I-Amoxiclav 375 mg isidakamizwa esihlanganisiwe esibanzi esibonakalayo se-antimicrobial. Isebenza kahle ekulweni nezifo eziningi ezithathelwanayo, ibekezelelwa kahle yiziguli eziningi, kepha idinga ukusetshenziswa okunekhono, ngakho-ke ayifanele ukuzelapha.
I-ATX
Lo muthi ungowokulwa namagciwane we-systemic ngekhodi ye-ATX J01CR02.
I-Amoxiclav 375 mg isidakamizwa esihlanganisiwe esibanzi esibonakalayo se-antimicrobial.
Khipha amafomu nokwakheka
I-Amoxiclav iyathengiswa njengo:
- amaphilisi we-gastroprotective camera;
- amaphilisi okusabalalisa;
- izimpuphu zokumiswa komlomo;
- i-powder lapho kulungiswa khona isixazululo sokuphathwa kwe-intravenous.
Isenzo sanoma yiluphi uhlobo lwesidakamizwa sinqunywa umsebenzi ohlanganyelwe wezinto ezi-2 ezisebenzayo - i-amoxicillin (semisynthetic penicillin) ne-clavulanic acid (i-inhibitor yama-enzyme athile angamagciwane).
Imithamo ye-375 mg ngamathebhulethi efile kuphela. Ziqukethe i-250 mg ye-amoxicillin kwifomu le-trihydrate kanye ne-125 mg ye-potassium clavulanate (2: 1 isilinganiso). Okuqukethwe okwengeziwe
- i-crospovidone;
- i-microcellulose;
- i-talc yemithi;
- i-magnesium stearate;
- i-colloidal silicon dioxide;
- crodarmellose sodium.
Umthamo we-375 mg ngamaphilisi we-Amoxiclav kuphela egobolondweni.
Ukuhlanganiswa kwefilimu kuqukethe i-talc, hypromellose, polysorbate, cellulose ethyl ester, triethyl citrate kanye ne-titanium dioxide.
Amacwecwe agcwele emabhulini noma emabhodleleni engilazi. Babekwe emasakeni ekhadibhodi kanye nemiyalo. Iphakheji ingaqukatha amaphilisi ayi-15, 16, 20 noma angama-21.
Isenzo se-Pharmacological
Umphumela wokwelapha umuthi okukhulunywa ngawo unikezwa i-amoxicillin ne-clavulanate. Owokuqala wabo yi-semi-synthetic antibiotic evela kumapenicillin amaningi. Ibonisa izakhiwo ze-bactericidal. Ukusebenza kwesimo sale khompiyutha kungukuvimbela okungenakuphikwa komsebenzi wama-bacterial transpeptidases. Lawa ma-enzyme ayadingeka ku-biosynthesis ye-mucopeptide, okuyisisekelo sesakhiwo sodonga lweseli lwamagciwane. Ngenxa yalokho, ama-microorganisms ayafa.
Ibanga lesenzo se-amoxicillin lilinganiselwe, ngoba ezinye izidalwa ezingamagciwane ziyakwazi ukufihla ama-β-lactamases, abhubhisa isakhiwo sawo. I-Clavulanate isiza ukuvimbela ukungasebenzi kwe-antibiotic. Ibopha ama-enymes we-ß-lactamase, yakha izakhi eziyinkimbinkimbi ze-pharmacologically ezingasebenzi nawo.
I-Amoxiclav 375 isiza ekuqedeni amathumbu kanye ne-hemophilic coli.
Lokhu kukuvumela ukuthi ukhulise umsebenzi we-antimicrobial we-amooticillin futhi ususe ngempumelelo abamele abahlukahlukene be-microflora ye-pathogenic, kufaka phakathi:
- amathumbu kanye ne-hemophilic coli;
- streptococci;
- igolide ne-pyogenic staphylococcus;
- i-coagulase-negative staphylococci;
- i-pneumococcus;
- Klebsiella;
- i-enterobacteria;
- clostridia;
- i-legionella;
- i-brucella;
- ISalmonella
- ama-bacteroids;
- I-Proteus
- ama-actinomycetes;
- UShigella
- uhlu;
- chlamydia
- treponema;
- ama-causative agents we-pertussis, i-anthrax, i-meningitis, i-gonorrhea, isifo se-Lyme.
I-Pharmacokinetics
Umuthi udonswa emgodini wokugaya ukudla. Ukuqoqwa okuphezulu kwezakhi zayo ezisebenzayo egazini kunqunywa ngemuva kwemizuzu engama-60-90 ngemuva kokusebenzisa ngomlomo. Izilinganiso ze-Bioavailability 70%. Ungawuphuza umuthi noma ngabe ungakanani isidlo, kepha kungcono ekuqaleni kokudla.
Zombili izinto ezisebenzayo zisatshalaliswa kahle ezakhiweni ezihlukene, zitholakala ngamanani anele emisipha, emathanjeni, emafulethini anamanoni, ezinsikeni, ku-alveoli, kwizitho zesikhala se-intra-isisu. Umuthi ungena ku-bile, secretion ye-bronchial, discharge, umchamo, i-synovia, i-pleural effusion, uketshezi lwe-peritoneal, into ye-intercellular. Amaprotheni egazi abopha cishe ama-25% ama-clavulanate kanye ne-18% antibiotic.
Umuthi wehlula i-placenta futhi udlulwa ubisi lwebele, kepha isithiyo sobuchopho egazini sisangeneka kuso.
Ukusebenza okuyingxenye kwe-amoxicillin, imikhiqizo yokubola engasebenzi. Kufika kuma-70% okukhishwa ngendlela yoqobo olwakhiwe ngamazinyo ezinso, ama-10- 20% akhishwe ngendle. Ukuphila kwesigamu kungamahora ayi-1-1,5, ngokuhluleka okungapheli kwe-renal - cishe amahora angama-8,5.
I-Clavulanate isetshenziswa ngokuqinile kwisibindi. Isabelo esikhulu sidalulwa emchameni, inani elincane lishiya umzimba ngokusebenzisa i-rectum kanye nemishini yokuphefumula. Ukuqedwa kwesigamu sempilo kungamahora angama-1.5, nomsebenzi wezinso ongasebenzi kahle, kuze kube amahora angama-4,5.
Izithako ezisebenzayo ze-Amoxiclav 375 zingasuswa kusetshenziswa inqubo ye-hemodialysis.
Izinto ezisebenzayo zingasuswa kusetshenziswa inqubo ye-hemodialysis. Imiphumela ye-peritoneal dialysis ayigculisi.
Izinkomba zokusetshenziswa
Umuthi wenzelwe ekwelapheni izifo zohlobo lwesifo esithathelwanayo esibangelwa amagciwane angena esenzweni sawo. Izinkomba zokuqokwa:
- Ukulimala kwempumulo, ama-sinuses, i-oral cavity kanye ne-periodontium, abezindaba ze-otitis, i-mastoiditis.
- I-Pharyngitis, i-tonsillitis, i-pharyngeal abscesses.
- I-bronchitis, i-legionellosis, ukukhwehlela okuqhamukayo, inyumoniya, ikati lokuhogela, ukuthikameza komoya.
- Izifo ezithathelwanayo zomgudu womchamo (cystitis, pyelitis, nephritis, bacteriuria, urethral syndrome).
- Izifo ze-gynecological, i-prostatitis, i-gonorrhea, i-chancre emnene.
- Izilonda zesitho sangasese zesisu, i-cholangitis, i-hepatic abscess, i-cholecystitis, i-pancreatic necrosis.
- Ukutheleleka kwamathambo, ukuhlangana kwamanxeba, izingqimba kanye nezendlalelo ezingaphansi, ukulunywa, ukuvimbela ukutheleleka kwe-postoperative.
- I-Peritonitis
- I-Sepsis.
- Izifo ezixubekile.
I-Amoxiclav 375 isetshenziselwa ukwelapha i-bronchitis.
Contraindication
I-Amoxiclav ayikwazi ukuthathwa uma ukwakheka kungabekezeleli futhi uma kunomlando wokungezwani nokwelashwa ngamakhambi we-β-lactam, kubandakanya i-penicillin, i-carbapenem, amalungiselelo we-cephalosporin. Okunye ukwephulwa:
- i-hepatitis yezidakamizwa;
- cholestasis ngenxa yokwelapha elwa namagciwane;
- i-lymphocytic leukemia engapheli;
- Isifo sikaFilatov;
- ubudala bufika eminyakeni eyi-6 (ngaleli fomu lemithamo).
Ngokunakekela
Kudingeka ukuqaphela ikakhulukazi lapho kunikezwa umuthi kwabesifazane abakhulelwe, omama abancelayo, iziguli ezinokulimala okuqinile kwe-renal kanye ne-hepatic, izilonda zesisu, kubandakanya i-enterocolitis yezidakamizwa.
Ungayithatha kanjani i-Amoxiclav 375
Kunconywe ngokuqinile ukwenqaba ukusebenzisa umuthi okungagunyaziwe. Ukuqokwa kwakhe kufanele kube ngudokotela. Izibhebhe zithathwa zingenamanzi anele. Kungcono ukuzidla ngokudla, ekuqaleni kokudla. Lokhu kuzonciphisa ukulimala emgodini wokugaya ukudla, ngenkathi kugcinwa amapharamitha wokufaka kahle wokumunca.
Izibhebhe zithathwa zingenamanzi anele.
Kwabadala
Imithamo inqunywa ngawodwana. Amathebulethi angama-375 mg enzelwe ukwelashwa kwezifo ezithambile. Zithathwa ngesikhawu samahora ayisishiyagalombili, ezinezilonda ezi-odontogenic, isikhathi sokuphakathi komthamo singamahora ayi-12. Uma kukhona umsebenzi we-renal ophazamisekile futhi izinga le-creatinine lehla ngaphansi kwama-30, khona-ke isidakamizwa sithathwa izikhathi ezi-1-2 ngosuku. Uma kungekho ukuchama, isikhathi phakathi kwemithamo singandiswa ukuya ezinsukwini ezi-2 noma ngaphezulu.
Isikhathi esincane sokwelashwa siyizinsuku ezi-5. Ngokuqhubeka kwesikhathi eside, ngemuva kwamasonto ama-2 elashwa, kuyadingeka ukuthi ahlolwe okwesibili. Ngemuva kokuqeda ukubonakaliswa okubonakalayo kwalesi sifo, amaphilisi kufanele aphuzwe okungenani amahora angama-48.
Ungayinikeza kanjani i-Amoxiclav ezinganeni ezingama-375
Imithamo yezingane incike eminyakeni yobudala kanye nesisindo sengane. Kuze kube yiminyaka eyi-6, kunconyelwa ukunika izingane ifomu lokumiswa kwalo muthi. Iziguli ezisukela eminyakeni engu-12 ubudala zinikezwa imithamo yabantu abadala uma isisindo sazo singaphezu kwama-40 kg. Isikhathi sokwelashwa ngemithi elwa namagciwane sinqunywa udokotela oya khona.
Ukuthatha umuthi wesifo sikashukela
I-Amoxiclav ingabekwa kwabanesifo sikashukela ukulwa nezilonda ezahlukahlukene ezithathelanayo nezivuvukelayo. Akubangeli i-hyperglycemia, kepha kunganikeza ukusabela okuhle kwe-pseudo ku-glucose lapho kuhlaziywa umchamo.
I-Amoxiclav ingabekwa kwabanesifo sikashukela ukulwa nezilonda ezahlukahlukene ezithathelanayo nezivuvukelayo.
Imiphumela emibi
Imiphumela engathandeki itholwa ngokuvamisile, ezimeni eziningi ibuyela emuva. Ezinye zazo zingavela isikhashana ngemuva kokuphela kwenkambo yokwelashwa.
Amapheshana wesisu
Iziguli ziye zabika izikhalazo zokucanuzelelwa kwenhliziyo, ukulahleka kokudla, ukugabha, ubuhlungu besisu, i-gastritis, ukukhubazeka kwamathumbu, ukumnyama kolimi namazinyo. Mhlawumbe ukuthuthukiswa kwe-stomatitis noma i-glossitis, i-colitis, kufaka phakathi i-pseudomembranous, i-cholestasis, ukulimala kwesibindi kufinyelela ku-hepatonecrosis, ukwanda komsebenzi wama-enzyme wesibindi, igxuma ku-bilirubin.
Izitho zeHematopoietic
Kwesinye isikhathi kuba noshintsho ekwakhekeni kwegazi amaselula, c. kufaka phakathi i-pancytopenia, isikhathi sokuphuma kwegazi singakhuphuka.
Isistimu yezinzwa ephakathi
Imvamisa, ikhanda, ubuthakathaka, isiyezi kuvela. Kwesinye isikhathi ukugxilwa kokunakwa kuyaphazamiseka, kuba nenjabulo eyethusayo, ukuqwasha, ukudideka, ukubonakaliswa okukholisayo.
Ukuthatha umuthi okukhulunywa ngawo kungadala isiyezi.
Kusuka ohlelweni lomchamo
Ukutholakala kwegazi kungatholakala kumchamo. I-Crystalluria kanye nephritis ye-tubulointerstitial kungenzeka.
Allergies
Ukubonakaliswa kwe-allergic kuvame ukuthatha isimo se-urticaria (ukuqubuka, ubomvu be-integument, ukuvuvukala, ukulunywa). I-erythema enobungozi, izehlakalo ze-necrotic, ukufana kokugula kwe-serum, i-edema kaQuincke, i-vasculitis, i-anaphylaxis akuvamile ukuba ikhule.
Imiyalo ekhethekile
Ngesikhathi sokwelashwa, isimo sesibindi, izinso, izitho ezakha igazi kumele zilawulwe.
Iziguli ezine-hypersensitivity kuma-penicillin zingahle zizwe i-cross-allergies ene-carbapenems ne-cephalosporins.
Uma kwenzeka ukungasebenzi kahle kwesibindi, ukunakekelwa okukhethekile kufanele kuthathwe. Ukwehluleka kwangempela kudinga ukusetshenziswa kwemithamo emincane kanye nokwehla kwemvamisa yokuthatha i-Amoxiclav. Ukuvimbela i-crystalluria, udinga ukuphuza uketshezi oluningi futhi ubheke i-diuresis.
Ngenxa yokwelashwa, ukuvelela kungakhula.
Uma kwenzeka ukungasebenzi kahle kwesibindi, ukunakekelwa okukhethekile kufanele kuthathwe ngenkathi kuthathwa i-Amoxiclav.
Ukuhambisana notshwala
Ukuthatha umuthi olwa-antibiotic akuhambisani nokusetshenziswa kotshwala noma izidakamizwa ezine-ethyl alcohol endaweni yokwakheka.
Umthelela ekhonweni lokulawula izindlela
Lapho ushayela noma wenza umsebenzi odinga ukushesha kokuphendula kwe-psychomotor, kufanele kuqashelwe ngoba kungenzeka kube nemiphumela emibi ehlukahlukene evela ohlelweni lwezinzwa oluphakathi.
Sebenzisa ngesikhathi sokukhulelwa nokukhishwa komzimba
Abesifazane abakhulelwe banikezwa imishanguzo kuphela uma kunesimo esiphuthumayo, lapho inzuzo engaba khona esigulini izophakama kunokuba ilimale engaba yingozi enganeni. Lapho ukuncelisa ibele isikhathi sokwelashwa ngamakhambi, ingane kufanele ilunyulwe kusuka ebeleni.
Ukweqisa
Uma imithamo emisiwe idluliwe, kuvela izimpawu zobuthi (izinhlungu esiswini, ukuhlanza, uhudo). Ukushintshana, ukweqa, ukuqwasha, ukulahleka kwengqondo kungabhekwa.
Uma weqa imithamo ebekiwe ye-Amoxiclav, kungahle kwenzeke.
Emahoreni angama-4 okuqala ngemuva kokuphathwa umuthi ngomlomo, udinga ukhipha isisu futhi unciphise ukumuncwa ngokuthatha i-activated Carbon. Ukwelashwa okubonakalayo kunqunyelwe, futhi ukomisa kuqedwe uma kunesidingo. Isiguli sidinga ukwelashwa. Isidakamizwa esiningi sisuswa ngesikhathi se-hemodialysis.
Ukuxhumana nezinye izidakamizwa
Ukuchithwa kwezakhi ezisebenzayo kuthuthukiswa yi-ascorbic acid futhi kwehliswe nge-glucosamine, ama-antacid, ama-aminoglycosides, kanye nama-laxatives. Okuqukethwe kwama-antibiotic kukhuphuka ngokusetshenziswa kanyekanye kwesidakamizwa nge-phenylbutazone, i-Allopurinol, i-diuretics, izidakamizwa ezingezona ezomzimba ezibangelwa ukuvuvukala, ama-tubular secretion blockers. Umsebenzi wamakhemikhali we-Amoxiclav uyancipha uma usetshenziswa kanye neRifampicin, iChloramphenicol, ama-tetracyclines, ama-sulfonamides, ama-macrolides.
Umuthi okukhulunywa ngawo ngokuhambisana nama-anticoagulants uthuthukisa ukusebenza kwawo futhi kwezinye izimo ubangela ukwanda okuphindayo kwesikhathi se-prothrombin, kanti ukusetshenziswa kwawo okufanayo ne-Ethinyl estradiol kungaholela ekhipha isibeletho. Iphinde inciphise ukusebenza kwezindlela zokuvimbela inzalo ngomlomo futhi ithuthukise imiphumela eseceleni ye-Allopurinol, Methotrexate, Disulfiram.
I-Amoxiclav inyusa imiphumela emibi ye-methotrexate.
Analogs of Amoxiclav 375
Ezinye izidakamizwa ezisebenzisa inhlanganisela ye-clavulanic acid ene-amooticillin zinomphumela ofanayo:
- I-Augmentin.
- Panclave.
- Flemoklav Solyutab.
- Amoxicillin + Clavulanic acid.
- I-Medoclav.
- I-Amoxil.
- I-Novaklav.
- I-Amoxivan.
- I-Verklav.
- I-Amovicomb.
- I-Clamosar.
- UFibell.
- I-Foraclav.
- I-Ecoclave.
- Bactoclav nabanye
Imibandela yekhefu lekhemisi
NgesiLatini, umuthi ubizwa nge-Amoksiklav. Akuhloselwe ukuthi kuthengiswe mahhala.
Ngingakwazi ukuthenga ngaphandle kadokotela
Umuthi kadokotela usatshalaliswa.
Intengo
Izindleko zamathebulethi zingama-250 mg + 125 mg - kusuka kuma-ruble angama-226. ama-pcs ayi-15.
Izimo zokugcina i-Amoxiclav 375
Umenzeli wemithi ugcinwa kude nezingane. Ukukhanya kwelanga okuqondile kanye namazinga okushisa angaphezu kuka-25 ° C akufanele avunyelwe.
Isikhathi sokuphelelwa yisikhathi
Amathebhulethi angagcinwa iminyaka engu-2 kusukela ngosuku lokukhiqizwa. Ekupheleni kosuku lokuphelelwa yisikhathi, ngeke zithathwe.
I-analogue ye-Amoxiclav - isidakamizwa i-Augmentin asikwazi ukusetshenziswa ekugcineni kosuku lokuphelelwa yisikhathi.
Ukubuyekezwa kwe-Amoxiclav 375
Kwabodokotela neziguli, umuthi uthola izimpendulo eziningi ezinhle.
Odokotela
Satimov K. G., udokotela wamazinyo, e-Uryupinsk
Enye yemithi elwa namagciwane esebenza ngempumelelo futhi ephephile. Uma kunesidingo, sinikeze iziguli zami. Imiphumela emibi incane, akuvamile ukwenzeka. Ukuvikela isisu, ngincoma ukuyithatha ngokudla, futhi ama-probiotic ayadingeka ukulawula i-microflora yamathumbu.
Brovkina A.A., udokotela ojwayelekile, uSaratov
I-antibiotic enhle esebenza ngempumelelo emaqenjini ahlukahlukene yobudala. Kubekezelelwa kahle ezimweni eziningi. Phakathi kokusabela okungahambi kahle, ukuqubuka kwesikhumba nohudo kuvame ukuvela.
Iziguli
U-Alla, oneminyaka engama-44, uMurmansk
Uthathe umuthi ngemuva kokulimala komhlathi nokukhishwa ngamazinyo okukhishwa ngamazinyo ambalwa ukuze i-supplement ingafiki. Umuthi awuzange ube nemiphumela emibi, futhi izinkinga ezazingavikeleka zazigwenywa.
U-Elena, oneminyaka engama-37, uRostov
Ikhambi elwa namagciwane ngentengo engabizi. Ngayithatha ukuze ngiqede i-sinusitis, ngasikhathi sinye ngaphuza umenzeli we-probiotic. Ngazizwa ngikhululekile ngokushesha. Ngosuku lokuqala, ikhanda lami libuhlungu, kepha lokhu kungenzeka kungabi ngenxa yomuthi, kodwa ngenxa yesifo uqobo. Angitholanga okunye ukusabela okubi kuboniswe kwimiyalo.
UGregory, oneminyaka engama-29, uKostroma
Indodana ihlala ihlushwa amakhaza. I-Amoxiclav yathunyelwa kuye kaninginingi. Umuthi ubonwa kahle ngumzimba wezingane obuthakathaka futhi usiza ekululameni ngokushesha.
