinga lokuqedwa kwe-carbamazepine kanye nama-metabolites liyanda.
Yini esiza?
Isidakamizwa sinconywa ukuthi sisetshenziswe kulezo zimo ze-pathological:
- ukuqondiswa okuyinhloko kokwelashwa - ukubanjwa kwesithuthwane, kuhambisana nokuqunjelwa: ifomu elijwayelekile, lendawo, elihlanganisiwe;
- i-neuralgia ye-glossopharyngeal, i-trigeminal facial nerve, kufaka phakathi izimo ezifanayo ze-pathological, kepha ikhula ngokumelene nesizinda se-sclerosis eminingi;
- i-hangover syndrome;
- i-neuropathy (onesifo sikashukela mellitus);
- ukuphazamiseka kwengqondo okuhlukahlukene, izimpawu ezivame kakhulu eziyinkomba yokusetshenziswa kwomuthi kuleli cala: ukukhathazeka, ulaka, ukudangala, ukuphazamiseka kokulala;
- i-neuralgia yemvelaphi ehlukahlukene, kufaka phakathi izimo ze-pathological ezavela ngokumelene nesizinda sokulimala.
Contraindication
Ithuluzi livinjelwe ukuthatha amacala amaningi:
- ukusabela okungekuhle komuntu ngamunye kunoma iyiphi ingxenye ekwakhiweni kwalesi sidakamizwa okukhulunywa ngaso nasemagqabini antidepressants eqembu lesithathu;
- ukuphazamiseka kohlelo lwe-hematopoietic, ngokwesibonelo, i-leukopenia, ukwehla kwe-hemoglobin;
- i-atrioventricular block;
- ukwephulwa kwe-pigment metabolism (i-hepatic porphyria), ehambisana nokubomvu kwesikhumba;
- ukusetshenziswa kotshwala ngenkuthalo.
Inani elithile lokulinganiselwa kuqashelwa lapho usebenzisa i-Carbamazepine Retard:
- ukungapheleli kokusebenza kwenhliziyo (isigaba esinqunyiwe);
- ukwephulwa kwe-adrenal cortex;
- izimo ze-pathological ezibangelwa ukuncipha kokusebenza kwesibindi nezinso;
- ingcindezi ekhuphukayo kwizitho zombono;
- ukukhula ngokweqile kwezicubu zomgogodla;
- ukwehla kokuxineka kwe-sodium emzimbeni, ngenxa yomthelela omubi emsebenzini weziteshi ze-sodium.
Ngokuqapha, iCarbamazepine Retard isetshenziswa ngengcindezi eyandayo kwizitho zombono.
Ungayithatha kanjani iCarbamazepine Retard?
Indlela yokwelashwa iyahlukahluka kuye ngohlobo lwesifo, iminyaka yesiguli, ukuba khona kwezinye izifo emzimbeni. Izinketho ezivamile:
- isithuthwane: abantu abadala bayanconywa ukuba baqale isifundo, bathathe izikhathi eziyi-100-200 mg zento 1 noma 2 ngosuku, umthamo uyakhuphuka kancane kancane, akufanele udlule umkhawulo ophezulu wenani lansuku zonke - i-1200 mg (ihlukaniswe imithamo emi-2);
- i-trigeminal neuralgia: ukwelashwa kuqala ngo-200-400 mg ngosuku, kancane kancane leli dosi likhuphuka izikhathi ezi-2, umuthi kufanele uthathwe kuze kuqedwe izimpawu zesifo;
- Ubuhlungu obudalwa ukungasebenzi kahle kohlelo lwezinzwa: izikhathi eziyi-100 mg ngosuku, leli dosi libuye likhuphuke kanye nokwelashwa, lilondoloze inani le-carbamazepine ngosuku - lingabi ngaphezu kwe-1200 mg (elihlukaniswe ngemithamo emi-2);
- isimo se-pathological esibangelwa ubuthi botshwala: i-200 mg izikhathi ezi-3 ngosuku, uma kuvela ubunzima obukhulu, kunconywa ukuthatha umthamo ophindwe kabili - 400 mg izikhathi ezi-3 ngosuku;
- ukuvikela ukuphazamiseka kwengqondo okubambekayo: ama-600 mg angekho ngaphezulu kwezikhathi ezine ngosuku, imvamisa yokuphuza umuthi inqunywa ngawodwana;
- Ukwelashwa kokuphazamiseka kwengqondo okuguquguqukayo kanye ne-manic kwenziwa ngokusebenzisa umthamo wento ebangeni ukusuka ku-400 kuye ku-1600 mg ngosuku, leli nani liyanconywa ukuba lihlukaniswe ngemithamo eminingana.
Ukwelashwa kwezingane ezinesithuthwane:
- ubudala kusukela eminyakeni emi-4 kuye kweyi-10: inkambo yokwelashwa iqala ngama-200 mg ngosuku, kancane kancane inyusa inani, imithamo yokulungisa imana kaningana (400-600 mg izikhathi ezi-2 ngosuku);
- ubudala kusukela eminyakeni eyi-11 kuye kweyi-15: ama-200 mg ngosuku (ikakhulukazi kusihlwa), bese ekuseni kunconywa ukuthatha i-200-400 mg, kusihlwa - 400-600 mg;
- iziguli ezisukela eminyakeni engu-15 zikhonjiswa umthamo wabantu abadala lowomuthi.
Ubudala bengane kusukela eminyakeni emi-4 kuya kweli-10: inkambo yokwelashwa nge-carbamazepine Retard iqala ngama-200 mg ngosuku.
Ngaphambi noma ngemuva kokudla?
Ukudla akuzithinti izindawo zesidakamizwa, ngakho-ke amaphilisi angaphuzwa nokudla.
Isikhathi esingakanani ukuphuza?
Isikhathi senkambo yokwelashwa sinqunywa esimweni ngasinye ngokwahlukana, ngoba irekhodi lokwelashwa livame ukulungiswa ngokuya ngesimo somzimba.
Ukuthatha umuthi wesifo sikashukela
Ezigulini zaleli qembu, umuthi unqunywa kumthamo wama-200 mg kaningana ngosuku.
Imvamisa yokuphatha incike ohlotsheni lwesimo se-pathological.
Ngakho-ke, uma ukwelashwa kwe-polyneuropathy kuyadingeka ngokumelene nesifo sikashukela mellitus, umuthi uthathwa izikhathi ezingama-2-4 ngosuku. Ukwelashwa kwezimo zokugula okwenzeka ngenxa yesifo sikashukela kwenziwa ngokwesikimu esihlanganisa ukuthatha amaphilisi hhayi izikhathi ezi-3 ngosuku.
Ezigulini ezinesifo sikashukela, umuthi unqunywa kumthamo wama-200 mg kaningana ngosuku.
Imiphumela emibi ye-carbamazepine retard
Ngesikhathi sokwelashwa, kunethuba eliphezulu lokuthola ukungaphenduki okuhle komuthi. Ngaphezu kwalokho, imiphumela emibi ibonakaliswa yizitho nezinhlelo ezahlukene.
Amapheshana wesisu
Umuzwa wesicanucanu, ukomisa ukuphuma kulwelwesi lwama-mucous, ushintsho ekwakhekeni kwezindunduma, i-stomatitis, isimo sokuvuvukala kwe-pathological kusuka ohlelweni lokugaya ukudla (i-pancreatitis, njll).
Izitho zeHematopoietic
Izifo eziningana ezihambisana nezinguquko ekwakhekeni nasezakhiweni zegazi, ngokwesibonelo, i-leukopenia, i-thrombocytopenia, i-leukocytosis nezinye izinkinga ziyejwayelekile.
Isistimu yezinzwa ephakathi
Isiyezi, ikhanda, ubuthakathaka emzimbeni, ukozela, ukulahleka kwesifiso, ukudangala, ukukhathazeka, i-hyperaxcitability, imoto ekhubazekile, ukusebenza kwezitho zombono, ukukhuluma, ukuphazamiseka kwendawo yokuhlala.
Eminye yemiphumela emibi yeCarbamazepine Retard ukudangala.
Kusuka ohlelweni lomchamo
Umsebenzi wezinso onganele, izinqubo zokuvuvukala ezicutshini zalesi sitho, ukugcinwa komchamo noma okuphambene nalesi simo - ukuchama kaningi. Ezigulini zabesilisa, ukwehla kwe-potency kuyaphawulwa.
Kusuka ohlelweni lokuphefumula
Umkhuhlane, ukubonakaliswa kokuphendula kwe-hypersensitivity, umsebenzi wokuphefumula okhubazekile ngenxa yokuthuthukisa inyumoniya.
Uhlelo lwe-Endocrine
Ukwehla kwenqwaba ye-sodium emzimbeni, i-edema, ukukhuluphala, ukuqina kwamathambo, ukukhiqizwa ngokweqile kwe-cholesterol, triglycerides, ukungalingani kwe-hormonal.
Allergies
Izifo ezahlukahlukene ezibangelwa yi-allergies: i-dermatitis, i-urticaria, i-vasculitis, i-edema ye-Quincke's, ukusabela kwe-anaphylactoid.
Umuthi okukhulunywa ngawo ungadala ukungezwani komzimba.
Umthelela ekhonweni lokulawula izindlela
Akukho okuphikisana okuqinile kokuzibandakanya emisebenzini edinga ukunakwa okuningi. Noma kunjalo, kubalulekile ukubonisa ukuqaphela lapho ushayela.
Imiyalo ekhethekile
Ngesikhathi sokwelashwa, kunconywa ukuthi uhlole njalo ukugxila kokuthile okusebenzayo ku-plasma yegazi.
Ngaphambi kokuthatha umuthi, ukuhlolwa kwenziwa, okokuqala, kubalulekile ukuhlola ukusebenza kwezitho zombono.
Sebenzisa ebudaleni
Isidakamizwa sinconywa ukuba sithathwe ngokuqapha. Kuyaphawuleka ukuthi ama-pharmacokinetics ezigulini zaleli qembu awafani nalawo kubantu abancane.
Isabelo sezingane
Ukwelashwa kweziguli ezingaphansi kweminyaka engu-4, kufaka phakathi izinsana, umuthi awusetshenziswa.
Ukwelashwa kwezingane ezisanda kuzalwa, i-Carbamazepine Retard ayisetshenziswa.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Umuthi ungasetshenziswa ezimeni ezinjalo zowesifazane. Noma kunjalo, kubalulekile ukubonisa ukuqaphela ngesikhathi sokwelapha. Ukwelashwa kufanele kube ngaphansi kokuqondisa kukadokotela, ukuhlolwa kwelabhoratri kuyadingeka njalo: ukwakheka kwegazi, izinhlaka zesibindi nezinso kuyahlolwa. Bheka isimo sesibeletho ngesikhathi sokukhulelwa.
Lapho ukuncelisa, ukuqapha kwezimpawu ezibalulekile zomzimba wengane kuyadingeka.
Isidakamizwa sinconywa ukuba sithathwe ngesikhathi sokukhulelwa nokuqunjelwa, kepha kuphela uma imiphumela emihle yokwelashwa idlula ukulimala okungenzeka. Umuthi osebenzayo wesidakamizwa okukhulunywa ngaso uvuselela ukwehla kwenqwaba yama-folic acid, futhi uqongelela esibindini nasezinsweni zezinso. Ngaphezu kwalokho, i-carbamazepine ngamanani amakhulu angena ubisi lukamama. Kulokhu, ukusabela okungekuhle kusuka ezinhlelweni ezahlukahlukene enganeni kungenzeka.
Ukweqisa kweCarbamazepine Retard
Uma irejimithi yokwelashwa yephulwa, izinkinga ezivela ezinhlakeni zenhliziyo, zokuphefumula nezesizinda sezinzwa zikhula kuqala.
Ngokunikezwe ukuthi ayikho i-antidote, ukwelashwa okwenziwa ngamandla ukuqeda izimpawu zokweqisa, kuyilapho umsebenzi wezitho ezibalulekile ulawulwa.
Ukuxhumana nezinye izidakamizwa
Akuhlanganisiwe ukuhlanganisa
Ukuphathwa kanyekanye kwe-carbamazepine Retard nezidakamizwa ezivimbela i-CYP ZA4, kanye nama-inhibitors we-MAO, kunomthelela ekuthuthukiseni imiphumela emibi eminingana.
Kukhona ukwanda kokuxutshwa kwezidakamizwa okukhulunywa ngazo ngenkathi uthatha i-Felodipine, Dextropropoxyphene, Viloxazine, Fluoxetine, Nefazodon, njll.
Kukhona ukwanda kokuhlungwa komuthi okukhulunywa ngawo ngenkathi uthatha i-Felodipine.
Inhlanganisela edinga ukuqashelwa
Izidakamizwa eziningi, ngenkathi uthatha ngazo i-carbamazepine isiza kanjani ukunciphisa ukubekelwa phansi: i-Clobazam, Clonazepam, Digoxin, Ethosuximide, Primidone, Alprazolam, glucocorticosteroids, njll.
Ukuhambisana notshwala
Akunconyelwe ukuphuza iziphuzo eziqukethe utshwala ngenkathi ulashwa nomuthi okukhulunywa ngawo.
Ama-Analog
Izikhwama ezingaphansi kweCarbamazepine Retard:
- I-Finlepsin;
- Carbamazepine-Akrikhin.
Imibandela yekhefu lekhemisi
Umuthi umuthi.
Ngingakwazi ukuthenga ngaphandle kadokotela?
Cha.
Malini iCarbamazepine Retard?
Intengo ejwayelekile ingama-ruble angama-50.
Izimo zokugcina zomuthi
Ukushisa okunconyiwe - hhayi okuphakeme kuno- + 25 ° ะก.
Isikhathi sokuphelelwa yisikhathi
Umuthi ugcina izakhiwo iminyaka emi-3 kusukela ngosuku lokukhishwa.
Umkhiqizi
I-CJSC Alsi Pharma, AO Akrikhin (Russia), njll.
I-analogue yeCarbamazepine Retard - isidakamizwa iFinlepsin singathengwa kuphela ngokubhaliwe.
Ukubuyekezwa kwe-Carbamazepine Retard
UValentina, oneminyaka engama-38, uSamara.
Umuthi awusebenzi ngokushesha njengoba besingathanda. Kepha ngenxa yokwelashwa kukhona ukuthuthuka okuqhubekayo. Ama-Convulsions avela kancane uma ngiqhathaniswa nesikhathi lapho ngiphuza khona ezinye izidakamizwa noma angizange ngiphathwe nakancane.
USvetlana, oneminyaka engama-44, uBryansk.
Inikeze ingane umuthi. Lapho umthamo ukhula, imiphumela emibi yaqala ukuvela: komzimba, ukuvuvukala, ukugcinwa komchamo. Kwakufanele ngiphathwe ngokwesikimu esihilela ukuphuza umthamo oncishisiwe ngosuku.
