I-Wheelworm yisidakamizwa esihlobene nama-acid asemuva kwama-acid. Iqembu lale mishanguzo kuhloswe ngalo ukwehlisa i-cholesterol emzimbeni wesiguli ehlushwa ukungezwani kwalesi sakhi se-plasma yegazi. Le mishanguzo isetshenziswa njengezihlanganisi ngesikhathi sokwelapha okuyinkimbinkimbi.
Ukusetshenziswa kwalezi zidakamizwa kunganciphisa amathuba okuthuthukisa ischemia.
Isici somuthi iKolesevelam ukungabikhona kokunambitheka okungathandeki kumkhiqizo, okuholela ekusebenziseni kwaso kaningi uma kuqhathaniswa nezinye izidakamizwa ezikuleli qembu.
Ukusebenzisa umuthi kunganciphisa i-cholesterol ephezulu egazini. Lokhu kusiza ukuvikela izinkinga ezinzima emzimbeni ezibangelwa ukuvaleka kwemithambo yegazi ngama-cholesterol deposits. Ukusetshenziswa kwomuthi futhi kukuvumela ukuthi wehlise izinga loshukela emzimbeni ezigulini ezinesifo sikashukela sohlobo 2.
Kwenqatshelwe ukuphuza umuthi weziguli ezinesifo sikashukela sohlobo 1.
Izicucu zama-asidi ze-bile zinikeza ukubopha kwe-cholesterol kanye ne-bile acid ehlanganiswe kumaseli wesibindi kusuka ku-cholesterol.
Ngenxa yokubopha kwama-bile acid, isibindi siyaphoqeka ukuthi sihlanganise inani elingeziwe lalezi zingxenye, sichitha i-cholesterol eningi kulokhu. Ukusetshenziswa kwevolumu eyengeziwe ye-cholesterol yokukhiqiza ama-bile acid kusiza ukunciphisa inani lotshwala be-lipophilic ku-plasma yegazi.
Izindlela zokuqapha ngenkathi usebenzisa i-WheelClevelam
Ngaphambi kokusebenzisa umuthi njenge-ejenti yokusiza yokwelapha, kufanele uthintane nodokotela wakho ngokuwusebenzisa. Ukwakheka kwalesi sidakamizwa kufaka i-Solesewelam hydrochloride esebenzayo, engavusa ukuvela kokungezwani kwamanye amaqembu eziguli.
Ngokubonisana nodokotela ohambelayo, kumele kuboniswe wonke amalungiselelo, ama-vitamin complexes, izithasiselo zokudla okunempilo kanye namalungiselelo amakhambi asetshenziswa ukufeza imiphumela yokwelashwa emzimbeni.
Lolu lwazi luzovumela udokotela oqondisa inkambo yokwelashwa ukuba akhethe kahle umthamo womuthi.
Ngaphezu kwalokho, lapho usebenzisa umuthi, isiguli kufanele sikhumbule ukuthi ukusetshenziswa kwakhe kufanele kwenziwe okungenani amahora ama-4 ngaphambi kokuthatha izidakamizwa ezinjengokuthi:
- amavithamini izakhiwo;
- ama-anticoagulants;
- insulin;
- I-Levothyroxine;
- izindlela zokuvimbela inzalo ngomlomo;
- EWarfarin;
- UVerapamil;
- Gliburide nabanye.
Ngaphambi kokugunyazwa ukwelashwa, udokotela kufanele azi ngokuvunduzela esigulini, kanye nokungenelela kokuhlinzwa emathunjini noma esiswini.
Ukunikezwa kwesidakamizwa nokuzimisela komthamo ophelele kwenziwa ngudokotela, kucatshangelwa yonke imiphumela yokuhlolwa etholakala kuyena kanye nokuba khona kwezimpawu ngazinye zomzimba wesiguli.
Udokotela kufanele aziswe uma i-tumor ye-pancreatic ecasulwe izinga eliphakeme le-triglycerides ikhona emzimbeni.
Imiyalo yokusebenzisa umuthi
Ngokuyalela imiyalo esetshenzisiwe, umuthi kufanele uphuzwe ngomlomo futhi ugezwe ngenani elanele lamanzi.
Lapho usebenzisa umuthi ngesikhathi sokwelapha i-mellitus yesifo sikashukela, kuyadingeka ukulandela ukudla okhethekile ngasikhathi sinye nokuthatha umuthi futhi ubheke njalo izinga likashukela emzimbeni.
Uma umuthi usetshenziselwa ukwelashwa kwe-cholesterol ephezulu ye-plasma, khona-ke kuyadingeka ukuthola imiyalo enemininingwane mayelana nokugcinwa kokudla kokudla kusuka kudokotela oholayo ngesikhathi sokulashwa.
Umthamo wezidakamizwa ezisetshenziswayo uhlukile eqenjini ngalinye leziguli.
Lapho ulungisa i-lipids yegazi, kunconywa ukuthatha umuthi kule mithamo elandelayo:
- Abantu abadala bayalulekwa ukuthi bathathe amaphilisi ayi-6 nsuku zonke. Lelinani lemithi lingathathwa kanye ngosuku noma lihlukaniswe ngemithamo emibili.
- Uma kudingekile ukuthatha lo muthi ebuntwaneni, umthamo womuthi unqunywa udokotela, kucatshangelwa imiphumela yokuhlolwa kwengane nezimpawu zomzimba wakhe ngamunye.
Ngokuhambisana nemihlahlandlela yokuphuza umuthi uma uphuthelwe ukuphuza umthamo olandelayo, khona-ke esikhathini esizayo akufanele uphuze umthamo ophindwe kabili womuthi
Uma kwenzeka kusetshenziswa i-overdose, kufanele ufune usizo esikhungweni sezokwelapha futhi uyeke ukuthatha umuthi.
Umthamo womuthi osetshenziswa ekwelapheni isiguli unqunywa udokotela ngokuya ngesimo sempilo sesiguli, futhi uyalungiswa ngesikhathi sokwelashwa.
Amaphuzu abalulekile adinga ukuthi kuxoxwe ngawo nodokotela futhi athole izincomo odabeni lokuphuza umuthi ngale ndlela elandelayo:
- isikhathi sokuncelisa;
- ukuba khona kwezinkinga emsebenzini we-esophagus;
- isikhathi sokuhlela ukukhulelwa nesikhathi sokukhulelwa;
- Izinkinga zokugwinya.
Ngemuva kokuqala ukusebenzisa umuthi, kufanele ubheke isimo somzimba ngokucophelela futhi uma kukhona ukuphambuka enhlalakahleni, kufanele uvakashele udokotela ngokushesha ukuze uqede ukuphambuka futhi ulungise umthamo womuthi uma kunesidingo.
Imiphumela emibi, izinkomba kanye ne-contraindication ukuze isetshenziswe
Ukusetshenziswa kweColesevelam enqubweni yokwelashwa kungavusa ukuvela kwenkimbinkimbi yemiphumela emibi. Le miphumela emibi evela ekusetshenzisweni komuthi ivela kaningi, kepha hhayi njalo.
Eminye imiphumela emibi ayivamile ngokwanele, kepha ingaba nemiphumela emibi impela emzimbeni womuntu.
Uma kutholakala izimpawu zokuqala zokungaphenduki kahle, kufanele uthintane nodokotela wakho ngokushesha. Ukunaka umzimba ikakhulukazi kuyadingeka esimweni somthelela ongemuhle isikhathi eside esanele.
Eminye yemiphumela emibi ejwayelekile yilena:
- ukubonakala kobuhlungu obuqinile emuva;
- ukwenzeka kokuqunjelwa njalo;
- ukuvela kwekhanda elinzima ngokwanele;
- ukuthuthukiswa kwe-dyspepsia;
- ukubonakala kobuhlungu obuqinile esiswini;
- ukubonakala kobuhlungu izicubu zomsipha nobuhlungu emalungeni.
Isibonakaliso esiyinhloko sokunquma umuthi wukuba khona kwenani eliphakeme le-cholesterol ku-plasma yegazi.
Lapho kunqunywa umuthi, umuntu kufanele acabangele ubukhona obukhona be-contraindication nokusetshenziswa kweKolesevelam esigulini.
I-contraindication esemqoka yilena elandelayo:
- Ukuhlinzwa amathumbu noma isisu.
- Yehlise umsebenzi wamathumbu.
- Isiguli sinemizwa engezwani nezinto ezenziwa umuthi.
Ngaphezu kwalokho, ukuba khona kwe-pancreatitis nganoma yiluphi uhlobo esigulini kungukuphikisana.
Ukufana kwezidakamizwa nokubuyekezwa
Gcina umuthi endaweni yokushisa yasekamelweni noma endaweni epholile, evikelwe elangeni eliqondile. Kwenqatshelwe ukumisa umuthi. Gcina ungafinyeleleki ezinganeni nasezifuyweni.
Impilo yeshalofu yesidakamizwa iyiminyaka emithathu. Ngemuva kwalesi sikhathi, ukusetshenziswa komuthi akuvunyelwe ngokuphelele.
Ukusetshenziswa kanye ngomuthi owodwa kungaholela ekuphazamisekeni okukhulu nasezinkingeni emzimbeni wesiguli.
IKolesevelam akuyona ukuphela kwesidakamizwa esiliqembu. Lo muthi unohlu oluphelele lwe-analogues ehlukene.
Le mithi elandelayo imidwebo yomuthi:
- I-Colestyramine noma i-Cholesterol;
- Colestipol.
Yonke le mishanguzo i-ion-exchange compounds yama-polymers engangehlisa izinga le-cholesterol emzimbeni nge-20% okungenani.
Umbuzo wokukhethwa kwezifanekiso zomuthi kufanele unqunywe nodokotela oholayo ngesisekelo sokuhlolwa komzimba wesiguli kanye nezimpawu zayo.
Lapho ukhetha umuthi, umuntu akufanele acabangele kuphela izinkomba kanye nemibandela yokusetshenziswa, kodwa amathuba emiphumela emibi lapho uthatha umuthi.
Namuhla, abahleliwe bama-asidi acid banqatshelwe ukuthengiswa kwamahhala. Esikhathini esithile ngaphambili, lokhu kwelashwa kwenziwa ngokusebenzisa i-Questranoma, isidakamizwa esiseqenjini lezidakamizwa ze-cholesterol. E-United States, lolu hlobo lwe-bile acid bile insulator luyavunyelwa.
Ukubuyekezwa mayelana nomuthi kuyindida impela, okungenzeka kakhulu ngenxa yokuhlukahluka kulwelwesi lweziguli kanye nokusetshenziswa okufanele komuthi ngokuhambisana nezincomo ezitholwe kudokotela.
Akunakwenzeka ukuthenga isidakamizwa endaweni ye-Russian Federation, ngoba umuthi awubhalisiwe kwi-Russian Federation.
Ungasithenga lesi sidakamizwa nge-Intanethi. Izindleko eJalimane zingama-euro ayi-110, okuthe ngesilinganiso samanje sokushintshana cishe ngama-ruble angama-7 700.
Ungayithoba kanjani i-cholesterol egazini izotshela uchwepheshe kule vidiyo ekulesi sihloko.
