I-Ultrashort insulin Glulizin - izici nezici zohlelo lokusebenza

Ngohlobo lwesifo sikashukela sohlobo 1, isiguli singasebenzisa i-insulin esebenza ngokushesha (ngokushesha), esifushane, esiphakathi, isikhathi eside futhi ngaphambi kokuxubana.

Ukuthi iyiphi okufanele inikezwe ngohlobo lwekhwalithi efanele yokwelashwa kuya ngezimpawu zomzimba ngamunye. Uma i-insulin efingqiwe emfishane iyadingeka, kuyasetshenziswa uGlulisin.

Kafushane nge-insulin Glulizin

I-insulin molecule

I-Insulin Glulisine iyi-analogue ye-insulin yabantu, efana nomgomo kule hormone. Kepha ngemvelo, isebenza ngokushesha futhi inomphumela omfushane.

I-Glulisin yethulwe njengesixazululo sokuphatha ngokungahambi kahle. Kubukeka njengoketshezi obonakalayo ngaphandle kokungcola.

Amagama wezohwebo ngemithi yokuba khona kwakhe: i-Apidra, i-Epidera, i-Apidra Solostar. Umgomo oyinhloko wesidakamizwa ukulawula i-glucose metabolism.

Ngokusho kokuhlangenwe nakho okusebenzayo, izinzuzo nezinzuzo ezilandelayo zingahlukaniswa:

• isebenza ngokushesha kunehomoni yomuntu (+);
• kwanelisa kahle isidingo sokudla e-insulin (+);
• ukungabikezeli okungenzeka komphumela womuthi emazingeni kashukela (-);
• amandla aphezulu - iyunithi yehlisa ushukela ngaphezu kwamanye ama-insulin (+).

I-Pharmacology ne-pharmacokinetics

Ngemuva kokuphathwa kwe-subcutaneous, kukhona ukwehla kwe-glucose ngenxa yokuthonya kokusetshenziswa kwayo okuphathelene nezicubu ezithweni nasekucindezelweni kwalezi zinqubo esibindini. Isenzo siqala imizuzu eyi-10 ngemuva komjovo.

Ngokuqala kukaGlulisin kanye ne-insulin ejwayelekile imizuzu embalwa ngaphambi kokudla, owangaphambilini unolawulo olungcono lwe-glycemic ngemuva kokudla. I-bioavailability yento cishe eyi-70%.

Ukuxhumana ngamaprotheni e-plasma akunakwenzeka. Kukhishwa ngokushesha okukhulu kune-hormone ejwayelekile yomjovo womuntu. Ukuphila kwesigamu semizuzu engu-13.5.

Imiyalo yokusebenzisa

Umuthi uphathwa ngokushesha ngaphambi kokudla (imizuzu eyi-10-15) noma ngokushesha ngemuva kokudla, kucatshangelwa irejimeni yokwelashwa ejwayelekile namanye ama-insulin (ngesikhathi sokwenza noma ngemvelaphi). Indlela yokuphatha: ngobuhlakani ethangeni, ehlombe. Ukuze ugweme ukulimala, isiza somjovo siyashahlazwa. Umuthi uphathwa ezindaweni ezahlukahlukene, kepha ngaphakathi kwendawo efanayo.

IGlulisin ihlanganiswe nama-insulin nama-ejenti alandelayo:

• nge-analog ye-basal hormone;
• ngokwesilinganiso;
• isikhathi eside;
• ngezidakamizwa ezibekwe etafuleni eligcwele i-hypoglycemic.

Amandla we-glycemia ngokufakwa kwe-insulin Glulizin ekwelapheni nge-insal insulin

Uma isixazululo senzelwe ukuphathwa kusetshenziswa amapeni wesirinji, imijovo yenziwa ngokuya ngemiyalo yale ndlela. Umthamo womuthi ukhethwa ngawodwana, kucatshangelwa isimo sesiguli kanye nezinga lesinxephezelo.

Ngaphambi kokusebenzisa i-Glulizin, egcwalisiwe ku-cartridge, kuhlolwa okwenziwayo - isisombululo esinodaka esine-inclusions asilungele ukusetshenziswa.

Imiyalo yevidiyo yokusebenzisa ipeni lesirinji:

Izinkomba, imiphumela emibi, i-overdose

Umuthi ubekiwe kulezi zimo ezilandelayo:

• Uhlobo 1 sikashukela;
• Uhlobo 2 sikashukela;
• Isifo sikashukela ezinganeni ezisuka eminyakeni engu-6.

Ukuxhumana ngokuqokwa komuthi okulandelayo:

• i-hypoglycemia;
• hypersensitivity to glulisin;
• hypersensitivity kuzakhi ezisizayo zomuthi.

Ngesikhathi sokulashwa nomuthi, kusenokuvela okungahambi kahle.

Imvamisa yemicimbi engemihle ngamanani, lapho i-4 ivame kakhulu, i-3 imvamisa, i-2 iyivelakancane, 1 iyivelakancane kakhulu:

Ngesikhathi se-overdose, i-hypoglycemia yobunzima obuhlukahlukene ibonwa. Ingenzeka cishe ngokushesha noma ikhule kancane.

Ngokuya ngobukhulu bokulashwa kwe-insulin, ubude besikhathi nobunzima besifo, izimpawu ze-hypoglycemia zingahle zibe nombala kakhulu. Isiguli kufanele sicabangele lolu lwazi ukuze kuvikelwe isimo ngendlela esifike ngesikhathi. Ukuze wenze lokhu, kufanele ube noshukela (uswidi, ushokoledi, amashubhu kashukela ahlanzekile) nawe.

Nge-hypoglycemia elinganiselayo nelinganiselayo, imikhiqizo equkethe ushukela iyathathwa. Ezimweni ezinzima, ezihambisana nokuphelelwa ukwazi, kuzodingeka umjovo.

Ukumiswa kwe-hypoglycemia kwenzeka ngosizo lwe-glucagon (s / c noma i / m), isixazululo se-glucose (i / v). Kungakapheli izinsuku ezintathu, isimo sesiguli siqashwa. Ukuvimbela ukuthuthukiswa kwe-hypoglycemia ephindaphindekayo, kubalulekile ukuthatha ama-carbohydrate ngemuva kwesikhashana.

Ukusebenzelana kwezidakamizwa

Ekuqaleni kokwelashwa nge-insulin ye-ultrashort, ukusebenzisana kwayo neminye imithi kuyabhekwa.

Izidakamizwa eziningi zingathinta i-glucose metabolism, zithuthukise noma zinciphise imiphumela ye-ultrashort insulin. Ngaphambi kokwelashwa, isiguli kufanele saziswe ukuze zivikele imiphumela engathandeki.

Le mithi elandelayo iqinisa umphumela weGlulisin: I-Fluoxetine, ama-hypoglycemic agents kumathebhulethi, ikakhulukazi, ama-sulfonylureas, ama-sulfonamides, ama-salicylates, i-fibrate, i-ACE inhibitors, i-Disopyramide, i-MAO inhibitors, i-Pentoxifylline, i-Propoxifen.

Izidakamizwa ezilandelayo zinciphisa imiphumela yokwelashwa kwe-insulin: i-atypical antipsychotic, sympathomimetics, izindlela zokuvimbela inzalo ngomlomo, ama-hormone egilo, i-glucagon, ama-hormone ocansi abesifazane, i-thiodiphenylamine, i-somatropin, i-diuretics, i-glucocorticosteroid drug (GCS), proteinase inhibitors,

I-Pentamidine, i-beta-blockers, ne-clonidine zidluliselwa ezidakamizweni ezingalindeleki ezingathinta amandla okuvezwa kwe-Glulisin kanye ne-glucose level (ukuncipha nokwanda). Utshwala bunezici ezifanayo.

Ukuqashelwa ikakhulukazi kuyabonakala lapho kunquma iPioglitazone ezigulini ezinokutholwa kwenhliziyo. Lapho kuhlanganiswa, amacala okuthuthuka kokuhluleka kwenhliziyo aye abikwa ezigulini ezinamaphutha alesi sifo.

Uma ukwelashwa ngePioglitazone kungakhanselwa, kuyadingeka ukuqapha isimo. Uma ngabe kuvela izibonakaliso zenhliziyo (ukukhuluphala kwesisindo, ukuvuvukala), ukusetshenziswa kwalesi sidakamizwa kukhanseliwe.

Imiyalo ekhethekile

Isiguli kufanele sicabangele okulandelayo:

1. Ngokungasebenzi kwezinso noma ukwephulwa emsebenzini wabo, isidingo se-insulin singancipha.
2. Ngokungasebenzi kwesibindi, isidingo naso siyancipha.
3. Ngenxa yokuntuleka kwemininingwane, umuthi awubekelwe izingane ezingaphansi kweminyaka engu-6.
4. Sebenzisa ngokuqapha kwabesifazane abakhulelwe ngokubheka njalo kwezinkomba.
5. Ngesikhathi sokukhipha isisu, kuthathwa ukulungiswa kokudla kanye nokudla.
6. Lapho ushintshela ku-Glulisin kwelinye i-hormone ngenxa ye-hypersensitivity, ukuhlolwa kokungezwani nokwenziwa komzimba kufanele kwenziwe ukuze kungafakwa i-cross-allergy.

Ukulungiswa komthamo

Ukulungiswa kwe-dose kwenziwa ngesikhathi soguquko kusuka kolunye uhlobo lwe-hormone yomjovo. Lapho udlulisela kusuka ku-insulin yezilwane uye eGlulisin, umthamo uvame ukuguqulwa ohlangothini lokunciphisela owokugcina. Isidingo somuthi singashintsha ngokugcwala ngokweqile kwemizwa / ukuphazamiseka ngokomzwelo, ngesikhathi sesifo esithathelwanayo.

Isikimu silawulwa ngosizo lwezidakamizwa ze-tablet hypoglycemic. Uma ushintsha noma iyiphi ingxenye yesikimu, ungadinga ukulungisa umthamo we-Glulisin.

Ezimweni ezivame kakhulu ze-hyperglycemia / hypoglycemia, izici ezilandela umthamo olandelayo zichazwa kuqala ngaphambi kokushintsha umthamo womuthi:

• inqubo nendawo yokulawulwa kwezidakamizwa;
• ukubambelela ngokuqinile kwirejimeni yokwelashwa;
• ukusetshenziswa kweminye imithi;
• isimo ngokwengqondo.

Imininingwane eyengeziwe

Okuhle - iminyaka emi-2

Impilo yeshelf ngemuva kokuvula - inyanga

Isitoreji - kusukela ku-+2 kuye ku- + 8ºC. Musa uqhwa!

Ukuphumula kungukuya kadokotela.

I-Glulisin iyi-analogous kwi-insulin yabantu:

• I-Insuman Rapid;
• I-Humulin;
• I-Humodar;
• IGensulin P;
• IVosulin P;
• I-Actrapid.

I-Glulisin yi-hormone ye-ultrashort yokulawula i-glucose metabolism. Kunqunywe ngokuhlanganiswa namanye ama-insulin, kucatshangelwa uhlelo olujwayelekile olukhethiwe. Ngaphambi kokuwusebenzisa, kubalulekile ukutadisha imiyalo ethile nokuxhumana neminye imithi.